6 results about "Brain natriuretic peptide" patented technology

The application relates to the technical field of immunochromatographic medical detection, in particular to a brain natriuretic peptide immunochromatographic test paper based on Yb 3+ core-shell shell upconversion nanocrystals, which comprises a PVC bottom plate, a sample pad, a combination pad, a nitrocellulose membrane and a water absorption pad which are sequentially connected and pasted on the PVC bottom plate; the nitrocellulose membrane is provided with a detection line T line and a quality control line C line which are separated from each other; the combination pad is loaded with a fluorescent detection probe and a quality control probe. Through the construction of a core-shell shell structure and the directional control of an energy gradient, near-infrared luminescence is significantly enhanced, and high-sensitivity quantitative detection is realized. Therefore, the problems of complex operation, low sensitivity, easy interference of sample background and difficulty in realizing accurate quantification of traditional brain natriuretic peptide detection methods are solved.

The invention relates to the field of biomedicine, in particular to a construction method of an old patient postoperative serious complication risk probability prediction column graph model based on preoperative human N-terminal brain natriuretic peptide. According to the method, five independent risk factors related to the occurrence of the postoperative serious complications of the elderly patient are provided, and the risk probability prediction column graph model is constructed by using multi-factor logistic regression and is used for evaluating the risk of the postoperative serious complications of the elderly patient. The method comprises the following steps: firstly, collecting clinical data of an operation of an elderly patient; then risk factor screening is carried out through multi-single-factor logistic regression; then, ranking the risk factors according to importance by using an optimal subset regression method to obtain characteristic variables with relatively high prediction values; and finally, establishing a multi-factor logistic regression risk probability prediction model, and constructing a column graph according to the prediction model. According to the method, the occurrence risk of the postoperative serious complications of the elderly patient can be accurately predicted based on the pre-operative N-terminal brain natriuretic peptide, clinical doctors can be helped to recognize the high-risk elderly patient suffering from the postoperative serious complications in the early stage, the doctors are guided to conduct individualized intervention, and occurrence of the postoperative serious complications of the elderly patient is reduced.

The invention belongs to the technical field of plasma protein markers, and discloses a plasma protein marker and a risk prediction system for a heart failure onset risk of a type 2 diabetes mellitus patient, and the protein marker combination is applied to preparation of a kit for predicting the heart failure onset risk of the type 2 diabetes mellitus patient. The protein marker combination comprises a C-C motif chemotactic factor 24, a C-C motif chemotactic factor 7, a carcino-embryonic antigen related cell adhesion molecule 6, a fiber gelling protein 1, a follistatin, a polypeptide N-acetylgalactosamino transferase 5, an ADP ribosylation factor binding protein GGA1, a kallikrein 4, a nerve bundle protein, renin, a plasma protease C1 inhibitor and cardiac troponin I, the brain natriuretic peptide comprises a brain natriuretic peptide precursor, an N-terminal brain natriuretic peptide precursor, apolipoprotein C1, tetramer connexin, a Mepin A beta subunit and multi-ligand proteoglycan-4. The invention further constructs a risk score and prediction model for predicting the attack risk of the heart failure of the type 2 diabetes mellitus patient based on the protein marker.

The invention discloses an application of a water-soluble fullerene nano material in preparation of a medicine for treating and / or relieving heart failure. The treatment and / or relief of heart failure is embodied in at least one of the following aspects: 1) improving the systolic function of the heart; (2) the increase of the brain natriuretic peptide precursor content caused by heart failure is reduced; (3) the content of Ca < 2 + > in the failure heart is reduced; 4) improving cardiac hypertrophy caused by heart failure; 5) inhibiting cardiac fibrosis caused by heart failure; 6) reducing the active oxygen level of a heart pathologic region; 7) inhibiting inflammation of the heart failure part; and 8) inhibiting pyroptosis, apoptosis and cardiac fibrosis of the heart failure part. In a coronary artery ligation post-myocardial infarction heart failure mouse model, the FPs can regulate redox balance in a pathological area, reduce excessive inflammation, pyroptosis, apoptosis, cardiac hypertrophy and fibrosis of a heart failure part and improve a mouse cardiac systolic function, shows a good treatment effect, and is an ideal medicine for treating heart failure.

The invention discloses application of a flavonoid compound or pharmaceutically acceptable salt or solvate thereof in preparation of a medicine for preventing, delaying and / or treating myocardial injury and / or heart aging. The flavonoid compound has a structure as shown in a formula (I). The flavonoid compound can increase the activity of cardiac muscle cells, inhibit the active oxygen level of the cardiac muscle cells, reduce the aging positive rate of the cardiac muscle cells, relieve neutrophil infiltration and muscle fiber breakage of cardiac muscle tissues and reduce the expression level of brain natriuretic peptide (BNP) and troponin T (cTnT) in serum. (I)