Surface modifying method for biological material
A technology of surface modification and biomaterials, which is applied in medical science, surgery, coating, etc., can solve the problems of difficult to control surface properties, difficult to effectively control implant materials by surrounding tissues, and difficult to achieve various molecular biological activities. Improves biocompatibility and implant success, eliminates interactions, and improves performance and function
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Example Embodiment
[0030] Example 1: Follow the steps below to process the surface of the material
[0031] (1) Surface activation and self-assembly: After the sample is fully cleaned, it is treated with oxygen plasma, the discharge power is 50W, and the treatment time is 5 minutes; the treated sample is immersed in a 5mM ethanol solution of allyltrimethoxysilane for reaction For 6 hours, take it out and wash it thoroughly with ethanol and distilled water in turn, and then dry it.
[0032] (2) Multi-functional chemical surface construction: First, add the ethanol mixture solution of compound 1 (20mM, 1ml) and DMPA (10mM, 1ml) dropwise to the surface of the stamp. After adsorbing for 1 minute, it will be slowly dried with argon and the double bond The surface of the modified material is fully contacted, the stamp is removed after 365nm ultraviolet light irradiation for 1 min, ultrasonically cleaned with ethanol solution, dried with Ar, and further immersed in the mixed solution of EDC (10mM, 2ml) / N...
Example Embodiment
[0034] Example 2: Follow the steps below to process the surface of the material
[0035] (1) Surface activation and self-assembly: After the sample is fully cleaned, it is treated with oxygen plasma, the discharge power is 150W, and the treatment time is 20 minutes; the treated sample is immersed in a 5mM ethanol solution of allyltriethoxysilane React for 12 hours, take it out and wash it thoroughly with ethanol and distilled water and then dry it;
[0036] (2) Multifunctional chemical surface construction: First, add the ethanol mixture solution of compound 1 (50mM, 1ml) and DMPA (25mM, 1ml) dropwise to the surface of the stamp. After adsorbing for 2 minutes, it is slowly dried with argon and then the double bond The surface of the modified material is fully contacted, and the stamp is removed after 2 minutes of irradiation with 365nm ultraviolet light, ultrasonically cleaned with ethanol solution and dried with Ar. The substrate is further immersed in the mixed solution of EDC (...
Example Embodiment
[0038] Example 3: Follow the steps below to process the surface of the material
[0039] (1) Surface activation and self-assembly: the sample is fully cleaned and treated with oxygen plasma, the discharge power is 300W, and the treatment time is 30 minutes; the treated sample is immersed in a toluene solution of 5mM allyltrichlorosilane and reacted for 24 hours , Take it out, wash it thoroughly with toluene, acetone and distilled water, and dry it;
[0040] (2) Multi-functional chemical surface construction: First, add the ethanol mixture solution of compound 1 (80mM, 1ml) and DMPA (40mM, 1ml) dropwise to the surface of the stamp. After adsorption for 3 minutes, it is slowly dried with Ar gas and then combined with the double bond The surface of the modified material is fully contacted, and the stamp is removed after 3 minutes of irradiation with 365nm ultraviolet light, ultrasonically cleaned with ethanol solution and dried with Ar. The substrate is further immersed in the mixed ...
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