50results about "Sedimentation analysis" patented technology

To provide a technique which enables accurate identification of a target portion of a biological sample to be measured regardless of a label orientation without using a large image capturing mechanism when measuring the biological sample that is stored in a labeled container and separated into multiple component regions.SOLUTION: A biological sample measurement device disclosed herein is configured to identify a midpoint of luminance values of a captured image to identify an upper surface boundary and lower surface boundary of a measurement target portion, and applies a correction amounting to a meniscus width to a position of the identified upper surface boundary.SELECTED DRAWING: Figure 1

Reading device (10) for measuring the erythrocyte sedimentation rate starting from a blood sample consisting of a drop of a few microliters, which exploits capillarity to move the sample.

The visible component detection accommodating device and the detection device comprise a detection part A and a detection part E; the detection part A comprises a cavity A, the cavity A is used for accommodating a sample A, the cavity A is used for shooting a microscopic magnification image of the microscopic examination sample, and the microscopic magnification image is used for visible component analysis; the detection part E comprises a cavity E; the cavity E is used for accommodating a sample E for static layering; the hierarchical information of the sample E is used to calculate the volume of the component in the visible component. The detecting device is matched with the visible component detecting and accommodating device; comprising a microscopic amplification digital imaging assembly and a layered detection assembly, the microscopic magnification digital imaging assembly is used for shooting a microscopic magnification image of the microscopic examination sample; obtaining an image of the sample in the cavity A for visible component analysis; the layering detection assembly is used for obtaining layering information of the sample E.

The invention discloses a POCT (Point of Care Testing) hematology analyzer. In the application, the first bearing position is arranged on the sample injection module to bear the detection card for receiving the first to-be-detected sample, and the second bearing position is arranged on the first detection module to bear the detection card after receiving the first to-be-detected sample, so that the receiving and detection of the first to-be-detected sample are separately carried out at different bearing positions of different modules; the transfer module is arranged at the output end of the driving module of the preprocessing module, so that the driving module can drive the transfer module to transfer the detection card from the first bearing position to the second bearing position after driving the pipetting consumable through the loading module to transfer the first to-be-detected sample into the detection card at the first bearing position; therefore, the driving module is ingeniously used for driving the transfer module, and a driving device special for driving the transfer module is avoided, so that the overall structure of the analyzer is simpler, the production cost is reduced, and the analyzer is more compact and miniaturized in structure.

The present invention relates to a method for acquiring an image of a biological sample in a cuvette.

An apparatus for analysing a sample, the apparatus comprising: a centrifuge rotor having an analysis site suitable for receiving a sample holder having an elongate sample chamber, the analysis site extending between an inner end, which is at a first distance from a centre of rotation of the rotor, and an outer end, which is at a second distance from the centre of rotation of the rotor, the inner end being closer to a centre of rotation of the rotor than the outer end; a carriage having an illumination arrangement and an image sensor; and a drive arrangement operable to drive the carriage along a trajectory with respect to the rotor, the trajectory extending between a first location which is relatively close to the centre of rotation of the rotor, and a second location which is relatively far from the centre of rotation of the rotor, the trajectory extending over at least part of the radial distance between the inner and outer ends of the analysis site; wherein the carriage is operable, at a plurality of locations along the trajectory, to illuminate a part of the analysis site with the illumination arrangement, and to capture an image of at least a portion of the illuminated part of the analysis site with the image sensor.

This invention belongs to the field of DNA detection technology, specifically a holographic dynamic analysis system for blood sedimentation assays. Addressing the limitation of existing systems that cannot simultaneously acquire high-dimensional dynamic phenotypic information (such as three-dimensional cell movement trajectories and instantaneous morphology) and corresponding molecular information (such as pathogen DNA and gene characteristics obtained through DNA detection) of the blood sedimentation process, and thus achieve automated correlation and intelligent interpretation between the two, thereby restricting the system's ability to directly infer microscopic etiologies from macroscopic sedimentation phenomena, this invention proposes the following solution. It includes a sample loading module connected to a sedimentation sample pool module. Through holographic dynamic three-dimensional analysis, simultaneous nucleic acid extraction and DNA detection, and multimodal AI fusion, this invention achieves correlation analysis and intelligent diagnosis of the blood sedimentation process from macroscopic dynamics to microscopic molecular mechanisms, significantly improving the system's ability to infer etiologies and support clinical decision-making.

This invention provides a means to obtain more clinically useful information when analyzing particles contained in blood samples using metachromatic positive dyes. In a particle analysis method for analyzing particles contained in blood samples, particles are stained with a metachromatic positive dye; the stained particles are irradiated with light; the intensity of a first fluorescence from the stacking component of the metachromatic positive dye and the intensity of a second fluorescence from the embedded component of the metachromatic positive dye are measured, the first and second fluorescence being emitted by each particle contained in the blood sample; the intensities of the first and second fluorescence emitted by each particle are normalized according to the size of each particle to obtain the fluorescence concentration of each of the first and second fluorescence in each particle; in a two-dimensional plot of the normalized fluorescence concentrations, each particle is clustered into multiple particle clusters, including at least two of erythrocyte clusters, platelet clusters, and nucleated cell clusters; and a histogram is created where the intensity of the first fluorescence is a histogram of the RNA amount of the class and the intensity of the second fluorescence is a histogram of the DNA amount of the class included in at least one of the multiple particle clusters.

Devices and methods of the disclosure use an intravascular catheter with deployable sealing elements to create a fluid trap around an outlet of a lymphatic duct and drain lymph passively to a collection vessel that may be pressurized to a predetermined pressure or a partial vacuum. Due to the fixed pressure, the device creates a low-pressure area at the lymphatic duct, which drains lymph passively without any mechanical pump or impeller. In certain aspects, a device includes a catheter for insertion into a vein of the venous angle of a patient, with proximal and distal sealing elements deployable to seal the vein to thereby define a fluid trap around the lymphatic outlet. A port within the fluid trap opens to a drainage lumen extending along the catheter to a collection vessel. The device may be configured such that the drainage lumen passively drains the fluid trap into the collection vessel.

Disclosed are methods, materials and devices for approximation of blood volume in a fluid, such as in a biological fluid collected during a surgical procedure. The method and devices may include the use of an RBC flocculant, for example polyDADMAC, and an approximate blood hematocrit from the type of animal blood being evaluated, as well as a calculated RBC packing ratio corresponding to the collection device being used. Also provided is a Blood Indicator Panel (BIP), comprising a series of markings calculated from an observed red blood settlement volume, the average animal blood hematocrit, and a calculated RBC packing ratio “η” value for the collection device. A collection device with a BIP is disclosed. Pediatric (about 200 ml or 250 ml size container), adult human (about 1,000 ml-1,500 ml) and veterinary (about 500 ml-2,500 ml) collection containers are also disclosed, that include a RBC flocculant, for use in approximating blood volume in a fluid.

A cuvette 300 suitable for use in analysis of biological samples comprises a collection chamber 340 and an analysis chamber 350, wherein 1-60% (parts 310, 330) of the surface area of the analysis cham

Systems and methods are provided for controlling the location of an interface between separated blood components within a centrifuge. An optical monitoring assembly determines the current position of the interface, with the current position and a plurality of input parameters being transmitted from a controller to a neural network. The neural network employs artificial intelligence techniques to analyze the current interface position and at least one of the input parameters to determine a modification to be made to at least one procedural parameter so as to move the interface from its current position to a target position. The neural network transmits a signal that is indicative of the modification to the controller, which implements the modification so as to move the interface toward the target position, with the modification being to an inflow rate, a centrifuge rotation rate, an outflow rate, and / or the location of the target interface position.

The invention discloses a blood precipitation and hematocrit integrated detection device for clinical examination, which comprises a device main body, a control panel is arranged on the front side of the device main body, and a touch screen is arranged on the control panel; an air inlet grille is arranged on the side surface of the device main body; the device main body is provided with a placing groove, the test plate is installed in the placing groove, and the test plate is provided with a plurality of detection channels distributed in a rectangular array; the sealing cover is in sealing connection with the placing groove, and the sealing cover covers the detection channel; the upper side of the sealing cover is connected with an upper-layer cover, the top of the inner side of the upper-layer cover is detachably provided with an ultraviolet lamp through a mounting buckle, the outer side of the upper-layer cover is provided with a power supply box, and the power supply box is electrically connected with the ultraviolet lamp. The erythrocyte sedimentation hematocrit detection device is provided with the cleaning device, the interior of the detection channel is automatically sterilized, disinfected and cleaned in an air blowing mode through cooperation of an ultraviolet lamp and air blowing, manual cleaning is not needed, operation is easy and convenient, and use is more convenient and faster.

A non-contact Widmannstatten method erythrocyte sedimentation rate detection device comprises a detection box, the detection box comprises an upper box body and a lower box body, the upper box body is located above the lower box body, the rear side and the left side of the top of the lower box body are connected to the bottom face of the upper box body through vertical plates respectively, and a space between the upper box body and the lower box body forms an erythrocyte sedimentation rate detection area; in conclusion, the device disclosed by the utility model solves some key problems in the traditional Widmannstatten erythrocyte sedimentation rate detection method, such as infection risk, low operation efficiency and high starting difficulty in a blood sample treatment process, and by introducing the concept of an automatic and closed system, the device not only improves the safety and convenience of operation, but also improves the detection accuracy of the Widmannstatten erythrocyte sedimentation rate. And the cleanness and disinfection of the experimental environment are ensured.

The invention discloses efficient and portable plateau study index detection equipment and a using method thereof.The efficient and portable plateau study index detection equipment comprises a micro-fluidic chip, a blood sampling device and a portable detector, and the micro-fluidic chip is provided with a three-electrode system used for collecting sample detection signals; a hematocrit detection module, an oxyhemoglobin saturation detection module, a control and processing module and a display and interaction module are arranged in the portable detector; the three-electrode system is connected to a receiving end of the hematocrit detection module through an electric signal; the blood collection device comprises a shell, a blood collection microneedle clamped in the shell and a blood storage device inserted and slidably connected into the shell, the blood collection end of the blood collection microneedle is located outside the shell, the blood discharge end of the blood collection microneedle is located in the shell, and the blood storage device can communicate with the blood discharge end of the blood collection microneedle. According to the invention, hematocrit detection is not limited by sites, and detection of two indexes of hematocrit detection and oxyhemoglobin saturation detection can be easily completed, so that response measures can be rapidly and accurately formulated.

A method of analyzing a blood sample from a subject includes loading the blood sample into a single chamber; acquiring, via an imaging system, a stack of serial focal plane images of the blood sample from a plurality of fields of view of the chamber; creating a virtual three dimensional image of the blood sample from selected ones of the stacks of serial focal plane images; and analyzing the virtual three dimensional image to identify blood formed elements within the blood sample. Identifying blood formed elements within the blood sample may include identifying a type and amount of white blood cells, and / or identifying an amount of red blood cells and / or hematocrit, and / or identifying an amount of platelets. Identifying blood formed elements within the blood sample may include determining numbers and percentage by volume in the blood sample of one or more types of white blood cells.

The utility model discloses a blood layer detection device and a centrifugal cup, which comprise a centrifugal support arranged at the bottom, a fixed cylinder extending outwards along the circumferential edge of the centrifugal support, a top cover assembly at least partially embedded in one side, far away from the centrifugal support, of the fixed cylinder, and a blood layer detection assembly sleeved in the circumferential direction of the fixed cylinder and close to one side of the top cover assembly, the blood layer detection assembly comprises a sleeving and fixing cylinder arranged in the circumferential direction of the fixing cylinder in a sleeving mode, a transverse fixing piece fixedly arranged on the side, away from the fixing cylinder, of the sleeving and fixing cylinder, an infrared light sensor arranged on the transverse fixing piece and used for detecting a blood layer, and a transverse shielding block arranged on the surrounding edge of the infrared light sensor in a sleeving mode. The blood layer detection assembly is additionally arranged on the surface of the fixed cylinder, infrared rays with the wavelength being 650 nm are emitted through the outer light sensor and accurately irradiate the preset liquid level height of the centrifugal inner cylinder, and the centrifugal liquid level detection device has the advantages of being easy and convenient to operate, low in cost, high in detection precision and the like.

The utility model discloses a blood sedimentation detection frame belongs to medical detection equipment technical field, include: blood sedimentation tube, rotating base, blood sedimentation observation frame, assembly structure and flatness adjusting structure, the blood sedimentation tube is by transparent test tube and can dismantle and install rubber test tube cap at the top of transparent test tube constitution, the rotating base contains the horizontal setting cylindrical support seat, the upper surface center position of support seat is equipped with the round groove, the round groove is rotated and is installed with the carousel through the bearing, the inside setting of support seat has the drive assembly of drive carousel rotation. The utility model discloses a blood sedimentation detection frame has the following advantages: utilize test tube insertion groove and test tube avoidance groove and can preliminarily position blood sedimentation tube, the cooperation of the inside diameter of clamping cylinder and rubber test tube cap, the sustained elastic compensation of cooperation tension spring, effectively eliminates the angle deviation problem existing in traditional clamping slot type positioning, test tube keeps absolute vertical, ensures the authenticity of red blood cell sedimentation trajectory.

The invention discloses a POCT (Point of Care Testing) hematology analyzer. In the application, a first bearing position is arranged on a sample introduction module and used for bearing a detection card, a second bearing position is arranged on a first detection module and used for bearing the detection card, and a first sample to be detected is transferred into the detection card located at the first bearing position through a pretreatment module; and transferring the detection card receiving the first to-be-detected sample at the first bearing position to the second bearing position through a transfer module, and detecting the settled first to-be-detected sample in the detection card at the second bearing position through the microscope unit, therefore, each detection card receives the first to-be-detected sample and the detection of the first to-be-detected sample after settlement is carried out at different bearing positions, so that the detection efficiency of the POCT hematology analyzer can be effectively improved.

A manual device (10) for measuring the erythrocyte sedimentation rate from a drop of blood taken from a finger prick, comprises a containment body (11), a reading chamber (20) located inside the containment body (11) and comprising a radiation emitter (40) and a corresponding radiation detector (50), and a fluidic channel (22), which extends from an inlet aperture (23), made through between the radiation emitter (40) and receiver (50), and configured to receive a blood sample consisting of a drop of a few microliters. The manual device (10) can be part of a kit.

An automatic analyzer capable of confirming the amount of sample aspirated by a sample dispensing unit is provided. The automatic analyzer includes an incubator which holds a reaction container in which a liquid mixture of the sample and a reagent is accommodated, a sample dispensing unit which dispenses the sample by aspirating the sample from a sample container in which the sample is accommodated and storing the aspirated sample in a storage portion and then discharging the sample to the reaction container, and a measurement portion which measures the amount of sample in the storage portion on the basis of a detected signal obtained by detecting light passing through the storage portion while irradiating the storage portion with light.

Manual device (10) for measuring the erythrocyte sedimentation rate comprising a reading chamber (20) containing a radiation emitter (22) and a corresponding radiation receiver (23), facing each other, and a fluidic channel (21) configured to receive a blood sample and made through between the emitter (22) and the receiver (23).

The utility model relates to a detection device capable of correcting hematocrit. The detection device comprises a dry chemical test paper clamping shell upper cover, hematocrit detection test paper, dry chemical test paper and a dry chemical test paper clamping shell lower cover, the hematocrit detection test paper comprises a double faced adhesive tape, a hydrophilic film, a double faced adhesive tape, a hematocrit detection electrode and a double faced adhesive tape from top to bottom; the dry chemical test paper clamping shell upper cover comprises a sample adding hole; and the lower cover of the dry chemical test paper clamping shell comprises a detection hole.

A device for spreading or staining and for determining a sedimentation rate comprises a first group (4) arranged to collect a blood sample from a tube and to produce a smear of this sample, and a second group (6) arranged to collect a blood sample from a tube and to carry out a sedimentation rate determination. The device comprises at least one sampling member (8) controllable for an operation by the first group (4) and an operation by the second group (6) for taking a blood sample so that a sample taken for the first group (4) is not used by the second group (6), and that a sample taken for the second group (6) is not used by the first group (4), the second group (6) being provided with a sensor (20) comprising an infrared light source (12) and an optical sensor (14) which are arranged substantially opposite each other around a tube (16) connected to an outlet end of the at least one sampling member (8) so that the light emitted by the infrared light source (12) reaches the optical sensor (14) after passing through said tube (16). The device further comprises a converter (10) arranged to receive one or more light-transmission measurements from the optical sensor (14) and to determine a sedimentation rate.

A method of inspecting a clinical specimen for a presence of one or more interferents, such as those that might be found within clinical analytical blood specimens by subjecting the specimen to centrifugation to separate the specimen into a red blood cell portion and a blood serum or plasma portion is provided. Subsequent to the centrifuging procedure, the serum or plasma portion of the clinical analytical specimen may be tested for the presence of one or more interferents such as hemolysis, icterus, lipemia, or liquid nonuniformities therein. Additionally, physical dimensional characteristics of the sample container and / or specimen may be determined. Apparatus for carrying out the method are described, as are other aspects.

Disclosed are methods, materials and devices for approximation of blood volume in a fluid, such as in a biological fluid collected during a surgical procedure. The method and devices include the use of a RBC flocculant, such as polyDADMAC, and an approximate blood hematocrit for the type of animal, as well as a calculated RBC packing ratio corresponding to the collection device being used. Also provided is a Blood Indicator Panel (BIP), comprising a series of markings calculated from an observed red blood settlement volume, the average animal type hematocrit, and a calculated RBC packing ratio “η” value for the collection device. Pediatric (about 200 ml or 250 ml size container), adult human (about 1,000 ml-1,500 ml) and veterinary (about 500 ml-2,500 ml) collection containers are also disclosed, that include a RBC flocculant, for use in approximating blood volume in a fluid.

The utility model discloses a quantitative sample adding device for erythrocyte sedimentation rate detection samples, which comprises a support component for fixing the quantitative sample adding device, a movable horizontal moving component and a vertical moving component are fixedly mounted on the upper surface of the support component, and a quantitative sampling component is mounted at the bottom of the vertical moving component in a driving manner; the vertical moving assembly comprises a second mounting plate, the second mounting plate and an electric push rod are mounted through bolts, a sliding rail is mounted on the upper surface of the second mounting plate through bolts, a servo motor is fixedly mounted at the top end of the second mounting plate, a supporting seat is fixedly mounted at the bottom end of the second mounting plate, and a threaded rod is arranged at the driving end of the servo motor. The threaded rod is in threaded installation with the top of the installation block, and a quantitative sampling assembly is fixedly installed at the bottom of the installation block. Through accurate control of the servo motor and the electric push rod, quantitative suction and discharge of a sample are realized, automatic operation is realized in the whole sample adding process, and the problems of blood dripping and sample pollution in the manual operation process are avoided.