10 results about "Raman microscope" patented technology

An automated portable Raman microscope combines the simplicity, ruggedness, and selectivity of Raman spectroscopy with the sensitivity of single-particle identification. It includes a visible camera, controllable illumination, and a moving optical head that together acquire images of the sample at different focal planes and under different lighting conditions. An internal processor automatically identifies particles or other targets in these images for Raman analysis, e.g., shifted excitation difference Raman spectroscopy. The moving optical head scans the Raman pump beam across the sample to different targets. A built-in user interface displays the results of the Raman analysis superimposed on visual images of the sample. The Raman microscope's simplicity, reliability, and low maintenance make it easy to use for a wide variety of applications, including analyzing and identifying particles and residues, linking chemical and biometric evidence, and forensics analysis.

The invention provides a method and a device for measuring the transverse spatial resolution of a confocal Raman microscope, and relates to the technical field of optical measurement and micro-spectrum. The method comprises the following steps: positioning a linear edge area on a single-layer graphene sample by using a confocal Raman microscope, and preparing the single-layer graphene sample on a silicon oxide substrate; determining a linear scanning path and a scanning step length from the exposed area of the substrate to the sample area in the positioned area of the linear edge along the direction vertical to the linear edge by using a confocal Raman microscope; in the moving process of the single-layer graphene sample, determining a plurality of scanning points on the linear scanning path based on the scanning step length, and collecting a Raman spectrum signal of each scanning point; and determining the transverse spatial resolution of the confocal Raman microscope based on the Raman spectrum of each scanning point. By adopting the method provided by the invention, the accuracy of the transverse spatial resolution of the confocal Raman microscope can be improved.

The application provides a method and device for measuring lateral spatial resolution of a confocal Raman microscope, and relates to the field of optical measurement and microscopic spectroscopy technology. The method comprises the following steps: positioning a region of a straight edge on a single-layer graphene sample by using a confocal Raman microscope, wherein the single-layer graphene sample is prepared on a silicon oxide substrate; determining a straight scanning path and a scanning step in a direction perpendicular to the straight edge from a bare region of the substrate to a sample region in the region of the straight edge which has been positioned by using the confocal Raman microscope; determining a plurality of scanning points on the straight scanning path based on the scanning step in the process of moving the single-layer graphene sample, and collecting Raman spectrum signals of the scanning points; and measuring the lateral spatial resolution of the confocal Raman microscope based on the Raman spectrum of each scanning point. By using the method provided in the application, the accuracy of the lateral spatial resolution of the confocal Raman microscope can be improved.

This invention discloses a hardware-software co-processing method for real-time spectral signal processing in Raman microscopy, belonging to the field of spectral signal processing technology. The method includes: establishing strict temporal constraints between physical displacement and cloud inference, and initiating asynchronous communication using the physical gaps in stage movement; simultaneously, deploying a deep learning model (F2P) pre-trained with a self-supervised masking strategy in the cloud. This pre-trained model utilizes the structural correlation between the Raman broadband background and narrowband characteristic peaks to directly perform real-time forward inference on the input single-frame noisy spectrum, achieving millisecond-level high-fidelity reconstruction of a single frame without any complex parameter tuning or the need for a clean control spectrum. This invention completely eliminates the physical lag in multi-frame processing and the general technical bias of supervised learning algorithms, achieving true "synchronization between acquisition and display," and significantly improving the real-time processing performance and cross-device automated deployment capabilities of in-situ Raman imaging.

This invention relates to a method for detecting indophenol sulfate based on surface-enhanced Raman spectroscopy. A liquid containing the indophenol sulfate to be detected is mixed with an oxidizing reagent to specifically oxidize the indophenol sulfate to indigo, yielding a mixed solution. This mixed solution is then mixed with gold nanoparticles, and the spectra of the mixed solution are acquired using a confocal Raman microscope. The acquired Raman spectra are baseline-removed to obtain the signal intensity at the target characteristic peak. Based on standard curves for different concentrations of indophenol sulfate and the signal intensity of the sample, the concentration of indophenol sulfate in the test sample is determined. This invention provides clear detection signals, accurate resolution, and a simple operation, enabling rapid and accurate detection of indophenol sulfate concentration in samples (such as serum). It is expected to promote research on the biological mechanisms of indophenol sulfate and its large-scale clinical application.

A battery cell, a battery device, and an electric device. The battery cell comprises a positive electrode sheet, a negative electrode sheet, and an electrolyte; the lithium ion conductivity of the electrolyte is greater than or equal to 10 mS / cm; the negative electrode sheet comprises a negative electrode current collector and a negative electrode film layer disposed on at least one side of the negative electrode current collector; the negative electrode film layer comprises a negative electrode active material; the negative electrode active material comprises a core portion and a coating layer at least partially coating the surface of the core portion; the core portion comprises graphite; and in an R value cumulative distribution curve of the negative electrode active material obtained in a surface scanning mode of a laser confocal Raman microscope / spectrometer, the concentration (R90-R10) / R50 of R values is less than or equal to 2.3.

This invention specifically relates to a method for determining the uniformity of acetylation reaction in modified starch granules. It employs the characteristic peak "intensity ratio method," using a confocal Raman microscope to acquire the Raman spectrum of individual starch granules. The Raman intensity ratio of the characteristic vibrational peak of the ester group (-C=O) to the internal standard peak of the starch skeleton represents the relative magnitude of the modification reaction in a single acetylated modified starch granule. Based on a large number of Raman intensity ratios, a frequency distribution histogram is plotted, and statistical parameters are used to quantify the uniformity of the reaction. Methodological validation results show that this method has good accuracy. This technology solves the technical problem that traditional methods cannot assess the uniformity of acetylation reaction between granules, providing a reliable means for quality control and process optimization of high-quality acetylated starch.

The present invention relates to an optical spectrometer (10) comprising: an aperture (13) configured to receive a light source beam; a first optical system configured to receive the light source beam and form a collimated light beam directed toward a diffraction grating; a diffraction grating configured to receive the collimated light beam and form a diffracted light beam; and a second optical system configured to form an image of the diffracted light beam on an image sensor. According to the present invention, the image sensor is a CMOS sensor comprising pixels (34) arranged in N rows oriented in a direction tilted by an angle alpha with respect to the spectral diffraction direction of the image of the diffracted light beam, where alpha is less than 10 degrees, N is at least 3, and each pixel has a height and width that define a pixel aspect ratio greater than 2.

This application discloses a negative electrode active material and a method for manufacturing the same, a negative electrode sheet, a lithium-ion battery, and a power consumption device. The lithium-ion battery includes one or more battery cells including a negative electrode sheet. The negative electrode sheet includes a negative electrode current collector and a negative electrode film layer located on at least one surface of the negative electrode current collector and including a negative electrode active material. The negative electrode active material includes a core including graphite and a coating layer located on at least a portion of the surface of the core and including a hard carbon. The negative electrode active material has an R50 of 0.15 to 0.40, which is the R value at which 50% of the cumulative distribution from the lower limit is obtained using a laser confocal Raman microscope in area scanning mode. The negative electrode active material provided herein enables batteries to combine high energy density with good dynamic and cycle characteristics.

This invention provides a Skin-Resolved Diffusion (SERS) Detection System for Deep-Resolved Drug Diffusion, comprising a SERS-active microneedle array and a confocal Raman microscope. The SERS-active microneedle array is used for in-situ drug detection at multiple depths in the skin. It consists of polymer microneedles of varying lengths, with noble metal core-shell nanostars uniformly immobilized on their surfaces. Each noble metal core-shell nanostar comprises a noble metal nanostar core modified with an internal standard reporter molecule and an outer noble metal shell. The confocal Raman microscope records the SERS signal generated after the microneedles penetrate the skin. A quantitative model is established by comparing the peak ratio of the target drug characteristic peak to the internal standard characteristic peak in the SERS signal to determine the drug concentration at different depths. This invention enables quantitative analysis of the diffusion behavior of topical drugs at different skin types and depths.