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Hollow gold nanospheres (haunss) and haunss-loaded microspheres useful in drug delivery

A technology of gold nanospheres and microspheres, which is used in drug delivery, drug combination, preparations for in vivo tests, etc., can solve the problems of inability to regulate the timing of drug release, ineffectiveness, etc.

Inactive Publication Date: 2012-04-18
BOARD OF RGT THE UNIV OF TEXAS SYST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, prior art delivery systems cannot modulate the timing of drug release (slow or speed it up) because ordinary solid spherical particles do not efficiently convert light energy into heat in the near-infrared region.

Method used

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  • Hollow gold nanospheres (haunss) and haunss-loaded microspheres useful in drug delivery
  • Hollow gold nanospheres (haunss) and haunss-loaded microspheres useful in drug delivery
  • Hollow gold nanospheres (haunss) and haunss-loaded microspheres useful in drug delivery

Examples

Experimental program
Comparison scheme
Effect test

Embodiment I

[0059] experiment

[0060] Reagent

[0061] PLGA (lactide:glycolide = 50:50, viscosity = 0.20 dl / g) was purchased from DUREECT Corp. (Cupertino, CA). Polyvinyl alcohol (PVA; MW ~25000, 88 mol% hydrolyzed) was purchased from Polysciences, Inc. (Warrington, PA). PTX was provided by Yunnan Hande Bio-Tech Co., Ltd. (Houston, TX). Trisodium citrate dehydrate (>99%), cobalt chloride hexahydrate (99.99%), sodium borohydride (99%), and chloroauric acid trihydrate (ACS reagent grade) were purchased from Fisher Scientific (Pittsburgh, PA) and used if accepted. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and Tween 80 were purchased from Sigma-Aldrich (St. Louis, MO). Dichloromethane was obtained from Baxter Healthcare Corp. (Deerfield, IL).

[0062] cell line

[0063] U87 (human glioma) and MDA-MB-231 (human breast cancer) cell lines were obtained from the American Type Culture Collection (Manassas, VA). Cells were maintained at 37°C in 5% CO 2 Dalbecco's M...

Embodiment II

[0114] Materials and Experiments

[0115] Reagent

[0116] DOX, methoxy-PEG-SH (MW, 5,000), PBS (pH 7.4), and a cytotoxicity kit for MTT assay were obtained from Sigma-Aldrich (St. Louis, MO). Trisodium citrate dehydrate (>99%), cobalt chloride hexahydrate (99.99%), sodium borohydride (99%), and chloroauric acid trihydrate (ACS reagent grade) were purchased from Fisher Scientific (Pittsburgh, PA) and used if accepted. Dichloromethane (ACS grade) was obtained from Baxter Healthcare Corp. (Deerfield, IL). Gold nanoparticles with an average diameter of 41.5 nm were purchased from BB International (Madison, WI).

[0117] cell culture

[0118] MDA-MB-231 (human breast cancer) cells were maintained at 37 °C in an atmosphere containing 5% CO 2 in a humidified atmosphere of Dalbecco's Modified Eagle's Medium and 10% fetal bovine serum (Life Technologies, Inc., Grand island, NY).

[0119] Synthesis of HAuNS and conjugation of PEG to HAuNS

[0120] HAuNS were synthesized accordin...

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Abstract

A near-infrared mediated drug delivery system comprising a plurality of microspheres made of polymeric material, each sphere containing a plurality of hollow gold nanospheres together with drug product, wherein upon NIR irradiation, the drug product is released from the microsphere.

Description

[0001] Cross References to Related Applications [0002] This patent application claims priority from US Patent Application Serial Nos. 61 / 158,570 and 61 / 233,566, which are incorporated herein by reference in their entirety. [0003] Statement Regarding Federally Sponsored Research or Development [0004] This invention was made with Government support under R01 CA119387, Near-Infrared Fluorescence Nanoparticles for Targeted Optical Imaging, awarded by the National Cancer Institute (NCI) . The government has certain rights in this invention. [0005] Names of parties to the joint research agreement [0006] none. [0007] The material presented on CD-ROM is incorporated by reference [0008] none. Background of the invention [0009] Nanocarriers currently on the market as drug delivery platforms for therapeutic agents are organic nanoparticles composed of lipids and / or synthetic polymers. These nanocarriers include liposomes and lipid nanospheres. Davis, S.S., Coming...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K9/16A61K49/00A61K47/02A61P35/00
CPCA61K31/704A61K9/5115A61K41/0028A61K41/0052A61K47/48861A61K9/5031A61K47/6923A61P35/00
Inventor C.李J.尤
Owner BOARD OF RGT THE UNIV OF TEXAS SYST
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