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Surface modifying method for biological material

A technology of surface modification and biomaterials, which is applied in medical science, surgery, coating, etc., can solve the problems of difficult to control surface properties, difficult to effectively control implant materials by surrounding tissues, and difficult to achieve various molecular biological activities. Improves biocompatibility and implant success, eliminates interactions, and improves performance and function

Active Publication Date: 2014-09-10
淮安市清江浦区市场监管综合服务中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods mainly rely on traditional surface modification techniques, which affect the activity of immobilized biomolecules and interact with each other. Therefore, it is difficult to achieve effective regulation of surrounding tissues and fundamentally improve the stability of implanted materials. performance and functionality; meanwhile, in the process of immobilizing multiple bioactive molecules by traditional surface modification techniques, the interaction between biomolecules (e.g., sequential grafting of biomolecules) and the coverage benefits of immobilized biomolecules before and after (e.g. Layer self-assembly) will lead to the interaction between various immobilized biomolecules, it is difficult to fully exert the biological activities of various molecules at the same time, and the surface properties are difficult to control

Method used

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  • Surface modifying method for biological material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: Treat the surface of the material according to the following steps

[0031] (1) Surface activation and self-assembly: After the sample is fully cleaned, it is treated with oxygen plasma, the discharge power is 50W, and the treatment time is 5 minutes; the treated sample is immersed in a 5mM allyltrimethoxysilane ethanol solution for reaction After 6 hours, take it out, wash it thoroughly with ethanol and distilled water in turn, and dry it in the air.

[0032](2) Construction of multi-functional chemical surface: firstly, drop the ethanol mixed solution of compound 1 (20mM, 1ml) and DMPA (10mM, 1ml) onto the surface of the stamp, absorb for 1 minute, blow dry slowly with argon gas, and combine with the double bond The surface of the modified material is fully contacted, and the stamp is removed after irradiating with 365nm ultraviolet light for 1min, ultrasonically cleaned with ethanol solution, dried with Ar, and further immersed in the mixed solution of E...

Embodiment 2

[0034] Example 2: Treat the surface of the material according to the following steps

[0035] (1) Surface activation and self-assembly: After the sample is fully cleaned, it is treated with oxygen plasma, the discharge power is 150W, and the treatment time is 20 minutes; the treated sample is immersed in an ethanol solution of 5mM allyltriethoxysilane React for 12 hours, take it out, wash it thoroughly with ethanol and distilled water, and then dry it;

[0036] (2) Multi-functional chemical surface construction: First, drop the ethanol mixed solution of compound 1 (50mM, 1ml) and DMPA (25mM, 1ml) onto the surface of the stamp, absorb it for 2 minutes, blow dry it slowly with argon gas, and combine with the double bond The surface of the modified material is in full contact, and the stamp is removed after irradiating with 365nm ultraviolet light for 2 minutes, ultrasonically cleaned with ethanol solution and dried with Ar, and the substrate is further immersed in the mixed so...

Embodiment 3

[0038] Example 3: Treat the surface of the material according to the following steps

[0039] (1) Surface activation and self-assembly: After the sample is fully cleaned, it is treated with oxygen plasma, the discharge power is 300W, and the treatment time is 30 minutes; the treated sample is immersed in a toluene solution of 5mM allyltrichlorosilane to react for 24 hours After taking it out, wash it thoroughly with toluene, acetone and distilled water and dry it;

[0040] (2) Construction of multi-functional chemical surface: firstly, drop the ethanol mixed solution of compound 1 (80mM, 1ml) and DMPA (40mM, 1ml) onto the surface of the stamp, absorb it for 3 minutes, then dry it slowly with Ar gas, and combine with the double bond The surface of the modified material is fully contacted, and the stamp is removed after 365nm ultraviolet light irradiation for 3 minutes, ultrasonically cleaned with ethanol solution and dried with Ar, and the substrate is further immersed in the...

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Abstract

The invention discloses a surface modifying method for a biological material. The surface modifying method comprises the step of carrying out oxygen gas plasma activation treatment on the material surface and then carrying out surface self-assembling; then, alternatively immobilizing chemical molecules with different functional groups in sequence by adopting a micro-contact printing technology, so that the biological active molecules with different biological functions are immobilized on the material surface to obtain the biological material with multifunctional biological activity. The method disclosed by the invention is adopted to treat the material surface, so that multifunctional biological activity is provided for the material surface, and therefore, the surface modifying method is applied to the fields such as biological materials, tissue engineering and implantable medical device research.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a surface modification method of biological materials. Background technique [0002] Biomaterials have important applications in improving human health and preventing diseases. Biomaterials implanted into the human body will inevitably interact with tissues and body fluids at the implantation site, causing a series of side effects and clinical complications. Therefore, the surface properties of materials often play a decisive role in the success or failure of implantation. [0003] The interaction between the implanted material and the surrounding environment is very complex. Therefore, the surface modification of biomaterials must fully consider the various interaction mechanisms between the material and the implanted environment, and regulate the material by constructing a multifunctional bioactive surface. The biological behavior of the interface with tissues o...

Claims

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Application Information

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IPC IPC(8): A61L31/16A61L31/08
Inventor 潘长江王亚楠刘涛侯彦华张临财
Owner 淮安市清江浦区市场监管综合服务中心
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