7 results about "Targeting chemotherapy" patented technology

The application discloses an ultrasonic guidance-based peritoneal perfusion and drainage integrated system, relates to the perfusion and drainage control technical field, and comprises an ultrasonic guidance module, a puncture and establishment module, a liquid medicine processing module, a perfusion and drainage execution module, a state determination module and a cooperative control module; first, a puncture target point, a puncture path and a peritoneal perfusion baseline image data before perfusion are determined based on real-time ultrasonic images, then puncture and establishment, peritoneal chemotherapy liquid preparation, peritoneal dialysis machine perfusion and drainage execution are completed, and the liquid diffusion state, the target area coverage state and the abnormal state are determined in combination with real-time ultrasonic images, execution parameters and vital signs, and then cooperative control instructions are generated; the accuracy of target area coverage determination in the peritoneal tumor targeted chemotherapy process can be improved, and the safety and adaptability of perfusion and drainage control can be enhanced.

This invention belongs to the field of precision oncology diagnosis and treatment technology, specifically involving a nanomedicine delivery system with tumor microenvironment regulation capabilities, its preparation method, and its application. S1: An organic phase is prepared by dissolving ionizable lipids, helper phospholipids, cholesterol, and functionally modified lipids in a solvent at a molar ratio of 50:38.5:10:1.5. S2: Capsaicin is dissolved in the organic phase obtained in S1, and doxorubicin is dissolved in the solvent to prepare an aqueous phase. The organic and aqueous phases are rapidly mixed in a microfluidic device at a volume ratio of 3:1 to obtain a mixture. S3: The mixture obtained in S2 is placed in a dialysis bag and immersed in Tris buffer for magnetic stirring and dialysis, followed by concentration to obtain (C+D)@LNPPRT. This invention significantly enhances the precision detection of tumors, enables efficient early tumor detection and targeted chemotherapy, and improves treatment efficacy.

This invention discloses an ultrasound-guided integrated peritoneal perfusion and drainage system, relating to the field of perfusion and drainage control technology. The system includes an ultrasound guidance module, a puncture and patency establishment module, a drug processing module, a perfusion and drainage execution module, a status determination module, and a collaborative control module. First, it determines the puncture target point, puncture path, and pre-perfusion peritoneal ultrasound baseline image data based on real-time ultrasound images. Then, it completes puncture and patency establishment, peritoneal chemotherapy drug preparation, peritoneal dialysis perfusion, and drainage execution. It combines real-time ultrasound images, execution parameters, and vital signs to determine the drug diffusion status, target area coverage status, and abnormal status, thereby generating collaborative control commands. This system can improve the accuracy of target area coverage determination during targeted chemotherapy for peritoneal tumors and enhance the safety and adaptability of perfusion and drainage control.

This application relates to a method for preparing magnetically responsive drug-loaded microspheres based on a high-throughput microfluidic chip in the field of biomedical microsphere preparation technology. The method involves encapsulating carboxylated magnetic nanoparticles via suspension polymerization, then co-forming them with biodegradable polymers and therapeutic drugs to create a magnetically responsive dispersed phase. Through structural design, multiple microsphere generation units are integrated on a single chip, arranged concentrically, to achieve one-step high-throughput generation of monodisperse oil-in-water emulsion droplets. Subsequent processing yields magnetically responsive drug-loaded microspheres with uniform particle size distribution and tunable saturation magnetization. This invention overcomes the problems of easy magnetic core aggregation, poor microsphere particle size uniformity, low throughput of traditional microfluidic preparation, and complex integration of magnetic response and drug-loading functions in existing technologies. It is suitable for various biomedical applications such as targeted chemotherapy, drug sustained release, magnetothermal synergistic therapy, and nucleic acid / protein delivery, and has advantages such as rapid and scalable preparation process, high batch stability, and precise magnetic field control.

The invention relates to the technical field of medical application, in particular to a liver-targeted chemotherapeutic drug nano-micelle preparation method, a chemotherapeutic drug and application, and the preparation method comprises the following steps: S100, preparing pluronic-succinimide formate; s200, preparing a pluronic-polyethyleneimine copolymer; s300, preparing divinyl sebacate; carrying out enzymatic synthesis on the Pluronic F127-SE; the preparation method comprises the following steps: preparing a Pluronic F127-C8-GalNAc nano micelle; and preparing the GalNAc (at) LFT-MMs / siCOP1 compound. The preparation method disclosed by the invention is beneficial to rapidly preparing the nano-micelle with multiple effects of active targeting, chemotherapy and gene therapy.

The invention discloses a method for simultaneously determining the concentrations of Venoclarias, Selanisol, voriconazole and fluconazole in human plasma, and belongs to the technical field of drug analysis and treatment drug monitoring. The invention aims to solve the problem that the prior art is lack of a method for synchronously monitoring the blood concentration of four drugs of'vinca + Sanisole 'double-targeted chemotherapy and'voriconazole + fluconazole' antifungal scheme. The method is characterized by comprising the following steps: taking a plasma sample, precipitating protein through an internal standard solution and an organic solvent, and taking supernatant as a test solution; carrying out gradient elution by adopting a C18 chromatographic column and taking an aqueous solution containing formic acid and an organic solvent as mobile phases; detecting elution components by adopting an electrospray ionization source positive ion mode and a multi-reaction monitoring mode; and finally calculating the concentrations of the four drugs according to a detection result by an internal standard method. The method is mainly used for rapid and synchronous treatment drug monitoring when a clinical patient jointly uses the four drugs, and a basis is provided for accurate dose adjustment.

The invention provides a digestive tract tumor targeting composite nano material and a preparation method thereof, and belongs to the field of medical products. The method comprises the following steps: preparing a ferroferric oxide-loaded mesoporous silica core-shell structure, loading a chemotherapeutic drug and potassium permanganate, and performing in-situ reduction through ascorbic acid to obtain drug-loaded core-shell nanoparticles; coating the nanoparticles with eudragit S100 to form a pH response layer, and performing amination to prepare an intermediate product; the preparation method comprises the following steps: aminating aldehyde hyaluronic acid through ethanediamine, coupling with MMP-2 sensitive peptide and connecting with folic acid-N-hydroxysuccinimide ester in sequence to prepare folic acid modified enzyme response hyaluronic acid; and finally covalently grafting to the intermediate product to obtain the target composite nano material. The material has pH response enteric protection, MMP-2 enzyme triggered drug release and folic acid-hyaluronic acid dual-targeting functions, is suitable for targeted chemotherapy of gastrointestinal tumors, and can improve the curative effect of drugs and reduce toxic and side effects.