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Gold nanosphere/melanin composite nanometer opto-acoustic probe with ultra-strong opto-acoustic effect and preparation thereof

A gold nanosphere and photoacoustic effect technology, which is applied in the direction of nanotechnology, nanotechnology, nanotechnology, etc. for sensing, can solve the problems of damage, high biotoxicity, and poor biocompatibility, and achieve low biotoxicity, The effect of high biological inertia and strong photoacoustic signal

Inactive Publication Date: 2017-08-22
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the composite probe has poor biocompatibility, high biotoxicity, and is easy to accumulate in biological tissues and cause damage.

Method used

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  • Gold nanosphere/melanin composite nanometer opto-acoustic probe with ultra-strong opto-acoustic effect and preparation thereof
  • Gold nanosphere/melanin composite nanometer opto-acoustic probe with ultra-strong opto-acoustic effect and preparation thereof
  • Gold nanosphere/melanin composite nanometer opto-acoustic probe with ultra-strong opto-acoustic effect and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A method for preparing a gold nanosphere / melanin composite nano-photoacoustic probe with a super-strong photoacoustic effect, comprising the following steps:

[0043] (1) Freshly prepared dodecanine-modified gold nanospheres with a diameter of about 5 nm were dissolved in tetrahydrofuran solvent to prepare a wine-red gold nanosphere solution with a concentration of 1 mg / ml. Wherein, the gold nanosphere modified by dodecylamine is made by the following method: the tetraoctyl ammonium bromide of 0.025mmol and the dodecylamine of 0.06mmol are dissolved in the toluene of 0.5ml, then add the chloroauric acid aqueous solution of 0.053mmol ( Concentration is 0.5M), mix well, then add 0.2mmol ice-cold sodium borohydride, stir vigorously for half an hour, finally add 4ml of poor solvent ethanol, collect the precipitate to obtain dodecaline-modified gold nanospheres with a size of about 5nm. figure 1 It is a transmission electron microscope photo of 1mg / ml gold nanosphere THF sol...

Embodiment 2

[0047] A method for preparing a gold nanosphere / melanin composite nano-photoacoustic probe with a super-strong photoacoustic effect, comprising the following steps:

[0048] (1) Freshly prepared dodecylamine-modified gold nanospheres of about 5 nm (preparation method is the same as in Example 1) were dissolved in tetrahydrofuran solvent, and a wine-red gold nanosphere solution with a concentration of 1 mg / ml was prepared.

[0049] (2) Melanin powder (preparation method is the same as in Example 1) is added to a certain amount of deionized water, and 0.1M aqueous sodium hydroxide solution is added to adjust the pH value to 12, and it is configured into a clear aqueous solution with a concentration of 0.8mg / ml, and then The alkaline sodium hydroxide is removed by dialysis to obtain a neutral aqueous solution of melanin nanoparticles.

[0050] (3) 0.5 ml of gold nanosphere solution was slowly added dropwise to 1 ml of neutral aqueous solution of melanin nanoparticles with a conce...

Embodiment 3

[0052] (1) Freshly prepared dodecylamine-modified gold nanospheres of about 5 nm (preparation method is the same as in Example 1) were dissolved in tetrahydrofuran solvent, and a wine red gold nanosphere solution with a concentration of 0.5 mg / ml was prepared.

[0053] (2) Melanin powder (preparation method is the same as in Example 1) is added to a certain amount of deionized water, and 0.1M aqueous sodium hydroxide solution is added to adjust the pH value to 12, and it is configured into a clear aqueous solution with a concentration of 0.1mg / ml, and then The alkaline sodium hydroxide is removed by dialysis to obtain a neutral aqueous solution of melanin nanoparticles.

[0054] (3) 0.5 ml of gold nanosphere solution was slowly added dropwise to 1 ml of neutral aqueous solution of melanin nanoparticles with a concentration of 0.1 mg / ml, and stirred for 6 hours at a stirring speed of 600 rpm. After the stirring was completed, the mixed solution was put into a probe-type ultraso...

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Abstract

The invention relates to a gold nanosphere / melanin composite nanometer opto-acoustic probe with ultra-strong opto-acoustic effect and preparation thereof. The gold nanosphere / melanin composite nanometer opto-acoustic probe is prepared by compounding dodecylamine-modified gold nanospheres with melanin nanometer particles coating the dodecylamine-modified gold nanospheres, wherein a mass ratio of the dodecylamine-modified gold nanospheres to the melanin nanometer particles is 0.1-10: 1. Compared with the prior art, the composite nanometer opto-acoustic probe provided by the invention can realize circulation in the body for a certain period of time and can be disposed at a focus part after completion of opto-acoustic imaging; and the dissociated small-sized gold nanospheres can be removed via metabolism of the kidney and are thus prevented from accumulation in biological tissue and incurrence of damage.

Description

technical field [0001] The invention relates to the field of photoacoustic detection of tumors, in particular to a gold nanosphere / melanin composite nano-photoacoustic probe with super-strong photoacoustic effect and its preparation. Background technique [0002] Photoacoustic imaging is an emerging biodetection technology. Because of its high spatial resolution and imaging depth, real-time dynamic imaging, and simple and convenient operation, it has great potential in clinical applications. In photoacoustic imaging tests, the signal strength of photoacoustic probes plays a key role in imaging quality, so the research and development of photoacoustic probes with super-strong photoacoustic signals has attracted extensive attention. According to the source, photoacoustic probes are divided into endogenous photoacoustic probes and exogenous photoacoustic probes. Endogenous photoacoustic probes are derived from living organisms and have good biocompatibility and low biotoxicity....

Claims

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Application Information

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IPC IPC(8): G01N21/17B82Y15/00
Inventor 刘萍李永勇任天斌董海青
Owner TONGJI UNIV
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