Star amphipathic polyurethane and preparation method thereof
An amphiphilic, polyurethane technology, applied in the field of polyurethane, can solve the problems of increasing toxicity, not involving star-shaped amphiphilic polyurethane, etc., and achieve the effects of reducing toxic side effects, excellent biodegradability, and improving drug loading rate
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Embodiment 1
[0026] A star amphiphilic polyurethane and a preparation method thereof. The preparation process of the preparation method is carried out under the conditions of 50-85°C, nitrogen protection and stirring, and the specific steps are:
[0027] Step 1: first mix polyester diol and diisocyanate, stir for 1-6 hours, then add polyethylene glycol monomethyl ether, and continue stirring for 1-7 hours to obtain a linear polyurethane prepolymer. in:
[0028] The mass ratio of polyethylene glycol monomethyl ether and polyester diol is 1: (1~5);
[0029] The mass ratio of polyethylene glycol monomethyl ether to diisocyanate is 1: (0.03-0.21).
[0030] Step 2: adding polyhydric alcohol into the linear polyurethane prepolymer, and continuing to stir for 1-5 hours to obtain star-shaped amphiphilic polyurethane. Wherein: the mass ratio of polyethylene glycol monomethyl ether to polyhydric alcohol is 1: (0.006~0.02).
[0031] In this embodiment: the polyester diol is polyca...
Embodiment 2
[0033] A star amphiphilic polyurethane and a preparation method thereof. The preparation process of the preparation method is carried out under the conditions of 50-85°C, nitrogen protection and stirring, and the specific steps are:
[0034] Step 1: firstly add polyester diol and diisocyanate into an aprotic solvent, stir for 1-6 hours, then add polyethylene glycol monomethyl ether, and continue stirring for 1-7 hours to obtain a linear polyurethane prepolymer. in:
[0035] The mass ratio of polyethylene glycol monomethyl ether and polyester diol is 1: (1~5);
[0036] The mass ratio of polyethylene glycol monomethyl ether to diisocyanate is 1: (0.03~0.21);
[0037] The mass ratio of polyethylene glycol monomethyl ether to the aprotic solvent is 1: (0.5-2).
[0038] Step 2: adding polyhydric alcohol into the linear polyurethane prepolymer, and continuing to stir for 1-5 hours to obtain star-shaped amphiphilic polyurethane. Wherein: the mass ratio of polyethylene...
Embodiment 3
[0041] A star amphiphilic polyurethane and a preparation method thereof. The preparation process of the preparation method is carried out under the conditions of 70-100°C, nitrogen protection and stirring, and the specific steps are:
[0042] Step 1: firstly add polyester diol and diisocyanate into an aprotic solvent, stir for 4-10 hours, then add polyethylene glycol monomethyl ether, and continue stirring for 5-10 hours to obtain a linear polyurethane prepolymer. in:
[0043] The mass ratio of polyethylene glycol monomethyl ether and polyester diol is 1: (5~10);
[0044] The mass ratio of polyethylene glycol monomethyl ether to diisocyanate is 1: (0.21~2.70);
[0045] The mass ratio of polyethylene glycol monomethyl ether to the aprotic solvent is 1: (2-5).
[0046] Step 2: adding polyhydric alcohol into the linear polyurethane prepolymer and continuing to stir for 3-7 hours to obtain star-shaped amphiphilic polyurethane. Wherein: the mass ratio of polyethylen...
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