75results about How to "Improve drug efficacy" patented technology

The present disclosure provides methods for improving drug efficacy in a patient having an obstructed airway in a lung. Such methods modulate nerve activity in the autonomic nervous system of a patient to reduce obstruction of an airway in a lung of the patient prior to administering a drug to the patient. These methods are especially useful in improving efficacies of bronchodilators in treating obstructive lung diseases, such as chronic obstructive pulmonary disease.

Compounds of Formula I, stereoisomers, and pharmaceutically acceptable salts or prodrugs thereof, their preparation, and their uses for the treatment of hepatitis C viral infection are described:

The invention belongs to the technical field of medicines. The invention provides an injectable medicated particle-inlaid porous composite microsphere preparation. The injectable medicated particle-inlaid porous composite microsphere preparation is prepared by the following steps: wrapping polypeptide and protein medicines or chemical medicines by using hydrophilic materials such as chitosan, collagen or albumin to form medicine-loading particles; constructing microspheres with three-dimensional (3D) porous structures by using medicated particles and porous microsphere materials; and inlaying the medicated particles in the porous microspheres. The invention also provides a preparation method of the porous composite microsphere preparation and an application of the porous composite microsphere preparation in preparation of tissue defect repair materials. The porous composite microsphere preparation provided by the invention can realize slow release of the medicines and is favorable for proliferation and differentiation of seed cells.

The invention provides a targeted tumor active oxygen responsive medicine carrying nano-micelle, a preparation method and application of the medicine carrying nano-micelle, a medicine carrying nano-micelle intermediate RGD-PEG-thioketal-anthracene ring chemotherapy medicine conjugate and a preparation method of the conjugate. The nano-micelle, the conjugate as well as the preparation methods and application thereof have the beneficial effects that laser irradiates for activating porphyrin type photosensitive molecules; a large number of active oxygen radicals are triggered to be generated; further, thioketal in the medicine carrying nano-micelle system is induced to fracture; the controlled release of the anthracene ring chemotherapy medicine in the tumor position is realized; the medicinecurative effect is enhanced; the toxic and side effects of the medicine are reduced; PDT is combined with chemotherapy; the prominent synergistic interaction effect is achieved; the alone antitumor effect of a photodynamic therapy is improved; the toxic and side effects of the anthracene ring chemotherapy medicine on important visceral organs are also reduced.

The invention belongs to the technical field of medicine, and provides an injectable PLGA porous composite microsphere preparation embedded with BMP-2 containing particles. A drug-carrying particle is formed by wrapping BMP-2 with hydrophilic materials such as chitosan, collagen or albumin; a microsphere with a 3D porous structure is constructed by the drug-carrying particle and a porous microsphere material PLGA; the drug-carrying particle is embedded inside the porous microsphere. The invention also provides a preparation method of the porous composite microsphere preparation, and an application in preparation of a repair material for defects of bone or cartilage tissue. The porous composite microsphere preparation of the invention can not only realize slow release of drugs at an administration site, but also facilitate proliferation and differentiation of porous supports of seed cells.

The present invention is directed to attaching drugs and other functional groups to surfaces of nano-sized diamonds (NDs) to enhance the efficacy of drugs and other substances. The method involved enhancing the efficacy of a drug having an active site by acquiring a plurality of nanodiamond (ND) particles having a plurality of carbon chain surface molecules on its surface. Intermediate amine entities are covalently attached to the surface molecules of the ND particles. These are then replaces with said drug molecules such that the active sites of said drug molecules point away from the ND particle exposing them for enhanced activity and enhanced drug efficacy. The efficacy of antimicrobial drugs are enhanced, however, this may be used with many different types of drugs.

The invention discloses a tumor-targeting albumin nano-lyophilized powder injection preparation and a preparation method thereof. The preparation comprises the following components: an insoluble antitumor drug (for example, taxol), albumin, tricaprylin, tributyrin, polyethylene glycol-12-hydroxy stearate and phospholipid. The tumor-targeting albumin nano-lyophilized powder injection preparation provided by the invention can spontaneously form a nanoemulsion with the particle size of about 100nm after being diluted by normal saline, and the drug can target the tumor tissues after intravenous injection, thus improving the effectiveness and safety. In addition, the tumor-targeting albumin nano-lyophilized powder injection preparation provided by the invention is simple in preparation process and suitable for industrialized production.

The invention discloses a nifuratel nysfungin vaginal soft capsule and a preparation process thereof. The nifuratel nysfungin vaginal soft capsule comprises nifuratel, nysfungin, matrix and a moisturizer, wherein a soft capsule shell comprises gelatin, a plasticizer, water, a bacteriostatic agent, a pigment and an opaquing agent; lactobacillus is effectively protected when bacteria, mycete, trichomonad and the like are killed; restoration of balance of vaginal beneficial flora is facilitated; and through improvement of the prescription and the prepration process, the medicine stability and the medicinal effectiveness are greatly improved.

The invention belongs to the technical field of medicine, and provides a PLGA (poly(lactic-co-glycolic acid)) porous composite microsphere preparation embedded with BMP-2 and TGF-beta1 containing microspheres therein, which not only can bring about benefits for the adhesion and the growth of seed cells by virtue of a 3D porous structure but also can undergo controlled- and sustained-release and can be applied to injection. The invention also provides a preparation method of the porous composite microsphere preparation as well as application of the porous composite microsphere preparation in preparing bone or cartilage tissue defect repairing materials. The porous composite microsphere disclosed by the invention, which can serve as a good carrier for cell adhesion and proliferation and can be directly injected to a target part, can offer a possibility of non-surgical repair to bone and cartilage tissue injuries; and the porous composite microsphere preparation is extensive in clinical application and market prospect.

The invention discloses a preparation method and application of drug sustained-release carrier hydrogel, and belongs to the technical field of medical polymers. The preparation method comprises the following steps: firstly, synthesizing beta-cyclodextrin with a bisacrylamide group with a hydrophobic cavity structure by taking beta-cyclodextrin and acryloyl chloride as raw materials, then preparing methylacryloylated gelatin from gelatin and methacrylic anhydride, and then performing free radical copolymerization under 365nm ultraviolet light by taking Irgacure2959 as an initiator, thereby obtaining the hydrogel. The drug loading capacity of the drug carrier hydrogel can reach 40.86 mg / g, and the drug carrier hydrogel can be continuously released for more than 96 hours in different environments (normal in-vivo physiological environment, lesion site environment and simulated gastric juice environment). A drug sustained-release carrier hydrogel system prepared by the invention is safe and non-toxic, has solubilization on hydrophobic drugs, improves the medication efficiency, and broadens the application range of the hydrogel in the field of medicines.

The present invention provides a cyclic amide derivative useful as a drug for treating thrombosis, which is represented by the formula (I)-: wherein R1 represents an optionally substituted cyclic hydrocarbon group or an optionally substituted heterocyclic group, W represents a bond or an optionally substituted divalent chain hydrocarbon group, a represents 0, 1, or 2, X1 represents an optionally substituted lower alkylene or an optionally substituted lower alkenylene, Y1 represents —C(O)—, —S(O)— or —S(O)2—, A represents a piperazine ring which may be further substituted or a piperidine ring which may be further substituted, X2 represents a bond or an optionally substituted lower alkylene, Y2 represents —C(O)—, —S(O)—, —S(O)2— or —C(═NR7)—, X3 represents an optionally substituted C1-4 alkylene or an optionally substituted C2-4 alkenylene, Z3 represents —N(R4)—, —O— or a bond, Z1 represents —C(R2)(R2′)—, —N(R2)—, etc., and Z2 represents —C(R3)(R3′)—, —N(R3)—, etc., or a salt thereof.

The present invention relates to a phenol derivative and the preparation method and use in medicine thereof, and particular to a phenol derivative represented by general formula (A) or a stereoisomer, a solvate, a metabolite, a prodrug, a pharmaceutically acceptable salt or a cocrystal thereof, a preparation method thereof, a pharmaceutical composition comprising the same, and use of the compound or composition of the present invention in the field of the central nervous system; wherein the definitions of substituents in general formula (A) are the same as those in the Description.

The invention belongs to the technical field of immunotherapy, and particularly relates to application of a hypoxia-adjustable promoter in CAR-T, a CAR structure of the hypoxia-adjustable promoter, anexpression vector, CAR-T cells, application of the CAR-T cells, a method for improving the IFN-gamma and / or IL-2 factor secretion capacity of the CAR-T cells in a hypoxia environment, and a method for improving the CAR-T cell killing capacity in the hypoxia environment. The CAR structure contains the hypoxia-adjustable promoter, the hypoxia-adjustable promoter is formed by connecting Hif1a adjusting elements and mini promoters, and the number of repetitions of the Hif1a adjusting elements is 3-5. The CAR structure induced and started by the hypoxia microenvironment not only can be effectivelyexpressed in T lymphocytes, but also can enhance the activation of the CAR-T cells in the hypoxia environment and enhance the effectiveness and safety of the CAR-T, and can be used for targeted therapy of tumors.

The invention relates to a traditional Chinese medicine ointment for treating bedsores and a preparation method thereof. The traditional Chinese medicine ointment comprises the components including Chinese angelica, myrrh, dragon blood, frankincense, coptis chinensis, radix angelicae, radix rehmanniae, lithospermum, cortex albiziae, liquorice, musk, white wax and sesame oil. The preparation method comprises the following steps of: adding the nine raw materials including Chinese angelica, myrrh, rankincense, coptis chinensis, radix angelicae, radix rehmanniae, lithospermum, cortex albiziae and liquorice into sesame oil, dipping for 60-70 h, and carrying out hot refining at 180-260 DEG C for 5-10 min till the mixture is slightly withered; adding dragon blood into oil solution obtained after filtering and residue removal to thoroughly dissolve and uniformly stir; adding white wax after 20-30 h, and continuously melting through low fire at 85 DEG C for 10 min; and cooling to form paste, adding musk to uniformly stir, and standing for 10-15 h so as to obtain the ointment. Proceeding from the links, such as pharmacology, use and production, the traditional Chinese medicine ointment disclosed by the invention is strong in pertinence, accurate in curative effect and convenient to use for treating bedsores; simultaneously, industrial production is satisfied; and the traditional Chinese medicine ointment has wide popularization and application prospects.

The invention provides an extraction method of a periplaneta americana extract for treating peptic ulcer, comprising the following steps of:A, crushing, B, soaking, C, extracting, D, primarily concentrating, E, degreasing, and F, secondarily concentrating. According to th invention, extraction is carried out by using the method, lots of proteins contained in periplaneta Americana can be effectively removed, and the degreasing rate is high; and moreover, 90-95% ethanol is used for soaking a coarse powder, so that preservation time is prolonged, and the yield of specific active ingredients for treating peptic ulcer is increased. Due to reasonable control on each process parameter, hydrolysis of the active ingredients for treating peptic ulcer in the extract can be prevented, and the curative effect of the medicine can be improved. With the process disclosed by the invention, the extraction method is low in production cost and high in production efficiency. Clinically applicable preparations (tablets, capsules, mixture, oral liquid, pellets, dripping pills, spray, aerosol, gels and the like) can be prepared by taking the periplaneta americana extract obtained by the method disclosed by the invention and adding proper pharmaceutical auxiliary materials, and are used for (oral-administration or spray) treatment for peptic ulcer.

The invention provides a voglibose tablet and a preparation method thereof. The voglibose tablet is prepared from 1 part by weight of voglibose, 450-550 parts by weight of lactose, 130-170 parts by weight of starch, 20-30 parts by weight of high substituted hydroxypropyl fibers, 3-4 parts by weight of magnesium stearate, 0.1-0.5 parts by weight of propolis, 5-10 parts by weight of sodium lauryl sulfate, 4-6 parts by weight of polysorbate 80, 30-40 parts by weight of a co-solvent and 40-50 parts by weight of a disintegrant. The voglibose is used as the main drug, and high-substituted hydroxypropyl fiber, propolis, polysorbate 80 synergistic voglibose, lactose, starch, magnesium stearate and sodium lauryl sulfate are used in a good ratio so that the tablet dissolution degree is greatly improved, the disintegration time limit is optimized and the drug efficacy is improved. The voglibose tablet has a good dissolution degree and good disintegration effects, can well exert the efficacy of the voglibose tablet and can improve the drug efficiency. Through combination of the initial mixing process and low / high-speed agitation, the tablet dissolution degree is further improved and the quality of the tablet is improved.

The invention relates to a controlled release preparation containing 5-methyltetrahydrofolate. The controlled release preparation comprises a 5-methyltetrahydrofolate osmotic pump tablet core and a polymeric semi-permeable membrane coating layer. The semi-permeable membrane coating layer accounts for 2-15% of the weight of the tablet core, and the 5-methyltetrahydrofolate osmotic pump tablet corecan be a single-layer tablet or a double-layer tablet. By means of the preparation, 5-methyltetrahydrofolate can be slowly and stably released for a long time, the dosing frequency is reduced, and themedication compliance of a patient is improved.

The invention provides skin care emulsion containing cannabidiol (CBD) nanoemulsion, and a preparation method of the skin care emulsion. The skin care emulsion is characterized by being prepared fromthe following components in percentage by mass: 10%-50% of CBD nanoemulsion, 0.5%-3% of a seville orange flower extract, 0.5%-3% of a flos gossampini extract, 0.3%-5% of a herba moslae extract, 1%-5%of hydrogenated lecithin, 1%-10% of silicone, 1%-5% of collagen, 1%-8% of carbamide, 0.01%-0.03% of potassium sorbate, 0.01%-0.05% of guar gum, 0.1%-0.5% of cholesterol, 0.5%-3% of 1,2-hexanediol, andthe balance of deionized water, wherein the sum of all the components is 100%. The surface effect and the small size effect of the nanoemulsion are achieved, the solubility of the skin care emulsioncan be changed, the drug efficacy can further be improved, and especially after the CBD nanoemulsion, the seville orange flower extract, the flos gossampini extract and the herba moslae extract are added, through synergy of the effects of skin whitening, inflammation resisting, oxidation resisting and free radical removing of the CBD nanoemulsion, the effects of fading spots, whitening, replenishing water, promoting skin metabolism, timely replenishing nutrients and blocking damage of the external environment to skin are achieved.

The invention discloses a Chinese traditional medicine preparation for treating coughs. The Chinese traditional medicine preparation is prepared from the seven kinds of Chinese traditional medicine of coastal glehnia root, radix ophiopogonis, rhizoma polygonati odorati, radix trichosanthis, folium mori, semen lablab album, radix glycyrrhizae. A preparation method of the Chinese traditional medicine preparation comprises the following steps: the seven kinds of Chinese traditional medicine are added with water and decocted in the water, or is subjected to heating reflux through an aqueous solution containing alcohol, so as to extract liquid extract; the liquid extract is collected, filtered and subjected to vacuum concentration; the concentrated liquid extract is treated with a macroporous absorbent resin column and eluted with water or an aqueous solution containing alcohol; the eluent is collected and concentrated; auxiliary materials are added to the concentrated eluent, so as to make the concentrated eluent into a dosage form suitable for clinical medication. According to the preparation method of the Chinese traditional medicine preparation, the active components of adenophora and radix ophiopogonis soup are concentrated, and the inactive components of the adenophora and radix ophiopogonis soup are reduced; the improvement on the curative effect of the Chinese traditional medicine preparation is facilitated; side effects and dose of the Chinese traditional medicine preparation are reduced; the medicine taking compliance of patients is improved. The invention further provides a novel Chinese patent drug for treating lung yin deficiency-type dry coughs. The Chinese traditional medicine preparation and the preparation method thereof are of great significance for meeting the demand of clinical medication.

The invention belongs to the technical field of pharmacies, relates to a traditional Chinese medicine raw material extract and an extraction method thereof, particularly relates to a ginkgo leaf extract and an extraction method thereof. The extraction method for the extract comprises the following steps: smashing dried ginkgo leaves with a smashing machine; and performing reflux extraction on thesmashed ginkgo leaves by ethanol to obtain the ginkgo leaf extract. By adopting the extraction method, the effective component content is controlled effectively, the medicinal effect of the medicine is improved.

A Chinese medicine for treating acute or chronic bronchitis is prepared from azalea and additive through distilling azalea to obtain its volatile oil, extracting the distilled residue by content 70-90 % alcohol to obtain active components, and proportionally mixing the volatile oil, active components and additive. Its advantages are high curative effect and high safety.

The invention provides a Qianlieping preparation used for treating prostatitis. The preparation comprises the following raw materials of patrinia herb, red sage root, radix paeoniae rubra, peach kernel, safflower, Japanese eupatorium, Pyrrosia lingua, frankincense, and myrrh. A preparation method of the preparation comprises the following steps: 1) weighing the raw materials; 2) crushing red sage root, radix paeoniae rubra and peach kernel, mixing the crushed material with patrinia herb, safflower, Japanese eupatorium and Pyrrosia lingua, adding a mixture in water, immersing the mixture, heating and extracting the material for 2-3 hours, filtrating the material to obtain a filtrate and filter residue; 3) adding the filter residue obtained in the step 2) in water, heating and extracting the material for 2-3 hours, filtrating the material to obtain the filtrate and filter residue; 4) adding the filter residue obtained in the step 3) in water, heating and extracting the material for 2-3 hours, filtrating the material to obtain the filtrate; and 5) merging the filtrates obtained in the step 2), the step 3) and the step 4), concentrating the material to obtain a clean paste, drying the clean paste, adding frankincense and myrrh, crushing the materials and uniformly mixing the materials. The Qianlieping preparation has the advantages of high content of effective composition, little administration amount, and high bioavailability, and is more suitable for absorption by human body.

The invention relates to the field of traditional Chinese medicine for animal disease treatment, in particular to a traditional Chinese medicine for treating otocariasis of dogs and cats and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine for treating otocariasis of dogs and cats is prepared from raw materials in parts by weight as follows: 8-15 parts ofsemen arecae, 10-20 parts of pericarpium granati, 10-20 parts of radix stemonae, 10-25 parts of radix euphorbiae lantu, 8-15 parts of fructus kochiae, 10-20 parts of radix sophorae flavescentis, 8-15parts of cortex phellodendri, 15-25 parts of fructus cnidii, 10-20 parts of zanthoxylum bungeanum, 15-30 parts of radix astragali, 10-20 parts of folium artemisiae argyi, 15-30 parts of herba patriniae and 3-8 parts of borneol. The raw materials of the traditional Chinese medicine are added to a traditional Chinese medicine extraction tank, water is added for decoction and reflux extraction twice,two decoctions are integrated and filtered, a filtrate is concentrated and then cooled to the room temperature, absolute ethanol is added for ethanol precipitation, and a supernatant obtained after filtering is a traditional Chinese medicine liquid. The traditional Chinese medicine can effectively treat symptoms of otocariasis of dogs and cats and, relieve symptoms such as pruritus, outer ear inflammation and local anaphylaxis.

This invention involves reorganization BCG vaccine for secretion of people interferon- alpha2a, and structuring method. Utilize gene engineering to clone BCG vaccine Ag85B signal peptide part and the genes of people IFN - alpha 2a playing a secreting role to pMV261 to receive the BCG vaccine shuttling expression carrier pMSIFN - alpha 2a. Adopt electric boring technology to lead pMSIFN - alpha 2a into BCG to recombinate rBGGIFN - alpha2a. Depending on rBGGIFN - alpha 2a duplicating in BCG and the secretion function of the signal peptide, can secrete IFN - alpha2a efficiently.

The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine extract. The traditional Chinese medicine extract comprises the following raw materials in parts by weight: 5-30 parts of vinegar cream, 30-100 parts of table vinegar and 47-119 parts of traditional Chinese medicinal materials, wherein the traditional Chinese medicinal materials include the following components in parts by weight: 4-10 parts of ginseng, 3-9 parts of aspongopus, 8-20 parts of turtle shells, 6-12 parts of glossy privet fruits, 3-10 parts of curcuma aromatica, 9-15 parts of selfheal, 5-20 parts of herb of clarke boea, 4-8 parts of fructus evodiae and 5-15 parts of liquorice. According to the traditional Chinese medicine extract provided by the invention, the table vinegar, the vinegar cream and the traditional Chinese medicinal materials are used as the raw materials; on one hand, the various raw materials themselves are rich in multiple active substanceshaving therapeutic and inhibitory effects on tumours; on the other hand, due to the synergistic effect among the table vinegar, the vinegar cream and the traditional Chinese medicinal materials, drugtherapeutic effects of the active substances in the traditional Chinese medicinal extract are effectively increased; furthermore, the table vinegar and the vinegar cream effectively reduce the toxic and side effects of the various traditional Chinese medicinal materials; and thus, the traditional Chinese medicinal extract has less toxic and side effect.

The invention discloses a Chinese patent medicine for treating the TKI (tyrosine kinase inhibitor) rash and a preparation method thereof. The preparation method comprises the following steps of: (1) in parts by weight, quickly washing 15-35 parts of geranium wilfordii, 15-35 parts of lithospermum, 15-35 parts of root bark of the peony tree, 15-35 parts of hairyvein agrimony, 15-35 parts of cotex dictamni and 15-35 parts of radix sophorae flavescentis; dipping in 400-1000 parts of water at the temperature of 25-50DEG C for 30-60 minutes; decocting with a casserole for 30-60 minutes; filtering; and eating filtrate.

The invention discloses a compound macleaya cordata composition used for treating animal diarrheal diseases, and belongs to the field of veterinary drug. The compound macleaya cordata composition contains macleaya cordata total alkaloids extract and quinolone compounds, and contains following active components, by mass, 1 to 1000 parts of macleaya cordata total alkaloids extract, and 1 to 2000 parts of quinolone compounds. The compound macleaya cordata composition can be prepared into solid preparations including liquid preparations such as injections, syrup, and oral solution, tablets, dispersing tablets, sustained release tablets, capsules, particles, and powder, and semi-solid preparations such as ointment, paste, and gel. Obvious synergistic effects are achieved in treatment of animaldiarrheal diseases using the compound macleaya cordata composition, infection of diseases can be controlled effectively, curative effect is obvious, quality is stable, safety is high, the preparationmethod is simple, and the preparation method is suitable for industrialized production.

The invention provides a voglibose tablet and a preparation method thereof. The voglibose tablet is prepared from 1 part by weight of voglibose, 450-550 parts by weight of lactose, 130-170 parts by weight of starch, 20-30 parts by weight of high substituted hydroxypropyl fibers, 3-4 parts by weight of magnesium stearate, 0.1-0.5 parts by weight of propolis, 5-10 parts by weight of sodium lauryl sulfate, 4-6 parts by weight of polysorbate 80, 30-40 parts by weight of a co-solvent and 40-50 parts by weight of a disintegrant. The voglibose is used as the main drug, and high-substituted hydroxypropyl fiber, propolis, polysorbate 80 synergistic voglibose, lactose, starch, magnesium stearate and sodium lauryl sulfate are used in a good ratio so that the tablet dissolution degree is greatly improved, the disintegration time limit is optimized and the drug efficacy is improved. The voglibose tablet has a good dissolution degree and good disintegration effects, can well exert the efficacy of the voglibose tablet and can improve the drug efficiency. Through combination of the initial mixing process and low / high-speed agitation, the tablet dissolution degree is further improved and the quality of the tablet is improved.

The invention relates to the technical field of traditional Chinese medicines, and in particular discloses moringa oleifera ferment for preventing and treating pneumoconiosis and a preparation method thereof. The moringa oleifera ferment is prepared from the following raw materials in percentage by weight: 1.0-3.0% of moringa oleifera leaf powder, 0.5-1.5% of licorice root, 0.5-1.5% of chrysanthemum, 0.5-1.5% of grosvener siraitia, 0.5-1.5% of European hop flower, 0.5-1.5% of boat-fruited scaphium seed, 0.1-1% of table salt, 5-15% of honey, 5-15% of fruit juice ferment and 58.5-86.4% of water. The probiotics of yeast and lactic acid bacteria in the fruit juice ferment cooperate with the moringa oleifera leaf powder to ensure that the prepared moringa oleifera ferment has a significant dust removal effect, and the medicine curative effect of traditional Chinese medicine active ingredients for resisting bacteria and diminishing inflammation is improved. The preparation method of the moringa oleifera ferment disclosed by the invention is simple and convenient to operate, and is suitable for industrial popularization and application.