Urchin-like gold nano-crystal with controllable lug spacing, as well as preparation method and application thereof

A gold nano, sea urchin-like technology, applied in the field of sea urchin-like gold nanocrystals and its preparation, can solve the problem of rare sea urchin-like AuNCs

Active Publication Date: 2019-02-22
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it remains challenging to precisely control the orientation and conformation of surface DNA and regulate its hybridization ability, and thus the distance between adjacent protrusions.
[0003] There have been many reports on the preparation methods of sea urchin-like AuNCs, but there are few reports on the preparation methods of sea urchin-like AuNCs with adjustable protrusion spacing.

Method used

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  • Urchin-like gold nano-crystal with controllable lug spacing, as well as preparation method and application thereof
  • Urchin-like gold nano-crystal with controllable lug spacing, as well as preparation method and application thereof
  • Urchin-like gold nano-crystal with controllable lug spacing, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] In this example, the synthesis of sea urchin-like AuNCs with controllable protrusion spacing includes the following steps (for the preparation schematic diagram, see Figure 2a ):

[0035](1) Synthetic guide solution: According to the molar ratio of dsDNA molecules and AuNSs of 1000:1, the dsDNA molecules are composed of diblock DNA and the complementary chain of its recognition chain, and the dsDNA molecules are recorded as PolyA type For dsDNA molecules, take a corresponding amount of AuNSs solution and mix with dsDNA solution. The radius of AuNSs in the AuNSs solution is 55nm. The dsDNA solution is a PolyA10 type dsDNA solution with 10 adenines in the PolyA segment. Then add sodium chloride to the molar concentration of 0.1mol / L, and then age for 40h to prepare the AuNSs / dsDNA complex solution, which is then centrifuged, and then the separated AuNSs / dsDNA complex precipitate is resuspended in 1.0 mL of pure water, the resulting solution is used as a guide solution f...

Embodiment 2

[0042] The steps and operating conditions for synthesizing sea urchin-shaped AuNCs with controllable protrusion spacing in this example are basically the same as in Example 1, except that the DNA solution used in step (1) is a PolyA20 type dsDNA solution with 20 adenines in the PolyA segment (The schematic diagram of its preparation can be found in Figure 2b ).

Embodiment 3

[0044] The steps and operating conditions for synthesizing sea urchin-shaped AuNCs with controllable protrusion spacing in this example are basically the same as in Example 1, except that the DNA solution used in step (1) is a PolyA30 type dsDNA solution with 30 adenines in the PolyA segment (The schematic diagram of its preparation can be found in Figure 2c ).

[0045] see Figure 2a ~c are the schematic diagrams of the preparation of Examples 1-3 of the present invention, respectively. It can be seen from the figure that PolyA-type dsDNA containing PolyA segments of different lengths will affect the distance between adjacent protrusions on the surface of sea urchin-shaped AuNCs generated by the corresponding directed self-assembly.

[0046] see image 3 , which are transmission electron microscope images (A-C) and corresponding UV-visible absorption spectra (D) of sea urchin-like AuNCs with controllable protrusion spacing obtained in Example 1-3, wherein A-C are respecti...

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Abstract

The invention relates to a method for preparing an urchin-like gold nano-crystal with controllable lug spacing. The method comprises the following steps: firstly modifying double-stranded DNA (dsDNA)molecules to the surface of gold nano-spheres (AuNSs) to prepare an AuNSs/dsDNA compound; and performing an in-situ reduction reaction on chloroauric acid and a reducing agent in a solution to generate the urchin-like gold nano-crystal under the guiding effect of the AuNSs/dsDNA compound. The invention further relates to the urchin-like gold nano-crystal prepared by the preparation method, the spacing of lugs on the surface of the nano-crystal and the location of largest resonance absorption peak of plasma on the surface of the nano-crystal can be controlled by changing the composition of dsDNA. Compared with the prior art, the preparation method has the advantages of easy implementation and low synthesis cost, and can regulate and control the surface spacing and performance of the urchin-like gold nano-crystal.

Description

technical field [0001] The invention relates to the technical field of nanomaterial synthesis, in particular to a sea urchin-shaped gold nanocrystal with controllable protrusion spacing, a preparation method and application thereof. Background technique [0002] The combination of DNA and gold nanoparticles has promoted the development of scientific research to a certain extent. Based on AuNSs, sea urchin-like gold nanocrystals (AuNCs) with many protrusions on the surface can be synthesized by DNA-directed self-assembly. However, it is still challenging to precisely control the surface DNA orientation and conformation, and regulate its hybridization ability, and thus control the distance between adjacent protrusions. [0003] There have been many literature reports on the preparation methods of sea urchin-like AuNCs, but there are few related reports on the preparation methods of sea urchin-like AuNCs with adjustable protrusion spacing. Contents of the invention [0004]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C30B29/02C30B29/66C30B7/14B22F9/24B22F1/00B82Y30/00B82Y40/00
CPCC30B7/14C30B29/02C30B29/66B82Y30/00B82Y40/00B22F9/24B22F1/0553B22F1/07B22F1/054
Inventor 张卓旻高嘉敏李攻科
Owner SUN YAT SEN UNIV
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