10 results about "Nitroglycerol" patented technology

The utility model relates to the technical field of pharmacy, in particular to a nitroglycerin liquid conversion tablet tabletting device which comprises a device frame, a driving motor is fixedly installed on the device frame, a reciprocating assembly is arranged at the output end of the driving motor and fixedly connected with a pressing plate, and a mold table is arranged below the pressing plate. The mold table is fixedly connected with a rotating assembly, the mold table is rotationally connected with a rotating disc, and a filtering plate is arranged below the rotating disc; automatic feeding and continuous tabletting of nitroglycerin liquid raw materials are achieved, the driving motor drives the first rotating shaft to rotate, then the pressing plate reciprocates up and down through the meshing effect of the incomplete gear and the rack, continuous tabletting is conducted on particles on the mold table, the working efficiency is improved, and the production cost is reduced. And the complexity of manual operation is reduced, so that the tabletting process is more automatic and continuous, the production efficiency is greatly improved, the dependence of manual operation is reduced, and the production cost is reduced.

The invention relates to an application of a halophenol compound 2, 4 ', 5'-trihydroxy-5, 2 '-dibromo benzophenone in preparation of an analgesic drug. Experiments prove that the compound has a definite analgesic effect, can significantly inhibit mouse writhing reaction induced by acetic acid and II-phase inflammatory pain induced by formalin, and prolongs the thermal stimulation tail retraction incubation period, and the effect is superior to that of aspirin. Furthermore, in a nitroglycerin-induced migraine rat model, the compound can effectively improve behavioral symptoms and brain tissue pathological damage and remarkably regulate key index levels of CGRP, PGE2, ET-1, IL-1beta, IL-6, TNF-alpha, 5-HT and the like in plasma, which shows that the compound can be applied to preparation of analgesic drugs, preparation of drugs for treating migraine, preparation of drugs for treating migraine and the like. The invention particularly has important application value in medicines for preventing and / or treating migraine.

The invention provides a preparation method of a traditional Chinese medicine dispersion liquid containing self-assembled nanoparticles, which comprises the following steps: mixing fructus piperis longi, rhizoma corydalis, radix angelicae, ligusticum wallichii, ligusticum and indigo naturalis, crushing, sieving to obtain a traditional Chinese medicine crushed material, adding purified water, carrying out ultrasonic extraction and suction filtration to obtain a traditional Chinese medicine extracting solution, centrifuging, removing precipitate, filtering supernate by a filter membrane, and drying to obtain the traditional Chinese medicine dispersion liquid containing the self-assembled nanoparticles. And carrying out ultrafiltration centrifugation, sucking liquid in the tube, and carrying out high-speed centrifugation to obtain the traditional Chinese medicine dispersion liquid containing the self-assembled nanoparticles. The invention also provides application of the traditional Chinese medicine dispersion liquid. The prepared traditional Chinese medicine dispersion liquid containing the self-assembled nanoparticles can relieve rat migraine caused by nitroglycerin, can remarkably improve the mechanical pain threshold and the heat pain threshold of model rats and remarkably promote callback of inflammatory factors and migraine markers in brain tissues of chronic migraine rats, and is used for preparing drugs for improving migraine through nasal administration.

This invention relates to the application of a traditional Chinese medicine composition in the preparation of a drug for neurogenic headache. The composition is characterized by being prepared from Rehmannia glutinosa (processed), Cornus officinalis, Dioscorea opposita, Alisma plantago-aquatica, Paeonia suffruticosa, and Poria cocos. The composition significantly reduces the number of head scratches in rats with nitroglycerin-induced neurogenic headache, decreases the levels of neurogenic headache-related factors (NO, CGRP) in plasma, improves reserpine-induced low serotonin (5-HT) symptoms in mice, and increases clotting time, suggesting that this traditional Chinese medicine composition has a good therapeutic effect on neurogenic headache.

A composition for topical application to the penis for the treatment of erectile dysfunction is provided, wherein the composition is free of glyceryl trinitrate (GTN), sildenafil and acetylcholinesterase inhibitors, but comprises a volatile and a non-volatile solvent, the volatile solvent comprising a lower alcohol and water, the non-volatile solvent comprising a polyol and a glycol. Preferably, the composition is free of any pharmaceutically active ingredient for the treatment of erectile dysfunction. A method of determining the cooling capacity of a test composition, e.g. the above-mentioned composition, is also provided.

There is provided a composition for topical application to the penis to treat erectile dysfunction wherein the composition is free of glyceryl trinitrate (GTN), sildenafil and an acetylcholin esterase inhibitor, but comprises volatile and non-volatile solvents, the volatile solvent comprising a lower alcohol and water, the non-volatile solvent comprising a polyol and a diol. Preferably, the composition is free of any pharmaceutically active ingredient for the treatment of erectile dysfunction. Also provided is a method of determining the cooling capacity of a test composition (e.g., the above composition).

The invention belongs to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition for treating headache and a preparation method thereof. According to the treatment principle, concha haliotidis and gastrodia elata have the effects of calming the liver, suppressing yang, dispelling wind and relieving pain, mother-of-pearl has the effects of calming the liver, suppressing yang, soothing the nerves and arresting convulsion, cape jasmine is bitter and cold in taste and can clear away heat of the heart, the lung and triple jiao, fried tribulus terrestris has the effects of calming the liver, relieving depression and promoting blood circulation to dispel wind, ligusticum wallichii and radix saposhnikoviae have the effects of dispelling wind and relieving pain, angelica sinensis has the effects of promoting blood circulation to remove blood stasis and dredging collaterals, cynanchum paniculatum has the effects of dispelling wind, resolving dampness and relieving pain, and pollen typhae has the effects of stopping bleeding and relieving pain. Radix angelicae has the effects of dispelling wind and relieving pain; animal experiments show that the traditional Chinese medicine composition obviously prolongs the appearance time of red ears, shortens the disappearance time of the red ears, obviously reduces the scratching frequency, can improve behavioral symptoms of rat migraine caused by nitroglycerin, plays a pharmacological role in treating the migraine, and provides a safe and efficient treatment scheme for the migraine.

The utility model discloses a novel medicine injection module and control system thereof, including valve subassembly, the valve subassembly includes the serially connected setting of several rotary valves in proper order before and after, realizes the switching of valve subassembly different pass by controlling the valve control handle rotation of each rotary valve, and several rotary valves include an output control valve and at least one medicine liquid supply valve, the output channel of valve subassembly is linked with the first output port of output control valve, and multiple medicine liquid supply valves are connected different medicine liquid supply device respectively. Medicine injection module and medicine injection control system cooperate with each other, can replace the injection of contrast medium, heparin saline, nitroglycerin etc. of the doctor in the radiation environment, avoid the radiation harm of doctor, and can make the automatic of complicated valve control and syringe bolus operation, avoid the situation that different doctors cooperate is not smooth.

The invention relates to the technical field of biology, in particular to a construction method and application of an animal blood stasis model. The nitroglycerin is utilized to successfully induce an animal blood stasis model. Experiments show that blood stasis related phenotypes of zebrafish embryos can be caused by nitroglycerin treatment, for example, blood flow velocity blocking, heart red blood cell dyeing intensity reduction, and blood coagulation factor and endothelial injury marker expression level increase, which indicates that a zebrafish blood stasis model can be successfully established by nitroglycerin treatment.