Wide field raman imaging apparatus and associated methods

Abstract

Apparatus and methods are presented herein that permit real-time, accurate detection of residual tumor in the operating room. The Raman-based wide-field imaging apparatus and methods described herein permit real-time imaging of tumor-targeted R-MR nanoparticles over a wide field.

Description

[0001] Cross References to Related Applications [0002] This application asserts the benefit of U.S. Provisional Application No. 61 / 767,241, filed February 20, 2013, and U.S. Provisional Application No. 61 / 834,854, filed June 13, 2013, both of which are incorporated by reference in their entirety way incorporated into this article. Background technique [0003] Various surgical techniques have been developed for the physical removal of cancerous or other diseased tissue. The goal of these methods is to remove cancerous / disease tissue with minimal damage to nearby healthy tissue. The surgeon will remove tissue that appears abnormal on visual inspection. [0004] Surgical resection is the standard of care for most cancer types. However, complete resection is hampered by the surgeon's ability to accurately identify tumor margins and smaller invasive tumor implants. The amount of residual tumor after surgery correlates with the likelihood of tumor recurrence and the developm...

AI Technical Summary

Problems solved by technology

Tissue can be analyzed during surgery to help determine the boundaries of abnormal tissue, but tissue biopsy and analysis by a pathologist during surgery is time-consuming and may be limited to one or two areas during a single surgery

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