Allicin multilayer enteric-coated tablet and preparation method thereof

A technology of allicin and enteric-coated tablets, which is applied in the fields of pharmaceutical formulations, medical preparations containing active ingredients, pill delivery, etc., and can solve the problems of multi-layer tablets, which are easy to fragment and have different weights, and are not suitable for industrial production.

Active Publication Date: 2017-10-17
新疆苏克天牧农业科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The invention provides an allicin multi-layer enteric-coated tablet and a preparation method thereof, which overcomes the above-mentioned deficiencies in the prior art, and can effectively solve the alliin / alliinase two The problem that multi-layer drug-release tablets are fragile and have large differences in tablet weight are not suitable for industrial production

Method used

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  • Allicin multilayer enteric-coated tablet and preparation method thereof
  • Allicin multilayer enteric-coated tablet and preparation method thereof
  • Allicin multilayer enteric-coated tablet and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0042] Example 1, the allicin multi-layer enteric-coated tablet is obtained according to the following preparation method: the first step, the preparation of the alliin layer: weigh 55.8 to 68.2 parts of filler I, viscose 3-5 parts of mixture I, 1.8-3.3 parts of internal disintegrant I, 1.8-3.3 parts of external disintegrant I, 1.8-2.2 parts of glidant I, 0.9 parts of lubricant I to 1.1 parts and 112.5 to 137.5 parts of alliin and crushed separately, and mixed evenly with alliin, filler Ⅰ, binder Ⅰ, and internal disintegrating agent Ⅰ to obtain mixture Ⅰ, and the weight of mixture Ⅰ per kilogram Add 100ml to 600ml of ethanol aqueous solution with a volume fraction of 10% to 99% to the mixture I. Add ethanol aqueous solution with a fraction of 10% to 99%. Stir while adding ethanol aqueous solution to obtain soft material I. I pass through a 10-mesh to 120-mesh sieve to obtain wet granules I, and vacuum-dry the wet granules I at a temperature of 0°C to 60°C to obtain dry granule...

Embodiment 2

[0047] Example 2, the allicin multilayer enteric-coated tablet is obtained according to the following preparation method: the first step, the preparation of the alliin layer: weigh 55.8 parts or 68.2 parts of filler I, viscose Mixture I 3 or 5 parts, internal disintegrant I 1.8 or 3.3 parts, external disintegrant I 1.8 or 3.3 parts, glidant I 1.8 or 2.2 parts, lubricant I 0.9 parts Or 1.1 parts and 112.5 parts or 137.5 parts of alliin and crushed separately, mix alliin, filler Ⅰ, binder Ⅰ, and internal disintegrating agent Ⅰ to obtain the mixture Ⅰ, and the mixture Ⅰ per kilogram Add 100ml or 600ml of ethanol aqueous solution with a volume fraction of 10% or 99% to the mixture I, add a fraction of 10% or 99% ethanol aqueous solution, stir while adding ethanol aqueous solution to obtain soft material I, and mix the soft material I pass through a 10-mesh or 120-mesh sieve to obtain wet granules I, vacuum dry the wet granules I at 0°C or 60°C to obtain dry granules I, pass the dr...

Embodiment 3

[0052] Embodiment 3, as the preference of the above embodiments, filler I is more than one of starch, powdered sugar, maltodextrin, lactose, compressible starch, microcrystalline cellulose, inorganic salts and mannitol; or / And, the binder I is one of starch slurry, sodium carboxymethylcellulose, sodium hydroxypropylcellulose, sodium hydroxypropylmethylcellulose, methylcellulose, ethylcellulose and polyvinylpyrrolidone or / and, internally added disintegrant I is sodium carboxymethyl starch, dry starch, effervescent disintegrant, croscarmellose sodium, etc., anhydrous sodium carbonate, glycine, modified starch, tartaric acid, One or more of magnesium aluminum silicate, microcrystalline wax, carmellose calcium, potassium carbonate and potassium dihydrogen phosphate; or / and, additional disintegrant I is sodium carboxymethyl starch, dry starch, effervescent Disintegrants, croscarmellose sodium, etc., anhydrous sodium carbonate, glycine, modified starch, tartaric acid, magnesium alu...

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Abstract

The invention relates to the technical field of medicine and pharmacy, and relates to an allicin multilayer enteric-coated tablet and a preparation method thereof. The allicin multilayer enteric-coated tablet is obtained according to the following preparation method: the first step, preparation of an alliin layer : Weigh 55.8 to 68.2 parts of filler I, 3 to 5 parts of binder I, 1.8 to 3.3 parts of internal disintegrant I, and 1.8 to 3.3 parts of external disintegrant I in parts by weight. 3.3 parts, 1.8 to 2.2 parts of glidant I, 0.9 to 1.1 parts of lubricant I and 112.5 to 137.5 parts of alliin were crushed separately. Beneficial effects of the present invention: the allicin multi-layer enteric-coated tablet obtained according to the method of the present invention is stable in properties, and its hardness, disintegration time limit and dissolution rate are all better than the existing alliin / alliinase binary release multi-layer tablet , the difference in tablet weight is not large and stable, and it is suitable for industrial production, and is a method with high economic benefits.

Description

technical field [0001] The invention relates to the technical field of medicine and pharmacy, and relates to an allicin multilayer enteric-coated tablet and a preparation method thereof. Background technique [0002] Allium family Allium genus Garlic ( Allium Sativum Linn ) is a dual-purpose treasure of medicine and food recognized by different regions and nations in the world, and has a long history. The earliest record of garlic as a medicinal and edible plant discovered since 2600-2100 BC Sumerian on human clay. According to ancient Egyptian medical texts Codex Ebers (About 1550 B.C.) records: The ancient Egyptians, especially the class engaged in heavy labor, used garlic as the main folk medicine. It records 800 kinds of treatment methods, among which garlic can treat 22 different diseases, such as: heart disease, headache, pain, intestinal parasites and tumors. In ancient Greece, especially when soldiers went to the battlefield, garlic was considered to strengthe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/28A61K38/51A61K31/255A61K31/198A61P31/04A61P31/10A61P31/12A61P3/06A61P7/02A61P9/12A61P9/10A61P35/00
Inventor 艾波王涛赵东升史荣梅陈坚
Owner 新疆苏克天牧农业科技有限公司
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