Application of ferrite nanobiomaterials in the preparation of targeted tumor diagnosis and treatment drugs

A technology of biomaterials and tumor drugs, which is applied in the application field of ferrite nano-biomaterials in the preparation of targeted tumor diagnosis and treatment drugs, and achieves the effects of simple process, low cost and small side effects

Active Publication Date: 2019-09-13
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to strong light scattering, the penetration depth of these imaging modalities is limited to the mean free path of optical transmission in biological tissue, e.g., about 1 mm below the skin

Method used

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  • Application of ferrite nanobiomaterials in the preparation of targeted tumor diagnosis and treatment drugs
  • Application of ferrite nanobiomaterials in the preparation of targeted tumor diagnosis and treatment drugs
  • Application of ferrite nanobiomaterials in the preparation of targeted tumor diagnosis and treatment drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1, the preparation of ferrite nano biomaterial

[0043] 1. Cobalt ferrite (CoFe 2 o 4 ) Core preparation

[0044] Synthesis of CoFe by co-precipitation method 2 o 4 Particles, weigh 1.35g FeCl 3 ·6H 2 O and 0.595 g CoCl 2 ·6H 2Dissolve O in ultrapure water, stir and mix at high speed, slowly add 5mL of NaOH solution (6mol / L), adjust the pH to 11-13, heat in an oil bath at 100°C and stir for 2h, after the reaction, filter with ultrapure water , and washed to PH=7, dried and calcined at 800°C for 2h to obtain CoFe 2 o 4 Nano powder (that is, the ferrite core), and detect the XRD spectrum, such as figure 1 shown.

[0045] 2. Preparation of ferrite nano-biomaterials

[0046] CoFe 2 o 4 The nanopowder was coated with silicon dioxide (SiO2) by Stber hydrolysis method 2 )shell. Weigh 50 mg of the above prepared CoFe 2 o 4 Nano-powder, dispersed in 50mL of absolute ethanol, stirred and added 0.5mL of ammonia water (25%), added 0.25mL of tetraethyl o...

Embodiment 2

[0047] Embodiment 2, photothermal performance experiment of ferrite nano biomaterial

[0048] 1) Weigh 10 mg of the ferrite nano-biological material prepared in Example 1 of the present invention (that is, nano-anticancer drug), disperse it in 1 mL of phosphate buffered saline solution (referred to as PBS solution), and configure it to 10 mg / mL CoFe 2 o 4 The solution is ready for use.

[0049] 2) Set up two groups of experiments: Group A is to take 100 μL of the above 1) CoFe 2 o 4 The solution is placed in a certain position of the 96-well plate; in group B, the same volume of PBS solution is placed in another position of the 96-well plate. Group A and Group B were all under the same laser conditions (the wavelength of the laser used was 880nm, the power of irradiation was 1W, and the power density was 1W / cm 2 ) irradiated for 0.5h, measured the temperature with an infrared imager every 2min, and recorded it to observe the photothermal properties of the drug in vitro, s...

Embodiment 3

[0051] Example 3, Targeted Photothermal Therapy Experiment of Ferrite Nano-Biomaterials

[0052] 1) Weigh 10 mg of the ferrite nano-biological material (nano-photothermal anti-cancer drug) prepared in Example 1 of the present invention, disperse it in 1 mL of PBS solution, and configure it into 10 mg / mL CoFe 2 o 4 The solution is ready for use.

[0053] 2) Inoculate the right leg of 4-week-old Balb / c mice with H 22 For tumors, the experiments were carried out after mice were kept eating and drinking normally for one week.

[0054] Inoculate H in 2) 22 Tumor mice (also known as tumor-bearing mice) were divided into three groups, anesthetized by intraperitoneal injection of 100 μL pentobarbital anesthetic (1.2%), respectively, and three groups of experiments were set up: Group A took 150 μL of the above-mentioned CoFe 2 o 4 The solution was injected intravenously into the inoculated H 22 In vivo tumor mice, immediately adopt the wavelength of 808nm, the power of 0.6W / cm 2...

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Abstract

The invention discloses application of a ferrite nano biological material in preparing targeted tumor diagnosis and treatment drugs, particularly application of the ferrite nano biological material in preparing targeted tumor photo-thermal treatment drugs and targeted optoacoustic imaging signal drugs. The ferrite nano biological material is composed of ferrite and silicon dioxide coated on the ferrite. The active component of the targeted tumor photo-thermal treatment drugs and / or targeted optoacoustic imaging signal drugs is the ferrite nano biological material. The ferrite nano biological material can be used for preparing targeted tumor photo-thermal treatment drugs or targeted optoacoustic imaging signal drugs, can be optionally massively enriched in the tumor position, and can be combined with a high-penetration-depth near-infrared laser, thereby greatly enhancing the tumor treatment efficiency of the drugs. The specific infrared absorption generates efficient and obvious tumor diagnosis and treatment effects, and thus, the ferrite nano biological material is applicable to tumor treatment or biomedical tumor diagnosis imaging.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to the application of ferrite nano-biological materials in the preparation of targeted tumor diagnosis and treatment drugs. Background technique [0002] Cancer remains by far the most serious public health problem in the world. The morbidity and mortality of cancer are still rising in China and even in the world, and malignant tumors have become one of the main diseases that cause human death. Therefore, new technologies are used to improve the existing cancer early warning and metastasis monitoring, curative effect prediction and effective The clinical method of treatment is a major problem to be solved urgently in the field of public health in our country. At present, the traditional cancer treatment methods include chemotherapy, radiation therapy, and surgical therapy. The environment converts light energy into heat energy and reaches a certain temperature (>42°C), thereby killing ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K49/00A61P35/00
Inventor 王春儒甄明明邓睿君李雪
Owner INST OF CHEM CHINESE ACAD OF SCI
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