The invention provides pH-sensitive
doxorubicin hydrochloride loaded
silver nano-cluster hydrogel. A preparation method of the
silver nano-cluster hydrogel comprises the following steps: (1), an AgNO3 solution is prepared, placed in a
microwave reactor, stirred and heated, a
cysteine solution is added dropwise, and a
silver nano-cluster dispersing agent is prepared through reaction; (2), a
citric acid solution is added to the silver nano-cluster dispersing agent, the mixture is placed on a small shaking table and subjected to
ultraviolet irradiation, an NaHCO3 solution is added to regulate pH after the solution is transparent, high-speed
centrifugation is performed,
doxorubicin hydrochloride powder is added, the mixture is placed in a high-
pressure reactor,
nitrogen is introduced, the pressure and the temperature in the reactor are adjusted, red and clear jelly, namely, the pH-sensitive
doxorubicin hydrochloride loaded silver nano-cluster hydrogel, is obtained through reaction. The silver nano-cluster hydrogel is taken as a carrier to coat
doxorubicin hydrochloride and is injected to a tumor position through orthotopic injection, the pH of the tumor position is responded, so that slow
drug release is realized, the
tumor inhibition rate is increased, and cardiac
toxicity is reduced.