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31 results about "Erythrocyte aggregation" patented technology

Erythrocyte aggregation is the reversible clumping of red blood cells (RBCs) under low shear forces or at stasis. Erythrocytes aggregate in a special way, forming rouleaux. Rouleaux are stacks of erythrocytes which form because of the unique discoid shape of the cells in vertebrate body. The flat surface of the discoid RBCs give them a large surface area to make contact and stick to each other; thus, forming a rouleau. Rouleaux formation takes place only in suspensions of RBC containing high-molecular, fibrilar proteins or polymers in the suspending medium (often Dextran-2000 in-vitro). The most important protein causing rouleaux formation in plasma is fibrinogen. RBC suspended in simple salt solutions do not form rouleaux.

Method of optical measurements for determining various parameters of the patient's blood

A method for optical measurements of desired parameters of the patient's blood is presented. A state of the blood flow cessation is provided within a measurement region and maintained during a predetermined time period. Measurement sessions are performed within this predetermined time period. Each measurement session includes at least two measurements with different wavelengths of incident light. Obtained measured data is representative of the time dependence of light response of the blood in the measurement region. The analyses of the measured data enables the determination of the desired blood parameters extracted from optical characteristics associated with the erythrocytes aggregation process during the state of the blood flow cessation.
Owner:ORSENSE LTD

Method of optical measurements for determining various parameters of the patient's blood

A method for optical measurements of desired parameters of the patient's blood is presented. A state of the blood flow cessation is provided within a measurement region and maintained during a predetermined time period. Measurement sessions are performed within this predetermined time period. Each measurement session includes at least two measurements with different wavelengths of incident light. Obtained measured data is representative of the time dependence of light response of the blood in the measurement region. The analyses of the measured data enables the determination of the desired blood parameters extracted from optical characteristics associated with the erythrocytes aggregation process during the state of the blood flow cessation.
Owner:ORSENSE LTD

Cell separation method

The present invention provides methods and compositions for separating cells from a sample containing erythrocytes. The method is for recovering desired cells from a sample containing the desired cells, erythrocytes and undesired cells comprising: a) contacting the sample with a composition, said composition comprising: i) an erythrocytes aggregation reagent ii) at least one antigen recognizing moiety coupled to a magnetic particle, wherein said particle with said at least one antigen recognizing moiety specifically binds to at least one antigen specific for one or more undesired cellular components; b) applying simultaneously i) gravity sedimentation for sedimentation of erythrocytes and ii) a magnetic field gradient to said sample for immobilizing said magnetic particle generating a pellet and a supernatant phase, and c) recovering the desired cells from the supernatant phase. Compositions for the use within the present method are also disclosed.
Owner:MILTENYI BIOTEC B V & CO KG

Health product compounds consisting of lecithin, grape seed extract and ginkgo leaf extract

The invention relates to a health care composite which consists of lecithin, grape pip extract and ginkgo leaf extract. The invention consists of the lecithin, the grape pip extract and the ginkgo leaf extract together; wherein, the lecithin accounts for 10 percent to 80 percent of the total weight, the grape pip extract accounts for 1-50 percent of the total weight and ginkgo leaf extract accounts for 1-50 percent of the total weight. The invention has the advantages that: the lecithin has the functions of nourishing the brain, improving intelligence, regulating blood lipid, eliminating fatigue, improving sleep, and so on; the grape pip extract has mighty antioxidation for the human body, can reduce erythrocyte aggregation and the permeability of capillary vessel; the ginkgo leaf extract can improve cerebrovascular circulation, protect brain cells from being damaged due to ischemia, dilate the coronary artery, prevent angina and myocardial infarction, eliminate harmful oxygen free radical, promote immunity and resist aging, and so on; the composite combined by three medicines brings convenience to consumers for oral administration and integrates three efficacies into a whole, thus enhancing the curative effect of the health care product.
Owner:JF PHARMALAND TECH DEV

Chitosan fiber-based efficient hemostatic material and preparation method thereof

The invention provides a chitosan fiber-based efficient hemostatic material and a preparation method thereof. The preparation method comprises the following steps of spinning chitosan to obtain a chitosan fiber base material, and grafting carboxyl and catechol structures on the chitosan fiber base material at the same time. The hemostatic material can quickly absorb moisture in blood to swell, so that the hemostatic rate is remarkably improved. The carboxyl is introduced, so that the hemostatic material has super-strong imbibition capacity, platelets in blood of a bleeding part are quickly adhered and aggregated to form thrombus, hydroxyl on the catechol group can be complexed with iron ions in red blood cells, the red blood cells are aggregated to play a role in stabilizing blood clots, and finally, the effect of quickly stopping bleeding is achieved. The efficient hemostatic material provided by the invention is especially suitable for the condition of massive bleeding.
Owner:WUHAN TEXTILE UNIV

Methods and apparatus for non-invasive determination of patient's blood conditions

InactiveUS7758505B2Diagnostics using pressureCatheterVirchow's triadPhysiology
A method and apparatus are presented for non-invasive determination of blood clotting related and blood circulation related parameters of a mammal. At least one stimulus ST is non-invasively induced in a blood containing medium in the mammal for a preset period of time tST. This at least one stimulus is selected to cause at least one of the following to occur: (a) inducing at least two of three Virchow's triad elements including abnormalities of blood flow; abnormalities of blood constituents and abnormalities of the blood vessel wall, and (b) inducing a change in red blood cell (RBC) aggregation or local blood viscosity. Measurements are non-invasively performed at a measurement location in the mammal by applying an external field thereto for a preset time period tm, a response of the measurement location to the applied field is detected, and measured data indicative thereof generated. At least a portion of the measured data and stimulus related data are processed so as to determine a relation between a time function of the at least one stimulus ST(t) and a time function of the measured data OR(t). This relation is indicative of at least one blood circulation and blood coagulation related parameter of the mammal.
Owner:ELFI TECH

Gamma sterilized dextran solutions and methods of use

Provided herein are kit for providing a gamma sterilized aqueous dextran solution that increase the efficiency of blood separation by allowing the dextran solution to be sterilized by exposure to gamma radiation while maintaining sufficient molecular weight to act as a red blood cell aggregate. Also provided are methods of use.
Owner:GENERAL ELECTRIC CO

Citrus bioflavonoid active beverage and making method thereof

The invention discloses a citrus bioflavonoid active beverage and a making method thereof. By means of bioflavonoid extracted from biological raw materials through deep processing, the beverage is prepared from, by mass, 80% of water, 8% of fructo-oligose, 7% of polydextrose and 5% of bioflavonoid. The flavonoid functional beverage obtained through the method creates the environment protection benefits, the economic benefits and the social benefits; meanwhile, citrus bioflavonoid has effects of vitamin P samples and can influence the functions of blood vessel wall cells and blood platelets, the functions of white blood cells, the coagulation process, the hemorheology and the formation of thrombus, multi-methoxy compounds such as nobiletin, sinensetin and tangeritin in citrus bioflavonoid have important pharmacological effects, erythrocyte aggregation in human bodies can be reduced, and the blood cell sedimentation rate is decreased.
Owner:ANHUI YUNING PECTIN CO LTD

Method of detecting red cell antigen-antibody reactions

A process for the detection of antibodies in a test sample by carrying out the following steps:(a) preparing a suspension of erythrocytes with a test serum or plasma by mixing a test serum or plasma with erythrocytes;(b)incubating the suspension formed in step (a) at a temperature of from 37° C. to 45° C. for a period of time from sixty seconds to 10 minutes to bind any antibodies in the test serum or plasma to the surface of said erythrocytes(c)combining said suspension with an amount of a solution of a macromolecule which is effective for agglutination of said erythrocytes;(d) packing the resultant red cell agglutinates by centrifugation from the suspension of step (c); and,(f) determining the presence of anti-erythrocyte antibodies by observing if antibody-dependent erythrocyte aggregation has occurred.
Owner:CLAVINA DIAGNOSTICS

Erythrocyte aggregation detection method and system thereof

The invention provides an erythrocyte aggregation detection method and a system thereof, which relate to the fields of biological and microbiological analysis detection. The method comprises the following steps: connecting an analysis module with an image information acquisition module and a control module for analyzing an obtained microscopic image; performing edge detection on erythrocyte in themicroscopic image, filling up an internal gas of the edge to form a complete erythrocyte shape image; performing a shrinkage analysis on an outer contour of the erythrocyte, and when the result is higher than a set value, determining the result as erythrocyte aggregation. calculating a ratio of an erythrocyte area with aggregation and an average area of the normal erythrocyte, and determining theerythrocyte aggregation degree according to the ratio. Compared with the prior art, the method employs a direct observation method and an image analysis method, the erythrocyte can be automatically identified, the area of an erythrocyte image and the area of the normal erythrocyte are compared, the erythrocyte aggregation degree is determined, the operation is convenient, the measurement efficiency is high, the identification precision is high, and the method can be used for quantitative analysis.
Owner:青岛汉朗智能科技有限公司

Chitosan hemostatic gel and preparation method thereof

The invention discloses a chitosan hemostatic gel and a preparation method thereof. The chitosan hydrogel is glycidyl ether modified chitosan dissolved in water. For the deficiency that the blood coagulation rate of the common chitosan material is relatively slow, a hydrophobic chitosan derivative is prepared by introducing the alkane long chain in the invention; when in contact with blood, the hydrophobic group thereof can promote erythrocyte aggregation to realize rapid blood coagulation; the chitosan hemostatic gel in the invention is the gel dosage form, which is convenient to use and carry; and the preparation method adopted in the invention is simple and convenient in process and convenient to operate, and can be used for large-scale industrial production.
Owner:ZHANGJIAGANG XIANGCHENG MEDICAL MATERIAL SSCI & TECH CO LTD

Inflammatory marker measurement method, inflammatory marker measurement apparatus, inflammatory marker measurement program, and recording medium storing the program

An inflammatory marker is calculated using a nonlinear function including, as variables, a parameter associated with an erythrocyte aggregation and another parameter associated with an erythrocyte density. The parameter associated with the erythrocyte aggregation is calculated based on a syllectogram measured from a blood specimen. The parameter associated with the erythrocyte density is measured from the blood specimen.
Owner:NIHON KOHDEN CORP

Method of analyzing platelet aggregation function according to platelet size changes

The invention discloses a method of analyzing a platelet aggregation function according to platelet size changes, and belongs to the field of clinical laboratory medicine. The method of analyzing the platelet aggregation function according to the platelet size changes measures the platelet size changes before after aggregation processing, and calculates the aggregation rate value of platelet according to the size changes of the platelet in a sample, and therefore the strength of the platelet aggregation function can be reflected. The method of analyzing the platelet aggregation function according to the platelet size changes also can be applied to erythrocyte aggregation rate analysis.
Owner:SINNOWA MEDICAL SCI & TECH

Polyvinyl alcohol sponge with ordered porous structure prepared on basis of 3D printing template and application thereof

The invention provides a polyvinyl alcohol sponge with an ordered porous structure prepared on the basis of a 3D printing template and an application thereof. When the sponge with ordered micro-channels makes contact with blood, the sponge can rapidly guide and absorb the blood, and a large number of regularly-arranged red blood cells are gathered in the micro-porous structure at the bottom of the sponge. The sponge prepared by combining structured ordered micro-channels and disordered holes greatly shortens the blood coagulation time and improves the hemostasis efficiency. The used raw materials have excellent biocompatibility, and potential biological safety and side effects are eliminated in the clinical use process. The used raw materials have excellent blood compatibility, do not cause hemolytic reaction and do not affect endogenous and exogenous blood coagulation pathways.
Owner:WENZHOU INST UNIV OF CHINESE ACAD OF SCI

Medicine for treating cerebral thrombosis and preparing method thereof

The invention relates to a medicine for curing cerebral thrombosis and a preparation method thereof. The medicine of the invention is prepared by raw medicines with portions according to the following weight ratio: 70-90 portions of Bupleurum chinense DC, 90-110 portions of RhizomaChuanxiong, 70-90 portions of root of red rooted salvia, 150-170 portions of radix astragali, 80-100 portions of earthworm, 50-70 portions of radix curcumae, 140-160 portions of core-removing hawthorn, 40-50 portions of radix notoginseng and 1.5-2.5 portions of borneol. The preparation method comprises that the radix notoginseng are ground into 120 meshes of fine powder, the borneol is ground into 120 meshes of fine powder, and the Bupleurum chinense DC, the RhizomaChuanxiong, the root of red rooted salvia, the radix astragali, the earthworm, the radix curcumae and the core-removing hawthorn are cut into chips which are decocted with 1000g water for three times and each time is decocted for one hour; the raw materials being decocted are extracted, filtered, compressed, dried and ground into 120 meshes of fine powder, in which the radix notoginseng fine powder and the borneol fine powder are added and mixed evenly, thus obtaining the medicine through split charging into 0.5g of capsules. The medicine of the invention can promote blood circulation by removing blood stasis, warm channels and expel cold, restore consciousness and resuscitate and resist platelet aggregation; moreover, the medicine of the invention also can replenish qi to secure the exterior, clear away heat and toxic material, nourish blood and tranquilize mind and resist thrombosis; furthermore, the medicine of the invention can relieve the depressed liver, cool blood and remove stagnation and reduce erythrocyte aggregation; the medicine further can relieve muscles and warm channels, promote salivation and activate yang, dispel wind and toxicity, relieve heart and restlessness and regenerate tissues.
Owner:肖永雪

Supported hemoglobin composition and preparation method thereof

The invention relates to a supported hemoglobin composition and a preparation method thereof. The preparation method comprises the following steps: (1) dissolving a carrier polyethylene glycol-poly(lactide-co-glycolide) into an organic solvent, mixing with a water solution of hemoglobin, and carrying out ultrasonic treatment to form primary emulsion; (2) adding a water solution of a surfactant to the primary emulsion obtained in the step (1), mixing and carrying out ultrasonic treatment to form a compound emulsion; and (3) removing the organic solvent, and centrifuging to obtain the supported hemoglobin composition. The supported hemoglobin composition is prepared by a double emulsion method; the method is simple and feasible; the prepared supported hemoglobin composition has oxygen carrying and releasing functions, has rheological characteristics similar to whole blood, is high in stability and good in blood compatibility, and does not cause erythrocyte aggregation; and the carrier material provided by the invention is prepared from abundant raw material, has the advantages of low cost, biocompatibility, biological affinity and no toxicity and is prone to be chemically modified.
Owner:THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA

A kind of loaded hemoglobin composition and its preparation method

The invention relates to a supported hemoglobin composition and a preparation method thereof. The preparation method comprises the following steps: (1) dissolving a carrier polyethylene glycol-poly(lactide-co-glycolide) into an organic solvent, mixing with a water solution of hemoglobin, and carrying out ultrasonic treatment to form primary emulsion; (2) adding a water solution of a surfactant to the primary emulsion obtained in the step (1), mixing and carrying out ultrasonic treatment to form a compound emulsion; and (3) removing the organic solvent, and centrifuging to obtain the supported hemoglobin composition. The supported hemoglobin composition is prepared by a double emulsion method; the method is simple and feasible; the prepared supported hemoglobin composition has oxygen carrying and releasing functions, has rheological characteristics similar to whole blood, is high in stability and good in blood compatibility, and does not cause erythrocyte aggregation; and the carrier material provided by the invention is prepared from abundant raw material, has the advantages of low cost, biocompatibility, biological affinity and no toxicity and is prone to be chemically modified.
Owner:THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA

Medicine for treating cerebral thrombosis and preparing method thereof

The invention relates to a medicine for curing cerebral thrombosis and a preparation method thereof. The medicine of the invention is prepared by raw medicines with portions according to the followingweight ratio: 70-90 portions of Bupleurum chinense DC, 90-110 portions of RhizomaChuanxiong, 70-90 portions of root of red rooted salvia, 150-170 portions of radix astragali, 80-100 portions of earthworm, 50-70 portions of radix curcumae, 140-160 portions of core-removing hawthorn, 40-50 portions of radix notoginseng and 1.5-2.5 portions of borneol. The preparation method comprises that the radixnotoginseng are ground into 120 meshes of fine powder, the borneol is ground into 120 meshes of fine powder, and the Bupleurum chinense DC, the RhizomaChuanxiong, the root of red rooted salvia, the radix astragali, the earthworm, the radix curcumae and the core-removing hawthorn are cut into chips which are decocted with 1000g water for three times and each time is decocted for one hour; the rawmaterials being decocted are extracted, filtered, compressed, dried and ground into 120 meshes of fine powder, in which the radix notoginseng fine powder and the borneol fine powder are added and mixed evenly, thus obtaining the medicine through split charging into 0.5g of capsules. The medicine of the invention can promote blood circulation by removing blood stasis, warm channels and expel cold,restore consciousness and resuscitate and resist platelet aggregation; moreover, the medicine of the invention also can replenish qi to secure the exterior, clear away heat and toxic material, nourishblood and tranquilize mind and resist thrombosis; furthermore, the medicine of the invention can relieve the depressed liver, cool blood and remove stagnation and reduce erythrocyte aggregation; themedicine further can relieve muscles and warm channels, promote salivation and activate yang, dispel wind and toxicity, relieve heart and restlessness and regenerate tissues.
Owner:肖永雪

Method for dissolving fat by using laser and magnetic field and use equipment

The invention discloses a method for dissolving fat by using laser and a magnetic field. The method comprises the following steps: S101, cleaning a to-be-weight-reduced part of a to-be-weight-reducedperson; S102, soaking the to-be-weight-reduced part in hot water for 10-15 minutes; S103, using 20mW and 650nm low-intensity laser to continuously irradiate the to-be-weight-reduced part for 10 to 15minutes; S104, continuously irradiating the to-be-weight-reduced part for 20-30 minutes by adopting a plurality of groups of pulse emission sources and emitting extremely low frequency PEMF; and S105,taking warm-keeping measures on the to-be-weight-reduced part. The red blood cell aggregation degree can be reduced, the blood flow rate is increased, oxygen utilization of whole body blood is promoted, and the human body vitality is enhanced; free radicals accumulated in the body are adjusted, mobilized and decomposed, metabolism is accelerated, blood circulation is promoted, the free radicals in the body are removed, and then the laser fat-reducing effect can be greatly improved.
Owner:吴洪飞

Ultrasonic erythrocyte aggregation degree detection, regulation and control system

The invention discloses an ultrasonic erythrocyte aggregation degree detection, regulation and control system. The equipment comprises an ultrasonic equipment end and a computer processing end connected with the ultrasonic equipment end; the ultrasonic equipment end is used for transmitting an ultrasonic pulse signal to a target human body and collecting blood ultrasonic radio frequency data of the target human body; the computer processing end is used for detecting the erythrocyte aggregation degree of the target human body according to the blood ultrasonic radio frequency data and sending a regulation and control signal to the ultrasonic equipment end when the erythrocyte aggregation degree is greater than a set aggregation degree; and the ultrasonic equipment end is further used for sending ultrasonic regulation pulse waves to the target human body according to the regulation and control signal until the erythrocyte aggregation degree of the target human body reaches the set aggregation degree. The erythrocyte aggregation degree can be detected and regulated in real time, and the detection and regulation efficiency and accuracy are improved.
Owner:YUNNAN UNIV

Technology for purifying NK cells and other cell types by concurrent gravity sedimentation and magnetic separation

The present invention provides methods and compositions for separating cells from a sample containing erythrocytes. The method is for recovering desired cells from a sample containing the desired cells, erythrocytes and undesired cells comprising: a) contacting the sample with a composition, said composition comprising: i) an erythrocytes aggregation reagent ii) at least one antigen recognizing moiety coupled to a magnetic particle, wherein said particle with said at least one antigen recognizing moiety specifically binds to at least one antigen specific for one or more undesired cellular components; b) applying simultaneously i) gravity sedimentation for sedimentation of erythrocytes and ii) a magnetic field gradient to said sample for immobilizing said magnetic particle generating a pellet and a supernatant phase, and c) recovering the desired cells from the supernatant phase. Compositions for the use within the present method are also disclosed.
Owner:MILTENYI BIOTEC B V & CO KG

Fat dissolving system and fat dissolving method

The invention provides a fat dissolving system and a fat dissolving method, and belongs to the technical field of medical cosmetology. The fat dissolving system comprises a laser module and a controller module and further comprises a pulse electromagnetic field module and a fusion handle. According to the system and the method, the laser module emits laser energy, active oxygen level of fat cellsis improved through laser heating effect, lipid peroxidation of the fat cells is caused, cell membranes of the fat cells are damaged and fused, and the fat cells are enabled to be liquefied. Bionic pulsed magnetic resonance is formed by the pulse electromagnetic field module, an extremely low-frequency PEMF (pulse electromagnetic field) is emitted, sodium and potassium ions and ATPase on surfacesof erythrocyte membranes are activated, cell membrane potential is repaired, the aggregation extent of erythrocytes is reduced, the blood flow velocity of an organism body is increased, and oxygen utilization by blood of the whole body is promoted; and besides, free radicals accumulated in the organism body are adjusted, mobilized and decomposed, the free radicals in the body are cleared away, metabolism is accelerated, decomposition speed of the liquefied fat cells is increased, and the laser fat reducing effect is greatly improved.
Owner:秦皇岛市惠斯安普医学系统股份有限公司

Polyvinyl alcohol sponge with ordered porous structure prepared based on 3D printing template

The polyvinyl alcohol sponge prepared based on the 3D printing template and provided with the ordered porous structure comprises a sponge body, a plurality of regular and ordered array hemostasis channel structures are arranged on the sponge body, each hemostasis channel structure is of a big-end-up inverted-cone-shaped structure, a big opening of each inverted-cone-shaped structure is an upper opening located in the surface of the sponge body, a small opening is the lower opening located inside the sponge body, and the taper of the hemostasis channel structure of the inverted-cone-shaped structure is 1 / 3-3 / 4, the sponge with the ordered micro-channels can quickly guide and absorb blood when making contact with the blood, a large number of regularly-arranged red blood cells gather in the micropore structure at the bottom of the sponge, According to the sponge prepared by combining the structured ordered microchannels and the disordered holes, the blood coagulation time is greatly shortened, and the hemostasis efficiency is improved.
Owner:WENZHOU INST UNIV OF CHINESE ACAD OF SCI

Curcuma zedoary extract and application thereof in preparation of medicine for preventing and treating coronary heart disease

PendingCN114732888AImprove dyslipidemiaReduce inflammationCardiovascular disorderPlant ingredientsGlyceride metabolismTherapeutic effect
The invention discloses a curcuma zedoary extract and application of the curcuma zedoary extract in preparation of a medicine for preventing and treating coronary heart disease. The curcuma zedoary extract is extracted by the following method: heating and extracting raw or vinegar curcuma zedoary decoction pieces with ethanol; extracting medicine residues with water; and merging the extracting solutions, adding ethanol until the alcohol concentration is 40-60%, standing, filtering, and concentrating the filtrate under reduced pressure until the crude drug content is 0.5-1.0 g / mL. The curcuma zedoary extract can significantly increase the liver index and spleen index of a rat with coronary heart disease, and improve the fatty degeneration, myocardial fibrosis, necrosis and inflammatory infiltration degree of liver cells; indexes such as the whole blood viscosity and the erythrocyte aggregation index of the coronary heart disease rats can be remarkably reduced, and the blood viscous state is reduced; the traditional Chinese medicine composition can significantly improve dyslipidemia, and meanwhile, achieves the treatment effects of relieving vascular cholesterol deposition and inflammation and recovering endothelial functions. Lipiomics results also show that the compound can regulate and control abnormal lipid metabolism of the coronary heart disease by inhibiting sphingolipid metabolism and promoting glyceride metabolism and fatty acyl metabolism.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

A medical device for treating microcirculation diseases

The invention discloses medical equipment for treatment of microcirculation diseases. The equipment includes a blood rheology detector, a resonance pool, magnetization coils and a control system. Ultrasonic wave of specific amplitude is transmitted to foot blood vessels through liquid to depolymerize erythrocyte rouleau flowing through the blood vessels, thus improving erythrocyte deformability, and also magnetization is carried out on venous blood flowing through legs, thus reaching the purpose of treating microcirculation diseases. The invention has the beneficial effects that: microcirculation disturbance is the source of all diseases, the therapeutic equipment for microcirculation diseases provided by the invention can break red blood cell aggregation in blood, improve red blood cell deformability, and reduce blood viscosity. The therapeutic equipment has the characteristics of fast and efficient use and low cost, thus providing treatment equipment for prevention and treatment of diseases caused by diabetes, high blood pressure, stroke, myocardial infarction and other microcirculations.
Owner:周相真
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