49 results about "Gold nanospheres" patented technology

The invention discloses composite gel with ROS and pH dual responsiveness and a preparation method and application thereof.The preparation method comprises the steps that gold nanoparticles are prepared, gold nanostars GNS grow, a surfactant and biguanide drugs are added to obtain drug-loaded gold nanostars GM, a metal organic framework is introduced to obtain drug-loaded nanoparticles GMZ of a core-shell structure, and the composite gel is prepared. And reacting with a TSPBA solution, an astaxanthin solution and a polyvinyl alcohol PVA solution for crosslinking to obtain the ROS and pH dual responsive composite gel. According to the invention, the gold nanostars are used as a photosensitizer to construct the multifunctional composite gel, and the metal organic framework structure degrades under a slightly acidic condition of a psoriasis epithelium microenvironment to release released zinc ions, so that the gel is endowed with various treatment effects, excellent photo-thermal treatment performance and controlled release performance of the zinc ions and drugs. The gel has ROS responsiveness, can remove excessive ROS in a psoriasis microenvironment, and realizes the treatment of oxidation resistance, inflammation resistance and keratinocyte proliferation inhibition of psoriasis by combining with a nano drug delivery system.

The invention belongs to the technical field of SERS (Surface Enhanced Raman Scattering) substrate preparation, and particularly relates to an optimized preparation method of a high-stability composite nanostructure SERS substrate, which comprises the following steps: obtaining three-dimensional morphology characteristic data of a nano rough surface; establishing an overall physical model of the composite substrate by utilizing simulation software, setting material attributes and initial conditions of simulation, dividing grids, and carrying out solution calculation; processing parameters are selected, and a transition metal oxide TiO2 nano rough surface is prepared; the method comprises the following steps: combining an ultrasonic field with a laser ablation method, and compounding gold nanosphere particles on a transition metal oxide TiO2 nano rough surface, so as to obtain a composite nanostructure SERS (Surface Enhanced Raman Scattering) substrate; and evaluating the SERS activity through a Raman spectrum to complete the preparation of the substrate. According to the method, contact points of the gold nanospheres and the surface can be increased, so that a nano narrow slit structure on the substrate is increased, and the'hot spot 'density and the detection intensity of the SERS substrate are further improved.

The invention discloses a microbial fermentation real-time monitoring and molecular analysis method based on a single-cell Raman spectrum technology. The method comprises the following steps: firstly, preparing basic gold nanospheres which are microcosmically spherical and have the particle size distribution of 20-40 nm through a chloroauric acid oxidation reduction method, and characterizing the morphology of the basic gold nanospheres; secondly, the surface of the basic gold nanosphere is coated with a silicon dioxide thin layer through tetraethoxysilane hydrolysis and polymerization reaction, and the silicon dioxide functionalized gold nanosphere with the core-shell structure is prepared to serve as the microorganism living cell probe. The probe and different microbial cells are co-cultured, Raman fingerprint spectrums of the cells are sensitively captured, the single-cell Raman fingerprint spectrums are deeply analyzed by adopting a machine learning technology, and differential analysis (including strain difference, environment difference, metabolic capability difference and the like) is combined to determine the single-cell Raman fingerprint spectrums of the cells. Molecular indexes of specific expression of the microbial cells in different industrial production processes and different culture periods are screened out. The invention provides a universal tool for accurately realizing real-time monitoring and molecular analysis of microbial cells in different industrial processes, and has a wide industrial application prospect.

This invention relates to the field of food testing technology, and more particularly to a colorimetric LAMP method for the simultaneous visual detection of Vibrio vulnificus and Vibrio alginolyticus. The method employs a LAMP detection system composed of DNA-functionalized gold nanospheres and gold nanorods for detecting Vibrio vulnificus and Vibrio alginolyticus, respectively, and LAMP primer pairs. This allows for the detection and determination of the following states of Vibrio vulnificus and Vibrio alginolyticus: when neither pathogen is present, the solution is transparent; when both pathogens are present, the solution is purplish-red; when only Vibrio alginolyticus is present, the solution is gray; and when only Vibrio vulnificus is present, the solution is purple. This method can accurately determine the presence or absence of Vibrio vulnificus and Vibrio alginolyticus, and the specific type of bacteria, avoiding misjudgments, missed detections, and inaccurate traceability of these two types of pathogen contamination in food safety monitoring, clinical practice, and aquaculture protection.

A rapid, ultrasensitive and inexpensive nanoplasmon-enhanced scattering (nPES) assay that directly quantifies tumor-derived EVs from as little as 1 μL of plasma is described herein. This assay uses binding of gold nanospheres and nanorods with EV- and tumor-derived EV-specificities to produce a local plasmon effect that enhances tumor-derived EV detection sensitivity and specificity. This nPES approach is also a non-invasive method for assessing pancreatic cancer stage and treatment response that can be easily refined for clinical use, and is readily adapted for diagnosis and monitoring of other conditions with disease-specific EV proteins.

The invention discloses a core-shell-satellite SERS (Surface Enhanced Raman Scattering) composite substrate with a copper-doped MOF (Metal Organic Framework) shell layer and a preparation method of the core-shell-satellite SERS composite substrate. According to the composite substrate, gold and silver nanoparticles are used as a core, a copper ion-doped MOF material is used as a shell, and gold nanospheres grown on the surface of the copper ion-doped MOF material are used as satellites; wherein the gold and silver nanoparticles comprise gold nanoparticles and silver layers wrapping the gold nanoparticles; the MOF material doped with the copper ions is a ZIF-8 material doped with the copper ions. The preparation method disclosed by the invention is low in energy consumption, simple to operate and high in efficiency, the synthesized nanostructure has the advantages of uniform structure and size, economy, effectiveness and good stability, the comprehensive performance of chemical enhancement and electromagnetic enhancement is good, and more accurate and sensitive detection results can be provided for subsequent SERS (Surface Enhanced Raman Scattering) detection.

The present invention relates to gold nanoparticles capable of loading aromatic drugs, and their preparation and application, belonging to the field of biomedicine technology. The gold nanoparticles of the present invention comprise gold nanospheres, 4-mercaptobenzoic acid ligands, and methoxy-terminated polyethylene glycol-amino groups, wherein the gold nanospheres, 4-mercaptobenzoic acid ligands, and methoxypolyethylene glycol are sequentially connected by chemical bonds; wherein the core diameter of the gold nanoparticles is less than 3 nm and the hydrodynamic diameter is less than 6 nm. The gold nanoparticles of the present invention can improve the activity and bioavailability of the aromatic drugs loaded thereon. The gold nanoparticles are small in size and can be cleared from the body by the kidneys, avoiding capture by the liver and reducing nonspecific uptake by other organs, thereby improving drug bioavailability while reducing side effects.

The present invention relates to the field of binary precious metal nanomaterials, and in particular to a gold-silver nanoarray and its preparation method and pattern anti-counterfeiting application. After sputtering and depositing a gold film on a monolayer polystyrene microsphere template, the present invention obtains a gold nanosphere array by high-temperature calcination, and then uses AMBI to modify the surface of the gold nanosphere array. The AMBI ligand is anchored to the surface of the gold nanosphere through the Au-S bond, so that the interface energy on the surface of the gold nanosphere is increased, helping silver ions to overcome the electrostatic potential well resistance between the substrate (Si) and the gold nanosphere and nucleate and further grow on the surface of the gold nanosphere. By changing the type of reducing agent, the morphology of silver nanoparticles is regulated to obtain gold-silver nanoarrays with different silver nanoparticle morphologies. The gold-silver nanoarray prepared by the present invention can be used as an information carrier in fields such as information anti-counterfeiting. The present invention solves the technical problems of high cost, difficult directional control, and complex reaction kinetics of existing gold-silver nanoarray material preparation methods.

The invention belongs to the field of preparation of organic-inorganic hybrid materials, and relates to a preparation method and application of cucurbit [n] uril-gold nanoparticles. Through a simple one-pot synthesis method, chloroauric acid, silver nitrate, a reducing agent and cucurbit [n] uril are added for co-reduction to prepare hollow gold nanoflowers; the gold nanospheres with different sizes are prepared by regulating and controlling the input amount of cucurbit [n] uril. The gold nanoparticle hybrid material shows excellent hydrogen evolution side reaction inhibition capability in the application of electro-catalysis CO2 reduction, and the CO selectivity is obviously improved.

The invention discloses a preparation method of a binary organic-inorganic ordered capsule structure. The preparation method of the binary capsule structure comprises the following steps: firstly, synthesizing gold nanocubes and gold nanospheres by using a tetrachloroauric acid trihydrate solution; then, grafting polystyrene on the surfaces of the gold nanocubes and the gold nanospheres; and finally, preparing the binary organic-inorganic ordered capsule structure by adopting an emulsion interface limited assembly method. By adjusting the molecular weight of the polymers on the surfaces of the two inorganic nanoparticles, the spacing, arrangement and orientation of the two nanoparticles can be effectively regulated and controlled.

The application provides a silver nanowire-graphene-gold nanosphere composite SERS substrate and a preparation method thereof, and belongs to the technical field of organic contaminant detection. The substrate comprises a substrate, a silver nanowire layer coated on the substrate, and a gold nanosphere layer located at the uppermost layer; wherein a graphene film and mercaptan are coated between the silver nanowire layer and the gold nanosphere layer; the coverage of the silver nanowire layer on the substrate is 60%-80%; and the adhesion rate of the gold nanosphere layer to the graphene film is 50%-70%. In the SERS substrate provided by the application, graphene and mercaptan are added, PAHs in a solution are synergistically adsorbed through π-π stacking and hydrophobic effects, and polycyclic aromatic hydrocarbon molecules are effectively adsorbed to the surface of the SERS substrate, so that the detection effect of the polycyclic aromatic hydrocarbon molecules is further improved.

This invention discloses an internal standard-assisted petal-shaped SERS nanoprobe, its preparation method, and its applications. The internal standard-assisted petal-shaped SERS nanoprobe of this invention is a core-molecule-shell structure gold nanoprobe consisting of a gold nanosphere core, an internal standard modifying molecule, a petal-shaped gold nanoshell, and a recognition molecule, 4-nitrobenzenethiophenol. The internal standard modifying molecule is a Raman signal molecule with nitrile, alkyne, or azide functional groups. This invention uses a Raman signal molecule as an internal standard modifying molecule to modify the gold nanosphere core. The corrected working curve exhibits good reproducibility and small error, improving the reliability of the detection results. Growing a petal-shaped gold nanoshell on the molecular layer of the internal standard modifying molecule enhances the SERS activity both inside and outside the SERS substrate, and the petal-shaped shell increases the surface area of ​​the SERS substrate. Furthermore, the recognition molecule of this invention enables ratiometric Raman detection of hydrogen sulfide, effectively reducing background signal interference and improving detection sensitivity.

The application discloses a construction method of a nano probe with an antenna structure, and comprises the following steps: S1, placing short primer probe thiol-modified P1 solution and lock probe P-circle solution in 90-95 DEG C respectively, heating for 5-10 min, and obtaining short chain probe P1 solution and circular secondary structure probe P-circle solution; S2, adding gold nanorods and short chain probe solution into a buffer solution, and obtaining gold nanorod-P1 probe; S3, adding the circular structure probe P-circle solution into a T4PNK buffer solution, and obtaining modified probe P-circle; S4, mixing the gold nanorod-P1 probe with the modified probe P-circle, and obtaining a composite probe; S5, mixing the composite probe with the buffer solution, adding primer probe P2, placing in 37 DEG C for incubation for 2 h, adding gold nanosphere particles, and incubating for 8 h, so that the nano probe is obtained.

This invention provides peony-shaped gold nanoparticles with an uneven core-shell structure, their preparation method, and applications. We first prepare 50 nm diameter gold nanospheres, then add HAuCl₄, and perform centrifugation and stirring to finally obtain the target product. This structure significantly improves surface roughness and increases the distribution density of electromagnetic "hot spots" while ensuring good particle stability, thereby enhancing the sensitivity of the SERS signal.

The application discloses a flexible enzyme glucose sensor capable of in-vitro detection, which comprises a flexible substrate and an electrode system arranged on the flexible substrate, the electrode system comprising a working electrode, a counter electrode and a reference electrode, a functional layer formed by compounding amino-graphene quantum dots and hollow gold nanospheres is modified on the working electrode, and glucose oxidase immobilized by chitosan is further modified on the functional layer. The sensor has a good linear relationship in the range of 50 muM to 1.4 mM, has the advantages of high sensitivity and good stability, and can be used for detecting urine glucose.

The invention belongs to the field of integrated optics, and particularly relates to an enhanced waveguide integrated photoelectric detector for an MIR wave band, in the photoelectric detector, a waveguide structure layer is mainly composed of a suspended waveguide in the center and sub-wavelength gratings on the two sides, buried oxide layers are removed below the suspended waveguide and the sub-wavelength gratings in an etching mode and the like, and therefore the photoelectric detector is formed. Forming an air gap; the light in the waveguide interacts with the two-dimensional material layer above through the evanescent field; compared with a traditional two-dimensional material heterogeneous integrated silicon waveguide photoelectric detector working in an NIR wave band, the enhanced waveguide integrated photoelectric detector has high response in the MIR wave band, meanwhile, the gold nanosphere array on the top can further limit a light field to a two-dimensional material layer, the interaction between light and substances is enhanced, and the photoelectric detector has the advantages that the photoelectric detector is simple in structure and convenient to operate. Therefore, the performance of the photoelectric detector is improved, and the influence on waveguide transmission loss is very small and even can be ignored.

A solid aluminum electrolytic capacitor comprises a core package and a shell, and the core package is arranged in the shell in a sealed mode. A conductive high-molecular polymer film is formed in the core package, the conductive high-molecular polymer film comprises PEDOT: PSS, hexadecyl trimethyl ammonium chloride and precious metal nanoparticles, and the precious metal nanoparticles comprise one or more of gold nano bipyramids, gold nanowires, gold nanospheres or silver nanowires; the hexadecyl trimethyl ammonium chloride and the noble metal nanoparticles are uniformly distributed in the PEDOT: PSS, and the total weight of the hexadecyl trimethyl ammonium chloride and the noble metal nanoparticles does not exceed 8% of the weight of the PEDOT: PSS. According to the preparation method, hexadecyl trimethyl ammonium chloride is added into the PEDOT: PSS thin film doped with the noble metal nanoparticles, so that the capacity and the cycling stability of the prepared solid aluminum electrolytic capacitor are further improved.

The invention relates to the field of biological recognition, in particular to a preparation method of a Raman composite substrate material with biological recognition activity, which comprises the following steps: S1, preparing a GO dispersion liquid; s2, gold nanospheres are prepared, and a gold nanosphere solution with OD 0.5 is prepared after purification; s3, respectively preparing a sodium chloride solution, a chloroauric acid solution and a single-stranded DNA solution; s4, mixing and reacting the GO dispersion liquid, the single-stranded DNA solution, NaCl, HAuCl4 and the gold nanosphere solution for 1 hour; s5, adding an NH2OH solution into the mixture prepared in the step S4, and reacting for 3 hours; and S6, centrifuging the reaction product obtained in the step S5, removing the supernatant, washing twice with ultrapure water, and re-suspending in ultrapure water to obtain the Au / DNA / GO composite nanomaterial. According to the invention, the compounding of the GO and the gold nanomaterial and the fixation of the DNA sequence are realized through the gold ion reduction regulated by DNA, the biological recognition activity of the fixed DNA sequence is maintained, and the prepared Raman composite substrate material has a better Raman signal enhancement effect.

An antibacterial nanoparticle (ANP) and related methods and antibacterial medical products are disclosed. An ANP includes a silica core with a plurality of gold nanospheres conjugated thereto and at least some of the gold nanospheres being silver-coated gold nanospheres. Iron oxide nanospheres may also be conjugated to the silica core, and at least some of the silver-coated gold nanospheres, or iron oxide nanospheres, if present, can be conjugated to one or more polycationic polymers and / or one or more antibacterial peptides.

This invention relates to the field of surface-enhanced Raman spectroscopy (SERS) detection technology, and discloses a thiol and graphene-modified SERS composite substrate, its preparation method, and its applications. The composite substrate comprises a substrate, silver nanowires attached to the substrate, a graphene layer, gold nanospheres, and thiols modified on the graphene layer and gold nanospheres. This composite substrate combines gold nanospheres, graphene, and silver nanowires to form a three-dimensional nanostructure of silver nanowires-graphene-gold nanospheres, effectively improving its detection performance. Furthermore, by modifying the three-dimensional nanostructure of silver nanowires-graphene-gold nanospheres with thiol, the resulting composite substrate exhibits high sensitivity for the detection of substances (e.g., organic pollutants). In addition, this invention provides a method for preparing the thiol and graphene-modified SERS composite substrate, which involves solution evaporation and self-assembly. This method is simple and rapid, does not involve expensive instruments, and the solid substrate facilitates storage and handling, making it easy to further promote and apply.

The invention provides a method for accurately measuring plasmon nanocavity-single molecule exciton strong coupling energy level Rabi splitting. The method is used for solving the problem that spectrum splitting measured through experiments is not equivalent to coupling system energy level Rabi splitting. The preparation method comprises the following steps: embedding a single dye molecule into a single CB [7] molecule to prepare a CB [7] at single dye molecule; coupling the CB [7] at single dye molecule with two gold nanospheres to obtain a gold nanosphere dimer (Au ND) / CB [7] at single dye molecule coupling system; the coupling system is transferred to a Si / SiO2 photonic substrate, and the photon mode frequency and line width are regulated and controlled by regulating the thickness of a SiO2 layer, so that the gold nanosphere dimer plasmon resonance line width is effectively regulated and controlled, and the gold nanosphere dimer plasmon resonance line width is matched with the exciton line width. According to the invention, the relative error between the spectral splitting obtained based on the spectral measurement of the single-molecule strong coupling system and the energy level Rabi splitting of the coupling system is reduced to-1.3% from the original-27.3%, so that the measurement error of the energy level Rabi splitting of the single-molecule strong coupling system is greatly reduced, and accurate measurement is achieved.

The application discloses a method for detecting benzaldehyde by using a three-dimensional hot spot SERS substrate, and belongs to the field of nanomaterials and biosensing technology, and the method comprises the following steps: detecting benzaldehyde in a to-be-detected sample by using a three-dimensional hot spot SERS substrate, and determining whether the to-be-detected sample contains benzaldehyde or the content of benzaldehyde in the to-be-detected sample by the change of a Raman characteristic peak before and after detection; the structure of the three-dimensional hot spot SERS substrate comprises a substrate and a gold nanosphere superlattice two-dimensional film attached to the substrate, the gold nanosphere superlattice two-dimensional film is modified with a beta-cyclodextrin-p-aminophenylthiophenol inclusion compound and loaded with gold@gold silver hollow nanorods; the SERS substrate has a three-dimensional hot spot superlattice-hollow rod structure. The method has low detection limit, high selectivity and specificity, and lays a foundation for realizing a high-performance and customizable sensing platform.

The application discloses a Raman determination method for the total flavone content in propolis extract, and comprises the following steps: gold nanospheres, metal-phenolic aldehyde network, epoxy resin and polymethyl methacrylate-microneedle composite detection materials for detecting flavone in propolis are prepared, and a rapid detection method for propolis flavone based on surface-enhanced Raman technology is established in sequence, so that rapid qualitative judgment and quantitative detection of propolis flavone are realized.

The invention provides a hydrothermal preparation method of a hollow CuPt alloy nanocrystal. According to the method, hydrothermal carbon nanospheres formed by hydrothermal decomposition of ascorbic acid are used as templates, hydrothermal carbon in the spheres is consumed by utilizing the Kirkendall effect, the templates are synchronously removed, and the high-purity hollow CuPt alloy nanospheres are obtained through a one-step method. According to the method, a strong reducing agent is not needed, inert gas protection and high-temperature heating treatment are not needed in the whole process, the highest preparation temperature is only 120 DEG C, the energy-saving and environment-friendly characteristics are achieved, and the influence of the preparation process on the environment is remarkably reduced. Application examples show that the obtained hollow CuPt alloy nanocrystal has activity far higher than that of commercial Pt / C on an electro-catalysis formic acid oxidation reaction, and shows excellent stability.

The application discloses an engineered hepatocyte micro-nanorobot and a preparation method and application thereof, and the preparation method comprises the following steps: adding gold nanosphere dispersion liquid drop by drop into isopropyl alcohol, then adding 4-mercapto benzoic acid and polyacrylic acid in sequence and performing reaction, adding tetraethyl orthosilicate and ammonia water and performing reaction, obtaining Au-SiO2 nanoparticles and performing reaction with chloroplatinic acid and ascorbic acid to obtain an intermediate, and performing etching on the intermediate to obtain AP nanorobots; the enucleated hepatocytes expressing CXCR4 are co-incubated with the AP nanorobots functionalized by DSPE-Hyd-PEG-SH polymer; the engineered hepatocyte micro-nanorobot is based on the synergistic mechanism of cell metabolism regulation-nano-physical sensitization, can overcome the radiotherapy resistance of solid tumors, combines specific chemotactic characteristics with radiotherapy, can be targeted to accumulate in tumor tissues, and can effectively reverse the metabolic-driven radiotherapy resistance barrier.

The application belongs to the technical field of surface enhanced Raman scattering spectrum, and particularly discloses a silver nanometer@ZIF-8@gold nanometer composite substrate and a preparation method and application thereof. The silver nanometer@ZIF-8@gold nanometer composite material provided by the application takes the silver nanometer ball with a particle size of 100-400 nm as a core, the silver ball is wrapped with a ZIF-8 film with a thickness of 1-10 nm, and the gold nanometer ball with a particle size of 30-50 nm is attached to the outer layer of the silver core ZIF-8 shell. The excellent material ZIF-8 in the MOF is combined with the two kinds of noble metal materials of gold and silver, and the noble metals form a multiple enhancement effect. Meanwhile, the design of taking the silver nanometer ball as the core, the ZIF-8 as the shell and the gold nanometer ball being uniformly attached to the surface of the core-shell avoids the plugging problem of the noble metal nanometer ball to the MOF material to a certain extent, improves the adsorption performance of the substrate and increases the number of the substrate surface "Raman hot spots", and greatly improves the detection sensitivity of the substrate.

A rapid, ultrasensitive and inexpensive nanoplasmon-enhanced scattering (nPES) assay that directly quantifies tumor-derived EVs from as little as 1 μ{umlaut over ({acute over (ι)})}, of plasma is described herein. This assay uses binding of gold nanospheres and nanorods with EV- and tumor-derived EV-specificities to produce a local plasmon effect that enhances tumor-derived EV detection sensitivity and specificity. This nPES approach is also a non-invasive method for assessing pancreatic cancer stage and treatment response that can be easily refined for clinical use, and is readily adapted for diagnosis and monitoring of other conditions with disease-specific EV proteins.

The invention belongs to the technical field of precious metal nano materials, and particularly relates to a hexagonal gold-platinum nano array material, a preparation method and application of the hexagonal gold-platinum nano array material in the field of hydrogen production through photo / electro-catalysis water decomposition. A structural unit of the Au-Pt nano array is composed of Au nano balls and attached Pt nano particles, and the whole array is distributed in a hexagonal non-close-packed mode. The preparation method comprises the following steps: firstly preparing a hexagonal non-close-packed gold (Au) nanosphere seed array, and then modifying the surfaces of Au nanospheres by using a sulfydryl-containing ligand, so that the sulfydryl-containing ligand is embedded into the surfaces of the Au nanospheres, the interface energy between Au and Pt is effectively regulated and controlled, reduced Pt0 atoms are directionally adsorbed on the surfaces of the Au nanospheres and continuously grow, and finally, the hexagonal non-close-packed Au-Pt nanoarray is prepared. The technical bottleneck of existing Au-Pt nano array preparation is broken through, low-cost, controllable and efficient large-scale preparation is achieved, a universal synthesis strategy is provided, and a foundation is laid for wide application of the material.

The invention discloses a nanogold and petal-shaped cuprous oxide SERS substrate and a preparation method and application thereof, and belongs to the technical field of surface enhanced Raman detection.The method comprises the steps that 1, an anionic surfactant, soluble copper salt and a sodium hydroxide solution are added into a gold nanosphere solution, a reaction is conducted for 10-30 min at the temperature of 25-35 DEG C, then a hydrazine hydrate solution is added, a reaction is conducted for 30-50 min at the temperature of 25-35 DEG C, and a reaction solution is obtained; a nanogold and petal-shaped cuprous oxide solution is obtained; (2) adding a coagulation agent into the nanogold and petal-shaped cuprous oxide solution to obtain a nanogold and petal-shaped cuprous oxide aggregate, dropwise adding the aggregate onto a substrate, and drying to obtain the nanogold and petal-shaped cuprous oxide SERS substrate, the gold nanospheres and petal-shaped cuprous oxide in the SERS substrate are compounded to form a unique morphology, the SERS substrate has physical and chemical dual enhancement effects, and the SERS substrate can be applied to the field of SERS. And the SERS detection effect is good and is obviously superior to that of the core-shell nanogold and cuprous oxide composite structure.

A new seedless synthesis of anisotropic nanoscale gold nanoflower (AuNF) particles uses bidentate thiolate ligands to protect the nanoparticle surface and a combination of reagents (for example, ligand, ascorbic acid, and hydroxide) to synthesis AuNF with controlled size and anisotropic properties. Compared to prior art gold nanospheres, AuNF produced approximately a 15-fold improvement in a drug delivery assay.