Matryoshka doll-type gold nanorod composite system loaded with novel sulfydryl N-heterocyclic silicon (IV) phthalocyanine complex

Abstract

The invention discloses a Matryoshka doll-type nano gold rod system loaded with di-(1-(4-hydroxyphenyl)-5-sulfydryl-tetrazolyl) silicon phthalocyanine as well as a preparation method and an application thereof. The preparation method comprises the following steps: firstly synthesizing a gold nanorod, then coating the surface of the gold nanorod with aminated silicon dioxide, and finally coating the surface of the gold nanorod with aminated silicon dioxide with a layer of gold nanospheres to prepare the Matryoshka doll-type gold nanorod with a three-layer cavity structure, enabling dichlorosilane phthalocyanine to react with 1-(4-hydroxyphenyl)-5-sulfydryl-tetrazole to synthesize di-(1-(4-hydroxyphenyl)-5-sulfydryl-tetrazole) silicon(IV)phthalocyanine; and finally, preparing a Matryoshka doll-type gold nanorod system loaded with di-(1-(4-hydroxyphenyl)-5-sulfydryl-tetrazolyl)silicon(IV)phthalocyanine and Matryoshka doll-type gold nanorods through a molecular assembly method, and takingthe Matryoshka doll-type gold nanorod system as photodynamic and photothermal therapy combined inactivation drug-resistant bacteria and tumors.

Description

technical field [0001] The invention belongs to the field of nano-biomedicine, in particular to azaphthalocyanine matryoshka-type nano-gold nanorod system and its preparation method and its application in photodynamic / photothermal therapy / photodynamic-photothermal synergistic inactivation of drug-resistant bacteria. Background technique [0002] Photodynamic antimicrobial chemotherapy (PACT) is a promising new strategy for the treatment of refractory bacterial infectious diseases. The basic principle is: the photosensitizer is preferentially and selectively enriched in bacteria, and the photosensitizer is excited from the ground state to the triplet state under light; the triplet photosensitizer directly reacts with biomolecules to generate free radicals and / or free electrons (type I reaction ), or react with molecular oxygen to produce more active singlet oxygen (type II reaction); free radicals and singlet oxygen are toxic to target microorganisms, thereby inactivating bac...

AI Technical Summary

Problems solved by technology

So far, there have been three generations of photosensitizers: the first generation photosensitizers include hematopoiphyrin derivative (HPD), dihaematoporphyrin ether (DHE) and photofrin II (photofrin II). Because of weak absorption in the infrared region with strong penetrating power, and high phototoxicity; the second-generation photosensitizer mainly includes chlorophyll, phthalocyanine complexes, purpurin, naphthalene cyanine, ferric pheofolate and bacterial ferric chlorophyllin Among them, phthalocyanine photosensitizers have become the second generation with potential application prospects because of their maximum absorption wavelength in the red light region, strong tissue penetration depth, low phototoxicity, and high singlet oxygen quantum yield. generation of photosensitizers; however, due to the high coplanarity and strong π-π hydrophobicity of the phthalocyanine molecule’s 18-electron structure, it is easy to aggregate in water, thereby reducing its fluorescence lifetime and singlet oxygen quantum yield, making it photosensitive Power Healing Effect Decreased

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