Medicine for treating acute chronic bronchitis and its preparation method

A bronchitis, acute and chronic technology, which is applied in the field of medicines for treating acute and chronic bronchitis and their preparation, can solve the problems of inability to use flavonoids, no utilization of volatile oils, etc.

Inactive Publication Date: 2004-07-21
SICHUAN GEWEI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, in the currently available information, only the volatile oils of Manshanhong and Liexiang Rhododendron are used as effective medicinal ingredients, but the flavonoids cannot be used; Medicinal raw materials such as rhododendron aurora are only used as effective medicinal ingredients using water extracts, and there are no reports on the use of their volatile oils

Method used

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  • Medicine for treating acute chronic bronchitis and its preparation method
  • Medicine for treating acute chronic bronchitis and its preparation method

Examples

Experimental program
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Effect test

example 1

[0059] Example 1 Oral liquid pharmaceutical preparation

[0060] Take 1000g of Liangshan Rhododendron, add 12 times of water, add steam for distillation, continue distillation for 6 hours to extract the volatile oil, filter the collected volatile oil, place it in a brown glass bottle, and store it in a refrigerator at 4°C for later use. Add 10 times water to the medicinal residue to decoct for 1 hour, filter, and concentrate the filtrate into a clear ointment with a relative density of 1.1-1.2 (70-80°C). Add appropriate amount of citric acid to adjust the pH to ~4.5. Add the clear ointment weight 3 times the amount of 2% gelatin solution, stir while adding to make the reaction complete, add ethanol to make the content (v / v) 70-90%, the best 75-85%, stand for 72 hours, filter The filtrate is recovered under reduced pressure and concentrated by ethanol to about 600ml, let stand for 24 hours, filter, add sucrose and sodium benzoate to the filtrate, boil to dissolve, add water to 1000...

example 2

[0061] Example 2 Injection pharmaceutical preparation

[0062]Take 1000g of Liangshan Rhododendron, add 12 times of distilled water without heat source, pass in steam for distillation, distill continuously for 6 hours to extract the volatile oil, filter the collected volatile oil, place it in a brown glass bottle, and store it in a refrigerator at 4°C for later use. Add 10 times the distilled water without heat source to decoct the medicine residue for 1 hour, filter, add distilled water without heat source to reach 6000ml. After mixing, each 250ml of the medicinal solution is equivalent to 10g of medicinal materials, and after adsorbing by the commonly used D101 or D201 type macroporous adsorption resin with a pore size of 8-10 nanometers, wash the unbound with distilled water of 2-5 times the bed volume Ingredients and impurities, eluted with 75.0%-85.0% ethanol (v / v) and collected the ethanol eluate, the eluate was decompressed to recover the ethanol to stop drying, and vacuum ...

example 3

[0063] Example 3 Dropping pills pharmaceutical preparation

[0064] After heating polyethylene glycol (PEG) 6000 in a water bath until it is completely melted, add the Liangshan Rhododendron extract thick paste extracted by the macroporous resin according to the above method, stir evenly, then add the Liangshan Rhododendron volatile oil to mix, and quickly transfer to storage In the liquid bottle, seal and keep the temperature at 80°C, drip into the cooled methyl silicone oil, collect the drop pellets, absorb the methyl silicone oil on the surface, dry, and package to get it. Each pill weighs 40mg-50mg, and the content of volatile oil and quercetin are both 8mg-12mg / pill

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Abstract

A Chinese medicine for treating acute or chronic bronchitis is prepared from azalea and additive through distilling azalea to obtain its volatile oil, extracting the distilled residue by content 70-90 % alcohol to obtain active components, and proportionally mixing the volatile oil, active components and additive. Its advantages are high curative effect and high safety.

Description

Technical field [0001] The invention relates to a medicine for treating acute and chronic bronchitis using natural medicine raw material extracts as effective medicinal ingredients and a preparation method thereof. Background technique [0002] Acute and chronic bronchitis is a common and frequently-occurring disease in respiratory diseases. The main clinical manifestations are dyspnea, phlegm, and asthma. The current treatment drugs are mainly bronchial antispasmodics, hormones, antibiotics, and sprays. Although these drugs can relieve the patient's symptoms at the time, they often take effect quickly and relapse quickly. [0003] There are many reports on the types of drugs that can be used to treat bronchitis in Chinese medicine, such as Manshanhong, Lixiang Rhododendron, Purple Rhododendron, and Zhaoshanbai. However, these raw materials contain flavonoids such as quercetin, quercetin, and hyperoside, which may have antitussive ingredients, as well as scopoletin and kaempferol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/48A61K31/7048A61P11/00
Inventor 冯艳秦力吴纬焦丽华杨刚虹
Owner SICHUAN GEWEI PHARMA
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