Provided are pharmaceutical compositions and methods for preparing pharmaceutical compositions using solventless mixing methods. Excess
coating material that is not bound to a coated API particle may be removed by a sieving process.
Coating and dosing ratios can also be optimized to minimize the amount of excess unbound
coating material. Specifically, a
coating ratio and / or a dosing ratio can be used to minimize the residual amount of excess unbound coating material to minimize agglomeration of coating material during storage. In some embodiments, a pharmaceutical composition is provided, the pharmaceutical composition comprising: 65-85 % w / w API particles; 15-30 % w / w coating material coating the API particles; and 3-15 % w / w matrix surrounding the coated API particles, wherein the pharmaceutical composition comprises a disintegration
time rate of less than 10 seconds for at least six months under storage conditions of at least 25° C. and at least 60 %
relative humidity.