Monodisperse hollow gold nanosphere and preparation method and application thereof

A technology of monodispersity and nanospheres, which is applied in the analysis of materials, material analysis through optical means, and measurement devices, etc., can solve the problems of limited use of wide excitation bands, low sensitivity, and high cost, and achieve good uniformity and adjustable wide range of effects

Inactive Publication Date: 2015-02-18
SOUTHEAST UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Monodisperse hollow gold nanosphere and preparation method and application thereof
  • Monodisperse hollow gold nanosphere and preparation method and application thereof
  • Monodisperse hollow gold nanosphere and preparation method and application thereof

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Embodiment 1

[0031] A monodisperse hollow metal nanosphere, the monodisperse hollow metal nanosphere has a monodisperse hollow inner core and a monodisperse metal nano outer layer, the metal nano outer layer is a gold nano layer, and the monodisperse hollow metal nanosphere The core is formed by corroding titanium dioxide nanospheres. The monodisperse hollow cores are 40 nm in diameter. The thickness of the gold nanolayer is 20 nm.

[0032] A preparation method of monodisperse hollow metal nanospheres, comprising the following steps:

[0033] 1) Add 1ml of freshly prepared 1 M sodium hydroxide to 500 ml of water, stir, then add 50 μl tetrakis hydroxymethyl phosphorus chloride, magnetically stir for 2 minutes, then add 5 ml of 1% chloroauric acid into the mixture, magnetically stir 2 nm gold nanoparticles were obtained in 10 minutes, and stored at 4°C in the dark;

[0034] 2) The ethanol suspension of monodisperse titanium dioxide nanospheres was aminated with 100 μl of 3-aminopropyltrie...

Embodiment 2

[0039] A monodisperse hollow metal nanosphere, the monodisperse hollow metal nanosphere has a monodisperse hollow inner core and a monodisperse metal nano outer layer, the metal nano outer layer is a silver nano layer, and the monodisperse The hollow core is formed by etching monodisperse polystyrene nanospheres. The monodisperse hollow cores are 800 nm in diameter. The thickness of the silver nanolayer is 500 nm.

[0040] A preparation method of monodisperse hollow metal nanospheres, comprising the following steps:

[0041] 1) Add 25 ml of freshly prepared 1 M sodium hydroxide to 1000 ml of water, stir, then add 1000 μl tetrakis hydroxymethyl phosphorus chloride, magnetically stir for 20 minutes, then add 100 ml of 1% chloroauric acid into the mixture, magnetically Stir for 50 minutes to obtain 3 nm gold nanoparticles, and store at 4°C in the dark;

[0042] 2) Aminate the ethanol suspension of monodisperse polystyrene nanospheres with 5000 μl of 3-aminopropyltriethoxysilan...

Embodiment 3

[0048] A monodisperse hollow metal nanosphere, the monodisperse hollow metal nanosphere has a monodisperse hollow inner core and a monodisperse metal nano outer layer, the metal nano outer layer is a copper nano layer, and the monodisperse The hollow core is formed by etching monodisperse silica nanospheres. The monodisperse hollow cores are 400 nm in diameter. The thickness of the copper nanolayer is 250 nm.

[0049] A preparation method of monodisperse hollow metal nanospheres, comprising the following steps:

[0050] 1) Add 12 ml of freshly prepared 1 M sodium hydroxide to 720 ml of water, stir, then add 500 μl tetrakis hydroxymethyl phosphorus chloride, magnetically stir for 10 minutes, then add 50 ml of 1% chloroauric acid into the mixture, magnetically Stir for 30 minutes to obtain 2 nm gold nanoparticles, and store at 4°C in the dark;

[0051] 2) Aminate the ethanol suspension of monodisperse silica nanospheres with 2500 μl of 3-aminopropyltriethoxysilane by stirring...

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Abstract

The invention discloses a monodisperse hollow gold nanosphere which is provided with a monodisperse hollow kernel and a monodisperse gold nano outer layer, wherein the monodisperse gold nano outer layer is one or more of a gold nano layer, a silver nano layer, a copper nano layer and a platinum nano layer; the monodisperse hollow kernel is formed by eroding a monodisperse organic or inorganic nanosphere. Compared with a conventional hollow gold nanosphere, the hollow gold nanosphere disclosed by the invention is high in monodispersity. Therefore, an SERS (surface enhanced raman scattering) probe prepared by the hollow gold nanosphere with high monodispersity has immunoassay characteristics of extremely high uniformity, sensitivity and repetitiveness. High-precision quantitative detection is facilitated during quantitative analysis of biological markers.

Description

technical field [0001] The invention relates to the technical field of preparation of enhanced Raman materials, more specifically, to a monodisperse hollow gold nanosphere and its preparation method and application. Background technique [0002] In the research and application of immunoassays based on surface-enhanced Raman scattering (SERS) detection, hollow metal nanoparticles are often used as SERS-labeled probes to construct sandwich immunoassays with high sensitivity, uniformity, and signal reproducibility. Ultrasensitive detection for common tumor markers can provide a lot of useful diagnostic data. Previously prepared hollow metal nanospheres usually use cobalt nanospheres as cores and grow gold shells on the surface; then remove the cobalt nanocores to obtain hollow metal nanospheres. However, since the current cobalt nanosphere preparation technology cannot realize the preparation of monodisperse cobalt nanospheres, this method cannot obtain uniform hollow gold nan...

Claims

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Application Information

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IPC IPC(8): G01N33/577
CPCG01N33/54313G01N21/658G01N33/531
Inventor 董健郭明德谢溦钱卫平
Owner SOUTHEAST UNIV
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