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Heart relaxing tablet and preparation method thereof

A technology of Yixinshu tablet and Yixinshu is applied in the field of Chinese patent medicine tablet and its preparation, which can solve the problems of splinter, too many fine powder, flower tablet and the like, and achieves uniform particle size, neat finished product particle and short preparation time. Effect

Active Publication Date: 2014-05-14
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Using 80% ethanol to granulate, the greater the concentration of ethanol during the operation, the lower the viscosity after wetting, resulting in a wide and uneven distribution of wet granules, and a lot of fine powder, resulting in flower flakes, lobes, etc. The disintegration time of the prepared Yixinshu tablet is long, and after a period of storage, there will be unqualified disintegration time limit, poor stability, and unqualified microorganisms.

Method used

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  • Heart relaxing tablet and preparation method thereof
  • Heart relaxing tablet and preparation method thereof
  • Heart relaxing tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Prescription: in 10,000 tablets

[0048]

[0049] Preparation:

[0050](1) For the above seven flavors, take 1500g of ginseng and crush it into fine powder for later use. 950g Schisandra chinensis and 2400g Salvia miltiorrhiza were extracted twice with 85% ethanol, the first time was 6 times the amount of 85% ethanol, and the reflux extraction was carried out for 3 hours. The filtrates were combined and concentrated under reduced pressure to a relative density of 1.15-1.12 (20°C) to obtain an alcohol extract. Then add 1500g of Ophiopogon japonicus, 1500g of Astragalus, 950g of Chuanxiong and 1500g of Hawthorn and decocted for 2 times. Add 10 times the amount of water (weight) for the first time, decoct for 2.5 hours, add 8 times the amount of water for the second time, decoct for 1.5 hours, and combine The decoction was filtered, the filtrate was concentrated to 3500ml, an equal amount of 85% ethanol was added, and after fully stirring, it was allowed to stand over...

Embodiment 2

[0056] Prescription: in 10,000 tablets

[0057]

[0058] Preparation:

[0059] (1) The extraction of Yixinshugan ointment is the same as that in Example 1.

[0060] (2) 70% syrup is the same as in Example 1.

[0061] (3) Yixinshu dry paste was crushed through a 100-mesh sieve, and sucrose was crushed through an 80-mesh sieve, for use.

[0062] (4) Mix 50g of silicon dioxide, 35g of magnesium stearate, 90g of sodium starch glycolate, and 50g of Yixinshu dry paste, and set aside.

[0063] (5) Weigh 1800g of Yixinshu Dry Ointment, 160g of PEG-4000, and 1100g of sucrose powder according to the prescription amount, mix them evenly, add 70% syrup of the prescription amount to granulate, dry at 70°C, granulate, and finally add step (3) The raw and auxiliary materials are mixed evenly, tableted, coated, aluminum-plastic, and packaged.

Embodiment 3

[0065] Prescription: in 10,000 tablets

[0066]

[0067] Preparation:

[0068] (1) The extraction of Yixinshugan ointment is the same as that in Example 1.

[0069] (2) 70% syrup is the same as in Example 1.

[0070] (3) Yixinshu dry paste was crushed through a 100-mesh sieve, and sucrose was crushed through an 80-mesh sieve, for use.

[0071] (4) Mix 30g of silicon dioxide, 25g of magnesium stearate, 80g of sodium starch glycolate, and 50g of Yixinshu dry paste, and set aside.

[0072] (5) Weigh 2150g of Yixinshu Dry Ointment, 130g of PEG-4000, and 800g of sucrose powder according to the prescription amount, mix them evenly, add 70% syrup of the prescription amount to granulate, dry at 70°C, granulate, and finally add step (3) The raw and auxiliary materials are mixed evenly, tableted, coated, aluminum-plastic, and packaged.

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Abstract

The invention discloses a heart relaxing tablet which is prepared from heart relaxing dry paste, PEG (Polyethylene Glycol)-4000, sucrose powder, carboxymethyl starch sodium, silica, magnesium stearate and a sirup agent, wherein the sirup agent is an adhesive which is relatively high in viscosity and suitable for a loose botanical drug with high elasticity, the prepared tablet is uniform in particle size, and the hardness and release rate of the tablet are both better than those of particles prepared by a traditional process. The invention also discloses a preparation method of the heart relaxing tablet; during preparation, the heart relaxing dry paste is added internally and externally so that the tablet is uniform in color after a coating is removed, the characters are improved and the medicinal absorption speed is increased as well. Through elaborate selection of auxiliary materials, the heart relaxing tablet is good-looking in appearance, good in color and gloss, good in taste, long in storage period, convenient to use, transport and carry, low in cost and high in yield.

Description

technical field [0001] The invention relates to the field of Chinese patent medicine tablets and their preparation, in particular to a Yixinshu tablet and a preparation method thereof. Background technique [0002] Cardiovascular and cerebrovascular diseases are currently one of the most important factors affecting human health and causing death. According to literature reports, more than 20 million people die from cardiovascular and cerebrovascular diseases in the world every year, and nearly 400,000 in my country. Traditional Chinese medicine has accumulated rich clinical experience in the diagnosis and treatment of this disease, and traditional Chinese medicine prescriptions have unique advantages in the treatment of cardiovascular and cerebrovascular diseases. Chest pain and coronary heart disease angina pectoris belong to the category of "chest pain" in traditional Chinese medicine. The etiology of chest pain is related to the internal invasion of cold pathogens, impro...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K9/20A61K47/36A61K47/26A61P9/00A61P9/10
Inventor 刘全国陈克领林文君
Owner HAINAN HULUWA PHARMA GRP CO LTD
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