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Manufacturing method of glucose sensor of gold nanosphere particle modified fiber bragg grating

A technology of glucose sensor and optical fiber grating, which is applied in instruments, scientific instruments, and material analysis through optical means, can solve the problems of unbalanced glucose metabolism, etc., and achieve the effect of improving sensitivity, high practical value and innovation

Active Publication Date: 2020-11-20
HEFEI UNIV OF TECH
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Problems solved by technology

[0005] The detection of glucose plays a pivotal role in daily life and industrial production, but excessive absorption of glucose by the human body will cause the imbalance of glucose metabolism in the body, leading to diabetes and various complications caused by diabetes
Although there is no way to completely cure diabetes, the disease can be reduced by controlling the stability of the blood sugar concentration level of the human body, so it is of great significance to invent the glucose sensor to detect the glucose concentration

Method used

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  • Manufacturing method of glucose sensor of gold nanosphere particle modified fiber bragg grating
  • Manufacturing method of glucose sensor of gold nanosphere particle modified fiber bragg grating
  • Manufacturing method of glucose sensor of gold nanosphere particle modified fiber bragg grating

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Embodiment Construction

[0026] Below in conjunction with the accompanying drawings and specific embodiments, a kind of preparation method of a gold nanosphere particle modified fiber grating glucose sensor will be further described:

[0027] A method for making a glucose sensor with gold nanosphere particles modified fiber grating, comprising fiber grating, gold nanosphere particles, dopamine molecules and concanavalin molecules; a layer of gold nanoparticles is modified on the surface of the fiber grating to form an optical fiber A grating sensor; the concanavalin molecules are fixed on the surface of the gold nanosphere particles by dopamine molecules, and the specific detection of glucose is realized by the specific binding of the concanavalin molecules and the glucose to be detected.

[0028] Specifically include the following steps:

[0029] (1) In order to remove the ions and dust on the surface of the fiber grating tilted at a large angle, soak the fiber grating in a 5% dilute nitric acid solu...

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Abstract

The invention discloses a preparation method of a fiber bragg grating glucose sensor based on gold nanosphere particle modification. The fiber bragg grating glucose biosensor comprises a large-angle inclined fiber bragg grating, a gold nanosphere particle layer, dopamine molecules and concanavalin molecules, wherein the wide-angle fiber bragg grating is subjected to silanization treatment and thenis covalently combined with gold nanosphere particles, and then the concanavalin molecules are connected with the gold nanosphere particles through the dopamine molecular layer, so that the biological functionalization process of the wide-angle tilted fiber bragg grating is realized. When glucose molecules and the concanavalin molecules are specifically combined, the spectrum of the fiber bragg grating is changed, and the resonance wavelength in the spectrum is remarkably changed along with the increase of the concentration of a glucose solution, so that the high-sensitivity specific detection of glucose is realized. The glucose biosensor has the advantages of low temperature cross sensitivity, ultrahigh sensitivity, simplicity in operation, no marking and the like, and has an important application prospect in the aspect of clinical medical detection.

Description

technical field [0001] The invention relates to the technical field of optical fiber grating biosensors, in particular to a preparation method of a glucose sensor modified by gold nanosphere particles with optical fiber gratings. Background technique [0002] Fiber Bragg grating is a kind of optical fiber passive device. It has been widely used in many sensing fields in the past ten years. It can realize high-precision detection of various physical, mechanical, electromagnetic, biological, medical, chemical and other sensing quantities. It has the advantages of small size, low cost, high sensitivity, strong anti-electromagnetic interference ability, good stability, real-time analysis, long-distance monitoring, marker-free, etc., and has important application prospects in sensing. The large-angle tilted fiber grating can realize the coupling of the core guided mode and the forward cladding mode. These cladding modes have an evanescent field in the outer surface area of ​​the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/41G01N21/01
CPCG01N21/41G01N21/01
Inventor 张俊喜梁泰铭王浩宇胡志家张维魏永清王飞王致远张令春
Owner HEFEI UNIV OF TECH
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