Polymer microneedle patch for treating acne and preparation method of polymer microneedle patch

A technology of microneedle patch and polymer, which is applied in the direction of microneedles, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of high cost and drug resistance of new antibiotics, and achieve the preparation method Simple and reasonable, easy to separate, enhance the effect of treatment effect

Active Publication Date: 2021-07-23
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since finding new antibiotics is very costly, it can also lead to further resistance

Method used

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  • Polymer microneedle patch for treating acne and preparation method of polymer microneedle patch
  • Polymer microneedle patch for treating acne and preparation method of polymer microneedle patch
  • Polymer microneedle patch for treating acne and preparation method of polymer microneedle patch

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Embodiment

[0030] Embodiment, the present invention is used for the polymer microneedle patch of treating acne and its preparation

[0031] Such as figure 1 As shown, the polymer microneedle patch for treating acne of the present invention consists of a base 1 and a needle point 2. The base 1 is a cuboid with a length of 10 cm, a width of 10 cm, and a height of 2 cm; It is a cone, evenly distributed on the base 1 , with a diameter of 300 μm, a height of 600 μm, and a pitch of 600 μm.

[0032] The needle tip is made of bioactive polymer compound, houttuyfonate sodium and erythromycin according to the following mass ratio.

[0033] group Carboxymethyl chitosan (mg) Sodium Houttuyniatin (mg) Erythromycin (mg) Example 1 600 75 150 Example 2 480 80 160 Example 3 600 60 180

[0034] Preparation method: S1. Synthesis of carboxymethyl chitosan: Suspend 10 g of chitosan in 75 mL of isopropanol, add 5 mL of 10 mg / mL NaOH solution every 5 min at 25 ° C,...

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Abstract

The invention belongs to the field of biomedical materials, and particularly discloses a polymer microneedle patch for treating acne and a preparation method of the polymer microneedle patch. The polymer microneedle patch is composed of a base and needle tips, the base is a cuboid, the needle tips are cones and are evenly distributed on the base, and the needle tips comprise bioactive high-molecular compounds, sodium houttuyfonate and erythromycin. Through the interaction between drugs and the bioactive high-molecular compounds, drug release can be effectively controlled, by combined use of the sodium houttuyfonate and the erythromycin, generation of drug resistance of propionibacterium acnes can be effectively prevented, the treatment effect of the acne is enhanced, meanwhile, the needle tips and the base are separated to achieve the effect that the drug-loaded needle tips are left in the skin, the drugs can achieve programmed release of the drugs, and the effect of treating the acne is further improved.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a polymer microneedle patch for treating acne and a preparation method thereof. Background technique [0002] Acne is a chronic inflammatory skin disease of the pilosebaceous unit, which is prone to occur on the face and upper body, forming pleomorphic skin lesions such as blackheads, papules, pustules, and nodules. The disease often occurs in adolescence and is one of the most common diseases affecting more than 80-85% of the world's population. The high incidence of acne has caused the long-term and widespread use of antibiotics, resulting in increased bacterial resistance, which has brought social damage. economic burden. Acne has a long course of disease, is easy to recur, sometimes mild and sometimes severe, and some patients often have persistent pigmentation spots, sunken or hypertrophic scars after the skin lesions subside. Different degrees of psychologi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/61A61K31/7048A61M37/00A61P17/10A61P31/04A61K31/185
CPCA61K9/0021A61K47/61A61K31/185A61K31/7048A61P17/10A61P31/04A61M37/0015A61M2037/0053A61M2037/0046A61K2300/00
Inventor 卢雪梅陈睛汝桂水清金小宝
Owner GUANGDONG PHARMA UNIV
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