52results about How to "Improved disintegration time" patented technology

The invention relates to a naproxen hydrate crystal, a preparation method thereof and a medicinal composition containing the naproxen hydrate crystal and sumatriptan. The naproxen hydrate crystal has the molecular formula as follows: C14H14O3.1.5H2O. The medicinal composition comprises the following components in parts by weight: 125-750 parts of naproxen, 25-100 parts of sumatriptan, 130-200 parts of gelatine, 10-45 parts of compressible starch, 10-35 parts of microcrystalline cellulose, 10-30 parts of low-substituted hydroxy propyl cellulose, 10-30 parts of cross-linked polyvinylpyrrolidone, 10-20 parts of sodium carboxymethylcellulose, 20-40 parts of maltodextrin, 5-20 parts of lecithin, 5-20 parts of magnesium stearate and 10-20 parts of sodium bicarbonate. According to the crystal provided by the invention, the dissolubility of naproxen is obviously improved, the medicinal composition of the naproxen hydrate crystal is prepared by using a direct tabletting method and has better disintegration time and dissolution rate, and the bioavailability of the naproxen is obviously improved.

The invention relates to a new multi-functional auxiliary material for orally disintegrating tablets and a preparation method thereof, and belongs to the field of pharmacy. The preparation method comprises the following steps of: weighting and mixing mannitol, isosorbide and crospovidone; under the condition of using water as a solvent, carrying out high-shear dispersion on the obtained mixture so as to obtain solution; and then carrying out spray drying on the solution to obtain the new multi-functional auxiliary material.

The invention relates to a medicament for treating metrorrhagia and metrostaxis, hematemesis, hematochezia and traumatic hemorrhage and a preparation method thereof. The preparation method comprises the following steps of: 1, mixing rhubarb, golden thread and dahurian angelica root, adding an ethanol, merging ethanol extract, and concentrating the ethanol extract; 2, adding sanchi into the ethanol, merging ethanol extract and concentrating the ethanol extract; 3, taking common bletilla pseudobulb decocting liquid and concentrating the liquid into a thick paste with a relative density between 1.15 and 1.30 at the temperature of 60 DEG C; 4, decocting dregs in the three steps, India madder root and liquoric root twice, merging decoction, concentrating the decoction, mixing the concentrated decoction with the thick paste obtained in step 3, reducing pressure and drying the mixture to obtain a dry paste and crushing the dry paste; 5, evenly mixing products obtained by step 1 and step 2, carrying out high-speed centrifugal spraying drying, and simultaneously spraying aqueous solution of hydroxypropyl-beta-cyclodextrin to prepare dispersed fine powder; and 6, mixing and crushing medicaments such as cuttlebone, calcined dragon bone and the like, evenly mixing the mixture with two fine powder obtained by the step 4 and step 5, adding medicaments such as microcrystalline cellulose and the like, and evenly mixing, drying and palletizing the mixture. The medicament simplifies production process, saves production cost and has obvious curative effect.

Provided are pharmaceutical compositions and methods for preparing pharmaceutical compositions comprising Ibuprofen using solventless mixing methods. Excess coating material that is not bound to coated Ibuprofen may be removed by a sieving process. Coating and dosing ratios can also be optimized to minimize the amount of excess unbound coating material. Additionally, the compositions can be formulated to preserve the functional coating of coated Ibuprofen and to minimize aeration of Ibuprofen when mixed into suspension.

The invention discloses a heart relaxing tablet which is prepared from heart relaxing dry paste, PEG (Polyethylene Glycol)-4000, sucrose powder, carboxymethyl starch sodium, silica, magnesium stearate and a sirup agent, wherein the sirup agent is an adhesive which is relatively high in viscosity and suitable for a loose botanical drug with high elasticity, the prepared tablet is uniform in particle size, and the hardness and release rate of the tablet are both better than those of particles prepared by a traditional process. The invention also discloses a preparation method of the heart relaxing tablet; during preparation, the heart relaxing dry paste is added internally and externally so that the tablet is uniform in color after a coating is removed, the characters are improved and the medicinal absorption speed is increased as well. Through elaborate selection of auxiliary materials, the heart relaxing tablet is good-looking in appearance, good in color and gloss, good in taste, long in storage period, convenient to use, transport and carry, low in cost and high in yield.

The invention relates to a gastrodine mouse mouse disintegration tablet, which uses gastrodine as main drug, with gastrodine coat capsule, diluter, and disintegrator. Wherein, the invention is characterized in that: said capsule is made from gastrodine, coated by acrylic acid resin and acrylic acid; and the disintegrator is low-replace hydroxypropyl cellulose and crosslink polyvinyl pyrrolidon. The invention has better disintegration time limit, with uniform solution.

The invention discloses an ambroxol hydrochloride oally disintegrating tablet and a preparation method thereof. The orally disintegrating tablet consists of effective dose of ambroxol hydrochloride and pharmaceutical adjuvants, wherein the pharmaceutical adjuvants include a taste masking agent, a filler, a flavoring agent, a disintegrant, an adhesive and a lubricant; and the disintegrant is a combination of cross-linked povidone and other disintegrants. The ambroxol hydrochloride oally disintegrating tablet prepared by the invention has the characteristics of being convenient to take without the use of water, rapid in disintegrating, rapid in absorption, high in bioavailability and the like. The preparation method of the finished product (the ambroxol hydrochloride oally disintegrating tablet) provided by the invention is low in cost, simple in processing equipment, easy and controllable in implementation, low in operating cost, economic and convenient, and applicable to large-scale production.

The invention belongs to the field of pharmaceutical preparation, relates to an alimentary canal drug preparation, and particularly relates to a pH dependent type colon positioning capsule. The pH dependent colon positioning hard capsule includes a hard capsule injected with drug ingredients and a coating film; a coating liquid for forming the coating film has the use amount which is 1-N times that of the following prescription: 2 g of a coating material comprising acrylic resin No.III, EudragitRL100 and/or EudragitRS100; the weight of EudragitRL100 and/or EudragitRS100 accounts for 18-25% of the total weight of the coating material; the coating liquid also comprises 2-3 ml of a plasticizer and 92-98 ml of a solvent of the coating material. An outermost layer of the hard capsule is coated with the polymer coating film, so that injected drugs are ensured not to leak, and the colon positioning drug release requirements can be met.

The invention discloses a tinidazole tablet and a preparation method thereof. The tinidazole tablet comprises a tablet core and a coating, wherein the tablet core comprises tinidazole, a diluent, an adhesive, a disintegrating agent and a lubricant. The preparation method disclosed by the invention comprises a step of preparing the tinidazole tablet by using a wet-method one-step pelletizing process. The disintegrating agent is added in different steps by external and external addition modes respectively, so that the time can be shortened, and the production efficiency can be improved; and witha prescription, the dissolution and hardness of the product can be improved, the powder properties of raw materials are improved, the smoothness of a tablet pressing process can be improved, the appearance can be improved, and the product quality can be effectively improved.

The invention relates to a Yixinshu tablet and a preparation method. Specifically, the Yixinshu tablet is prepared by extraction of ginseng, radix ophiopogonis, Schisandra chinensis, radix astragali,Salvia miltiorrhiza, Ligusticum wallichii and hawthorn as the raw materials. During preparation of the tablet, 75% ethanol is employed for granulation, has strong viscosity, and is suitable for botanical drugs with loose texture and strong elasticity, and the obtained particles are subjected to size stabilization, the hardness and taste are good, and after tabletting, the obtained tablet has smooth and flat surface, and has good application value.

The invention discloses a pentoxyverine voltoide and a preparation method thereof. The tablet uses citric acid pentoxyverine dipping pill as a tablet core, and adopts a dry pressure coating technology to press ammonium chloride, the citric acid pentoxyverine dipping pill and an excipient to a coated tablet. The weight ratio of the ammonium chloride to the citric acid pentoxyverine in the tablet is 12:1, and the balance is the excipient. The invention solves the technical problem of sticky punch in tabletting and leads the whole tabletting process to be easier to realize, and the tabletted tablet has reliable quality and is beautiful. The pentoxyverine voltoide can be clinically used for treating coughing and sputum including acute and chronic bronchitis and pneumonia, and the like caused by various reasons.

A Chinese medicine in the form of tablet for nourishing qi and Yin, promoting blood circulation and pulse, heart blood stagnation, cardialgia, palpitation, etc is prepared from 6 Chinese-medicinal materials including ginseng, astragalus root, red sage root, Chuan-xiong rhizome, etc, lubricant and diluent (microcrystalline cellulose) through extracting in water, removing solvent to obtain powder and other conventional steps.

The invention belongs to the technical field of medicines, and particularly relates to a nitroglycerin micro-tablet as well as a preparation method and a preparation thereof. The diameter of the micro-tablet is 1-4 mm, the weight of the micro-tablet is 2-50 mg, and each micro-tablet contains 0.1-2.5 mg of nitroglycerin. The invention also provides a preparation method of the micro-tablet. The compound used by the micro-tablet can obviously improve the stability of the preparation and accelerate the disintegration time limit; and the micro-tablet is rapidly disintegrated and dissolved and is absorbed by sublingual mucosa at a higher speed, so that the first-pass effect of the liver on the medicine can be avoided, and the onset time of first aid is accelerated. And the problem that the bioavailability is reduced due to the fact that the conventional sublingual tablet is directly swallowed after being taken due to overlong disintegration and dissolution time can also be avoided.

The invention discloses a tinidazole tablet and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The tinidazole tablet disclosed by the invention is prepared by controlling the dosage and the particle size of the raw materials and the auxiliary materials and adopting a dry granulation process. The tinidazole tablet prepared by the preparation method can effectively improve the dissolution rate, disintegration time limit, hardness and friability of the medicine tablet, effectively overcomes the problem that the nitrite content is increased due to high temperature and high humidity in the existing wet granulation process, and is good in production compliance and high in production efficiency.

The invention discloses a method for improving disintegration time limit of fuke qianjin tablet. The fuke qianjin tablet is prepared from the following raw materials: philippine flemingia root, Chinese mahonia stem, herba andrographitis, folium zanthoxyli dissiti, caulis spatholobi, radix angelicae sinensis, radix codonopsis pilosulae and Cherokee rose root. During the preparation process of the fuke qianjin tablet, the content of Z-3-butylidene phthalide and the total volume of andrographolide and dehydrated andrographolide are regulated; in each fuke qianjin tablet, the content of Z-3-butylidene phthalide is not less than 0.015mg and the total volume of andrographolide and dehydrated andrographolide is not less than 1.1mg; HPLC method is optimally adopted for detecting the content. According to the invention, the important influences of the content of Z-3-butylidene phthalide and the total volume of andrographolide and dehydrated andrographolide in the fuke qianjin tablet on the product performances are confirmed and the accurate limitation is performed. Compared with the present fuke qianjin tablet, the fuke qianjin tablet prepared according to the invention has the advantages that the disintegration time limit is improved, the active ingredients are quickly released and can quickly take effect, and the clinical efficacy is further promoted.

The invention provides an atorvastatin calcium tablet and a preparation process thereof, the atorvastatin calcium tablet is composed of a core material and a coating, the core material is prepared from the following raw materials by weight: 10 parts of atorvastatin calcium, 15-20 parts of a filler, 4-6 parts of an adhesive, 8-12 parts of a disintegrating agent, and 3-5 parts of a lubricant; the coating film is prepared from hydroxypropyl methyl cellulose, nano titanium dioxide and polyvinylpyrrolidone according to the mass ratio of (2 to 3): (16 to 18): 1. The atorvastatin calcium tablet is composed of the core material and the coating film, the coating film is prepared from hydroxypropyl methyl cellulose, nano titanium dioxide and polyvinylpyrrolidone according to a certain proportion, the coating uniformity is good, the coating effect is stable, and the prepared atorvastatin calcium tablet is high in coating rate and small in tablet weight difference. The atorvastatin calcium tablet prepared by the invention is good in disintegration time limit, high in stability and good in strong light resistance, high temperature resistance and high humidity resistance.