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Pentoxyverine voltoide and preparation method thereof

A technology for pentoverine and pentoxaverine citrate, which is applied in the field of pentoverine ammonium chloride tablets and their preparation, can solve problems such as inability to be compressed into tablets, and achieve beautiful quality, beautiful appearance and easy realization. Effect

Inactive Publication Date: 2009-09-23
XINAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the compound tablet of pentoxyverine citrate and ammonium chloride has obvious defects and cannot be compressed into tablets

Method used

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  • Pentoxyverine voltoide and preparation method thereof
  • Pentoxyverine voltoide and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Components 1000 tablets dosage (grams)

[0033] Pentoxyverine citrate 25

[0034] Ammonium chloride 300

[0035] Octadecanol 8

[0036] Pregelatinized Starch 9

[0037] starch 22

[0038] Dextrin 15

[0039] Sodium starch glycolate 8

[0040] Magnesium Stearate 3.5

[0041] Talc 3.5

example 2

[0043] Components 1000 tablets dosage (grams)

[0044] Pentoxyverine citrate 25

[0045] Ammonium chloride 300

[0046] Stearic acid 8

[0047] Pregelatinized starch 6.5

[0048] Sodium starch glycolate 12

[0049] Tween-80 0.43

[0050] Starch 32

[0051] Dextrin 15

[0052] Magnesium Stearate 3.5

[0053]Talc 3.5

example 3

[0055] Components 1000 tablets dosage (grams)

[0056] Pentoxyverine citrate 25

[0057] Ammonium chloride 300

[0058] Glyceryl monostearate 9

[0059] Sorbitol 1

[0060] Microcrystalline Cellulose 5

[0061] Sodium starch glycolate 8

[0062] starch 20

[0063] Dextrin 20

[0064] Sucrose 5.5

[0065] Magnesium stearate 3.5

[0066] Talc 3.5

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PUM

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Abstract

The invention discloses a pentoxyverine voltoide and a preparation method thereof. The tablet uses citric acid pentoxyverine dipping pill as a tablet core, and adopts a dry pressure coating technology to press ammonium chloride, the citric acid pentoxyverine dipping pill and an excipient to a coated tablet. The weight ratio of the ammonium chloride to the citric acid pentoxyverine in the tablet is 12:1, and the balance is the excipient. The invention solves the technical problem of sticky punch in tabletting and leads the whole tabletting process to be easier to realize, and the tabletted tablet has reliable quality and is beautiful. The pentoxyverine voltoide can be clinically used for treating coughing and sputum including acute and chronic bronchitis and pneumonia, and the like caused by various reasons.

Description

technical field [0001] The invention relates to a pentoxyverine ammonium chloride pharmaceutical preparation, in particular to a pentoxyverine ammonium chloride tablet and a preparation method thereof. Background technique [0002] Respiratory diseases such as cough and sputum are common diseases in today's society, which seriously affect people's life and health. With the rapid development of the global economy, the continuous increase of industrial and civil pollution sources, the increasingly serious air pollution, and the weak environmental governance, the incidence of various respiratory diseases has increased, and the mortality rate has also increased year by year. At present, respiratory diseases have become one of several major "killers" of human beings. As an important part of respiratory diseases, the market for antitussive and expectorant drugs is also increasing year by year, with an average annual growth rate of more than 10%. Therefore, the development of ant...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K33/00A61K31/215A61P11/14A61P11/10
Inventor 冉隆富曾志陈彪蒲道俊李标余春梅骆绍君肖七琪
Owner XINAN PHARMA
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