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Kanggongyan tablet and its preparation process

A preparation process and anti-uterine inflammation technology, which is applied in the field of medicine, can solve the problems that the preparation process needs to be improved, the tablet stability of anti-uterine inflammation tablets is not ideal, and the degree of color change is serious, and the time to achieve drug absorption is shortened, Better tablet appearance and better product stability

Active Publication Date: 2021-01-05
YAOSHENGTANG HUNAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the stability of the Kanggongyan Tablet prepared by this traditional method is not ideal, and it is still easy to absorb moisture, and the degree of color change is serious, and the preparation process still needs to be improved.

Method used

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  • Kanggongyan tablet and its preparation process
  • Kanggongyan tablet and its preparation process
  • Kanggongyan tablet and its preparation process

Examples

Experimental program
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Effect test

preparation example Construction

[0049] The preparation of the Kanggongyan Tablet of the present invention needs to be completed in a clean area of ​​grade D or above, the temperature is kept at 18°C-26°C, and the relative humidity is controlled between 45%-65%. The number of air changes in the D-level clean area should be ≥15 times / h, the sedimentation bacteria should be ≤100cfu / 4 hours, the number of suspended particles under static conditions should not exceed 3520000 per cubic meter, and the particle size should not exceed 5.0um per cubic meter 29000.

[0050] The raw materials used in the examples of the present invention are common commercially available products.

Embodiment 1

[0051] Embodiment 1 A kind of prescription of Kanggongyan Tablet and its preparation method

[0052] 1. Prescription

[0053] Prescription of anti-uterine tablets

[0054]

[0055] 2. Preparation process of Kanggongyan Tablets

[0056] A kind of preparation technology of Kanggongyan tablet comprises the following steps:

[0057] 1. Ingredients:

[0058] According to the production prescription, accurately weigh a batch of Guangdong Zizhu dry extract 304.36kg, Wuyao dry extract 71.08kg, Motherwort dry extract 80.19kg, starch 10.7kg, talc powder 53.52kg, put them in a clean stainless steel bucket, wait use.

[0059] 2. Crushing:

[0060] Mix and pulverize the Guangdong Zizhu dry extract, Wuyao dry extract, Leonurus dry extract, starch, and talcum powder handed over from the previous process into a fine powder, pass through a 100-mesh sieve, put it in a clean stainless steel bucket, and transfer it to the granulation process.

[0061] 3. Granulation:

[0062] The fine p...

Embodiment 2

[0069] Embodiment 2 A kind of prescription and preparation technology of Kanggongyan tablet

[0070] 1. Prescription

[0071] 1. Prescription of Kanggongyan Tablets

[0072]

[0073] 2. Prescription of film coating solution

[0074] product name 1.215 million tablets consumption Pharmaceutical film coating premixed excipients (stomach-soluble type) 2.0％～3.0％ talcum powder 6~10kg purified water 70~90kg

[0075] 2. Preparation process

[0076] The preparation process of embodiment 2 is basically the same as that of embodiment 1, the difference is that, with reference to figure 1 The preparation process flow chart of embodiment 2, on the basis of steps 1 to 6 of embodiment 1, also increases the steps of film coating and packaging, specifically:

[0077] Steps 1-6: the same as steps 1-6 of the embodiment.

[0078] 7. Film coating

[0079] Receive qualified substrates, each batch is divided into four pots for film coating, each pot is ab...

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Abstract

The invention relates to an anti-cervicitis tablet and a preparation technology thereof. The preparation technology comprises the following steps: providing raw materials: 300 to 310 parts by weight of callicarpae caulis et folium dry extract, 80 to 85 parts by weight of herba leonuri dry extract, 70 to 75 parts by weight of radix linderae dry extract, 60 to 65 parts by weight of a filler, 2 to 3parts by weight of magnesium stearate and proper amount of a wetting agent; crushing, uniformly mixing and sieving the callicarpae caulis et folium dry extract, the radix linderae dry extract, the herba leonuri dry extract and the filler to obtain a first mixture; mixing the first mixture with the wetting agent, carrying out spraying granulation and drying to obtain dry particles; granulating thedry particles, adding the magnesium stearate while granulating and tabletting to obtain the anti-cervicitis tablet. The preparation technology can obviously improve the humidity resistance of a product.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a Kanggongyan tablet and a preparation process thereof. Background technique [0002] Kanggongyan tablets are developed from folk secret recipes, with astringent and slightly bitter taste. Heat-clearing, damp-dispelling, stasis-removing, belt-stopping. It is used for leukorrhea caused by hot and humid betting, symptoms include red and white leukorrhea, profuse odor; cervical erosion sees the above syndromes. [0003] Kanggongyan Tablets is one of the varieties of Chinese patent medicines that are full extract tablets. Due to its characteristic physical properties, Kanggongyan Tablets are very easy to absorb moisture and deliquescence. Improper handling during production and processing can easily absorb moisture. It is also easy to absorb moisture and change color, which affects the efficacy of the medicine. [0004] In view of the hygroscopicity of medicines, the traditional ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/36A61K47/38A61K47/36A61K47/02A61K47/12A61K36/85A61P15/00
CPCA61K9/2009A61K9/2013A61K9/2059A61K9/2866A61K36/533A61K36/54A61K36/85A61P15/00A61K2300/00
Inventor 颜家伟张光贤祝建华邓忠胡丽娜刘畅
Owner YAOSHENGTANG HUNAN PHARMA
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