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129 results about "Surface plasmon resonance" patented technology

Surface plasmon resonance (SPR) is the resonant oscillation of conduction electrons at the interface between negative and positive permittivity material stimulated by incident light. SPR is the basis of many standard tools for measuring adsorption of material onto planar metal (typically gold or silver) surfaces or onto the surface of metal nanoparticles. It is the fundamental principle behind many color-based biosensor applications, different lab-on-a-chip sensors and diatom photosynthesis.

Multi-dimensional light pressure regulation and control method and device based on metasurface microstructure array

The invention relates to the technical field of optical metasurface and light field regulation and control, in particular to a light pressure multi-dimensional regulation and control method and device based on a metasurface microstructure array. The method comprises the following steps: designing and preparing a metasurface microstructure array, wherein the microstructure array is composed of a plurality of sub-wavelength scale three-dimensional microstructure units arranged on a dielectric substrate; surface plasmon resonance is excited by adjusting structural parameters of the three-dimensional microstructure units and adjusting working parameters of a light source acting on the microstructure array, and near-field localization and enhancement are achieved. And calculating, regulating and controlling the light pressure borne by the metasurface microstructure array based on the Maxwell stress tensor. The method can keep a remarkable light pressure enhancing effect in a wide spectrum range of 380-1300 nm, and is suitable for various material systems such as silver, gold and the like. The method can be applied to the fields of optical tweezers systems, optical control devices, precision measurement and the like, and has the advantages of flexible design, simplicity and convenience in preparation, high regulation and control precision and the like.
Owner:TIANJIN UNIV

Cu2O-based heterogeneous composite material as well as preparation method and application thereof

The invention provides a Cu2O-based heterogeneous composite material as well as a preparation method and application thereof. The preparation method comprises the following steps: coating the surface of a Cu2O hollow sphere substrate with a carbon layer, and depositing layered double hydroxides (LDHs) and metal palladium (Pd) nanoparticles on the carbon layer. According to the material, through a Cu2O-carbon layer-LDHs-Pd multistage heterostructure design, space optimization of light absorption, charge transfer and catalytic sites is realized; cu2O-carbon layer-LDHs interface coupling promotes directed migration of photo-induced electron-hole pairs, and the surface plasmon resonance effect of Pd nanoparticles enhances the charge separation efficiency; the LDHs optimizes a charge transfer path through surface oxygen vacancy or metal valence cycle, so that synergistic oxidation of non-free radicals and free radicals is realized, the organic matter degradation efficiency is remarkably improved, the oxidation path is widened, and the performance bottleneck of a single material is broken through.
Owner:CHINA THREE GORGES CORPORATION +1

SPR image optimization processing method based on image segmentation and edge enhancement

The invention discloses an SPR (Surface Plasmon Resonance) image optimization processing method based on image segmentation and edge enhancement, which comprises the following steps: acquiring SPR image data, and preprocessing to generate standardized SPR image data; inputting a structure boundary extraction model constructed based on CGNet, generating a structure boundary label graph, and aligning the structure boundary label graph with the image; gradient amplitude and local entropy mutation detection is executed, and an artifact guide graph is generated; respectively inputting the standardized image into details and context branches of the improved CSDNet, and extracting edge and semantic feature maps; inputting a guide perception gating module, executing structure enhancement and artifact suppression fusion, and generating a fusion feature map; inputting into a multi-scale detail recovery module, and outputting an edge enhanced image; and executing structural similarity and marginal definition scoring based on the original image and the enhanced image, and generating an optimization result. According to the method, synchronous optimization of SPR image edge enhancement and structure maintenance is realized, and the image definition and diagnosis availability are remarkably improved.
Owner:SUZHOU YAOSHENG INTELLIGENT TECH CO LTD

Preparation method of flexible infrared metasurface absorber based on MDM

The invention discloses a preparation method of a flexible infrared super-surface absorber based on MDM, and belongs to the field of micro-nano machining patterning. The method comprises the following steps: pretreating a polymer material; depositing a layer of bottom metal film on the pretreated substrate by adopting magnetron sputtering; a metal reflecting layer, a dielectric insulating layer and a metal surface functional layer are sequentially deposited through magnetron sputtering, a periodic nano microstructure is constructed on the surface of a flexible composite film, a nano round pit array is etched in situ on a surface metal layer of an MDM structure by using a femtosecond laser selective etching process, and an MDM laminated structure is formed. According to the invention, stable integration of the MDM structure and the flexible substrate can be realized, and meanwhile, high absorptivity and good flexibility of the device in an infrared band are ensured. The absorber prepared by the invention can generate resonance absorption on incident infrared electromagnetic waves through a surface plasmon and F-P cavity resonance coupling mechanism, and meanwhile, the characteristic size variation is changed through physical excitation, so that effective absorption and frequency regulation of the electromagnetic waves at the infrared band of 3-14 microns are realized.
Owner:BEIJING INFORMATION SCI & TECH UNIV

Bonding wire welding method based on bare chip interconnection

The invention relates to the technical field of semiconductor packaging, and discloses a bonding wire welding method based on bare chip interconnection, and the method comprises the steps: collecting and fusing acoustic response and optical reflection signals of a bonding interface in real time through a multi-mode in-situ sensing mechanism integrating acoustic resonance and surface plasmon resonance; dynamically calculating the thickness, the mechanical coupling deformation and the energy dissipation state of the intermetallic compound layer; and the ultrasonic power and the bonding force are subjected to closed-loop adjustment in combination with a model prediction control algorithm, so that the welding process is evolved along a preset optimal physical path all the time. The system comprises a multi-mode sensing welding head, a synchronous data acquisition module, a state resolving module and a self-adaptive control module. The transparent and intelligent welding process is realized, and the bonding consistency, reliability and yield of high-density interconnection are remarkably improved.
Owner:SHENZHEN TONGFANG ELECTRONGIC NEW MATERIAL CO LTD

Method and system for constructing non-reciprocal emission / absorption device with Fizeau drag effect

The invention provides a construction method and system of a non-reciprocal emission / absorption device with a Fizeau dragging effect. The construction method comprises the following steps: selecting a metal substrate, a dielectric grating and a two-dimensional material; applying a bias voltage in the x-axis direction to the two-dimensional material layer to generate a Fizeau dragging effect; the bias voltage is adjusted under TM polarization, so that the electron drift speed is close to the Fermi speed, asymmetric surface plasmon resonance is excited, and unequal emissivity and absorptivity are achieved; an adjustable singular point is generated in an angle-frequency space by adjusting the filling ratio of the grating, so that the numbers of spectral formants of emissivity and absorptivity near the singular point are different, and the wavelength integral nonreciprocity intensity is improved. The non-reciprocal heat radiation characteristic can be realized through voltage regulation and control without an external magnetic field.
Owner:SHANGHAI JIAOTONG UNIV

Surface plasma resonance hydrogen sensor based on Ag / PDMS / Pt-WO3 multilayer structure

The invention discloses a surface plasmon resonance (SPR) hydrogen sensor based on an Ag / PDMS / Pt-WO3 multilayer structure. The SPR hydrogen sensor is characterized by comprising a halogen lamp light source, two sections of multimode optical fibers, a spectrometer and an SPR hydrogen sensing head, wherein the SPR hydrogen sensing head is composed of a different-core structure formed by multimode-single-mode-multimode optical fibers, a silver film, PDMS (polydimethylsiloxane) and Pt-WO3 (platinum-tungsten trioxide). The SPR hydrogen sensor based on the Ag / PDMS / Pt-WO3 multi-layer structure, which is simple to prepare, high in sensitivity and capable of being repeatedly used for a long time, is provided aiming at the defects that an existing optical fiber SPR hydrogen sensor is low in sensitivity and complex in device manufacturing, and PdH is changed from an alpha phase to a beta phase when Pd is used as a hydrogen sensitive material, so that the use of the device is influenced, and the like. When the hydrogen concentration is increased, the Pt-WO3 reacts with the hydrogen to generate heat, so that the refractive index of the PDMS film is changed, the SPR resonance spectrum is moved, and the hydrogen concentration is obtained by observing the offset of the PDMS film. The high refractive index sensitivity of SPR is brought into full play by utilizing the high refractive index change of PDMS, so that high-precision detection of hydrogen leakage is realized.
Owner:CHINA JILIANG UNIV

Functionalized glass for sers detection and method of making the same

The application relates to a functionalized glass for SERS detection and a preparation method thereof, characterized by the following steps: a. tetraethyl orthosilicate and oxalic acid are mixed into a 0.02-0.10 moL / L sol in anhydrous ethanol according to a molar ratio of 1:2-5, a stabilizer with a volume of 5-50% is added, and then the mixture is stirred and transferred into a four-necked flask; b. after being heated and stirred for 12-16 hours, an anhydrous ethanol emulsion of polystyrene small balls with a mass fraction of 5-20% and a volume of 6-18% is added; c. an anhydrous ethanol solution of a surfactant P123 with a total mass of 2-8% and a weight concentration of 3-8% is added, and then the mixture is stirred and aged; d. a wet film is prepared on a glass substrate, and then the wet film is dried and kept warm; (2) a nano-silver particle dispersion liquid with a concentration of 5-25 mg / mL is prepared; and (3) the glass substrate prepared in the step d is coated with the nano-silver particle dispersion liquid and dried. The application has the advantages of simple process and low cost; the surface of the porous structure silica nano-particles has a large number of nanoscale gap structures, which is beneficial to obtaining an enhanced silver nano-particle surface plasmon resonance electromagnetic field, and greatly enhances the Raman signal of the adsorbed molecules.
Owner:CNBM RESEARCH INSTITUTE FOR ADVANCED GLASS MATERIALS GROUP CO LTD

Surface plasma imaging method and device

The invention provides a surface plasma imaging method and a surface plasma imaging device, which are used for imaging surface plasma signals caused by interaction of biomolecules. More specifically, the invention provides a method and a device capable of imaging a surface plasmon resonance mode in a frequency domain through tiny change by comparing the light intensity in two sections of surface plasmon frequency domains.
Owner:ACAD SINICA

A light field regulation detection method and device based on computational spectral reconstruction

PendingCN122384983ANanopillarQuartz substrate
The application discloses a kind of light field regulation detection method and device based on computing spectral reconstruction, belong to spectral analysis technical field.The method is by introducing medium-metal composite nanostructure, integrates metal nanoisland array and silicon nitride nanocolumn array on quartz substrate, realizes electric field enhancement using the local surface plasmon resonance effect excited by metal nanoisland array, simultaneously realizes wide spectral range phase coding by medium nanocolumn array;Super surface chip is integrated with single point detector, combines pre-calibrated super surface sensing matrix A and enhancement factor matrix E, and reconstructs spectrum using compressed sensing or Tikhonov regularization algorithm.The application keeps the advantages of miniaturization and no moving parts, realizes directional high sensitivity detection to weak signal, and signal-to-noise ratio is improved.
Owner:HANGZHOU INNOWAY TECH CO LTD

Cyclic peptide molecules specifically targeting cd5 and uses thereof

The application belongs to the technical field of biological medicine, and discloses a cyclic peptide molecule specifically targeting CD5 and purposes thereof. The surface receptor CD5 of immune cells (T cells, B cells) has been proved to be a potential tumor treatment target, the present application uses the phage display technology widely applied to the development of polypeptide or antibody drugs to carry out multiple rounds of in vitro screening on human CD5 protein, and obtains a cyclic peptide molecule with drug potential and capable of specifically combining with CD5 through second-generation sequencing. The cyclic peptide molecule contains two cysteines, is modified into a ring through a specific chemical crosslinking agent, and the affinity of the cyclic peptide molecule to CD5 is determined to be in the low micromolar level through surface plasmon resonance technology, thereby laying a foundation for the development of a CD5-targeting inhibitor.
Owner:SHANGHAI JIAOTONG UNIV

On-chip spectrum sensing structure, pixel unit and preparation method and application thereof

The invention discloses an on-chip spectrum sensing structure, a pixel unit and a preparation method and application thereof. The on-chip spectrum sensing structure comprises a metal layer, a dielectric layer and a detector, nano-pore channels are formed in the metal layer and the dielectric layer, and the nano-pore channels extend into the dielectric layer from the surface of the metal layer; near-infrared light forms surface plasmon resonance at the interface of the metal layer and the dielectric layer in the nanopore channel, so that part of near-infrared light in a selected narrow wavelength range is transmitted to the detector, and a corresponding electric signal is formed. According to the on-chip spectrum sensing structure provided by the invention, near-infrared broadband calculation spectrum sensing with high spectral fidelity can be realized, radiation and ohmic loss are effectively inhibited by a nonlinear parameterized design framework, and high transmission efficiency is ensured; the multi-channel super-pixel system structure generated by the method realizes simultaneous point spectrum and snapshot hyperspectral imaging, and shows the potential of the compact platform for field deployment and chip spectrum sensing application.
Owner:INST OF PHYSICS HENAN ACAD OF SCI +1

Preparation method and application of doxycycline molecularly imprinted SPR (Surface Plasmon Resonance) sensing chip

The invention provides a preparation method and application of a doxycycline (DOX) molecularly imprinted surface plasmon resonance (SPR) sensing chip. According to the chip, an SPR bare gold chip is used as a substrate, DOX is used as a template molecule, a molecularly imprinted polymer (MIP) recognition membrane is constructed on the surface of the chip, and collaborative integration of the MIP technology and the SPR technology is achieved. According to the strategy, the chip is endowed with specific recognition capability on template molecules DOX, and local refractive index change caused by combination of the DOX and the recognition film can be detected in real time in an unmarked manner, so that the detection sensitivity and accuracy are remarkably improved. By utilizing an SPR (Surface Plasmon Resonance) analyzer, the chip can realize rapid quantitative detection of DOX in a low concentration range, shows good reproducibility, and can be applied to detection of actual samples.
Owner:ZHEJIANG UNIV CITY COLLEGE

Colorful ITO conductive film with heat insulation performance and preparation method thereof

The invention relates to the technical field of thin films, and discloses a colorful ITO conductive film with heat insulation performance and a preparation method thereof, the conductive film is characterized in that a functional lamination layer is arranged between two transparent conductive layers, and the functional lamination layer comprises a first composite functional layer, an optical isolation layer and a second composite functional layer from bottom to top. The first composite functional layer and the second composite functional layer are both composed of silver nanoparticles dispersed in a high-refractive-index dielectric matrix, and the silver nanoparticles in the two layers have different size distributions. According to the structure, a precursor film is co-deposited through a magnetron sputtering method, and then silver is self-assembled into nanoparticles through in-situ rapid thermal annealing. By arranging the double composite functional layers and utilizing surface plasmon resonance of two groups of silver nanoparticles with different sizes formed after annealing, broadband high-efficiency blocking of near infrared spectrum is realized, and meanwhile, the film is endowed with stable and non-iridescent color by resonance scattering of the nanoparticles; the film has the advantages of high visible light transmittance, low square resistance and excellent environmental stability.
Owner:ZHONGHE SCI & TECH (CHANGZHOU) CO LTD

Aflatoxin detection method based on surface plasma resonance effect, kit and application

The invention belongs to the technical field of aflatoxin detection, and relates to an aflatoxin detection method based on a surface plasma resonance effect, a kit and application. Comprising the following steps: S1, preparing a lysine functionalized gold / silver nanoparticle solution; s2, adding an aflatoxin standard solution with known concentration into the Hg < 2 + > standard solution, oscillating and incubating, and then adding the lysine functionalized gold / silver nanoparticle solution to construct an aggregation colorimetric reaction system; and a series of aggregation colorimetric reaction systems. S3, acquiring color data by a machine image recognition technology, wherein the color data comprises an R value, a G value and a B value; s4, constructing a standard curve; s5, color data of a to-be-detected sample are obtained, and the content of aflatoxin in the to-be-detected sample is obtained through the standard curve. Visual quantitative analysis detection of aflatoxin is realized, the sensitivity is ensured, the detection process is simple, and the test efficiency is high.
Owner:SHAANXI NORMAL UNIV

Preparation method of bismuth single element / bismuth oxide / carbon nitride composite material and application thereof as chlorine removal agent

The application discloses a preparation method of a bismuth single element / bismuth oxide / carbon nitride composite material and application of the bismuth single element / bismuth oxide / carbon nitride composite material as a chlorine removal agent, and the bismuth single element / bismuth oxide / carbon nitride composite chlorine removal agent is prepared by taking bismuth nitrate pentahydrate as raw material and introducing melamine precursor. In the process of calcination, the melamine generates elemental carbon and carbon monoxide, and plays a regulating role in the morphology of the chlorine removal agent; the reducing property generated in the forming process can convert Bi 3+ into Bi single element, and the surface plasmon resonance effect of the Bi single element is utilized to improve the photocatalytic chlorine removal performance of the composite chlorine removal agent.
Owner:JIANGSU UNIV OF TECH

Digital metasurface infrared spectrum chip integrating photoelectric detection and sensing and preparation method

The application relates to the technical field of trace molecule detection, in particular to a photoelectric detection and sensing integrated digital metasurface infrared spectrum chip and a preparation method thereof. The chip comprises, from bottom to top, a substrate, a metal reflection layer, a metal nanoparticle layer, a pyroelectric photosensitive layer and a digital metasurface structure layer; the digital metasurface structure layer is in a discrete pattern composed of a pixel array in the transverse direction of the device, the digital metasurface structure layer can excite surface plasmon resonance under the irradiation of preset light waves, the light field energy is localized in the target molecules and the pyroelectric photosensitive layer, so that the responsivity and sensing sensitivity of the infrared spectrum chip are improved; and the array coding of the discrete pattern of the digital metasurface structure layer is designed through a preset algorithm, so that the electric field intensity at the preset spatial position is enhanced. The chip has the advantages of high responsivity, high sensing sensitivity and high signal-to-noise ratio.
Owner:CHONGQING UNIV

UCNPs modified AgNPs (at) MgAl LDH composite material and preparation and application thereof

The invention discloses a UCNPs modified AgNPs (at) MgAl LDH composite material and a preparation method of the UCNPs modified AgNPs (at) MgAl LDH composite material. According to the preparation method, MgAl LDH is synthesized through a solvothermal method, AgNPs is loaded on the MgAl LDH through a reduction precipitation method, and the AgNPs-coated MgAl LDH composite material is successfully prepared; liYF4: Yb and Tm-coated LiYF4 UCNPs are prepared at the same time, the LiYF4: Yb and Tm-coated LiYF4 UCNPs are subjected to hydrophilic modification by adopting a ligand exchange method, and finally the LiYF4: Yb and Tm-coated LiYF4 UCNPs and the LiYF4: Yb and Tm-coated LiYF4 UCNPs are compounded to prepare the AgNPs-coated MgAl LDH / According to the ternary composite system, through surface plasma resonance (SPR) of AgNPs, the up-conversion luminescence effect of UCNPs and the layered structure synergistic effect of MgAl LDH, efficient degradation of TCH can be achieved, and meanwhile a new thought is provided for the near-infrared driven environment restoration technology.
Owner:FUZHOU UNIV

Z-scheme photocatalyst for treatment of wastewater

A novel photocatalyst Bi2WO6 / NiO / Ag with hierarchical flower-like Z-scheme heterojunction, which exhibited excellent stability and photocatalytic activity over a wide light spectrum, was synthesized. The as-prepared composites were used in the remediation of real oil sands process water (OSPW) and achieved complete removal of aromatics, classical naphthenic acids (NAs). and heteroatomic NAs after 6 h of photocatalytic treatment. The acute toxicity of OSPW was completely eliminated after only 2 hours of treatment. h+, ·OH and O2·—were found to be the major oxidative species in the photocatalytic system. The enhanced photocatalytic efficiency is the result of the unique Z-scheme electron transfer among electron mediator Ag, NiO, and Bi2WO6 and the SPR effect near Ag, which was supported by the DFT calculations of the electronic properties of Bi2WO6 / NiO / Ag heterostructure.
Owner:THE GOVERNORS OF THE UNIV OF ALBERTA

SPR (Surface Plasmon Resonance) phase imaging system and method based on four polarization filter arrays

The invention discloses an SPR phase imaging system based on a four-polarization filtering array, and the system comprises an incident light path which is used for generating area array laser; the SPR module is used for receiving the area array laser and carrying out SPR sensing to obtain an area array laser modulation result related to a to-be-detected substance; and the imaging light path is used for carrying out amplification and filtering modulation on the area array laser modulation result so as to carry out imaging on a four-polarization array, and carrying out matched filtering and double-differential phase resolving on a four-polarization image so as to obtain an imaging result. According to the invention, through polarization virtual image generation and cross-channel block matching, and in combination with four-dimensional collaborative filtering, the noise suppression efficiency is improved; and through double differential phase resolving, the dynamic range is expanded to 0.06 RIU, and the resolution ratio is superior to that of the RIU. The invention solves the problem of mutual restriction of dynamic range and resolution in the traditional SPR technology, and is suitable for high-sensitivity biomolecule interaction detection.
Owner:TSINGHUA UNIVERSITY

Porous carbon-based multifunctional composite phase change material and preparation method thereof

The invention provides a porous carbon-based multifunctional composite phase change material and a preparation method thereof, and belongs to the technical field of phase change materials. The porous carbon-based multifunctional composite phase change material provided by the invention comprises a porous carbon carrier, a phase change material loaded on the surface of the porous carbon carrier and in pores, and noble metal nanoparticles. The phase change material is loaded on the surface and in the pore channels of the porous carbon carrier, and active groups on the surface of the porous carbon carrier can adsorb the phase change material, so that liquid phase leakage of the phase change material in the phase change process is prevented; the porous carbon carrier, the noble metal nanoparticles and the phase-change material are synergistically matched, so that the heat conduction capability of the phase-change material is remarkably improved; meanwhile, the absorption of sunlight by the composite material is remarkably improved through the LSPR (Local Surface Plasmon Resonance) effect of the noble metal nanoparticles, and efficient conversion and storage from solar energy to heat energy are realized.
Owner:HENAN ACADEMY OF SCI CHEM RES INST CO LTD +1

A humidity sensing device and system

ActiveCN117110245BEngineeringPrism
The embodiment of the present application discloses a humidity sensing device and system, which comprises a prism, a metal film, a sensitizing layer and a sensing layer. Wherein, the light enters the prism to excite the surface of the metal film to generate surface plasmon resonance phenomenon, which can change with the amount of water absorbed by the sensing layer. The sensitizing layer improves the sensitivity of the humidity sensing device. The sensing layer captures water in the air while having strong coupling effect with the metal film, which converts the original single SPR resonance peak into coherent double peaks. The user uses the above effect to design a proportional SPR humidity sensing device, eliminates the error in humidity detection, facilitates calculation and enhances the reliability of data. In addition, the sensing layer protects other structures by using its own structural characteristics. The present application provides a humidity detection device with high measurement accuracy and reliability, and the overall structure is not easy to be damaged.
Owner:UNIV OF SHANGHAI FOR SCI & TECH

Skin pricking liquid for allergy detection in safflower injection as well as preparation method and kit of skin pricking liquid

The invention discloses a preparation method of a skin pricking liquid for allergy detection in a safflower injection preparation, and provides an efficient screening method of allergens in the safflower injection preparation and a preparation method of an allergen skin pricking liquid in order to solve the problems that chemical components in the safflower injection preparation are complex, sensitization components are not clear and the like. According to the method, chemical components in the safflower injection preparation are rapidly clarified by adopting a high performance liquid chromatography-mass spectrometry technology; carrying out molecular docking on the identified chemical components, human serum albumin, MRGPRX2 protein and RhoA protein by using a molecular docking technology, and screening out compounds combined with the proteins; further performing allergen evaluation and confirmation on the compound screened by the molecular docking technology by using a surface plasmon resonance instrument; according to the SPR technology, it is confirmed that the safflower injection preparation allergen is prepared into skin pricking liquid which is used for clinically screening safflower injection preparation potential allergy people, and the purpose of greatly reducing the allergy occurrence rate is achieved.
Owner:SHANXI DEYUANTANG PHARM CO LTD

Preparation method and application of ciprofloxacin molecularly imprinted SPR (Surface Plasmon Resonance) sensing chip

The invention provides a preparation method and application of a molecularly imprinted surface plasmon resonance (SPR) sensing chip of ciprofloxacin (CFX). According to the chip, molecularly imprinted polymers (MIPs) are combined with an SPR technology, so that the detection sensitivity and accuracy are effectively improved, the chip has obvious signal response to CFX with lower concentration, and the detection limit can be as low as nanomole level. When the CFX molecularly imprinted SPR chip prepared by the invention is used for CFX detection, the operation steps are simple, the analysis time is short, the specificity and reproducibility are good, the operation is simple and rapid, and the chip has important practical application value.
Owner:ZHEJIANG UNIV CITY COLLEGE

A polypeptide targeting the nsp5 protein of porcine viral diarrhea virus

The application is based on machine learning model, and the polypeptide WFKDWY (166953) with potential is screened through polypeptide virtual screening technology based on the analysis of PEDV Nsp5 protein crystal structure. The sequence of 166953 is artificially synthesized by solid phase, and the polypeptide is screened by using artificially expressed PEDV Nsp5 protein through ELISA experiment. The affinity constant of the polypeptide and the target protein is identified by surface plasmon resonance experiment (SPR). The cytotoxicity of the polypeptide 166953 is tested by CCK-8 kit. The virus infection inhibiting activity of the polypeptide is tested by fluorescence quantitative PCR and indirect immunofluorescence experiment. The results show that the sequence 166953 can significantly inhibit the infection of PEDV.
Owner:HENAN ACAD OF AGRI SCI

Imaging sensor based on full stokes polarized superlens

The application discloses an imaging sensor based on a full-Stokes polarization superlens, and relates to the field of optical sensing.The imaging sensor comprises a sensing excitation light source, an adjustable attenuator, a polarizer, a coupling prism, a sensing chip, a first objective lens, a full-Stokes polarization superlens, a second objective lens, an imaging lens and a CCD imaging camera; the sensing excitation light source emits monochromatic light as system incident light, which sequentially passes through the adjustable attenuator and the polarizer, and is incident onto the surface of the sensing chip to generate surface plasmon resonance after passing through the coupling prism; reflected light is converged onto the polarization superlens by the first objective lens, and then converged onto the second objective lens; subsequently, the imaging lens is used for imaging to the CCD camera; the property change of a to-be-measured sample leads to surface plasmon resonance of the sensing chip, which causes the analysis information of the full-Stokes polarization superlens to change, and further causes the image obtained by the CCD imaging camera to change.The application can perform single-shot phase imaging on a refractive index sample.
Owner:台州安奇灵智能科技有限公司

Inhibitory peptide that binds to PEDV Nsp5 protein

ActiveCN116486897BBiostatisticsProteomicsProtein targetIndirect Immunofluorescence Assays
This invention utilizes a machine learning model to analyze the crystal structure of the PEDV Nsp5 protein. Through virtual peptide screening technology, a peptide sequence with potential affinity for the target protein, YKKLHK(162860), was artificially synthesized in a solid phase. Using artificially expressed PEDV Nsp5 protein, the peptide was screened using an ELISA assay. The affinity constant between the peptide and the target protein was determined using surface plasmon resonance (SPR) assays. The cytotoxicity of peptide 162860 was tested using a CCK-8 assay kit. Its inhibitory activity against viral infection was tested using quantitative real-time PCR and indirect immunofluorescence assays. The results showed that the 162860 sequence significantly inhibited PEDV infection.
Owner:HENAN ACAD OF AGRI SCI

Material and structure combined sensibilization optical fiber SPR sensor and manufacturing and using method thereof

The invention belongs to the field of optical fiber sensing, and particularly relates to a material and structure combined sensitization optical fiber SPR (surface plasmon resonance) sensor and a manufacturing and using method thereof, the sensor comprises a cladding mode attenuation area, a fiber core angle regulation and control area, an SPR sensing area and a thick core light receiving area which are connected in sequence; the cladding mode attenuation area is a six-core optical fiber of which the surface is provided with a coating layer; the fiber core angle regulation and control region is a torsion type six-core optical fiber; a gold film, an MOF-808 material and a medicine component are sequentially arranged on the surface of the SPR sensing area. Cladding mode light is attenuated to zero under the absorption of the cladding and the high-refractive-index coating layer, SPR incident angles when light beams in the six fiber cores are incident to a gold film in an SPR sensing area are adjusted, and then the intensity of an electric field is enhanced through MOF-808, so that the sensitivity of the sensor is improved; when the drug component is combined with the target spot, the SPR resonance valley moves to realize drug-target spot affinity detection; the invention solves the problem of low sensitivity of the traditional optical fiber SPR sensor, and has the advantage of high mechanical strength.
Owner:CHONGQING THREE GORGES UNIV

Low-thermal-conductivity light-heat conversion composite phase change material, and preparation method and application thereof

The application belongs to the technical field of phase change heat storage materials, and particularly relates to a low-thermal-conductivity light-heat-conversion composite phase change material and a preparation method and application thereof, and comprises the following steps: (1) after the pretreated expanded perlite is immersed in a silver nitrate solution, a sodium citrate solution is added to perform a hydrothermal reaction, and a silver / expanded perlite composite is prepared; (2) after the hydrated inorganic salt and a nucleating agent are mixed and melted, the silver / expanded perlite composite is added and mixed, and after cooling, the low-thermal-conductivity light-heat-conversion composite phase change material is obtained. The expanded perlite is used as an adsorption material, and compared with carbon materials such as expanded graphite and graphene, the price is low, and the low thermal conductivity of the composite material is ensured; the silver nanoparticles are prepared by using a mild hydrothermal method, the process is simple and economical, and the surface plasmon resonance effect is used to compensate for the poor light absorption capacity of the expanded perlite. The expanded perlite and the silver nanoparticles synergistically act, and low thermal conductivity and high light-heat conversion are simultaneously achieved.
Owner:SHANDONG JIANZHU UNIV

Localised surface plasmonic sensing

A localised surface plasmonic sensing device is disclosed. This comprises: a substrate; a first, second, third and fourth (at least) array of localised surface plasmon resonance island structures on the substrate, each array located to be spaced apart and isolated from each other on the substrate. Each array also has different surface functionalisations for selective interaction with respective analytes. The selective interaction with respective analytes of the first, second, third and fourth surface functionalisations is other than by specific binding of the respective analytes, thereby allowing for cross-reactive sensing by simultaneous analysis of localised surface plasmons at each array of localised surface plasmon resonance island structures. Also disclosed is a method of analysing a fluid to detect the presence and / or concentration of at least one analyte, using such a device.
Owner:THE UNIV COURT OF THE UNIV OF GLASGOW