2-(9-methylene anthracene) thiosemicarbazide and TAT modified gold nanoparticle drug delivery system and application

A technology of methylene anthracene and thiosemicarbazide, which is applied in the field of biomedicine, can solve problems such as the application limitation of chemotherapeutic drugs, and achieve the effects of good biocompatibility, low cytotoxicity and enhanced Raman signal.
CN106983732AInactive Publication Date: 2017-07-28CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Publication Date
2017-07-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a 2-(9-methylene anthracene) thiosemicarbazide and TAT modified gold nanoparticle drug delivery system. The 2-(9-methylene anthracene) thiosemicarbazide and TAT modified gold nanoparticle drug delivery system has the advantages that a gold nanosphere drug delivery system with the particle size being 3.8nm (sodium borohydride reduction method) and a gold nanosphere drug delivery system with the particle size being 22.1nm (sodium citrate reduction method) are built, the surfaces of the systems are modified with polypeptide TAT, the systems modified by the polypeptide TAT are used as the carriers of 2-(9-methylene anthracene) thiosemicarbazide, the fact that the drug-resistance index of large-particle-size gold nanospheres to drug-resistance cells is smaller is discovered through the antitumor activity evaluation of MCF-7 sensitive cells and MCF-7 / ADR drug-resistance cells, and the fact shows that large-particle-size carriers are more suitable for tumor drug resistance treatment and the 22.1nm gold nanospheres have an enhancing effect on the Raman signal of the 2-(9-methylene anthracene) thiosemicarbazide and can be used for cellular-level Raman imaging.
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Description

technical field

[0001] The invention relates to the field of biomedicine, in particular to a 2-(9-methyleneanthracene) thiosemicarbazide and TAT-modified gold nanometer drug-carrying system and its application. Background technique

[0002] Due to unique physical and chemical properties, such as local surface plasmon resonance, good biocompatibility, and simple and effective surface modification, gold nanoparticles have received extensive attention. They are widely used in biosensors, drug delivery, and tumor targeting. Diagnosis and treatment and other fields have shown great application potential and prospects.

[0003] RGRKKRRQRRR is a classic cell membrane-penetrating peptide derived from HIV-1 TAT protein, which is rich in arginine (amino group). The high density of positive charges enables it to interact strongly with the head group of phospholipids, thereby being able to pass through the cell membrane , so it is widely used in the construction of nano-drug loading sy...

Claims

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