Preparation method and application of drug sustained-release carrier hydrogel

A slow-release carrier and hydrogel technology, which is applied in the application fields of drug sustained-release carrier hydrogel preparation, loading and sustained release, can solve problems that have not been reported, and achieve a wide range of applications, improve utilization, and provide good drugs. The effect of sustained release properties

Inactive Publication Date: 2021-06-08
DALIAN MARITIME UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Combining gelatin molecular chains with cyclodextrin to prepare drug carrier hydrogels can not only obtain the excellent biocompatibility of gelatin (an indispensable characteristic of drug carriers), but also obtain the amphiphilic cavity of cyclodextrin structure (as the key to the solubilization of hydrophobic drugs), which has broad application prospects. Research not yet reported

Method used

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  • Preparation method and application of drug sustained-release carrier hydrogel
  • Preparation method and application of drug sustained-release carrier hydrogel
  • Preparation method and application of drug sustained-release carrier hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A preparation method of a drug sustained-release hydrogel (CDGM) based on bisacrylamide β-cyclodextrin / methacrylylated gelatin is as follows:

[0043] (1) Bisacrylamide β-cyclodextrin β-CDA 2 Preparation of:

[0044] Dissolve 5g (4.4mmol) of β-cyclodextrin in N,N-dimethylformamide, pass through nitrogen, add triethylamine, and slowly add 2.85mL (35.2mmol) of acryloyl chloride dropwise to the above solution under ice-cooling (The dropping time is controlled to be 30 min). After stirring at room temperature for 1 hour, the triethylamine hydrochloride precipitate was removed by filtration, and the filtrate was precipitated with cold acetone, and the crude product was obtained by filtration. The crude product was dissolved in methanol and centrifuged to remove the cross-linked product part. The supernatant was concentrated under reduced pressure and then filtered with cold acetone. 2 ). Characterization of β-CDA by infrared spectroscopy 2 ,Such as figure 1 shown; throu...

Embodiment 2

[0055] A preparation method of CDGM drug carrier hydrogel is as follows:

[0056] (1) β-CDA 2 Preparation of:

[0057] With the step (1) of embodiment 1;

[0058] (2) Preparation of GelMA:

[0059] With the step (2) of embodiment 1;

[0060] (3) Preparation of CDGM drug sustained-release hydrogel:

[0061] (a) Prepare a GelMA solution with a monomer concentration of 0.15 g / mL in a three-necked flask, the solvent is PBS buffer, and stir to dissolve at 50 ° C;

[0062] (b) 6wt% β-CDA of solution is added in the there-necked flask 2 , 0.5wt% initiator Irgacure2959 of the solution, stirring and dissolving at 50°C;

[0063] (c) After stirring evenly, draw the liquid in the flask with a syringe, then slowly inject it into the pre-made glass mold, and then crosslink the glass mold under a 365nm ultraviolet lamp for 1 hour;

[0064] (d) Take out the hydrogel and soak it in deionized water for 24 hours to remove unreacted monomers, and wipe the surface of the hydrogel with filte...

Embodiment 3

[0068] A preparation method of CDGM drug carrier hydrogel is as follows:

[0069] (1) β-CDA 2 Preparation of:

[0070] With the step (1) of embodiment 1;

[0071] (2) Preparation of GelMA:

[0072] With the step (2) of embodiment 1;

[0073] (3) Preparation of CDGM drug sustained-release hydrogel:

[0074] (a) Prepare a GelMA solution with a monomer concentration of 0.15 g / mL in a three-necked flask, the solvent is PBS buffer, and stir to dissolve at 50 ° C;

[0075] (b) 9wt% β-CDA of solution is added in the there-necked flask 2 , 0.5wt% initiator Irgacure2959 of the solution, stirring and dissolving at 50°C;

[0076] (c) After stirring evenly, draw the liquid in the flask with a syringe, then slowly inject it into the pre-made glass mold, and then crosslink the glass mold under a 365nm ultraviolet lamp for 1 hour;

[0077] (d) Take out the hydrogel and soak it in deionized water for 24 hours to remove unreacted monomers, and wipe the surface of the hydrogel with filte...

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Abstract

The invention discloses a preparation method and application of drug sustained-release carrier hydrogel, and belongs to the technical field of medical polymers. The preparation method comprises the following steps: firstly, synthesizing beta-cyclodextrin with a bisacrylamide group with a hydrophobic cavity structure by taking beta-cyclodextrin and acryloyl chloride as raw materials, then preparing methylacryloylated gelatin from gelatin and methacrylic anhydride, and then performing free radical copolymerization under 365nm ultraviolet light by taking Irgacure2959 as an initiator, thereby obtaining the hydrogel. The drug loading capacity of the drug carrier hydrogel can reach 40.86 mg/g, and the drug carrier hydrogel can be continuously released for more than 96 hours in different environments (normal in-vivo physiological environment, lesion site environment and simulated gastric juice environment). A drug sustained-release carrier hydrogel system prepared by the invention is safe and non-toxic, has solubilization on hydrophobic drugs, improves the medication efficiency, and broadens the application range of the hydrogel in the field of medicines.

Description

technical field [0001] The invention belongs to the technical field of preparation and application of medical polymer materials, and in particular relates to a preparation method of a drug slow-release carrier hydrogel and its application to the loading and slow release of methyl orange molecules. Background technique [0002] In recent years, the study of host-guest supramolecular hydrogels has attracted widespread attention. The host molecules often contain cavities of a certain size, which can contain guest molecules. The host molecules and guest molecules interact through weak non-covalent bonds. Combine. Therefore, when the guest molecule is a drug molecule, the host-guest interaction can not only avoid the failure of the drug molecule due to light, heat, radiation, etc., but also achieve a longer-lasting drug release behavior. [0003] Cyclodextrin has a unique bio-macrocyclic structure, the hydrophobicity of the inner cavity and the hydrophilicity of the outer wall a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/69A61K31/655A61P17/02
CPCA61K9/06A61K47/6951A61K47/6949A61K31/655A61P17/02
Inventor 王沛朱金妹吴启迪
Owner DALIAN MARITIME UNIVERSITY
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