Human pancreatic cancer cell line and its application

A technology for pancreatic cancer cells and pancreatic cancer, applied in the field of cell lines, can solve the problems of low biodiversity and large differences in biological properties of pancreatic cancer, and achieve the effect of stable properties
CN102250840AActive Publication Date: 2011-11-23开拓者医学研究(上海)有限公司 +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
开拓者医学研究(上海)有限公司
Publication Date
2011-11-23

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Abstract

The invention provides a human pancreatic cancer cell line and its preparation method and application. The human pancreatic cancer cell line is preserved in the China Center for Type Culture Collection and the preservation number is CCTCC C201007. The human pancreatic cancer cell line can be utilized for producing human pancreas cancer in mammals, preparing human pancreas cancer models and screening candidate drugs for treating human pancreas cancer. The human pancreatic cancer cell line has stable characters and is subcultured multiple times. Characters are stably maintained in 20th to 50th generation obtained by subculture in vitro. The human pancreatic cancer cell line has clinical biological characters of human pancreas cancer and provides an experimental material for pancreas cancer research, wherein biological characteristics of the experimental material are close to clinical tumor biological characteristics. Compared with a subcultured parent tumor in a nude mouse, the human pancreatic cancer cell line can be utilized for analysis of correlation of tolerance and susceptibility to drugs in vivo or vitro thus can establish two associated anti-pancreatic cancer drug screening platforms in vitro and in vivo.
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Description

technical field

[0001] The invention belongs to the field of cell lines, in particular to a human pancreatic cancer cell line and application thereof. Background technique

[0002] Pancreatic cancer is a highly malignant disease. Although the relative incidence rate is generally 9-10 / 100,000, it is still the disease with the highest tumor-related mortality in Western countries; the incidence rate in my country is also increasing year by year. trend. Pancreatic cancer is not easy to detect at an early stage. No specific clinical manifestations and tumor markers have been found so far, and imaging features are not typical. Moreover, due to the anatomical and biological characteristics of the pancreas, it is easy to invade surrounding organs and metastasize. At that time, the disease is already in the advanced stage and has metastasized to the liver, lung, spine, kidney or adrenal gland and other organs, so only exploratory or palliative surgery can be performed, but the long-t...

Claims

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