Skin care emulsion containing cannabidiol (CBD) nanoemulsion, and preparation method of skin care emulsion
A technology of cannabidiol nano and cannabidiol, which is applied in medical preparations containing active ingredients, skin care preparations, skin diseases, etc., can solve low bioavailability, slow medicinal efficacy, and poor transdermal absorption effect To achieve the effect of promoting metabolism, increasing the curative effect of drugs, and maintaining the curative effect of drugs
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Embodiment 1
[0039] A skin care lotion containing cannabidiol CBD nanoemulsion, prepared through the following steps:
[0040] (1) Prepare materials according to the following mass ratio:
[0041]
[0042]
[0043](1) After fully mixing guar gum and deionized water, place it in a refrigerator at 4°C overnight to fully swell to obtain a swelling liquid, add cholesterol and 1,2-hexanediol, and ultrasonicate in an ice bath at 4°C. The ultrasonic power is 10%, the ultrasonic on time is 5s, the ultrasonic off time is 5s, and the ultrasonic duration is 15min. After the ultrasonic is finished, return to room temperature, add potassium sorbate and CBD nanoemulsion, and stir at a constant temperature of 45°C and 600r / min for 5min. , get material A;
[0044] (2) Mix collagen, urea, silicone, hydrogenated lecithin and appropriate amount of deionized water evenly, stir at 50°C and 500r / min until dissolved, and obtain material B;
[0045] (3) After adding material B in step (2) to material A in...
Embodiment 2
[0056] A skin care lotion containing cannabidiol CBD nanoemulsion, prepared through the following steps:
[0057] (1) Prepare materials according to the following mass ratio:
[0058]
[0059]
[0060] (1) After fully mixing guar gum and deionized water, place it in a refrigerator at 4°C overnight to fully swell to obtain a swelling liquid, add cholesterol and 1,2-hexanediol, and ultrasonicate in an ice bath at 4°C. The ultrasonic power is 15%, the ultrasonic on time is 10s, the ultrasonic off time is 5s, and the ultrasonic duration is 15min. After the ultrasonic is finished, return to room temperature, add potassium sorbate and CBD nanoemulsion, and stir at a constant temperature of 40°C and 400r / min for 10min. , get material A;
[0061] (2) Mix collagen, urea, silicone, hydrogenated lecithin and an appropriate amount of deionized water evenly, stir at 50°C and 300r / min until dissolved, and obtain material B;
[0062] (3) After adding material B in step (2) to materia...
Embodiment 3
[0073] A skin care lotion containing cannabidiol CBD nanoemulsion, prepared through the following steps:
[0074] (1) Prepare materials according to the following mass ratio:
[0075]
[0076]
[0077] (1) After fully mixing guar gum and deionized water, place it in a refrigerator at 4°C overnight to fully swell to obtain a swelling liquid, add cholesterol and 1,2-hexanediol, and ultrasonicate in an ice bath at 4°C. The ultrasonic power is 20%, the ultrasonic on time is 8s, the ultrasonic off time is 5s, and the ultrasonic duration is 10min. After the ultrasonic is finished, return to room temperature, add potassium sorbate and CBD nanoemulsion, and stir at a constant temperature of 50°C and 500r / min for 15min. , get material A;
[0078] (2) Mix collagen, urea, silicone, hydrogenated lecithin and an appropriate amount of deionized water evenly, and stir until dissolved at 65°C and 600r / min to obtain material B;
[0079] (3) After adding material B in step (2) to materi...
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