PH-responsive anti-tumor drug carrier material and preparation and application of pH-responsive anti-tumor drug carrier material

An anti-tumor drug and carrier material technology, applied in the field of core-shell nanomaterials, can solve the problems of limited drug loading and inability to achieve drug loading, and achieve the effects of simple and rapid preparation method, strong designability, and high specific surface area.

Active Publication Date: 2017-12-01
HUAZHONG UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the solid structure of zinc oxide quantum dots, the loading of drugs cannot be realized, and the surface needs to be modified when it is used in tumor treatment
Although the modified ZnO QD can be used as a nano-drug carrier, its drug loading capacity is very limited

Method used

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  • PH-responsive anti-tumor drug carrier material and preparation and application of pH-responsive anti-tumor drug carrier material
  • PH-responsive anti-tumor drug carrier material and preparation and application of pH-responsive anti-tumor drug carrier material
  • PH-responsive anti-tumor drug carrier material and preparation and application of pH-responsive anti-tumor drug carrier material

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preparation example Construction

[0050] The preparation method of the anti-tumor drug carrier material with pH response in the present invention may comprise the following steps:

[0051] (1) Preparation of gold nanospheres coated with mesoporous silica: with HAuCl 4 4H 2 O is the precursor of gold nanospheres, formaldehyde is the reducing agent, CTAB is the surfactant and template, and TEOS is the silicon source. where HAuCl 4 4H 2 The molar ratio of O to TEOS is 1:10~1:80, HAuCl 4 4H 2 The molar ratio of O to CTAB is 2:7~1:3, HAuCl 4 4H 2 The molar ratio of O to formaldehyde is 3:1 to 5:1, and the pH is 9 to 11, and the reaction is 20 to 60 minutes at 80°C (or 60 to 100°C) to obtain mesoporous silica-coated gold. Nanosphere composites (AuNP@mSiO 2 );

[0052] (2) Preparation of gold nanorods coated with mesoporous silica: 9.75 mL ultrapure water, 0.25 mL HAuCl 4 4H 2 O solution (concentration can be 10-100mM) and 0.6mL NaBH 4 An aqueous solution (such as a sodium borohydride ice solution with a ...

Embodiment 1

[0060] The preparation method of the pH-responsive anti-tumor drug carrier material in this embodiment comprises the following steps:

[0061] (1) Preparation of gold nanospheres coated with mesoporous silica: with HAuCl 4 4H 2 O is the precursor of gold nanospheres, formaldehyde is the reducing agent, CTAB is the surfactant and template, and TEOS is the silicon source. where HAuCl 4 4H 2 The molar ratio of O to TEOS is 1:10, HAuCl 4 4H 2 The molar ratio of O to CTAB is 1:3, HAuCl 4 4H 2 The molar ratio of O to formaldehyde is 3:1 (HAuCl 4 The concentration in the whole mixed system can be 50mM), and the pH is 11, reacted for 20min (i.e. sealed and stirred) at 80°C to obtain the gold nanosphere composite material coated with mesoporous silica, such as figure 1 a, the particle size of gold nanospheres is about 23nm, and the monodispersity is good, figure 1 c is a gold nanosphere coated with mesoporous silica, in which the thickness of the mesoporous layer is 10nm, and ...

Embodiment 2

[0067] The preparation method of the pH-responsive anti-tumor drug carrier material in this embodiment comprises the following steps:

[0068] (1) Preparation of gold nanospheres coated with mesoporous silica: with HAuCl 4 4H 2 O is the precursor of gold nanospheres, formaldehyde is the reducing agent, CTAB is the surfactant and template, and TEOS is the silicon source. where HAuCl 4 4H 2 The molar ratio of O to TEOS is 1:30, HAuCl 4 4H 2 The molar ratio of O to CTAB is 1:3, HAuCl 4 4H 2 The molar ratio of O to formaldehyde was 3:1, and the pH was 11, and the reaction was carried out at 80°C for 60 min to obtain the gold nanosphere composite material coated with mesoporous silica. Such as figure 1 As shown in b, AuNP@mSiO 2 Spherical, uniform particle size, regular structure, clear pores, the core particle size is about 15nm, and the shell thickness is about 30nm;

[0069] (2) Preparation of gold nanospheres coated with carboxylated mesoporous silica: the above-menti...

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Abstract

The invention discloses a pH-responsive anti-tumor drug carrier material and a preparation and application of the pH-responsive anti-tumor drug carrier material. The preparation method comprises the following steps that (1) gold nanoparticles wrapped by mesoporous silica are prepared, and the gold nanoparticles comprise gold nanospheres or gold nanorods; (2) gold nanoparticles wrapped by carboxylation mesoporous silica are prepared; (3) water-soluble zinc oxide quantum dots are prepared; and (4) the pH-responsive anti-tumor drug carrier material is prepared. According to the pH-responsive anti-tumor drug carrier material and the preparation and application of the pH-responsive anti-tumor drug carrier material, the whole technological process design of the preparation method, the parameter conditions adopted by the reaction steps and the like are optimized, and the existing problems that drug releasing is uncontrollable, the drug loading capacity is low, and side effects are prone to being caused when the gold nanoparticles wrapped by the mesoporous silica serve as a drug carrier can be effectively solved.

Description

technical field [0001] The invention belongs to the field of advanced nanocomposite materials and biomedicine, and more specifically relates to a pH-responsive anti-tumor drug carrier material and its preparation and application. The pH-responsive anti-tumor drug carrier material uses gold nanoparticles as the core, Mesoporous silica as the shell and water-soluble zinc oxide quantum dots as the core-shell nanomaterials for the pH-responsive drug release switch. Background technique [0002] Malignant tumors have become a major disease that threatens human life and health. At present, radiation therapy and chemotherapy are mainly used in tumor treatment. During the treatment, these methods will produce side effects such as destroying normal cells and healthy tissues and eventually eliminating the patient's immunity, which brings a lot of pain to patients and their families. How to reduce the toxic and side effects of drugs without reducing the efficacy of drugs has become an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/02A61K47/04A61K31/704A61K41/00A61P35/00
CPCA61K9/5115A61K9/5192A61K31/704A61K41/0052
Inventor 朱锦涛刘丽平陶娟许楠王奎李钰策郭晨
Owner HUAZHONG UNIV OF SCI & TECH
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