Preparation method and application of drug sustained-release carrier hydrogel

A slow-release carrier and hydrogel technology, which is applied in the application fields of drug sustained-release carrier hydrogel preparation, loading and sustained release, can solve problems that have not been reported, and achieve a wide range of applications, improve utilization, and provide good drugs. The effect of sustained release properties
CN112915064AInactive Publication Date: 2021-06-08DALIAN MARITIME UNIVERSITY
5 Cites 8 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DALIAN MARITIME UNIVERSITY
Publication Date
2021-06-08
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a preparation method and application of drug sustained-release carrier hydrogel, and belongs to the technical field of medical polymers. The preparation method comprises the following steps: firstly, synthesizing beta-cyclodextrin with a bisacrylamide group with a hydrophobic cavity structure by taking beta-cyclodextrin and acryloyl chloride as raw materials, then preparing methylacryloylated gelatin from gelatin and methacrylic anhydride, and then performing free radical copolymerization under 365nm ultraviolet light by taking Irgacure2959 as an initiator, thereby obtaining the hydrogel. The drug loading capacity of the drug carrier hydrogel can reach 40.86 mg / g, and the drug carrier hydrogel can be continuously released for more than 96 hours in different environments (normal in-vivo physiological environment, lesion site environment and simulated gastric juice environment). A drug sustained-release carrier hydrogel system prepared by the invention is safe and non-toxic, has solubilization on hydrophobic drugs, improves the medication efficiency, and broadens the application range of the hydrogel in the field of medicines.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of preparation and application of medical polymer materials, and in particular relates to a preparation method of a drug slow-release carrier hydrogel and its application to the loading and slow release of methyl orange molecules. Background technique

[0002] In recent years, the study of host-guest supramolecular hydrogels has attracted widespread attention. The host molecules often contain cavities of a certain size, which can contain guest molecules. The host molecules and guest molecules interact through weak non-covalent bonds. Combine. Therefore, when the guest molecule is a drug molecule, the host-guest interaction can not only avoid the failure of the drug molecule due to light, heat, radiation, etc., but also achieve a longer-lasting drug release behavior.

[0003] Cyclodextrin has a unique bio-macrocyclic structure, the hydrophobicity of the inner cavity and the hydrophilicity of the outer wall a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More