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A kind of voglibose tablet and preparation method thereof

A technology for voglibose and sugar tablets, which can be applied to pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problem of poor dissolution and affect the curative effect of voglibose and other problems, to achieve the effects of excellent dissolution, good disintegration, and improved efficacy

Active Publication Date: 2020-01-21
HAINAN HUALON PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the in vitro dissolution rate of ordinary tablets is only about 83% in 30 minutes, and its dissolution rate is relatively poor, which affects the efficacy of voglibose to varying degrees.

Method used

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  • A kind of voglibose tablet and preparation method thereof
  • A kind of voglibose tablet and preparation method thereof
  • A kind of voglibose tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A voglibose tablet, comprising the following raw materials in parts by weight: 1 part of voglibose, 450 parts of lactose, 130 parts of starch, 20 parts of high-substituted hydroxypropyl fiber, 3 parts of magnesium stearate, and 0.1 part of propolis , 5 parts of sodium lauryl sulfate, 4 parts of polysorbate 80, 30 parts of co-solvents and 40 parts of disintegrants; said co-solvents are hydroxypropyl methylcellulose; Sodium Methylcellulose.

Embodiment 2

[0027] A voglibose tablet, comprising the following raw materials in parts by weight: 1 part of voglibose, 550 parts of lactose, 170 parts of starch, 30 parts of high-substituted hydroxypropyl fiber, 4 parts of magnesium stearate, and 0.5 part of propolis , 10 parts of sodium lauryl sulfate, 6 parts of polysorbate 80, 40 parts of cosolvents and 50 parts of disintegrants; said cosolvents are cyclodextrin and polyethylene glycol 6000, cyclodextrin and polyethylene glycol The weight ratio of alcohol 6000 is 1:1; the disintegrant is sodium carboxymethyl starch and microcrystalline cellulose, and the weight ratio of sodium carboxymethyl starch and microcrystalline cellulose is 1:1.

Embodiment 3

[0029] A voglibose tablet, comprising the following raw materials in parts by weight: 1 part of voglibose, 487.5 parts of lactose, 150 parts of starch, 25 parts of high-substituted hydroxypropyl fiber, 3.25 parts of magnesium stearate, and 0.3 part of propolis , 8 parts of sodium lauryl sulfate, 805 parts of polysorbate, 35 parts of co-solvent and 45 parts of disintegrating agent; The co-solvent is hydroxypropyl methylcellulose, cyclodextrin and polyethylene glycol 6000, hydroxyl The weight ratio of propyl methylcellulose, cyclodextrin and polyethylene glycol 6000 is 2:2:1; the disintegrating agent is croscarmellose sodium, sodium carboxymethyl starch and microcrystalline cellulose , The weight ratio of croscarmellose sodium, sodium carboxymethyl starch and microcrystalline cellulose is 1:2:2.

[0030] The preparation method of the voglibose tablet of above-mentioned embodiment 1~3, comprises the following steps:

[0031] S1, pretreatment: take lactose, starch, magnesium stea...

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Abstract

The invention provides a voglibose tablet and a preparation method thereof. The voglibose tablet is prepared from 1 part by weight of voglibose, 450-550 parts by weight of lactose, 130-170 parts by weight of starch, 20-30 parts by weight of high substituted hydroxypropyl fibers, 3-4 parts by weight of magnesium stearate, 0.1-0.5 parts by weight of propolis, 5-10 parts by weight of sodium lauryl sulfate, 4-6 parts by weight of polysorbate 80, 30-40 parts by weight of a co-solvent and 40-50 parts by weight of a disintegrant. The voglibose is used as the main drug, and high-substituted hydroxypropyl fiber, propolis, polysorbate 80 synergistic voglibose, lactose, starch, magnesium stearate and sodium lauryl sulfate are used in a good ratio so that the tablet dissolution degree is greatly improved, the disintegration time limit is optimized and the drug efficacy is improved. The voglibose tablet has a good dissolution degree and good disintegration effects, can well exert the efficacy of the voglibose tablet and can improve the drug efficiency. Through combination of the initial mixing process and low / high-speed agitation, the tablet dissolution degree is further improved and the quality of the tablet is improved.

Description

technical field [0001] The invention relates to the technical field of voglibose, in particular to a voglibose tablet and a preparation method thereof. Background technique [0002] Voglibose is an α-glucosidase inhibitor. Its mechanism of action is to competitively inhibit maltase, isomaltase, glycosidase, etc. on the intestinal mucosa to reduce the decomposition of disaccharides to monosaccharides. It leads to a reduction in the formation of D-glucose, thereby delaying the digestion and absorption of starch and sucrose, lowering blood sugar, and especially controlling postprandial hyperglycemia. Voglibose has a stable hypoglycemic effect and does not stimulate the secretion of insulin. There is no hyperinsulinemia after meals, and hypoglycemia is not easy to occur. [0003] Although voglibose has good water solubility, because its crystal form is needle-like in a matrix, it dissolves slowly when it encounters a dissolution medium and takes a long time to take effect. At ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/133A61K47/46A61K47/38A61K47/36A61K47/26A61P3/10
CPCA61K9/2018A61K9/2054A61K9/2059A61K9/2068A61K31/133
Inventor 陈雪君郑松
Owner HAINAN HUALON PHARM
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