A pH-dependent colon-localized hard capsule

A colon positioning and hard capsule technology, applied in the field of digestive tract pharmaceutical preparations and pH-dependent colon positioning capsules, can solve the problems of high water and oxygen permeability, easy water loss and aging of rubber skin, unqualified product disintegration, etc. Improved compliance, improved bioavailability, improved stability

Active Publication Date: 2015-09-02
惠州市九惠药业有限公司
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  • Abstract
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AI Technical Summary

Problems solved by technology

However, the production of soft capsules is more complicated, and the rubber treatment and the packaging of the contents must be carried out at the same time. Compared with hard capsules, soft capsules have significantly higher moisture and oxygen transmission rates, which is not conducive to the storage of drugs, and the rubber is prone to dehydration and aging. Cause the product to disintegrate and fail

Method used

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Examples

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Embodiment Construction

[0032] Homemade javanica oil hard capsules, only put javanica oil into the hard capsules and oil leakage will occur soon, so the hard capsules must be sealed after filling the oil. According to the records of the existing technology (Chinese invention patent ZL200710031234.2), and the proof of the preliminary experiment, the acrylic resin No. Ⅲ disintegrates in the buffer solution of pH 6.8, and disintegrates quickly in the buffer solution of pH 7.8 Completely, but with acrylic resin No. III as the coating material to seal, the hard capsule is intact without oil leakage, so the main coating material of the coating liquid of the present invention still adopts acrylic resin No. III. Acrylic resin No. Ⅲ is a copolymer formed by the reaction of methacrylic acid and methyl methacrylate in a ratio of 1:2. In the prescription, acrylic resin No. Ⅲ is produced by Lianyungang Wantai Pharmaceutical Materials Co., Ltd.

[0033] Eudragit RL100 (hereinafter referred to as RL) and Eudragit ...

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Abstract

The invention belongs to the field of pharmaceutical preparations, and relates to a medicinal preparation for the digestive tract, in particular to a pH-dependent colon-localized capsule. A pH-dependent colon-localized hard capsule, comprising a hard capsule injected with pharmaceutical ingredients and a coating film thereof, the coating liquid used to form the coating film and its dosage are 1 to N times that of the following prescription: coating Material 2g, the coating material is, acrylic resin No. Ⅲ, Eudragit RL100 and / or Eudragit RS 100; the Eudragit RL100 and / or Eudragit RS 100 account for 18-25% of the total weight of the coating material; 2~3ml of agent, 92~98ml of solvent for coating material. The outermost layer of the hard capsule of the invention is covered with a polymer coating film, which ensures that the injected medicine does not leak and can meet the requirement of colon-specific drug release.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a medicinal preparation for the digestive tract, in particular to a pH-dependent colon-localized capsule. Background technique [0002] Colonic diseases (such as colitis, colon cancer, etc.) have no specific drugs at present, and the reason is that the concentration of the drugs reaching the colon is very low after oral administration or injection. Its bioavailability is low, mainly because the drug has been absorbed or decomposed before entering the colon at the lesion site. Oral colon-specific drug delivery system (OCDDS) refers to the use of appropriate methods to avoid the release of drugs in the stomach, duodenum, jejunum and ileum, and directly deliver them to the ileocecal part of the human body before release. A drug delivery system that exerts a local or systemic therapeutic effect. The advantages of colon-targeted drug delivery include: improving the bioavaila...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/32A61K9/52A61K36/185A61P1/00A61P35/00
Inventor 高崇凯黄辉球
Owner 惠州市九惠药业有限公司
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