486 results about "Bound property" patented technology

Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.

A unique method is disclosed for identifying and replacing immunoglobulin surface amino acid residues which converts the antigenicity of a first mammalian species to that of a second mammalian species. The method will simultaneously change immunogenicity and strictly preserve ligind binding properties. The judicious replacement of exterior amino acid residues has no effect on the ligind binding properties but greatly alters immunogenicity.

The present invention provides antibodies and antigen-binding fragments thereof that specifically bind proprotein convertase subtilisin/kexin-9 (PCSK9) with greater affinity at neutral pH than at acidic pH. The antibodies of the invention may possess one or more amino acid changes as compared to antibodies that do not exhibit pH-dependent binding properties. For example, the present invention includes anti-PCSK9 antibodies which possess one or more histidine substitutions in one or more complementarity determining regions. The antibodies of the invention, with pH-dependent binding properties, remain in circulation and exhibit cholesterol lowering activity for prolonged periods of time in animal subjects as compared to anti-PCSK9 antibodies that do not exhibit pH-dependent binding properties. The antibodies of the invention are therefore useful for treating diseases and disorders related to elevated HDL cholesterol, wherein the antibodies of the invention can be administered to a patient at a lower dose and/or with less frequent dosing as compared to antibodies that do not exhibit pH-dependent binding properties.

The invention discloses a thermoplastic resin-based carbon fiber composite and a preparation method thereof. The thermoplastic resin-based carbon fiber composite comprises the following components in percentage by volume: 50 to 70 percent of carbon fibers and 30 to 50 percent of thermoplastic resin. In the preparation method, according to rheological properties of the thermoplastic resin, the thermoplastic resin-based carbon fiber composite with good interface binding property is prepared by utilizing hot-roller hot-pressing continuous equipment and adjusting process conditions such as machining temperature, machining pressure, machining time and the like. Compared with the prior art, the thermoplastic resin-based carbon fiber composite has the advantages of simple structure, good interface binding property, high impact resistance and recycling property; and the preparation method can realize the uniform distribution of the carbon fibers and the thermoplastic resin and ensure the carbon fibers are immersed by the thermoplastic resin completely, so that the defect of the conventional method is overcome.

A polymer assisted deposition process for deposition of metal oxide films is presented. The process includes solutions of one or more metal precursor and soluble polymers having binding properties for the one or more metal precursor. After a coating operation, the resultant coating is heated at high temperatures to yield metal oxide films. Such films can be epitaxial in structure and can be of optical quality. The process can be organic solvent-free.

The invention relates to a glass fiberreinforced thermoplastic composite and a continuous fiber-reinforced composite, which are prepared with the following raw materials percentagewise by weight: 35-60 % of resin, 35-60 % of dip treated glass fiber and 0.5-5 % of auxiliary agent. The invention adopts resin and dip treated glass fiber as main raw materials, mixtures of antioxidant, ultraviolet absorbent and light-stability agent as main auxiliary agents, with logical formulations, eliminates the damage to glass fibrous surface caused by twin-screw with continuous fiber-reinforced composite producted by this manufacturing technique, improves product lustrous surface, binding properties between fiberglass and resins by a treatment for glass fibrous surface and mechanical properties of products, protects the materials for long periods from destruction because of addition of various stabilizing agents, and solves the limitation that general materials can not be used for a long time in extreme conditions such as high temperature, high humidity, radiation and so on.

The invention discloses a bi-component condensed type organic silicon pouring sealant as well as a preparation method and an application thereof. The bi-component condensed type organic silicon pouring sealant consists of a component A and a component B, wherein the component A comprises the following raw materials in parts by weight: 350-500 parts of linear hydroxyl-terminated polydimethylsiloxane, 300-600 parts of filler, 50-150 parts of base gum and 0.1-5 parts of a deep curing agent; the component B comprises the following raw materials in parts by weight: 200-500 parts of a cross linker, 300-800 parts of a plasticizer, 50-100 parts of a coupling agent and 0.5-2 parts of a catalyst; and the weight ratio of the component A to the component B is (100:5) to (100:20). Under an airtight condition, the sealant, which is aged for 30d at 150 DEG C, is free from the abnormal phenomenons of peeling off, pores, failure, reduction and the like, and the sealant can completely meet the requirements of an LED driving power supply or a waterproof power supply on waterproofing and binding properties.

The invention relates to a method for preparing a high polymerization degree bacterial cellulose fiber. The method comprises the following steps: (1) dissolving the bacterial cellulose in solvent to prepare bacterial cellulose solution with mass fraction of 1-30 percent, filtering and standing the solution for deaeration, thus obtaining spinning solution; (2) forming the spinning solution in the step (1) by solidifying after the solution is sprayed through a spinneret orifice, and preparing a finished product after several conventional processes, such as stretching, washing, shaping and drying. The preparation method is simple and is applicable to industrial production; compared with other cellulose fibers, the bacterial cellulose fiber has high rupture strength and module reaching the level of high-tensile industrial yarn, and has the advantages of good biocompatibility, odegradability, hydrophilicity and binding property with rubber.

The invention relates to the tire manufacture field, especially to a tire apex composition for improving a bond system and its preparation method and application. The tire apex composition for improving the bond system is formed by the mixing of the following ingredients of: by weight, 70-100 parts of natural rubber, 0-30 parts of styrene-butadiene rubber, 55-75 parts of carbon black, 1.0-4.0 parts of resorcinol, 0.2-3.0 parts of cobalt decanoate, 3-8 parts of a methylene donator adhesive, 0-20 parts of white carbon black, 3-8 parts of a vulcanizing agent and a sulfuration promoter and other processing auxiliary agents. The tire apex composition for improving a bond system obviously raises modulus and binding property, decreases heat generation, minimizes modulus loss at high temperature,and simultaneously reduces formula cost. By employing BTR tires under the precondition of unchanged structure, the hard apex strength and hardness can be guaranteed not to be decreased, the modulus is substantially increased, the bond performance between the apex and steel wires/steel wire cords is remarkably improved, and the anti-destroy performance of tire bead positions is raised.

The invention provides engineered heteromultimeric protein complexes constructed using one, two, or three tethers and methods for making, using, and purifying such complexes, such as antibodies with different binding properties.

Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.

The invention discloses a micro-arc oxidation-electrodeposition preparation method of a magnesium-based bioactive coating. The preparation method comprises the following steps: putting a magnesium-based base material in micro-arc oxidation electrolyte after pretreatment to perform micro-arc oxidation reaction to obtain a micro-arc oxidation coating sample; then, putting the micro-arc oxidation coating sample in electrodeposition electrolyte to perform electrodeposition reaction; and after electrodeposition, taking the sample out, and washing and drying the sample. The micro-arc oxidation-electrodeposition preparation method has the advantages that a biologic coating prepared by the method has high binding property with a base material; and the entire biologic coating has excellent corrosion resistance, bioactivity and compatibility; moreover, the formed bioactive coating is a composite coating (comprising HA, OCP, Mg3(PO3)2 and MgO); and because the composite coating comprises OCP, problems that the degradation of pure HA is difficult are avoided and only an HA crust is left after the degradation of formed magnesium alloy can be avoided.

The invention discloses a direct forming manufacturing method of a metal-based multilayer/gradient composite board and a process unit of the direct forming manufacturing method. Scale, corrosion materials and other impurities on the joint surface of a base board are removed through chemical cleaning, the cleaned surface is subjected to gradient power electromagnetic induction heating or laser bombardment surface treatment, all phases near the joint surface are fully dissolved, a solid solution is enhanced, toughness and corrosion resistance are improved, the surface stress of the board is eliminated, and surface laser treatment is conducted to improve the binding property of a composite layer; raw materials of the composite layer are added and injected through powder laying, a high-energy heat source is adopted for irradiation or induction heating to melt powder, metallurgical bonding is formed between the composite layer and a base, and control over the final shape of a cold/hot-rolled board is conducted. The obtained multilayer/gradient composite board is compact in surface structure, bonding between the composite layer and the base and between layers is good, and the interlayer bonding performance of the composite board is remarkably improved. The process is high in flexibility, and the production period of the metal-based composite board can be greatly shortened after the process is combined with an existing continuous casting technology.

The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.

Granules comprise binder-agglomerated active particles for liquid treatment or filtration. Each granule has a center core of a material that itself has binding properties without the addition of other binders or sprays or adhesives, or, alternatively, each granule comprises a matrix of active materials stuck together with the binder. The binder structure preferably ranges from a non-uniform matrix of binder formed by heat-deformed binder particles, to a clump of binder particles generally retaining the original shape or the binder particles, to non-continuous connectors of binder between active particles. The invented two-part media has high surface area per volume of media, which, because the outer surface and inner void surfaces of the particles are preferably substantially covered with active particles, translates to high activity for the preferred treatment process. Therefore, while a mixture of active particles may be used and a mixture of binders may be use, each media granule preferably consists only of a matrix, clump, or plurality of connectors of binder coated with active particles, with preferably no support for the active component other than the binder material.

The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.

The invention relates to a preparation method of a hard alloy with a clad structure, comprising the following steps of: selecting a WC-Co-based hard alloy as a base material; selecting a multicomponent alloy to which TiN, TiC and Al2O3 or TiC and TiN are added from WC-Co-based hard alloys as a cladding material; respectively obtaining a base material feed and a cladding material feed by mixing and granulating; sequentially injecting the cladding material feed and the base material feed into a mold cavity by coinjection molding to obtain a product billet; and performing solvent degreasing and hot degreasing processes on the product billet, and sintering after removing a binder to obtain the hard alloy product with the clad structure. The method provided by the invention has a simple process, simplicity of operation, short consumed time and good binding property between the shell and the base matrix, can flexibly adjust the shell thickness by selecting different shell materials and controlling the coinjection process parameters, effectively improves the mechanical and physical properties of the surface of a mechanical part, and is suitable for preparation of a hard alloy workpiece with a clad structure.

The present invention describes novel beta-sheet proteins having specific binding properties and catalytic properties and also methods for preparing these proteins.

The invention provides a method for electrochemically modifying surface of ultrasonic-enhanced carbon fiber. The method comprises the following steps of: firstly, pretreating the surface of the carbon fiber material, secondarily, soaking the pretreated carbon fiber material into an electrolytic bath filled with strong electrolyte solution; and by taking the carbon fiber material as an electrochemically oxidized anode and graphite as an electrochemically oxidized cathode, guiding in current through control of a voltage-stabilizing power supply, wherein the current intensity is 1A/g-2A/g; and under the conditions of ultrasonic power of 200W-2000W, ultrasonic frequency of 20kHz-100kHz, and water bath temperature of 20 DEG C-70 DEG C, carrying out ultrasonic oscillation for three minutes to 15 minutes to produce surface modification, and finally washing and drying to obtain surface-modified carbon fiber. With the method, the surface roughness of the carbon fiber can be increased, the wetting property of the carbon fiber can also be improved due to introduction of polar group into the surface of the fiber, the binding property between the carbon fiber and a resin matrix can be enhanced, and the interface property of binding the carbon fiber with other materials can be increased.