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Responsive drug-release microneedle patch and preparation method thereof

A responsive, microneedle patch technology, applied in microneedles, drug delivery, pharmaceutical formulations, etc., can solve the problems of microneedle patches that cannot be administered continuously, lack of drug transdermal efficiency, etc., to improve drug loading capacity, Easy to insert into the human body and improve the effect of treatment

Pending Publication Date: 2020-11-20
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The sandwich layer between the needle tip and the base of this technical solution can be loaded with a large amount of solid powder drug, which greatly increases the drug loading capacity of the microneedle patch, but there are still shortcomings in drug sustained release.
[0005] In summary, the prior art still lacks a microneedle patch that can solve the problems of low drug transdermal efficiency and unsustainable drug delivery.

Method used

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  • Responsive drug-release microneedle patch and preparation method thereof
  • Responsive drug-release microneedle patch and preparation method thereof
  • Responsive drug-release microneedle patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A microneedle patch for responsive release of drug-loaded methotrexate, comprising the following steps:

[0035] (1) Polydimethylsiloxane (PDMS) and Sylgard 184The PDMS curing agent is mixed and stirred evenly in a mass ratio of 10:1, and then poured on the microneedle template, the length of the needle tip is 600 μm, the length of the base is 600 μm, and the distance between two adjacent needle tips is 500 μm, and then - Vacuum at 0.09Mpa for 30 minutes to remove air bubbles, dry in an oven at 80°C for 5 hours to solidify and form, and separate the microneedle template after cooling at room temperature to obtain a microneedle array mold;

[0036] (2) First prepare the functional polymer, dissolve 100mg of hyaluronic acid in the mixed solution of water and DMF, the volume ratio of water and DMF is 3:2, then add 22mg of 3-aminophenylboronic acid, 70mg of 4-(4,6 -Dimethoxytriazin-2-yl)-4-methylmorpholine hydrochloride, under stirring conditions, adjust the pH to 6.5, rea...

Embodiment 2

[0039] A microneedle patch for responsive release of drug-loaded methotrexate, comprising the following steps:

[0040] (1) Polydimethylsiloxane (PDMS) and Sylgard 184 Mix and stir the PDMS curing agent in a mass ratio of 8:1, then pour it on the microneedle template, the length of the needle tip is 600 μm, the length of the base is 600 μm, and the distance between two adjacent needle tips is 500 μm, and then - Vacuum at 0.09Mpa for 30 minutes to remove air bubbles, dry in an oven at 80°C for 5 hours to solidify and form, and separate the microneedle template after cooling at room temperature to obtain a microneedle array mold;

[0041] (2) First prepare the functional polymer, dissolve 100mg chitosan oligosaccharide in 10ml water, then add 22mg 3-aminophenylboronic acid, 70mg 4-(4,6-dimethoxytriazin-2-yl)- 4-Methylmorpholine hydrochloride, under stirring conditions, adjust the pH to 6.5, react for 24 hours, dialyze with deionized water for 3 days after the reaction, and use...

Embodiment 3

[0044] A microneedle patch for responsive release of drug-loaded methotrexate, comprising the following steps:

[0045] (1) Polydimethylsiloxane (PDMS) and Sylgard 184 The PDMS curing agent is mixed and stirred evenly in a mass ratio of 10:1, and then poured on the microneedle template, the length of the needle tip is 600 μm, the length of the base is 600 μm, and the distance between two adjacent needle tips is 500 μm, and then - Vacuum at 0.09Mpa for 30 minutes to remove air bubbles, dry in an oven at 80°C for 5 hours to solidify and form, and separate the microneedle template after cooling at room temperature to obtain a microneedle array mold;

[0046] (2) First prepare the functional polymer, dissolve 100mg of hyaluronic acid in 10ml of water, then add 35mg of 3-aminomethylphenylboronic acid, 70mg of 4-(4,6-dimethoxytriazin-2-yl) -4-Methylmorpholine hydrochloride, under stirring conditions, adjust the pH to 6.5, react for 24 hours, dialyze with deionized water for 3 days...

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Abstract

The invention belongs to the field of biomedical materials, and specifically relates to a responsive drug-release microneedle patch and a preparation method thereof. The microneedle patch provided bythe invention comprises a needle tip and a base, wherein the base extends outwards in the direction of the needle tip to form a column base; the needle tip is located on the column base and comprisesresponsive cross-linked macromolecules, drugs and bioactive macromolecules; the responsive cross-linked macromolecules and the bioactive macromolecules are subjected to a cross-linking reaction to generate a response group and then wrap the drugs; and the response group can be decrosslinked under the triggering of active oxygen to release the drugs. According to the invention, the drug-carrying needle tip can be left in the skin through separation of the needle tip and the base, and programmed release of the drugs can be achieved through wrapping of the drugs with the responsive cross-linked macromolecules of the needle tip, so the purpose of continuous treatment is achieved, and the treatment effect is improved.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a method for preparing a responsive drug release microneedle patch. Background technique [0002] Biological psoriasis is an autoimmune disease that usually presents with red, dry, itchy, scaly plaques that are difficult to clear away, hence the name "cancer that never dies." Commonly used treatment methods include topical therapy (glucocorticoids / tretinoin / vitamin D3 analogues), systemic therapy (methotrexate / cyclosporin / eprashit), phototherapy, biological therapy (etanercept / adalimumab), etc., but these current treatment methods all have different degrees of shortcomings. Local treatment often uses the method of smearing, which is suitable for mild to moderate psoriasis, but the disease is prone to relapse, and the efficiency of drugs penetrating the stratum corneum is poor. The utilization rate is low; systemic treatment is usually oral or intravenous injecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K45/00A61K47/69A61K47/54A61K47/36
CPCA61K9/0021A61K45/00A61K47/36A61M37/0015A61M2037/0053A61K47/54A61K47/6957
Inventor 毕舵航付阳雪刘奕静朱锦涛张连斌
Owner HUAZHONG UNIV OF SCI & TECH
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