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69 results about "Surface plasmon resonance" patented technology

Surface plasmon resonance (SPR) is the resonant oscillation of conduction electrons at the interface between negative and positive permittivity material stimulated by incident light. SPR is the basis of many standard tools for measuring adsorption of material onto planar metal (typically gold or silver) surfaces or onto the surface of metal nanoparticles. It is the fundamental principle behind many color-based biosensor applications, different lab-on-a-chip sensors and diatom photosynthesis.

Multi-dimensional light pressure regulation and control method and device based on metasurface microstructure array

The invention relates to the technical field of optical metasurface and light field regulation and control, in particular to a light pressure multi-dimensional regulation and control method and device based on a metasurface microstructure array. The method comprises the following steps: designing and preparing a metasurface microstructure array, wherein the microstructure array is composed of a plurality of sub-wavelength scale three-dimensional microstructure units arranged on a dielectric substrate; surface plasmon resonance is excited by adjusting structural parameters of the three-dimensional microstructure units and adjusting working parameters of a light source acting on the microstructure array, and near-field localization and enhancement are achieved. And calculating, regulating and controlling the light pressure borne by the metasurface microstructure array based on the Maxwell stress tensor. The method can keep a remarkable light pressure enhancing effect in a wide spectrum range of 380-1300 nm, and is suitable for various material systems such as silver, gold and the like. The method can be applied to the fields of optical tweezers systems, optical control devices, precision measurement and the like, and has the advantages of flexible design, simplicity and convenience in preparation, high regulation and control precision and the like.
Owner:TIANJIN UNIV

Preparation method of flexible infrared metasurface absorber based on MDM

PendingCN121878891AOptical filtersMetal membraneResonant absorption
The invention discloses a preparation method of a flexible infrared super-surface absorber based on MDM, and belongs to the field of micro-nano machining patterning. The method comprises the following steps: pretreating a polymer material; depositing a layer of bottom metal film on the pretreated substrate by adopting magnetron sputtering; a metal reflecting layer, a dielectric insulating layer and a metal surface functional layer are sequentially deposited through magnetron sputtering, a periodic nano microstructure is constructed on the surface of a flexible composite film, a nano round pit array is etched in situ on a surface metal layer of an MDM structure by using a femtosecond laser selective etching process, and an MDM laminated structure is formed. According to the invention, stable integration of the MDM structure and the flexible substrate can be realized, and meanwhile, high absorptivity and good flexibility of the device in an infrared band are ensured. The absorber prepared by the invention can generate resonance absorption on incident infrared electromagnetic waves through a surface plasmon and F-P cavity resonance coupling mechanism, and meanwhile, the characteristic size variation is changed through physical excitation, so that effective absorption and frequency regulation of the electromagnetic waves at the infrared band of 3-14 microns are realized.
Owner:BEIJING INFORMATION SCI & TECH UNIV

A light field regulation detection method and device based on computational spectral reconstruction

PendingCN122384983ANanopillarQuartz substrate
The application discloses a kind of light field regulation detection method and device based on computing spectral reconstruction, belong to spectral analysis technical field.The method is by introducing medium-metal composite nanostructure, integrates metal nanoisland array and silicon nitride nanocolumn array on quartz substrate, realizes electric field enhancement using the local surface plasmon resonance effect excited by metal nanoisland array, simultaneously realizes wide spectral range phase coding by medium nanocolumn array;Super surface chip is integrated with single point detector, combines pre-calibrated super surface sensing matrix A and enhancement factor matrix E, and reconstructs spectrum using compressed sensing or Tikhonov regularization algorithm.The application keeps the advantages of miniaturization and no moving parts, realizes directional high sensitivity detection to weak signal, and signal-to-noise ratio is improved.
Owner:HANGZHOU INNOWAY TECH CO LTD

On-chip spectrum sensing structure, pixel unit and preparation method and application thereof

The invention discloses an on-chip spectrum sensing structure, a pixel unit and a preparation method and application thereof. The on-chip spectrum sensing structure comprises a metal layer, a dielectric layer and a detector, nano-pore channels are formed in the metal layer and the dielectric layer, and the nano-pore channels extend into the dielectric layer from the surface of the metal layer; near-infrared light forms surface plasmon resonance at the interface of the metal layer and the dielectric layer in the nanopore channel, so that part of near-infrared light in a selected narrow wavelength range is transmitted to the detector, and a corresponding electric signal is formed. According to the on-chip spectrum sensing structure provided by the invention, near-infrared broadband calculation spectrum sensing with high spectral fidelity can be realized, radiation and ohmic loss are effectively inhibited by a nonlinear parameterized design framework, and high transmission efficiency is ensured; the multi-channel super-pixel system structure generated by the method realizes simultaneous point spectrum and snapshot hyperspectral imaging, and shows the potential of the compact platform for field deployment and chip spectrum sensing application.
Owner:INST OF PHYSICS HENAN ACAD OF SCI +1

Preparation method and application of doxycycline molecularly imprinted SPR (Surface Plasmon Resonance) sensing chip

The invention provides a preparation method and application of a doxycycline (DOX) molecularly imprinted surface plasmon resonance (SPR) sensing chip. According to the chip, an SPR bare gold chip is used as a substrate, DOX is used as a template molecule, a molecularly imprinted polymer (MIP) recognition membrane is constructed on the surface of the chip, and collaborative integration of the MIP technology and the SPR technology is achieved. According to the strategy, the chip is endowed with specific recognition capability on template molecules DOX, and local refractive index change caused by combination of the DOX and the recognition film can be detected in real time in an unmarked manner, so that the detection sensitivity and accuracy are remarkably improved. By utilizing an SPR (Surface Plasmon Resonance) analyzer, the chip can realize rapid quantitative detection of DOX in a low concentration range, shows good reproducibility, and can be applied to detection of actual samples.
Owner:ZHEJIANG UNIV CITY COLLEGE

Aflatoxin detection method based on surface plasma resonance effect, kit and application

The invention belongs to the technical field of aflatoxin detection, and relates to an aflatoxin detection method based on a surface plasma resonance effect, a kit and application. Comprising the following steps: S1, preparing a lysine functionalized gold / silver nanoparticle solution; s2, adding an aflatoxin standard solution with known concentration into the Hg < 2 + > standard solution, oscillating and incubating, and then adding the lysine functionalized gold / silver nanoparticle solution to construct an aggregation colorimetric reaction system; and a series of aggregation colorimetric reaction systems. S3, acquiring color data by a machine image recognition technology, wherein the color data comprises an R value, a G value and a B value; s4, constructing a standard curve; s5, color data of a to-be-detected sample are obtained, and the content of aflatoxin in the to-be-detected sample is obtained through the standard curve. Visual quantitative analysis detection of aflatoxin is realized, the sensitivity is ensured, the detection process is simple, and the test efficiency is high.
Owner:SHAANXI NORMAL UNIV

Preparation method of bismuth single element / bismuth oxide / carbon nitride composite material and application thereof as chlorine removal agent

The application discloses a preparation method of a bismuth single element / bismuth oxide / carbon nitride composite material and application of the bismuth single element / bismuth oxide / carbon nitride composite material as a chlorine removal agent, and the bismuth single element / bismuth oxide / carbon nitride composite chlorine removal agent is prepared by taking bismuth nitrate pentahydrate as raw material and introducing melamine precursor. In the process of calcination, the melamine generates elemental carbon and carbon monoxide, and plays a regulating role in the morphology of the chlorine removal agent; the reducing property generated in the forming process can convert Bi 3+ into Bi single element, and the surface plasmon resonance effect of the Bi single element is utilized to improve the photocatalytic chlorine removal performance of the composite chlorine removal agent.
Owner:JIANGSU UNIV OF TECH

SPR (Surface Plasmon Resonance) phase imaging system and method based on four polarization filter arrays

PendingCN121805205AMaterial analysis by optical meansDifferential phaseImage resolution
The invention discloses an SPR phase imaging system based on a four-polarization filtering array, and the system comprises an incident light path which is used for generating area array laser; the SPR module is used for receiving the area array laser and carrying out SPR sensing to obtain an area array laser modulation result related to a to-be-detected substance; and the imaging light path is used for carrying out amplification and filtering modulation on the area array laser modulation result so as to carry out imaging on a four-polarization array, and carrying out matched filtering and double-differential phase resolving on a four-polarization image so as to obtain an imaging result. According to the invention, through polarization virtual image generation and cross-channel block matching, and in combination with four-dimensional collaborative filtering, the noise suppression efficiency is improved; and through double differential phase resolving, the dynamic range is expanded to 0.06 RIU, and the resolution ratio is superior to that of the RIU. The invention solves the problem of mutual restriction of dynamic range and resolution in the traditional SPR technology, and is suitable for high-sensitivity biomolecule interaction detection.
Owner:TSINGHUA UNIVERSITY

A humidity sensing device and system

ActiveCN117110245BEngineeringPrism
The embodiment of the present application discloses a humidity sensing device and system, which comprises a prism, a metal film, a sensitizing layer and a sensing layer. Wherein, the light enters the prism to excite the surface of the metal film to generate surface plasmon resonance phenomenon, which can change with the amount of water absorbed by the sensing layer. The sensitizing layer improves the sensitivity of the humidity sensing device. The sensing layer captures water in the air while having strong coupling effect with the metal film, which converts the original single SPR resonance peak into coherent double peaks. The user uses the above effect to design a proportional SPR humidity sensing device, eliminates the error in humidity detection, facilitates calculation and enhances the reliability of data. In addition, the sensing layer protects other structures by using its own structural characteristics. The present application provides a humidity detection device with high measurement accuracy and reliability, and the overall structure is not easy to be damaged.
Owner:UNIV OF SHANGHAI FOR SCI & TECH

Skin pricking liquid for allergy detection in safflower injection as well as preparation method and kit of skin pricking liquid

The invention discloses a preparation method of a skin pricking liquid for allergy detection in a safflower injection preparation, and provides an efficient screening method of allergens in the safflower injection preparation and a preparation method of an allergen skin pricking liquid in order to solve the problems that chemical components in the safflower injection preparation are complex, sensitization components are not clear and the like. According to the method, chemical components in the safflower injection preparation are rapidly clarified by adopting a high performance liquid chromatography-mass spectrometry technology; carrying out molecular docking on the identified chemical components, human serum albumin, MRGPRX2 protein and RhoA protein by using a molecular docking technology, and screening out compounds combined with the proteins; further performing allergen evaluation and confirmation on the compound screened by the molecular docking technology by using a surface plasmon resonance instrument; according to the SPR technology, it is confirmed that the safflower injection preparation allergen is prepared into skin pricking liquid which is used for clinically screening safflower injection preparation potential allergy people, and the purpose of greatly reducing the allergy occurrence rate is achieved.
Owner:SHANXI DEYUANTANG PHARM CO LTD

Preparation method and application of ciprofloxacin molecularly imprinted SPR (Surface Plasmon Resonance) sensing chip

The invention provides a preparation method and application of a molecularly imprinted surface plasmon resonance (SPR) sensing chip of ciprofloxacin (CFX). According to the chip, molecularly imprinted polymers (MIPs) are combined with an SPR technology, so that the detection sensitivity and accuracy are effectively improved, the chip has obvious signal response to CFX with lower concentration, and the detection limit can be as low as nanomole level. When the CFX molecularly imprinted SPR chip prepared by the invention is used for CFX detection, the operation steps are simple, the analysis time is short, the specificity and reproducibility are good, the operation is simple and rapid, and the chip has important practical application value.
Owner:ZHEJIANG UNIV CITY COLLEGE

Imaging sensor based on full stokes polarized superlens

The application discloses an imaging sensor based on a full-Stokes polarization superlens, and relates to the field of optical sensing.The imaging sensor comprises a sensing excitation light source, an adjustable attenuator, a polarizer, a coupling prism, a sensing chip, a first objective lens, a full-Stokes polarization superlens, a second objective lens, an imaging lens and a CCD imaging camera; the sensing excitation light source emits monochromatic light as system incident light, which sequentially passes through the adjustable attenuator and the polarizer, and is incident onto the surface of the sensing chip to generate surface plasmon resonance after passing through the coupling prism; reflected light is converged onto the polarization superlens by the first objective lens, and then converged onto the second objective lens; subsequently, the imaging lens is used for imaging to the CCD camera; the property change of a to-be-measured sample leads to surface plasmon resonance of the sensing chip, which causes the analysis information of the full-Stokes polarization superlens to change, and further causes the image obtained by the CCD imaging camera to change.The application can perform single-shot phase imaging on a refractive index sample.
Owner:台州安奇灵智能科技有限公司

Inhibitory peptide that binds to PEDV Nsp5 protein

ActiveCN116486897BBiostatisticsProteomicsProtein targetIndirect Immunofluorescence Assays
This invention utilizes a machine learning model to analyze the crystal structure of the PEDV Nsp5 protein. Through virtual peptide screening technology, a peptide sequence with potential affinity for the target protein, YKKLHK(162860), was artificially synthesized in a solid phase. Using artificially expressed PEDV Nsp5 protein, the peptide was screened using an ELISA assay. The affinity constant between the peptide and the target protein was determined using surface plasmon resonance (SPR) assays. The cytotoxicity of peptide 162860 was tested using a CCK-8 assay kit. Its inhibitory activity against viral infection was tested using quantitative real-time PCR and indirect immunofluorescence assays. The results showed that the 162860 sequence significantly inhibited PEDV infection.
Owner:HENAN ACAD OF AGRI SCI

Material and structure combined sensibilization optical fiber SPR sensor and manufacturing and using method thereof

The invention belongs to the field of optical fiber sensing, and particularly relates to a material and structure combined sensitization optical fiber SPR (surface plasmon resonance) sensor and a manufacturing and using method thereof, the sensor comprises a cladding mode attenuation area, a fiber core angle regulation and control area, an SPR sensing area and a thick core light receiving area which are connected in sequence; the cladding mode attenuation area is a six-core optical fiber of which the surface is provided with a coating layer; the fiber core angle regulation and control region is a torsion type six-core optical fiber; a gold film, an MOF-808 material and a medicine component are sequentially arranged on the surface of the SPR sensing area. Cladding mode light is attenuated to zero under the absorption of the cladding and the high-refractive-index coating layer, SPR incident angles when light beams in the six fiber cores are incident to a gold film in an SPR sensing area are adjusted, and then the intensity of an electric field is enhanced through MOF-808, so that the sensitivity of the sensor is improved; when the drug component is combined with the target spot, the SPR resonance valley moves to realize drug-target spot affinity detection; the invention solves the problem of low sensitivity of the traditional optical fiber SPR sensor, and has the advantage of high mechanical strength.
Owner:CHONGQING THREE GORGES UNIV

A polypeptide sequence capable of inhibiting PEDV

The application is used for analyzing the S1-CTD region of the PEDV S protein crystal structure by means of a machine learning model, and a polypeptide sequence FWKSKR (110766) with potential is screened from the target protein by polypeptide virtual screening technology. The 110766 sequence is artificially synthesized on a solid phase, and the polypeptide is screened by means of ELISA experiment using artificially expressed PEDV S1 protein. The affinity constant of the polypeptide and the target protein is identified by means of surface plasmon resonance experiment (SPR). The cytotoxicity of the polypeptide 110766 is tested by CCK-8 kit. The virus infection inhibiting activity of the polypeptide is tested by means of fluorescent quantitative PCR and indirect immunofluorescence experiment. The results show that the 110766 sequence can significantly inhibit the infection of PEDV.
Owner:HENAN ACAD OF AGRI SCI

Molybdenum-doped nano-zinc oxide with high visible-light photocatalytic performance and preparation method and application thereof

ActiveCN119793438BWater/sewage treatment by irradiationWater contaminantsNitrogen gasVisible light photocatalytic
The application discloses molybdenum-doped nano zinc oxide with high visible light photocatalytic performance and a preparation method and application thereof. The molybdenum-doped nano zinc oxide is prepared from 1-octadecene, 1-dodecanol, oleic acid, a zinc source and a molybdenum source through vacuum degassing treatment, uniform stirring under a nitrogen atmosphere, heating to 100-140 DEG C, keeping warm until solid particles are dissolved, heating to 220-250 DEG C, keeping warm for 0.5-1 h of reaction, and cooling, washing and drying. The molybdenum-doped nano zinc oxide produces a local surface plasmon resonance absorption peak in the range of 600-700 nm through molybdenum ion doping, and the nano powder has a diameter of 5-20 nm; and the visible light photocatalytic performance of the zinc oxide material is greatly improved under the condition of visible light.
Owner:SOUTH CHINA UNIV OF TECH

Plasmon imaging-based real-time monitoring system and method for nano-enzyme polymer degradation kinetics

PendingCN121740804AScattering properties measurementsPolymer degradationMaterials science
The invention discloses a real-time monitoring system and method for nano-enzyme degradation polymer dynamics based on plasmon imaging, and the system comprises a monochromatic laser emission module which is used for generating excitation light with a fixed wavelength, and adjusting a light path to excite surface plasmon resonance; the sample reaction module comprises a plasmon resonance gold sheet of which the surface is modified with a polymer molecular layer, and a sample pool for accommodating a reaction solution; the optical detection module is used for collecting and detecting scattered light signals from the sample reaction module and carrying out image acquisition; wherein the monochromatic laser emission module, the sample reaction module and the optical detection module are sequentially connected according to a light path; the invention provides a new important research means for researching the local change of the single nano enzyme and the interaction of biomolecules.
Owner:NANJING UNIV +1

Magnetofluid filling-based photonic crystal fiber surface plasmon resonance electric field sensing system and method

The invention relates to the technical field of optical fiber sensors, in particular to a photonic crystal fiber surface plasmon resonance electric field sensing system and method based on magnetic fluid filling, a sensing unit and an optical measurement unit. The sensing unit comprises a photonic crystal fiber and a magnetic fluid, at least one flat sensing area is formed on the outer side of a fiber core area of the photonic crystal fiber, and a metal film and a dielectric protection film are sequentially arranged in the sensing area; a cladding area of the photonic crystal fiber is provided with a plurality of layers of air through holes; the magnetic fluid is arranged around the sensing area; and the optical measurement unit is connected with the sensing unit and is used for providing incident light for the photonic crystal fiber, receiving output light which is returned from the photonic crystal fiber and carries electric field sensing information, analyzing the spectral response of the output light and determining the intensity of the electric field to be measured based on the spectral response. Compared with the prior art, the detection precision is higher, and the loss is smaller.
Owner:GUANGDONG UNIV OF TECH

An inhibitory polypeptide targeting the s1 protein of porcine viral diarrhea virus

This invention utilizes a machine learning model to analyze the S1-CTD region of the PEDV S protein crystal structure. Through virtual peptide screening, a peptide sequence of FWKEAK (110616) with potential affinity for the target protein was identified. The 110616 sequence was artificially synthesized in a solid phase, and the peptide was screened using ELISA with artificially expressed PEDV S1 protein. The affinity constant between the peptide and the target protein was determined using surface plasmon resonance (SPR) assays. The cytotoxicity of peptide 110616 was tested using a CCK-8 assay kit. Its inhibitory activity against viral infection was assessed using quantitative real-time PCR and indirect immunofluorescence assays. The results showed that the 110616 sequence significantly inhibited PEDV infection.
Owner:HENAN ACAD OF AGRI SCI

A vortex beam orbital angular momentum detector and detection method based on surface plasmon resonances

This invention discloses a vortex beam orbital angular momentum detector and detection method based on surface plasmons, belonging to the field of micro-nano photonics and photoelectric detection. The detector is based on a planar photodetector of the "metal-semiconductor-metal" type. A vortex beam-splitting structure, including an incident coupling grating, is provided on a metal electrode on one side of the detector or between two metal electrodes. This structure can split the incident light field carrying different orbital angular momentum into plasmons in different directions. By utilizing the differences in the direction and propagation loss of the plasmons, single-detector resolution of the vortex beam's orbital angular momentum is achieved. The detector of this invention is compatible with existing semiconductor processes, has a simple structure, can detect vortex beams carrying high-order orbital angular momentum, and can also detect the rotation direction of the vortex beam.
Owner:PEKING UNIV

Preparation method of material with plasmon array and material

PendingCN121806170AAnodisationPhotomechanical apparatusResonance wavelengthPhysical chemistry
The invention discloses a preparation method of a material with a plasmon array and the material. The method comprises the steps that based on a preset nickel female template, imprinting is carried out on a pretreated first original metal sheet; performing anodic oxidation on the first surface of the first original metal sheet to prepare an initial mask plate with an anodic oxidation layer; performing reprocessing on the initial mask plate so as to remove redundant materials on the first original metal sheet under the condition of protecting the anodic oxide layer, thereby obtaining the mask plate; and on the basis of a mask plate, imprinting is performed on the preprocessed second original metal sheet, and the material with the plasmon array is prepared. The material with the array period distance equivalent to the resonance wavelength and coupled with the Bloch wave can be prepared in a secondary imprinting mode, it can be guaranteed that the uniformity and stability of the photon local area are improved under resonance, in addition, the material can inhibit radiation damping through surface plasmon resonance, photons are strongly localized at the nanoscale, and the performance of the material is improved. Therefore, the interaction between the light and the substance is enhanced.
Owner:HARBIN ENG UNIV +1

Method for preparing patterned molybdenum dioxide film through laser induction and flexible electronic device

The invention relates to a method for preparing a patterned molybdenum dioxide thin film through laser induction and a flexible electronic device, and belongs to the technical field of functional material preparation and processing, precursor ink containing molybdenum trioxide nanoparticles, polyvinylpyrrolidone and isopropanol is prepared, a substrate is coated with the precursor ink to form a precursor thin film, and the patterned molybdenum dioxide thin film is prepared. And after drying and curing, carrying out laser direct writing reduction sintering on the precursor film, and reducing and sintering into molybdenum dioxide by utilizing a photothermal effect generated by surface plasmon resonance. The invention aims to overcome the dependence of a traditional process on a high-temperature vacuum environment, and provides a method for efficiently preparing a molybdenum dioxide film with high conductivity and biocompatibility in an environment atmosphere in a patterning manner, and a multifunctional flexible electronic device is constructed based on the film.
Owner:ZHEJIANG UNIV

A method, apparatus, electronic device, and medium for determining sample deformation information.

ActiveCN119063644BUsing optical meansReflectivity measurementLight excitation
This application provides a method, apparatus, electronic device, and medium for determining sample deformation information, relating to the field of photothermal detection technology. The method includes: after the sample surface of the sample to be tested is excited by pump light and a probe light detects any point on the excited sample surface, acquiring the difference signal between the signal light and the reference light determined by the detection device and converted into electrical signals; processing the difference signal using a preset algorithm to determine the change in reflectivity of an SPR element (Surface Plasmon Resonance Optical Element); determining the change in reflection angle corresponding to the change in reflectivity of the SPR element based on the correspondence between the reflectivity of the configured SPR element and the reflection angle of the probe light on the sample to be tested; and determining the deformation information of the corresponding point on the sample surface of the sample to be tested based on the change in reflection angle. This method utilizes an SPR element to achieve direct conversion between the reflectivity measurement of the sample to be tested and surface deformation information, ensuring the accuracy of deformation information measurement.
Owner:SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY

A method for preparing a raman silent zone magnetic sers substrate

The application discloses a preparation method of a Raman silent zone magnetic SERS substrate, and belongs to the technical field of surface enhanced Raman spectroscopy. The preparation method of the Raman silent zone magnetic SERS substrate comprises the following steps: firstly, a layer of gold nanoshell is wrapped on the surface of a ferroferric oxide particle to obtain Fe3O4@Au nanoparticles; then, a Raman beacon molecule 4-mercaptobenzonitrile is modified on the surface of the Fe3O4@Au; and further, a layer of silver nanoshell is wrapped on the surface of the Fe3O4@Au@4-mercaptobenzonitrile to obtain the Raman silent zone magnetic SERS substrate Fe3O4@Au@4-mercaptobenzonitrile@Ag. The Fe3O4@Au@4-mercaptobenzonitrile@Ag prepared by the method has uniform size and morphology, has a strong spectral peak at a Raman silent zone 2226 cm ‑1 ; and in combination with the local surface plasmon resonance property of the core-shell structure, the sensitivity of SERS detection can be effectively enhanced, and the Raman silent zone magnetic SERS substrate has a good practical application prospect in the field of rapid detection of food and the like.
Owner:NANJING FOOD & DRUG SUPERVISION & INSPECTION INST

Gain-type fiber-optic surface plasmon sensor and its detection sensing system

The application discloses a gain type optical fiber surface plasmon sensor and a detection sensing system thereof, and comprises a multimode optical fiber with an optical fiber end face at one end, which comprises a noble metal layer, a plasmon active layer and a perfect absorber array from outside the optical fiber end face in sequence; wherein the noble metal layer is solidified on the optical fiber end face of the multimode optical fiber; the plasmon active layer is solidified on the upper surface of the noble metal layer; and the perfect absorber array is solidified on the upper surface of the plasmon active layer and is composed of a plurality of regularly arranged cross-shaped nanometer gold units. The plasmon sensor of the application can produce strong local surface plasmon resonance at the absorption wavelength by using the MIM perfect absorber composed of metal-dielectric layer-metal, and at this time, the incident light is effectively captured in the middle layer, so that the incident light has enough time to dissipate through the ohmic loss of the gold film and the cross-shaped nanometer gold array, thereby achieving the purpose of perfect absorption.
Owner:TIANJIN UNIV

Nanometer antibody targeting membrane protein LRRC15 and application thereof

The invention provides a nano antibody of a targeted membrane protein LRRC15 and application of the nano antibody of the targeted membrane protein LRRC15. According to the present invention, the specific LRRC15 targeting nano-antibody is successfully obtained through screening, and the nano-antibody has three complementary determining regions of the amino acid sequences represented by SEQ ID NO: 6-SEQ ID NO: 8; the nano antibody has the outstanding advantages of strong tissue penetrating power, low immunogenicity, good stability and the like. Through surface plasmon resonance technology determination, the dissociation constant (KD) of the polypeptide and LRRC15 protein is 3.52 [mu] M, and the polypeptide shows excellent specific binding activity. The nano antibody provided by the invention provides a brand new core tool for preparing an osteosarcoma targeted molecular imaging probe, a therapeutic drug or a detection kit, overcomes the defect of insufficient permeability of a traditional macromolecular antibody in solid tumor treatment, opens up a new technical path for realizing accurate diagnosis and efficient treatment of osteosarcoma, and has a wide application prospect. The application prospect is very wide.
Owner:ZHONGNAN HOSPITAL OF WUHAN UNIV

Surface enhanced Raman scattering substrate, preparation method and application thereof

The invention discloses a surface enhanced Raman scattering substrate, a preparation method and application thereof, and belongs to the technical field of Raman spectrum detection, and the surface enhanced Raman scattering substrate sequentially comprises a substrate layer, a distributed Bragg reflector, a chalcogenide phase change material functional layer and a nanoscale metal structure layer from bottom to top. The distributed Bragg reflector is formed by stacking periodic structures composed of dielectric materials with different refractive indexes. The distributed Bragg reflector and the nanoscale metal structure layer are coupled to excite the Tamm state, the chalcogenide phase change material functional layer can achieve reversible regulation and control of the amorphous state and the crystalline state under external light excitation, and the Tamm state resonance wavelength is changed to regulate and control the SERS enhancement effect. High-sensitivity detection is realized through dual enhancement of Tamm state and local surface plasmon resonance, and the sensor has the characteristics of non-volatility, reconfigurability, high reproducibility and flexible design, is convenient to operate and stable in performance, and is suitable for the fields of chemical biosensing, laboratory chip systems, optical encryption and the like.
Owner:DALIAN UNIV OF TECH

A method for glucose detection using a hollow anti-resonant optical fiber based on a polylysine and phenylboronic acid composite membrane.

This invention relates to the field of biomedical detection technology and provides a method for glucose detection based on a hollow antiresonant optical fiber using a polylysine and phenylboronic acid composite membrane. The detection method includes a light source, an optical fiber isolator, a first single-mode optical fiber patch cord, a microfluidic device, a hollow antiresonant optical fiber, a second single-mode optical fiber patch cord, a spectrometer, and a computer. The hollow antiresonant optical fiber is fabricated using a stacked drawing and pressure-assisted splicing process. Gold wires are filled within two selected symmetrical small antiresonant tubes, and the outer wall of these tubes is coated with a polylysine and phenylboronic acid composite membrane. The microfluidic device integrates filtration, temperature control, flow rate control, and pressure monitoring functions. When the polylysine and phenylboronic acid composite membrane specifically binds to glucose molecules in the test solution, the refractive index of the composite membrane is changed, further altering the resonance conditions of surface plasmon resonances, ultimately causing a quantitative shift of the loss peak. The spectrometer collects data, and the computer analyzes the glucose concentration. This method features high sensitivity, strong specificity, good anti-interference, good stability, and integration, providing a new solution for glucose detection and meeting the needs of medical testing and health monitoring.
Owner:HARBIN UNIV OF SCI & TECH

Molecular interaction sample preparation system

The utility model relates to the technical field of sample preparation, in particular to a molecular interaction sample preparation system, which is used for sample preparation and concentration preparation of a molecular interaction instrument, and comprises a base, a sample tray, a sample preparation device and a sample preparation device, the composite pipetting device is arranged above the base, and the composite pipetting device comprises an eight-channel pipetting module which is used for executing simultaneous pipetting operation of a plurality of samples and is suitable for batch sample treatment and gradient dilution; the single-channel pipetting module is used for transferring and distributing small-volume samples and is suitable for micro-sample treatment; and the composite moving device is used for driving the eight-channel pipetting module and the single-channel pipetting module to move in the horizontal direction and the vertical direction. The scheme is used for supporting sample preparation and concentration preparation work of molecular interaction instruments such as a surface plasmon resonance instrument (SPR), a biological layer interference analyzer (BLI) and a micro thermophoretic mover (MST).
Owner:PEKING UNIV +2

A method for preparing a programmable composite carbon-based evaporator for water desalination

This invention belongs to the field of photo-evaporation for water desalination, specifically relating to a programmable composite carbon-based evaporator (Janus-Fe3O4-CPS) and its preparation method. It utilizes a woven, natural, flexible *Ophiopogon japonicus* as the water transport substrate, combined with Fe3O4 as the photothermal conversion layer. The naturally hierarchical porous structure within the *Ophiopogon japonicus*-derived carbon enables rapid water transport through strong capillary action, promoting salt cycling and inhibiting crystallization. Furthermore, the metal-organic coordination bonds formed between Fe3O4 and the conjugated nitrogen structure of the plant-derived carbon enhance the local surface plasmon resonance effect. The hydrophobic properties of the upper surface and the hydrophilic properties of the lower surface of the photo-evaporator together constitute a salt-resistant Janus structure. Based on this, the applicant has designed various evaporators with good performance using porous carbon derived from *Ophiopogon japonicus*, demonstrating excellent performance.
Owner:YANCHENG INST OF TECH