The invention relates to a special nutrient package fertilizer for Honghua Dajinyuan species tobacco and a preparation method thereof. The nutrient package fertilizer is composed of a base fertilizer and an organic-inorganic compound fertilizer, wherein the base fertilizer comprises the following raw materials in parts by weight: 60-75 parts of oil cake, 5-10 parts of bagasse pith, 0.5-2 parts of Bacillus subtilis, 0.5-2 parts of Thermophilic sporotrichum, 10-15 parts of potassium humate, 10-12 parts of potassium magnesium sulfate and 27-41 parts of water; the organic-inorganic compound fertilizer comprises the following raw materials in parts by weight: 60-75 parts of oil cake, 0.5-2 parts of Bacillus subtilis, 0.5-2 parts of Thermophilic sporotrichum, 1-4 parts of Trichoderma viride, 1-4 parts of Streptomyces jingyangensis, 5-15 parts of potassium humate, 5-10 parts of amino acid, 5-15 parts of potassium nitrate, 10-20 parts of potassium sulfate, 2.5-5 parts of borax, 1.25-2.5 parts of zinc sulfate and 27-41 parts of water; and the special organic-inorganic compound fertilizer contains microbial inoculum and can activate soil microbes, so that molecular nitrogen, phosphorus and potassium in soil are converted into organic nitrogen, phosphorus and potassium which can be easily absorbed by crops under the action of the soil microbes, thus realizing equilibrium absorption of the nutrient elements.