Star amphipathic polyurethane and preparation method thereof

An amphiphilic, polyurethane technology, applied in the field of polyurethane, can solve the problems of increasing toxicity, not involving star-shaped amphiphilic polyurethane, etc., and achieve the effects of reducing toxic side effects, excellent biodegradability, and improving drug loading rate

Inactive Publication Date: 2015-07-15
WUHAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

"Star-shaped multi-arm PLGA / PEG amphiphilic block copolymer and its application" (CN 102464874 A) patent technology, although it involves the synthesis of star-shaped multi-arm amphiphilic block copolymer, but this material does not contain carbamate repeat unit
Therefore, the above research on biomedical materials has the following deficiencies: the introduction of some metal catalysts increases the toxicity of the material to human cells; the synthesis of star-shaped amphiphilic polyurethane is not involved

Method used

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  • Star amphipathic polyurethane and preparation method thereof

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Embodiment 1

[0026] A star amphiphilic polyurethane and a preparation method thereof. The preparation process of the preparation method is carried out under the conditions of 50-85°C, nitrogen protection and stirring, and the specific steps are:

[0027] Step 1: first mix polyester diol and diisocyanate, stir for 1-6 hours, then add polyethylene glycol monomethyl ether, and continue stirring for 1-7 hours to obtain a linear polyurethane prepolymer. in:

[0028] The mass ratio of polyethylene glycol monomethyl ether and polyester diol is 1: (1~5);

[0029] The mass ratio of polyethylene glycol monomethyl ether to diisocyanate is 1: (0.03-0.21).

[0030] Step 2: adding polyhydric alcohol into the linear polyurethane prepolymer, and continuing to stir for 1-5 hours to obtain star-shaped amphiphilic polyurethane. Wherein: the mass ratio of polyethylene glycol monomethyl ether to polyhydric alcohol is 1: (0.006~0.02).

[0031] In this embodiment: the polyester diol is polyca...

Embodiment 2

[0033] A star amphiphilic polyurethane and a preparation method thereof. The preparation process of the preparation method is carried out under the conditions of 50-85°C, nitrogen protection and stirring, and the specific steps are:

[0034] Step 1: firstly add polyester diol and diisocyanate into an aprotic solvent, stir for 1-6 hours, then add polyethylene glycol monomethyl ether, and continue stirring for 1-7 hours to obtain a linear polyurethane prepolymer. in:

[0035] The mass ratio of polyethylene glycol monomethyl ether and polyester diol is 1: (1~5);

[0036] The mass ratio of polyethylene glycol monomethyl ether to diisocyanate is 1: (0.03~0.21);

[0037] The mass ratio of polyethylene glycol monomethyl ether to the aprotic solvent is 1: (0.5-2).

[0038] Step 2: adding polyhydric alcohol into the linear polyurethane prepolymer, and continuing to stir for 1-5 hours to obtain star-shaped amphiphilic polyurethane. Wherein: the mass ratio of polyethylene...

Embodiment 3

[0041] A star amphiphilic polyurethane and a preparation method thereof. The preparation process of the preparation method is carried out under the conditions of 70-100°C, nitrogen protection and stirring, and the specific steps are:

[0042] Step 1: firstly add polyester diol and diisocyanate into an aprotic solvent, stir for 4-10 hours, then add polyethylene glycol monomethyl ether, and continue stirring for 5-10 hours to obtain a linear polyurethane prepolymer. in:

[0043] The mass ratio of polyethylene glycol monomethyl ether and polyester diol is 1: (5~10);

[0044] The mass ratio of polyethylene glycol monomethyl ether to diisocyanate is 1: (0.21~2.70);

[0045] The mass ratio of polyethylene glycol monomethyl ether to the aprotic solvent is 1: (2-5).

[0046] Step 2: adding polyhydric alcohol into the linear polyurethane prepolymer and continuing to stir for 3-7 hours to obtain star-shaped amphiphilic polyurethane. Wherein: the mass ratio of polyethylen...

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Abstract

The invention relates to star amphipathic polyurethane and a preparation method thereof. According to the technical scheme, the preparation method, which is performed at 50-100 DEG C in the presence of nitrogen gas under a stirring condition, comprises the following steps: adding polyester diol and diisocyanate into a non-proton solvent, stirring for 1-10 hours, then, adding methoxy polyethylene glycol and further stirring for 1-10 hours to obtain linear polyurethane prepolymer; and then, adding polyalcohol into the linear polyurethane prepolymer and further stirring for 1-7 hours to obtain the star amphipathic polyurethane. According to the star amphipathic polyurethane and the preparation method thereof, the raw material source is rich and the preparation process is simple; the prepared star amphipathic polyurethane has the characteristics of good biocompatibility, excellent biodegradability, relatively small critical micelle concentration and relatively high medicine-carrying capacity, and can achieve efficient, low-toxic and sustained-release effects while being used as a medicine carrier.

Description

technical field [0001] The invention belongs to the technical field of polyurethane. It specifically relates to a star-shaped amphiphilic polyurethane and a preparation method thereof. Background technique [0002] Since the beginning of the 21st century, with people's attention to life sciences, nano-drug delivery systems have increasingly become a research hotspot, and amphiphilic biodegradable polymer materials as drug delivery carriers have attracted widespread attention. The amphiphilic polymer used as a drug carrier is composed of a hydrophobic segment and a hydrophilic segment. This material can be self-assembled in an aqueous solvent. Under the action of molecular force, it associates inwardly to form a tight inner core, and the hydrophilic segments are arranged in an orderly manner outside the inner core due to the hydrophilic effect, forming a micellar structure spontaneously. And its hydrophilic segment can stabilize and protect the micelles, thereby improvi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/66C08G18/42C08G18/32C08G18/34C08G18/10A61K47/34
Inventor 周瑜王士海庄波陈红祥
Owner WUHAN UNIV OF SCI & TECH
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