A kind of vegetable soft capsule rubber composition and preparation method thereof

A soft capsule and plant-based technology, which is applied in the field of plant-based soft capsule rubber composition and its preparation, can solve the problems of rubber elasticity and toughness deviation, high price of pullulan polysaccharide, and high cost, and achieve low friability, The effect of abundant sources and excellent cost

Active Publication Date: 2018-06-29
XIAMEN KINGDOMWAY BIOTECH CO LTD +1
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chinese patent CN201410159754 discloses an adjuvant that can improve the properties of soft capsules, as well as an opacifier that can change the appearance and smell of soft capsules, using hydroxypropyl starch as the main raw material, and supplemented with gelling agent, softener and film-forming agent. The disadvantage of the starch-based rubber prepared from coloring agents and flavoring agents is that compared with other colloidal materials, the rubber mainly made of hydroxypropyl starch is more brittle, the elasticity and toughness of the rubber deviate, and the final pellets are broken. more likely
Chinese patent CN201210181762 discloses that pullulan polysaccharide is used as the main raw material, mixed with various biological polysaccharides or seaweed polysaccharides respectively, and formed into a film after several processes, and pressed into pills by a rotary film method soft capsule machine, which is characterized in that The prepared soft capsule pills can reach a level similar to gelatin in terms of transparency, elasticity and mechanical strength, and completely disintegrate within the relevant specified time. The disadvantage is that the price of pullulan is relatively high and the cost is expensive

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of vegetable soft capsule rubber composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] By mass percentage, the group distribution ratio is as follows:

[0035] Hydroxypropyl starch: 15%;

[0036] Hydroxypropyl methylcellulose: 7%;

[0037] Pullulan: 5%;

[0038] Carrageenan: 2%;

[0039] Glycerol: 7%;

[0040] Polyethylene glycol 400: 5%;

[0041] Potassium citrate: 0.2%;

[0042] Titanium dioxide: 0.5%;

[0043] Purified water: 58.3%.

[0044] The hydroxypropyl starch is dissolved and dispersed in purified water of the same amount as the hydroxypropyl starch, and heated in a 55° C. water bath to obtain solution A. The remaining components except the hydroxypropyl starch were added to the remaining purified water to disperse evenly, and the solution B was obtained by heating and dissolving in a 65°C water bath for 20min. Add solution A to solution B, stir and mix well, then gradually heat to 90 °C, keep the temperature for 1.5 hours, then cool down to 75 °C, keep warm and defoaming for 3 hours, and directly pass through the glue feeding equipment ...

Embodiment 2

[0046] By mass percentage, the group distribution ratio is as follows:

[0047] Hydroxypropyl starch: 15%;

[0048] Hydroxypropyl methylcellulose: 8%;

[0049] Pullulan: 4.5%;

[0050] Gellan Gum: 2%;

[0051] Glycerin: 8%;

[0052] Sorbitol: 4%;

[0053] Sodium alginate: 1%;

[0054] Carboxymethyl cellulose: 0.2%;

[0055] Potassium citrate: 0.2%;

[0056] Paprika: 0.1%;

[0057] Purified water: 57%.

[0058] The hydroxypropyl starch was dissolved and dispersed in purified water of the same amount as the hydroxypropyl starch, and heated and kept warm in a 60° C. water bath to obtain solution A. The remaining components except hydroxypropyl starch were added to the remaining purified water to disperse evenly, and the solution B was obtained by heating and dissolving in a 60°C water bath for 30min. Add solution A to solution B, stir and mix well, then gradually heat to 95°C, keep warm for 2 hours, then cool to 80°C, keep warm and defoamed for 2 hours. , to prepare soft...

Embodiment 3

[0060] By mass percentage, the group distribution ratio is as follows:

[0061] Hydroxypropyl starch: 15%;

[0062] Hydroxypropyl methylcellulose: 8%;

[0063] Pullulan: 4%;

[0064] Carrageenan: 1.5%;

[0065] Gellan Gum: 1%;

[0066] Glycerin: 10%;

[0067] Sorbitol: 4%;

[0068] Carboxymethyl cellulose: 0.2%;

[0069] Potassium citrate: 0.2%;

[0070] Titanium dioxide: 1%;

[0071] Paprika: 0.5%;

[0072] Purified water: 54.6%.

[0073] The hydroxypropyl starch is dissolved and dispersed in purified water of the same amount as the hydroxypropyl starch, and heated in a 65° C. water bath to obtain solution A. The remaining components except hydroxypropyl starch were added to the remaining purified water to disperse evenly, and the solution B was obtained by heating and dissolving in a 55°C water bath for 50min. Add solution A to solution B, stir and mix well, then gradually heat to 90°C, keep the temperature for 0.5h, then cool down to 75°C, keep warm and defoaming...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a vegetable soft capsule shell composition and a preparation method thereof. The composition comprises the following ingredients by content: 0-30% of hydroxypropyl starch, 0-20% of hydroxypropyl methyl cellulose, 0-20% of pullulan, 0.1-10% of one or more gels, 0.5-30% of one or more plasticizers, 0-5% of one or more soluble salts, 0-4% of an opacifier, 0-4% of one or more colorants and 10-90% of water, wherein the contents of hydroxypropyl starch, hydroxypropyl methyl cellulose and pullulan are not zero, and the total content is 100%. The preparation method comprises the following steps: adding hydroxypropyl starch into water for dispersion, so as to obtain a solution A; adding other ingredients except hydroxypropyl methyl cellulose into water for dispersion, so as to obtain a solution B; mixing the solution A with the solution B, heating to 90-95 DEG C, carrying out stirring and heat preservation for 0.5-2 hours, cooling to 75-80 DEG C, and carrying out heat preservation, still standing and defoaming to obtain a glue solution; measuring the viscosity of the glue solution after defoaming, wherein the composition is obtained when the viscosity reaches 20,000-30,000 mPa.s.

Description

technical field [0001] The invention relates to a soft capsule rubber composition, in particular to a vegetable soft capsule rubber composition and a preparation method thereof. Background technique [0002] Soft capsule refers to the liquid or molten drug mixture containing certain active ingredients, or the solution, suspension, emulsion or semi-solid (paste, etc.) mixture containing solid drug dispersed and dissolved, sealed in a spherical or oval shape. soft capsular capsules. The advantage of soft capsules is that the embedded contents are completely isolated from external factors such as air, so as to avoid the effective components in the contents from being destroyed by external factors; the volatile and easily oxidized components can be effectively maintained, and a single capsule particle The content or net content of each active ingredient can be maintained stable to ensure the medicinal and health care value of the content; it can effectively cover up the odor of...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/36A61K47/38A23P10/30
CPCA61K9/4816
Inventor 朱林静陈中科林木荣刘锦洪
Owner XIAMEN KINGDOMWAY BIOTECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap