Docetaxel-loading mixed micelle preparation and preparation method thereof

A technology for loading docetaxel and docetaxel, which is applied in the field of docetaxel-loaded mixed micelle preparation and its preparation, can solve the problems of low bioavailability, increase drug loading, solve poor water solubility, and clinical drug use convenient effect
CN102885772AInactive Publication Date: 2013-01-23SHANDONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANDONG UNIV
Publication Date
2013-01-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a docetaxel-loading mixed micelle preparation and a preparation method thereof. The mixed micelle preparation is prepared by the following steps of: preparing docetaxel mixed micelle by using a thin-film dehydration method; and coating the docetaxel with hydrophobic nuclei by taking amphiphilic TPGS, MPEG-PLA and CSO-SA as carrier materials of the mixed micelle. The docetaxel-loading mixed micelle preparation is prepared by using the amphiohilic materials of TPGS, MPEG-PLA and CSO-SA, so that drug-loading rate is increased, solubility and oral bioavailability are improved, and the problems of poor water solubility, low medicine release speed, improper particle size and the like when hydrophilic medicines are prepared are solved.
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Description

technical field

[0001] The invention relates to a docetaxel-loaded mixed micelle preparation and a preparation method thereof. Background technique

[0002] Docetaxel (DTX), also known as docetaxel, is a new type of antineoplastic drug developed in recent years, and it is the second-generation synthetic drug of paclitaxel. The mechanism of action of docetaxel is similar to that of paclitaxel, and its anti-tumor activity is 1.3-12 times that of paclitaxel. It plays an anti-tumor effect by interfering with the microtubule network necessary for cell function during cell mitosis and division. Docetaxel can bind to free tubulin, promote the assembly of tubulin into stable microtubules, and inhibit its depolymerization, resulting in the loss of normal function of microtubule bundles and the fixation of microtubules, thereby inhibiting cell mitosis . It is clinically used in breast cancer, pancreatic cancer, non-small cell lung cancer, soft tissue sarcoma, head and neck cancer, g...

Claims

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