13 results about "Targeting chemotherapy" patented technology

The present invention belongs to the field of biomedical materials and specifically relates to anti-tumor nanoparticles, their preparation methods, and applications. The present invention claims protection for an anti-tumor nanoparticle comprising compound PTe N25, wherein the nanoparticles are simultaneously encapsulated with a camptothecin compound and compound PTe N25 using a phospholipid. The structural formula of compound PTe N25 is: #imgabs0# The present invention utilizes cRGD and camptothecin compounds in conjunction with an organic conjugated polymer material to prepare a dual-targeted chemotherapy-photothermal therapy combined treatment system. This system achieves cRGD-targeted recognition of cancer cells, controlled drug release responsive to spatiotemporal light dual stimulation in the context of a diseased environment, and integrated chemotherapy and photothermal therapy synergistic treatment, significantly reducing drug toxicity and side effects while maintaining anti-tumor efficacy.

The application discloses an ultrasonic guidance-based peritoneal perfusion and drainage integrated system, relates to the perfusion and drainage control technical field, and comprises an ultrasonic guidance module, a puncture and establishment module, a liquid medicine processing module, a perfusion and drainage execution module, a state determination module and a cooperative control module; first, a puncture target point, a puncture path and a peritoneal perfusion baseline image data before perfusion are determined based on real-time ultrasonic images, then puncture and establishment, peritoneal chemotherapy liquid preparation, peritoneal dialysis machine perfusion and drainage execution are completed, and the liquid diffusion state, the target area coverage state and the abnormal state are determined in combination with real-time ultrasonic images, execution parameters and vital signs, and then cooperative control instructions are generated; the accuracy of target area coverage determination in the peritoneal tumor targeted chemotherapy process can be improved, and the safety and adaptability of perfusion and drainage control can be enhanced.

This invention belongs to the field of precision oncology diagnosis and treatment technology, specifically involving a nanomedicine delivery system with tumor microenvironment regulation capabilities, its preparation method, and its application. S1: An organic phase is prepared by dissolving ionizable lipids, helper phospholipids, cholesterol, and functionally modified lipids in a solvent at a molar ratio of 50:38.5:10:1.5. S2: Capsaicin is dissolved in the organic phase obtained in S1, and doxorubicin is dissolved in the solvent to prepare an aqueous phase. The organic and aqueous phases are rapidly mixed in a microfluidic device at a volume ratio of 3:1 to obtain a mixture. S3: The mixture obtained in S2 is placed in a dialysis bag and immersed in Tris buffer for magnetic stirring and dialysis, followed by concentration to obtain (C+D)@LNPPRT. This invention significantly enhances the precision detection of tumors, enables efficient early tumor detection and targeted chemotherapy, and improves treatment efficacy.

This invention discloses an ultrasound-guided integrated peritoneal perfusion and drainage system, relating to the field of perfusion and drainage control technology. The system includes an ultrasound guidance module, a puncture and patency establishment module, a drug processing module, a perfusion and drainage execution module, a status determination module, and a collaborative control module. First, it determines the puncture target point, puncture path, and pre-perfusion peritoneal ultrasound baseline image data based on real-time ultrasound images. Then, it completes puncture and patency establishment, peritoneal chemotherapy drug preparation, peritoneal dialysis perfusion, and drainage execution. It combines real-time ultrasound images, execution parameters, and vital signs to determine the drug diffusion status, target area coverage status, and abnormal status, thereby generating collaborative control commands. This system can improve the accuracy of target area coverage determination during targeted chemotherapy for peritoneal tumors and enhance the safety and adaptability of perfusion and drainage control.

This application relates to a method for preparing magnetically responsive drug-loaded microspheres based on a high-throughput microfluidic chip in the field of biomedical microsphere preparation technology. The method involves encapsulating carboxylated magnetic nanoparticles via suspension polymerization, then co-forming them with biodegradable polymers and therapeutic drugs to create a magnetically responsive dispersed phase. Through structural design, multiple microsphere generation units are integrated on a single chip, arranged concentrically, to achieve one-step high-throughput generation of monodisperse oil-in-water emulsion droplets. Subsequent processing yields magnetically responsive drug-loaded microspheres with uniform particle size distribution and tunable saturation magnetization. This invention overcomes the problems of easy magnetic core aggregation, poor microsphere particle size uniformity, low throughput of traditional microfluidic preparation, and complex integration of magnetic response and drug-loading functions in existing technologies. It is suitable for various biomedical applications such as targeted chemotherapy, drug sustained release, magnetothermal synergistic therapy, and nucleic acid / protein delivery, and has advantages such as rapid and scalable preparation process, high batch stability, and precise magnetic field control.

The present invention relates to a compound having a pyridinium salt central ring structure, a preparation method thereof, and an application thereof. The compound has a structure shown in the following general formula I. Compared with the near-infrared II region fluorescent probes in the prior art, the maximum absorption and emission wavelengths of the fluorescent probe of the general formula I compound of the present invention are both red-shifted. The fluorescent probe of the present invention can be specifically taken up by tumor cells and has the functions of early tumor diagnosis, targeted chemotherapy, surgical navigation, and photothermal therapy in one.

The invention provides a programmable multivalent nucleic acid aptamer as well as a preparation method and application thereof, a section of extension chain is designed on the nucleic acid aptamer, a central bracket is designed, and the nucleic acid aptamer is respectively connected with the central bracket through the extension chain, so that the multivalent nucleic acid aptamer which is uniformly dispersed from the center to the periphery is constructed; the size, the type and the valence of the aptamer and the type, the position and the like of the coupled medicine can be flexibly regulated and controlled, and the programmable property can be really realized. The multivalent nucleic acid aptamer can recognize and combine with specific target molecules in a high-affinity and high-specificity manner, and forms a multivalent nucleic acid aptamer drug conjugate by carrying chemotherapeutic drugs and immune agonists, so that the targeting property, the stability and the long-acting circulation capability in tumor treatment can be improved, and the tumor treatment effect is improved. The synergistic treatment effect of precise targeting, chemotherapy induction and immune activation is achieved, an innovative solution is provided for multi-drug precise targeting treatment of tumors, and the clinical application potential and social value are remarkable.

The invention relates to the technical field of medical application, in particular to a liver-targeted chemotherapeutic drug nano-micelle preparation method, a chemotherapeutic drug and application, and the preparation method comprises the following steps: S100, preparing pluronic-succinimide formate; s200, preparing a pluronic-polyethyleneimine copolymer; s300, preparing divinyl sebacate; carrying out enzymatic synthesis on the Pluronic F127-SE; the preparation method comprises the following steps: preparing a Pluronic F127-C8-GalNAc nano micelle; and preparing the GalNAc (at) LFT-MMs / siCOP1 compound. The preparation method disclosed by the invention is beneficial to rapidly preparing the nano-micelle with multiple effects of active targeting, chemotherapy and gene therapy.

The present invention discloses an iron-based metal nano-diagnostic agent and its preparation method and application, wherein the iron-based metal nano-diagnostic agent comprises an iron-based metal nano-material and a loaded therapeutic nuclide. 177 Lu and / or small molecule chemotherapy drug F16 diagnostic and therapeutic agents. Iron-based metal nanodiagnostic and therapeutic agents contain iron elements and can be used for MRI imaging and can induce tumor iron death and radionuclides. 177 Lu can emit gamma rays for SPECT imaging and beta rays for internal radiotherapy of tumors. The tumor mitochondria-targeted small molecule drug F16 has its own fluorescent properties and can be used for real-time fluorescence imaging of tumors. It also has a mitochondrial-targeted tumor-killing effect. Therefore, the iron-based metal nanodiagnostic and therapeutic agent of the present invention can achieve a comprehensive synergistic treatment of tumor internal radiotherapy, targeted chemotherapy, and ferroptosis under the guidance of MRI, SPECT, and fluorescence imaging multimodal imaging, improving the precision diagnosis and treatment of tumors.

The invention discloses a preparation method and an application of a biotin modified ultrathin two-dimensional As2Te3 nano material. The preparation method comprises the following steps: performing hydrothermal crystallization on As2Te3 amorphous powder, performing ultrasonic liquid phase stripping to obtain the ultrathin two-dimensional As2Te3 nano material, and finally performing biotin modification to obtain the biotin-modified ultrathin two-dimensional As2Te3 nano material. The biotin-modified ultrathin two-dimensional As2Te3 nano material prepared by the invention has an excellent chemotherapy effect, and can effectively target tumor tissues to realize a tumor inhibition effect; meanwhile, anti-tumor immune response can be activated, tumor growth is inhibited, an excellent anti-tumor treatment effect is achieved, and a new scheme is provided for novel targeted chemotherapy and immunotherapy.

The invention belongs to the technical field of clinical precise tumor diagnosis and treatment, and particularly relates to a novel nano-drug delivery system with tumor microenvironment regulation and control performance, a preparation method and application. The preparation method comprises the following steps: S1, dissolving ionizable lipid, auxiliary phospholipid, cholesterol and functional modified lipid in a solvent according to a molar ratio of 50: 38.5: 10: 1.5 to prepare an organic phase; s2, dissolving capsaicin in the organic phase obtained in S1, dissolving adriamycin in a solvent to prepare a water phase, and rapidly mixing the organic phase and the water phase in a microfluidic device according to a volume ratio of 3: 1 to obtain a mixed solution; and S3, putting the mixed solution obtained in the S2 into a dialysis bag, putting the dialysis bag into a Tris buffer solution, carrying out magnetic stirring dialysis, and concentrating to obtain the (C + D)-coated LNPPRT. According to the present invention, the precise tumor detection effect is significantly enhanced, the efficient early tumor detection and the targeted chemotherapy are achieved, and the treatment effect is improved.

The invention discloses a method for simultaneously determining the concentrations of Venoclarias, Selanisol, voriconazole and fluconazole in human plasma, and belongs to the technical field of drug analysis and treatment drug monitoring. The invention aims to solve the problem that the prior art is lack of a method for synchronously monitoring the blood concentration of four drugs of'vinca + Sanisole 'double-targeted chemotherapy and'voriconazole + fluconazole' antifungal scheme. The method is characterized by comprising the following steps: taking a plasma sample, precipitating protein through an internal standard solution and an organic solvent, and taking supernatant as a test solution; carrying out gradient elution by adopting a C18 chromatographic column and taking an aqueous solution containing formic acid and an organic solvent as mobile phases; detecting elution components by adopting an electrospray ionization source positive ion mode and a multi-reaction monitoring mode; and finally calculating the concentrations of the four drugs according to a detection result by an internal standard method. The method is mainly used for rapid and synchronous treatment drug monitoring when a clinical patient jointly uses the four drugs, and a basis is provided for accurate dose adjustment.

The invention provides a digestive tract tumor targeting composite nano material and a preparation method thereof, and belongs to the field of medical products. The method comprises the following steps: preparing a ferroferric oxide-loaded mesoporous silica core-shell structure, loading a chemotherapeutic drug and potassium permanganate, and performing in-situ reduction through ascorbic acid to obtain drug-loaded core-shell nanoparticles; coating the nanoparticles with eudragit S100 to form a pH response layer, and performing amination to prepare an intermediate product; the preparation method comprises the following steps: aminating aldehyde hyaluronic acid through ethanediamine, coupling with MMP-2 sensitive peptide and connecting with folic acid-N-hydroxysuccinimide ester in sequence to prepare folic acid modified enzyme response hyaluronic acid; and finally covalently grafting to the intermediate product to obtain the target composite nano material. The material has pH response enteric protection, MMP-2 enzyme triggered drug release and folic acid-hyaluronic acid dual-targeting functions, is suitable for targeted chemotherapy of gastrointestinal tumors, and can improve the curative effect of drugs and reduce toxic and side effects.