Matryoshka doll-type gold nanorod composite system loaded with novel sulfydryl N-heterocyclic silicon (IV) phthalocyanine complex

A technology of silicon phthalocyanine and nano-gold rods, which is applied in the field of nano-biomedicine, can solve the problems of reduced fluorescence lifetime, singlet oxygen quantum yield, reduced photodynamic therapy effect, and high phototoxicity, so as to increase singlet oxygen quantum yield efficiency, fluorescence intensity enhancement, and the effect of isolation protection enhancement

Inactive Publication Date: 2020-08-04
湖南科诺康美生命科技有限公司
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Problems solved by technology

So far, there have been three generations of photosensitizers: the first generation photosensitizers include hematopoiphyrin derivative (HPD), dihaematoporphyrin ether (DHE) and photofrin II (photofrin II). Because of weak absorption in the infrared region with strong penetrating power, and high phototoxicity; the second-generation photosensitizer mainly includes chlorophyll, phthalocyanine complexes, purpurin, naphthalene cyanine, ferric pheofolate and bacterial ferric chlorophyllin Among them, phthalocyanine photosensitizers have bec...

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  • Matryoshka doll-type gold nanorod composite system loaded with novel sulfydryl N-heterocyclic silicon (IV) phthalocyanine complex
  • Matryoshka doll-type gold nanorod composite system loaded with novel sulfydryl N-heterocyclic silicon (IV) phthalocyanine complex
  • Matryoshka doll-type gold nanorod composite system loaded with novel sulfydryl N-heterocyclic silicon (IV) phthalocyanine complex

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Embodiment Construction

[0027] Below in conjunction with embodiment the present invention is described in detail:

[0028] 1) Preparation of dichlorosilicon (IV) phthalocyanine

[0029] Add 7.28g of 1,3-diiminoisoindoline and 83mL of quinoline into the three-neck flask. After gradually raising the temperature to 60°C, add 8.3mL of silicon tetrachloride, raise the temperature to 220°C, react for 30min, and cool to At room temperature, the reactant was poured into 200 mL of methanol solution, stirred ultrasonically for 30 min, allowed to stand for 1 h, then filtered with suction, washed with solvents such as acetone, methanol, dichloromethane, acetone, etc. until the supernatant was clear. After drying, 4.1256 g of blue-purple powdery solid (1) was obtained, with a yield of 49.2%.

[0030] 2) Preparation of di-(1-(4-hydroxyphenyl)-5-mercapto-tetrazolyl) axially substituted silicon (IV) phthalocyanine

[0031] In a round bottom flask was added 1-(4-hydroxyphenyl)-5-mercapto-tetrazolium (0.0611 g), 1-(...

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Abstract

The invention discloses a Matryoshka doll-type nano gold rod system loaded with di-(1-(4-hydroxyphenyl)-5-sulfydryl-tetrazolyl) silicon phthalocyanine as well as a preparation method and an application thereof. The preparation method comprises the following steps: firstly synthesizing a gold nanorod, then coating the surface of the gold nanorod with aminated silicon dioxide, and finally coating the surface of the gold nanorod with aminated silicon dioxide with a layer of gold nanospheres to prepare the Matryoshka doll-type gold nanorod with a three-layer cavity structure, enabling dichlorosilane phthalocyanine to react with 1-(4-hydroxyphenyl)-5-sulfydryl-tetrazole to synthesize di-(1-(4-hydroxyphenyl)-5-sulfydryl-tetrazole) silicon(IV)phthalocyanine; and finally, preparing a Matryoshka doll-type gold nanorod system loaded with di-(1-(4-hydroxyphenyl)-5-sulfydryl-tetrazolyl)silicon(IV)phthalocyanine and Matryoshka doll-type gold nanorods through a molecular assembly method, and takingthe Matryoshka doll-type gold nanorod system as photodynamic and photothermal therapy combined inactivation drug-resistant bacteria and tumors.

Description

technical field [0001] The invention belongs to the field of nano-biomedicine, in particular to azaphthalocyanine matryoshka-type nano-gold nanorod system and its preparation method and its application in photodynamic / photothermal therapy / photodynamic-photothermal synergistic inactivation of drug-resistant bacteria. Background technique [0002] Photodynamic antimicrobial chemotherapy (PACT) is a promising new strategy for the treatment of refractory bacterial infectious diseases. The basic principle is: the photosensitizer is preferentially and selectively enriched in bacteria, and the photosensitizer is excited from the ground state to the triplet state under light; the triplet photosensitizer directly reacts with biomolecules to generate free radicals and / or free electrons (type I reaction ), or react with molecular oxygen to produce more active singlet oxygen (type II reaction); free radicals and singlet oxygen are toxic to target microorganisms, thereby inactivating bac...

Claims

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Application Information

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IPC IPC(8): C07F7/10A61K41/00A61P31/04
CPCC07F7/10A61K41/0071A61K41/0052A61P31/04
Inventor 黄义德彭亦如姜愈峰叶邱豪
Owner 湖南科诺康美生命科技有限公司
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