30 results about "C-type natriuretic peptide" patented technology

A means of measuring and monitoring skeletal growth rate using a plasma analyte, amino-terminal C-type natriuretic peptide (NT-CNP). Plasma NT-CNP concentrations reflect the potential for further growth of the immature skeleton. Measurement of plasma NT-CNP in a subject, when related to the mean of an appropriate age and gender matched set of control subjects, provides an index of the severity of a growth disorder not otherwise available and facilitates diagnosis in children with undetected osteo-chondrodysplasias or other intrinsic disorders of the growth plate. The invention also provides a means of detecting and monitoring potentially harmful effects of drugs and other factors on skeletal growth long before they are evident using current methods in clinical practice.

The disclosure relates to the use of variants of C-type natriuretic peptide (CNP) to treat osteoarthritis, to ameliorate one or more symptoms of osteoarthritis, and to treat disorders having an osteoarthritis component.

The invention provides a method and system for developing and using diagnoses of cancer and sepsis in canine subjects using Thymidine kinase (TK), c-reactive protein (CRP), and C-type natriuretic peptide (CNP) as biomarkers. The level of each biomarker may be measured and an index may be computed using a two- or a three-biomarker method. The invention provides a predefined scale for the index where each range of the index matches a health condition. The latter allows a practitioner, through computing an index value of a patient, to determine the health status of the patient by comparing the index value to the predefined scale.

The invention relates to an application of C-type natriuretic peptide in preparation of an external contraceptive and a sperm function detection reagent. According to research findings, at the time of ovulation, the C-type natriuretic peptide is expressed at the ampulla on the fertilization position of the fallopian tube, and the chemotactic movement of sperms toward ovum can be induced to finish fertilization. If the genital tract of a female mammal is added with certain amount of C-type natriuretic peptide or the C-type natriuretic peptide and the sperms are incubated, the concentration gradient distribution of C-type natriuretic peptide in the fallopian tube is changed, and the sperms cannot make chemotactic movement toward ovum along the concentration gradient so as to block fertilization. Based on the sperm chemotaxis principle, the invention provides an external contraceptive taking endogenous protein C-type natriuretic peptide as an active ingredient. The contraceptive does not cause toxic or side effects or adverse reaction, is suitable for contraception of most women of childbearing age and convenient to use and has a broad application prospect. Moreover, the sperm function detection reagent prepared from the C-type natriuretic peptide is adopted for identifying the sperm quality, the operation is simple, the result is easy to observe, a small semen volume is required, and the sperm function detection reagent is suitable for in-vitro detection of sperm function.

The object of the present invention is to find new effects of natriuretic peptides in an ophthalmological field. The present invention provides eyedrops for promoting lacrimal secretion or for treating keratoconjunctival disorders containing the natriuretic peptide as active ingredient. The natriuretic peptides are atrial natriuretic peptides (ANP), brain natriuretic peptides (BNP) and C-type natriuretic peptides (CNP). Typical examples of the keratoconjunctival disorder are dry eye, corneal erosion and corneal ulcer.

The present disclosure provides for use of variants of C-type natriuretic peptide (CNP), and novel pharmaceutical compositions and formulations comprising CNP variant peptides for the treatment of skeletal dysplasias, one or more symptoms of skeletal dysplasias, such as long bone growth or growth velocity, and other disorders having a skeletal dysplasia and/or CNP-associated symptom or component.