94 results about "Optical biosensor" patented technology

Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices.

The instant invention provides compositions and methods for determining cell interactions that are faster than conventional methods and that require the use of fewer reagents than conventional methods.

An optical biometric sensor includes an array of light sensing elements, an array of diverging optical elements, and an array of apertures disposed between the array of light sensing elements and the array of diverging optical elements. Light incident on the diverging optical elements within a limited acceptance angle passes through the apertures and towards the light sensing elements and light incident on the diverging optical elements outside of the limited acceptance angle diverges away from the apertures.

An optical biosensor has a first enclosure with a pathogen recognition surface, including a planar optical waveguide and grating located in the first enclosure. An aperture is in the first enclosure for insertion of sample to be investigated to a position in close proximity to the pathogen recognition surface. A laser in the first enclosure includes means for aligning and means for modulating the laser, the laser having its light output directed toward said grating. Detection means are located in the first enclosure and in optical communication with the pathogen recognition surface for detecting pathogens after interrogation by the laser light and outputting the detection. Electronic means is located in the first enclosure and receives the detection for processing the detection and outputting information on the detection, and an electrical power supply is located in the first enclosure for supplying power to the laser, the detection means and the electronic means.

Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices.

The invention relates to compositions and methods for detecting biomolecular interactions. The detection can occur without the use of labels and can be done in a high-throughput manner. The invention further relates to self-referencing colorimetric resonant optical biosensors and optical devices.

Ear-mounted apparatus are provided for secure and comfortable load bearing in support of optical, biosensor, and mobile communication functionalities. In particular, a load-bearing ear unit is provided which includes an anchor for stable attachment in an ear and a member extending from the anchor. The member has therein a rotational stabiliser adapted to provide stability in relevant planes for secure ear mounting. Also provided is an ear-mounted optical device, comprising the load-bearing ear unit and one of a camera, a light source, a virtual reality device, a IrDA-device, and a photo diode. Further provided is an ear-mounted wearable device, comprising the load-bearing ear unit and one or more biosensors. A particular such wearable device is an ear-mounted EAG device.

The invention provides an optical biosensor used for detecting surface cleanliness rapidly, and a testing method thereof. The sensor comprises a sampling stick, a detection cavity, a liquid storage tank and a reaction chamber. The sampling stick comprises a handle, a spacing ring, a sampling swab and a pointed casing; the liquid storage tank is provided with a plurality of uniform sealing pieces which are in fixed connection through screw threads, and an ATP extractant and a neutralization reagent used for neutralizing the remaining extractant are sealed therein; and the lateral wall of the reaction chamber allows light to pass through, and a sensitive reagent is fixed at the bottom part in advance. When in detection, firstly, the sampling swab of the sampling stick is used for daubing and sampling the surface of an object to be detected; then, the pointed casing is screwed downwards; the sampling stick is inserted into the sampling detection cavity; and with the consideration of the fluorescence strength during the detection of a sample by an optical device, the surface cleanliness of the object to be tested can be determined by comparing the light intensity value with the standard sanitary threshold value. The sensor provided by the invention has the advantages of simple operation, convenient use, rapid response and disposability, and can be widely applied to the object surface cleanliness real-time detection and the field hygiene supervision in industries, such as food processing, cosmetics production, medical service and the like.

A waveguide-based sensor is disclosed that uses one or more grating patterns of a bioreceptor on a surface of the waveguide to provide a wavelength-specific sensor response without the requirement of labeling the target molecule or the bioreceptor. Furthermore, there is provided a biosensor that, at least to a first order, is insensitive to non-specific binding.

An optical biosensor that is capable of reading a fingerprint or a vein pattern with high efficiency of light reception. A louver is provided between a backlight unit and a substrate in a sensor for identifying a fingerprint by a process in which light emitted from the backlight unit passes through the substrate and is radiated to a fingerprint that is in contact with the upper surface of a protective layer, and light that is reflected according to the surface irregularity of the fingerprint is received by a semiconductor layer that is a light-receiving element. The emitted light is thereby provided with sharp directivity, and the efficiency of light reception by the sensor is therefore increased.

The invention discloses a fabrication method of an optical micro-nano biosensor integrated with a microfluidic system. The method comprises the steps that a substrate is cleaned; a micro-nano slab-guide optical device is fabricated through photoetching, developing, etching, and the like on the top layer of the substrate; the surface of the device is coated with SU-8 thick glue in a spinning manner; an SU-8 glue microfluidic channel is obtained through alignment exposure, postbaking, developing, and the like; an SU-8 layer is coated and permanently bonded with a PDMS (polydimethylsiloxane) sheet, so that the integration of the micro-nano slab-guide optical device with a microfluidic is achieved; a relevant reagent is injected from a liquid inlet; chemical modification of a micro-ring region is completed; a reagent solution to be tested is injected; and a function of on-chip biological detection is achieved by observing variations of optical power or resonance. The method has the advantages of simplicity in operation and high reliability, and is suitable for fabricating the microfluidic systems of the most slab-guide micro-nano optical biosensors.

The invention discloses an optical biosensor for detecting brain natriuretic peptide (BNP) and a preparation method of a reagent thereof, relating to the biosensing technology. A sensor reaction zone is a capillary channel filled with magnetic nano probe solution, the inner surface of the channel is assembled with a layer of hydrophilic nano material, the upper surface of the channel is an euphotic insulating encapsulation layer with an injection hole, the side surface of the channel is encapsulated by plastics, the two ends thereof encapsulated with plastics are respectively provided with a controllable electromagnet. The preparation method of the reagent is as follows: preparing magnetic nano probes, fully reacting the magnetic nano probes, a brain natriuretic peptide (BNP) sample to bedetected and specificity BNP antigen marked by a marker under the united action of the electromagnet and the capillary channel, forming a compound of magnetic nano probes, BNP antigen to be detected and marked antibody, and adding substrate for catalytic luminescence or exciting luminescent quantum dots for luminescence. By the sensor detection system, the BNP concentration can be rapidly detected. The sensor in the invention can rapidly detect the BNP concentration in a sample, and has the characteristics of high specificity, high sensitivity, a great quantity of saved biological reagent andthe like.

A distal tip, and associated method of producing, of a biosensor ion sensing transducer for use in detecting an analyte comprising an halogenated organic compound in an environment such as soil or an aqueous environment. Features include: a biocomponent comprising at least one enzyme for carrying out a dehalogenation of the compound; the biocomponent is immobilized to a surface of the tip; a treatment of the biocomponent for maintaining a period of enzymatic efficacy; and the biocomponent stabilized by means preferably selected from the group consisting of crosslinking a surface of the immobilized biocomponent, crosslinking a polymer layer to the biocomponent, adding a gel-hardening agent to the biocomponent, adding a stabilizing agent to the biocomponent, and modifying a component of the immobilizing means. Immobilization can be carried out by: (a) entrapment within a hydrogel; (b) entrapment within a polymeric network; (c) (micro)encapsulation; (d) covalent-bonding; and (e) adsorption. The dehalogenase of the biocomponent may be selected from the group consisting of hydrolases, subclass EC 3.8, and lyases, subclass EC 4.5 as listed in Table 2A.

The invention relates to the field of surface waves based optical devices particularly tuneable optical filter, optical biosensors and spatial light modulators. An optical sensor and tuneable filter is disclosed based on high contrast periodic structures deposited on a substrate and using a compact reading method for low detection limit using a one dimensionally diverging quasi-monochromatic beamand a camera.

The invention discloses a dual-ring resonant cavity-based Mach-Zehnder interferometer optical biosensor, comprising a laser light source, a Mach-Zehnder interferometer, two ring-shaped waveguide resonant cavities and two detectors; the surface of a core layer of the first ring-shaped waveguide resonant cavity is modified with a biological antibody with a specific adsorption function; the surface of a core layer of the first ring-shaped waveguide resonant cavity is modified with a competition antigen for adsorbing the biological antibody; after a to be detected antigen in to be detected liquid is combined with the biological antibody, the effective refractive index of the first ring-shaped waveguide resonant cavity is caused to be increased, while the effective refractive index of the second ring-shaped waveguide resonant cavity is reduced, so that phase difference of inside light in the two ring-shaped waveguide resonant cavities is increased, the change of the phase difference is converted into the change of output power through the Mach-Zehnder interferometer, and the content of the to be detected antigen in the to be detected liquid is obtained by measuring the ratio of output powers of two ports of the Mach-Zehnder interferometer, thus greatly reducing the requirement on light source power stability.

The present provides optical sensor based sensitive, label-free binding assay methods and kits for isothermal real-time detection of the binding of specific analytes (such as nucleic acids, proteins and low molecular weight antigenic or receptor binding ligands) present in low amount in different biological samples. In the binding assays of the invention, the analyte is captured at the specifically pretreated solid surface of optical biosensors in specific recognition reactions (such as hybridization, specific protein-protein interactions and receptor-ligand interactions). The specificity of the methods of the invention is further enhanced by a second specific recognition step using a padlock probe comprising an indicator sequence designed to keep the products of a subsequently performed isothermal nucleic acid amplification method (e.g. rolling circle amplification: RCA) anchored on the sensor surface, enhancing thereby the sensitivity of the detection of the specific binding of the analyte occurred on the sensor surface.

The invention discloses a dual-ligand Janus nano-particle as well as a preparation method and application thereof, and belongs to the field of the polymer and inorganic nano-composite material. The preparation method comprises the following steps: preparing a simple-layer film from inorganic nano-particles modified by the first polymer through self-assembling, and then performing etching, removingpartial first polymer, and then grafting the second polymer to the exposed part of the surface of the nano-particle, thereby obtaining Janus structure nano-particle. Two different polymers on the Janus structure nano-particle surface are respectively grafted to a first region and a second region, and the first region and the second region are uncrossed regions; the first region and the second region form the whole surface of the inorganic nano-particle. The preparation method disclosed by the invention is simple in operation and capable of controlling the proportion of two polymer ligands onthe surface of the nano-particle. The obtained Janus structure nano-particle can be used in applications for preparing a solid surfactant, an emulsifier, a hydrophilic and hydrophobic conversion material, an asymmetric catalyst, a medicine targeting vector or an optical biosensor.

An electricity-optics joint urine analysis biochemical system and a production method thereof relate to functional materials for biosensors. The system is provided with a urine reaction cell, an LED (light-emitting diode) light source, an optical fiber spectrometer, a singlechip and a display circuit; an optical biosensor, an electrochemical biosensor and a pH (Potential Of Hydrogen) meter are arranged in the reaction cell, the upper end of the reaction cell is provided with a urine inlet, the bottom of the reaction cell is provided with a urine outlet, and a modified electrode and a reference electrode of the electrochemical biosensor are arranged on a lower protective jacket end of the urine reaction cell; the output end of the optical biosensor is connected with the input end of the optical fiber spectrometer, the output end of the optical fiber spectrometer is connected with the singlechip, the output end of the electrochemical biosensor is connected with the singlechip, and the output end of the pH meter is connected with the singlechip; and the singlechip is connected with the display circuit. The polypyrrole/platinum nano-hair-based modified porous alumina foil electrode is first prepared, the bipyridyl ruthenium fluorescence quenching reaction-based optical biosensor is then prepared, and finally, the electricity-optics joint urine analysis biochemical system is constructed.

The instant invention provides compositions and methods for determining cell interactions that are faster than conventional methods and that require the use of fewer reagents than conventional methods.

Provided are nanoporous silicon nitride membranes and methods of making such membranes. The membranes can be part of a monolithic structure or free-standing. The membranes can be made by transfer of the nanoporous structure of a nanoporous silicon or silicon oxide film by, for example, reactive ion etching. The membranes can be used in, for example, filtration applications, hemodialysis applications, hemodialysis devices, laboratory separation devices, multi-well cell culture devices, electronic biosensors, optical biosensors, active pre-concentration filters for microfluidic devices.