Tumor-targeting albumin nano-lyophilized powder injection preparation and preparation method thereof
A nano-albumin and tumor-targeting technology, which is applied in the field of albumin nano-lyophilized powder injection preparations and its preparation, can solve the problems of staying in the research stage and achieve the goal of improving drug efficacy, water solubility, and stability Effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Example Embodiment
[0036] Example 1. Preparation and quality evaluation of paclitaxel albumin nano freeze-dried powder injection preparation
[0037] Composition of prescription:
[0038]
[0039]
[0040] Preparation Process:
[0041] (1) Weigh the insoluble anti-tumor drugs according to the prescription and add the latent solvent to ultrasonic dissolve, mix with soy lecithin, tricaprylin, tributyrin and polyethylene glycol-dodecanoic acid stearate, and stir. Evenly, get solution A;
[0042] (2) Weigh out albumin and freeze-dried excipients according to the prescription amount, add them to water for injection, and obtain solution B after dissolution;
[0043] (3) Mix solutions A and B, stir evenly, and filter with a microporous membrane (0.22μm);
[0044] (4) Put the solution obtained in step 3 in a freeze dryer, and set the freeze-drying parameters as follows: pre-freezing temperature is -50°C, pre-freezing time is 2.5h; set the total number of sublimation stages to 18, gradually increase the temperatur...
Example Embodiment
[0046] Example 2: Preparation and quality evaluation of paclitaxel albumin nano freeze-dried powder injection preparation
[0047] Composition of prescription:
[0048]
[0049] Preparation Process:
[0050] (1) Weigh the insoluble anti-tumor drugs according to the prescription and add the latent solvent to ultrasonic dissolve, mix with phospholipids, tricaprylin, tributyrin and polyethylene glycol-dodecanoic acid stearate, and stir well. Get solution A;
[0051] (2) Weigh out albumin and freeze-dried excipients according to the prescription amount, add them to water for injection, and obtain solution B after dissolution;
[0052] (3) Mix solutions A and B, stir evenly, and filter with a microporous membrane (0.22μm);
[0053] (4) Put the solution obtained in step 3 in a freeze dryer, and set the freeze-drying parameters as follows: pre-freezing temperature is -50°C, pre-freezing time is 2.5h; set the total number of sublimation stages to 18, gradually increase the temperature, and subl...
Example Embodiment
[0055] Example 3. Preparation and quality evaluation of paclitaxel albumin nano freeze-dried powder injection preparation
[0056] Composition of prescription:
[0057]
[0058] Preparation Process:
[0059] (1) Weigh the insoluble anti-tumor drugs according to the prescription and add the latent solvent to ultrasonic dissolve, mix with phospholipids, tricaprylin, tributyrin and polyethylene glycol-dodecanoic acid stearate, and stir well. Get solution A;
[0060] (2) Weigh out albumin and freeze-dried excipients according to the prescription amount, add them to water for injection, and obtain solution B after dissolution;
[0061] (3) Mix solutions A and B, stir evenly, and filter with a microporous membrane (0.22μm);
[0062] (4) Put the solution obtained in step 3 in a freeze dryer, and set the freeze-drying parameters as follows: pre-freezing temperature is -50°C, pre-freezing time is 2.5h; set the total number of sublimation stages to 18, gradually increase the temperature, and subl...
PUM
Property | Measurement | Unit |
---|---|---|
Particle size | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap