Chinese traditional medicine preparation for treating coughs and preparation method of same

A technology of traditional Chinese medicine preparations and Chinese medicinal materials, which is applied in the field of traditional Chinese medicine preparations for treating cough and its preparation, can solve the problems of unguaranteed curative effect and safety, poor drug compliance of patients, and simple and extensive process, so as to improve drug compliance, Improve drug stability and control the effect of drug quality

Active Publication Date: 2013-12-11
HUBEI LIYI PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In addition, Shashen Maidong Decoction is a traditional decoction, which has disadvantages such as difficult storage, large dosage, and poor compliance of patients with medication. M

Method used

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  • Chinese traditional medicine preparation for treating coughs and preparation method of same
  • Chinese traditional medicine preparation for treating coughs and preparation method of same
  • Chinese traditional medicine preparation for treating coughs and preparation method of same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Take 30Kg of Radix Ginseng, 20Kg of Radix Ophiopogon japonicus, 10Kg of Polygonatum Polygonatum, 15Kg of Trichosanthum Fensis, 30Kg of Mulberry Leaves, 15Kg of White Kidney Bean, and 15Kg of Licorice Root, and decoct them twice with water for 1.0 hour each time. 5 times), combined the extracts, and centrifuged in a tube to obtain the filtrate. The filtrate was concentrated under reduced pressure to a relative density of 1.14, and the concentrated solution was placed on a DA-201 macroporous adsorption resin column (405Kg DA-201 resin was packed into the column, and the weight of the resin was the medicinal material 3 times the weight of the macroporous adsorption resin column), elute the resin column with 9000L water (20 times the volume of the macroporous adsorption resin column), collect the eluate, concentrate under reduced pressure at 50°C to an extract with a relative density of 1.35, add stevioside and dextrin Appropriate amount, granulate, dry, pass through a 10-me...

Embodiment 2

[0028] Take 23Kg of North Radix Ginseng, 20Kg of Radix Ophiopogon japonicus, 15Kg of Polygonatum Polygonatum, 10Kg of Trichosanthum Fensis, 28Kg of Mulberry Leaves, 15Kg of White Kidney Bean, and 17Kg of Licorice Root, and heat and reflux once with 30% ethanol aqueous solution (the weight of ethanol accounts for 50% of the total weight of the solution). For 2 hours, the amount of solvent used is 1900L (15 times the weight of the medicinal material), the extracts are combined, filtered under reduced pressure to obtain the filtrate, the filtrate is concentrated under reduced pressure to a relative density of 1.05, and the concentrated solution is placed on an AB-8 macroporous adsorption resin column (128Kg AB-8 resin column, the weight of the resin is 1 times the weight of the medicinal material), elute the resin column with 30% ethanol 600L (5 times the volume of the macroporous adsorption resin column), collect the eluate, and depressurize at 60°C Concentrate the extract to a r...

Embodiment 3

[0030] Take 40Kg of Radix Ginseng, 30Kg of Radix Ophiopogon japonicus, 10Kg of Polygonatum Polygonatum, 15Kg of Trichosanthes pollen, 30Kg of mulberry leaves, 15Kg of white lentils, and 25Kg of licorice, and heat and reflux three times with 70% methanol solution, each time for 0.5 hours, and the amount of solvent used each time is 1650L ( 10 times the weight of the medicinal material), combine the extracts, and filter through filter cloth to obtain the filtrate. The filtrate is concentrated under reduced pressure to a relative density of 1.10, and the concentrated solution is placed on a HPD-722 macroporous adsorption resin column (330Kg HPD-722 resin column, The weight of the resin is 2 times the weight of the medicinal material), elute the resin column with 70% methanol 3600L (10 times the volume of the macroporous adsorption resin column), collect the eluate, concentrate under reduced pressure at 80°C to an extract with a relative density of 1.30 , add an appropriate amount ...

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Abstract

The invention discloses a Chinese traditional medicine preparation for treating coughs. The Chinese traditional medicine preparation is prepared from the seven kinds of Chinese traditional medicine of coastal glehnia root, radix ophiopogonis, rhizoma polygonati odorati, radix trichosanthis, folium mori, semen lablab album, radix glycyrrhizae. A preparation method of the Chinese traditional medicine preparation comprises the following steps: the seven kinds of Chinese traditional medicine are added with water and decocted in the water, or is subjected to heating reflux through an aqueous solution containing alcohol, so as to extract liquid extract; the liquid extract is collected, filtered and subjected to vacuum concentration; the concentrated liquid extract is treated with a macroporous absorbent resin column and eluted with water or an aqueous solution containing alcohol; the eluent is collected and concentrated; auxiliary materials are added to the concentrated eluent, so as to make the concentrated eluent into a dosage form suitable for clinical medication. According to the preparation method of the Chinese traditional medicine preparation, the active components of adenophora and radix ophiopogonis soup are concentrated, and the inactive components of the adenophora and radix ophiopogonis soup are reduced; the improvement on the curative effect of the Chinese traditional medicine preparation is facilitated; side effects and dose of the Chinese traditional medicine preparation are reduced; the medicine taking compliance of patients is improved. The invention further provides a novel Chinese patent drug for treating lung yin deficiency-type dry coughs. The Chinese traditional medicine preparation and the preparation method thereof are of great significance for meeting the demand of clinical medication.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a traditional Chinese medicine preparation for treating cough and a preparation method thereof. Background technique [0002] Nearly 300 million people in my country are infected with respiratory diseases every year, among whom there are more than 50 million cough patients. Among outpatients in the respiratory department, 70% to 80% of patients will have cough symptoms, and 85% of cough patients will choose to take medicine. Experts predict that the cough, phlegm, and asthma drug market will be one of the top ten drug markets with the most development potential in the next 20 years. [0003] Chemical medicine can only cure the symptoms and relieve symptoms. In contrast, traditional Chinese medicine has great advantages. Traditional Chinese medicine believes that cough is caused by the invasion of the lung system by exogenous evils caused by six exogenous pathogens, ...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61P11/14
Inventor 刘博陈四艳王强黄琨王玲玲杨若婧史自东
Owner HUBEI LIYI PHARM TECH CO LTD
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