5 results about "Erythrocyte binding" patented technology

The present disclosure relates to synthetic Plasmodium reticulocyte binding protein 2b (mRBP2b) antigens that have improved properties such as thermal stability, as well as the use of these antigens to detect a Plasmodium infection in a diagnostic device or for use in a vaccine.

A polypeptide specifically binding to an erythrocyte membrane or a mutant thereof. The polypeptide or mutant thereof can be fused with various recombinant proteins. By using the binding property of the polypeptide or mutant thereof to erythrocytes and dynamically balancing the binding to and releasing from an erythrocyte membrane, the sustained release of a drug can be achieved, thereby prolonging the circulation half-life of the drug.

Biomarkers, such as erythrocyte-bound C4d. B-lymphocyte-bound C4d. anti-nuclear antibody. Sjögren's syndrome type B antigen, Scl-70 antibody. Jo-1 antibody, and anti-centromere protein B. can be used to diagnose. prognose, monitor, and treat subjects having systemic lupus erythematosus.

Methods of detecting biomarkers in a blood sample obtained from a human subject include detecting an erythrocyte-bound C4d (EC4d) marker, a B-lymphocyte-bound C4d (BC4d) marker, and an anti-nuclear antibody (ANA) in the blood sample; and detecting a level of double-stranded DNA antibody in the blood sample, wherein the human subject is negative for systemic lupus erythematosus based on the level of double-stranded DNA antibody. The methods optionally further include determining a systemic lupus erythematosus risk score by: (a) adjusting the level of EC4d marker by a weighting coefficient to produce a weighted score for EC4d marker; (b) adjusting the level of BC4d marker by a weighting coefficient to produce a weighted score for BC4d marker; (c) adjusting the level of ANA by a weighting coefficient to produce a weighted score for ANA; and (d) combining the weighted score for EC4d marker, the weighted score for BC4d marker, and the weighted score for ANA to generate the systemic lupus erythematosus risk score; wherein the systemic lupus erythematosus risk score does not include a score for double-stranded DNA antibody.

To solve the problems that sepsis is a disease with a high mortality rate, that since sepsis caused by gram-negative bacteria has a particularly poor prognosis, early diagnosis and appropriate treatment are necessary, and although detection of endotoxin is an important method for quickly diagnosing sepsis, there are still challenges in detecting endotoxin in blood.SOLUTION: In the present invention, erythrocytes, which have not received much attention in a blood sample until now, are used as a target for measuring endotoxin, thereby establishing a method for measuring total endotoxin in blood, which contributes to diagnosis of gram-negative bacterial sepsis.SELECTED DRAWING: Figure 1