The invention discloses a safe computer network communication system. The system comprises a sending end sandbox isolation system, a file transmission unit and a receiving end; the sending end sandboxisolation system comprises an analog signal copy output module, an analog signal storage module, a file compression system, a security encryption system, a key file conversion unit, a file decryptionprogram, a signal key binding module and a firewall protection system. The invention relates to the technical field of communication systems. The invention discloses the safe computer network communication system. A secret key is divided into two parts according to a specified coding sequence, wherein the two parts are bound to a transmitted compressed packet and a transmitted file decryption program respectively and are transmitted twice, wherein the secret keys in one time are incomplete, and files cannot be cracked even if one group is stolen, so the safety of data is further guaranteed, and the method is suitable for transmission of confidential files; meanwhile, a file decryption program is attached to the method, after all the data are completely received, the decryption and decompression can be rapidly and automatically conducted, and manual step-by-step operation is not needed.