166results about "Sedimentation analysis" patented technology

The invention relates to a detection device capable of correcting hematocrit and a measurement method thereof. The detection device comprises a dry chemical test paper clamping shell upper cover, hematocrit detection test paper, dry chemical test paper and a dry chemical test paper clamping shell lower cover, the hematocrit detection test paper comprises a double faced adhesive tape, a hydrophilic film, a double faced adhesive tape, a hematocrit detection electrode and a double faced adhesive tape from top to bottom; the dry chemical test paper clamping shell upper cover comprises a sample adding hole; and the lower cover of the dry chemical test paper clamping shell comprises a detection hole. According to the invention, the test paper for detecting the hematocrit by the impedance method is adhered to the upper cover of the card shell of the dry chemical test paper and is attached to the dry chemical test paper, so that the dry chemical test paper detection and the hematocrit detection can be realized, and the dry chemical test paper detection result is corrected according to the hematocrit detection result. And a specific detection and correction method is adopted, so that the influence of hematocrit on a detection result is reduced to the greatest extent.

A device for spreading or colouring and for determining a sedimentation rate comprises a first group (4) arranged so as to sample a blood sample from a tube and to carry out a smear test on this sample, and a second group (6) arranged so as to sample a blood sample from a tube and to carry out a sedimentation rate determination. The device comprises at least one sampling member (8) which could be controlled for an operation by the first group (4) and an operation by the second group (6) for sampling a blood sample so that a sample sampled for the first group (4) is not used by the second group (6), and that a sample sampled for the second group (6) is not used by the first group (4), the second group (6) being provided with a sensor (20) comprising an infrared light source (12) and an optical sensor (14) arranged substantially opposite one another around a tube (16) connected to an outlet end of the at least one sampling member (8) so that the light emitted by the infrared light source (12) reaches the optical sensor (14) after having crossed said tube (16). This device further comprises a converter (10) arranged so as to receive one or more light-transmission measurement(s) from the optical sensor (14) and to determine a sedimentation rate.

The invention relates to the technical field of biochemical detection, and discloses a blood analysis system and method and a controller. In the blood analysis system, a sample introduction module comprises a sample storage container and a sample introduction driving device mounted on a sample introduction pipeline; a detection space is arranged on the sample cell assembly; the sample discharging module comprises a recovery container and a sample discharging driving device mounted on a sample discharging pipeline; the recovery container is communicated with the sample storage container through the detection space; the blood analysis module is mounted on the sample pool assembly; after the to-be-analyzed blood sample is driven by the sample injection driving device to enter the detection space from the sample storage container and the detection space is filled with the to-be-analyzed blood sample, the blood analysis module is controlled to perform blood analysis on the blood sample in the detection space according to preset analysis setting parameters, and a blood analysis result is obtained; and the blood sample in the detection space is driven to be output into the recovery container through the sample output driving device. According to the invention, batch continuous detection of blood samples can be realized, and blood analysis stability and blood analysis efficiency are improved.

To provide a technique which enables accurate identification of a target portion of a biological sample to be measured regardless of a label orientation without using a large image capturing mechanism when measuring the biological sample that is stored in a labeled container and separated into multiple component regions.SOLUTION: A biological sample measurement device disclosed herein is configured to identify a midpoint of luminance values of a captured image to identify an upper surface boundary and lower surface boundary of a measurement target portion, and applies a correction amounting to a meniscus width to a position of the identified upper surface boundary.SELECTED DRAWING: Figure 1

Reading device (10) for measuring the erythrocyte sedimentation rate starting from a blood sample consisting of a drop of a few microliters, which exploits capillarity to move the sample.

A system (1) for the analysis of blood samples is described, comprising at least one detection unit (4) configured to perform optical absorption measurements on a blood sample contained in a tube (P), moving means (4m) configured to cause a relative movement between the detection unit (4) and the tube (P), and a processing unit (C); the processing unit (C) is suitably configured to command the execution, by the detection unit (4), of at least two distinct optical absorption measurements on the blood sample, wherein, in each measurement, the processing unit (C) is programmed to set respective parameters of the detection unit (4), said parameters being different from measurement to measurement; to create, for each of said distinct measurements, a reading curve (L) corresponding to the absorption of radiation emitted by the detection unit (4) as a function of the relative movement between said detection unit (4) and the tube (P); to perform a comparison of the distinct reading curves based on one or more references; to select, based on said comparison, a single reading curve (Lopt) among said distinct reading curves, and to estimate desired measurement parameters, such as for example parameters for the measurement of erythrocyte sedimentation rate, starting from said selected single reading curve (Lopt).

A system for measuring erythrocyte sedimentation rates in blood samples is described having a support for a tube containing a blood sample, an agitating element to agitate the tube, a detection unit to perform an optical measurement on the blood sample, moving means to cause movement between the detection unit and the tube during the optical measurement, and a processing unit to process signals from the detection unit. The processing unit creates a reading curve corresponding to the absorption of radiation emitted by the detection unit as a function of the relative movement between the detection unit and the tube and defines an ideal trapezoidal curve to approximate the reading curve to generate an optimized ideal curve, and generate a value indicative of the erythrocyte sedimentation rate of the blood sample in the tube. The system also includes output means to output measurement results based on the generated values.

Device and method for determining sedimentation rate A device for determining sedimentation rate comprises at least one member (8) for collecting a blood sample, and a sensor (20) comprising an infrared light source (12) and an optical sensor (14) arranged substantially opposite each other around a substantially transparent portion (16) of the sampling member (8) so that the light emitted by the infrared light source (12) reaches the optical sensor (14) after passing through said substantially transparent portion (16). The optical sensor (14) is arranged to carry out a blank measurement, the device further comprising a converter (10) arranged to receive one or more light transmission measurements from the optical sensor (14), to calculate the ratio between the blank measurement and the one or more light transmission measurements and to return a sedimentation rate. Fig.1

The visible component detection accommodating device and the detection device comprise a detection part A and a detection part E; the detection part A comprises a cavity A, the cavity A is used for accommodating a sample A, the cavity A is used for shooting a microscopic magnification image of the microscopic examination sample, and the microscopic magnification image is used for visible component analysis; the detection part E comprises a cavity E; the cavity E is used for accommodating a sample E for static layering; the hierarchical information of the sample E is used to calculate the volume of the component in the visible component. The detecting device is matched with the visible component detecting and accommodating device; comprising a microscopic amplification digital imaging assembly and a layered detection assembly, the microscopic magnification digital imaging assembly is used for shooting a microscopic magnification image of the microscopic examination sample; obtaining an image of the sample in the cavity A for visible component analysis; the layering detection assembly is used for obtaining layering information of the sample E.

The present invention relates to reduction of erythrocyte sedimentation rate in a blood sample. In particular, formulations, compositions, articles of manufacture, kits and methods for reduced erythrocyte sedimentation rate in a blood sample are provided.

The invention discloses a POCT (Point of Care Testing) hematology analyzer. In the application, the first bearing position is arranged on the sample injection module to bear the detection card for receiving the first to-be-detected sample, and the second bearing position is arranged on the first detection module to bear the detection card after receiving the first to-be-detected sample, so that the receiving and detection of the first to-be-detected sample are separately carried out at different bearing positions of different modules; the transfer module is arranged at the output end of the driving module of the preprocessing module, so that the driving module can drive the transfer module to transfer the detection card from the first bearing position to the second bearing position after driving the pipetting consumable through the loading module to transfer the first to-be-detected sample into the detection card at the first bearing position; therefore, the driving module is ingeniously used for driving the transfer module, and a driving device special for driving the transfer module is avoided, so that the overall structure of the analyzer is simpler, the production cost is reduced, and the analyzer is more compact and miniaturized in structure.

A method of analyzing a blood sample from a subject includes loading the blood sample into a single chamber; acquiring, via an imaging system, a stack of serial focal plane images of the blood sample from a plurality of fields of view of the chamber; creating a virtual three dimensional image of the blood sample from selected ones of the stacks of serial focal plane images; and analyzing the virtual three dimensional image to identify blood formed elements within the blood sample. Identifying blood formed elements within the blood sample may include identifying a type and amount of white blood cells, and / or identifying an amount of red blood cells and / or hematocrit, and / or identifying an amount of platelets. Identifying blood formed elements within the blood sample may include determining numbers and percentage by volume in the blood sample of one or more types of white blood cells.

An apparatus for diffusion or staining and determination of sedimentation rate, comprising a first group (4) arranged to sample and perform a smear test on a blood sample in a test tube, and a second group (6) arranged to sample and perform a sedimentation rate determination on a blood sample in a test tube. The apparatus comprises at least one sampling member (8) which is controllable by said first group (4) and by said second group (6) to sample a blood sample, such that the sample taken for said first group (4) is not used by said second group (6) and the sample taken for said second group (6) is not used by said first group (4), said second group (6) being equipped with a sensor (20) comprising an infrared light source (12) and an optical sensor (14), said infrared light source (12) and said optical sensor (14) being arranged substantially opposite each other around a test tube (16) connected to an output of said at least one sampling member (8), such that light emitted by said infrared light source (12) reaches said optical sensor (14) after passing through said test tube (16). The apparatus further comprises a converter (10) arranged to receive one or more light transmission measurements from the optical sensor (14) and determine a sedimentation rate.

An object of the disclosure is to provide a technique in which when measuring a biological sample stored in a container, to which a label is attached, and separated into a plurality of component regions, a target portion that is a measurement target can be accurately specified regardless of an orientation of the label without using a large-sized imaging mechanism. A biological sample measuring device according to the disclosure specifies an upper surface boundary and a lower surface boundary of a measurement target portion by specifying an intermediate point of luminance values of a captured image, and applies a correction amount of a meniscus width to a position of the specified upper surface boundary (see FIG. 1).

To provide methods, instruments, and devices for approximation of blood volume in a fluid, such as in a biological fluid collected during a surgical procedure.SOLUTION: The methods and the devices include the use of a RBC flocculant, such as polyDADMAC, and an approximate blood hematocrit for the type of animal, as well as a calculated RBC packing ratio corresponding to the collection device being used. Also provided is a Blood Indicator Panel (BIP), comprising a series of markings calculated from an observed red blood settlement volume, the average animal type hematocrit, and a calculated RBC packing ratio "η" value for the collection device. Pediatric (about 200 ml-250 ml), adult human (about 1,000 ml-1,500 ml), and veterinary (about 500 ml-2,500 ml) collection containers are also disclosed, that include a RBC flocculant, for use in approximating blood volume in a fluid.SELECTED DRAWING: Figure 18

The utility model provides a novel Westernstatten method erythrocyte sedimentation stand which is a cube. The novel Westernstatten method erythrocyte sedimentation stand comprises a base, wherein four adjusting screws are arranged below the base; the two sides and the back face of the upper portion of the base are each provided with a vertical supporting plate, and the whole blood sedimentation frame is firm and not prone to shaking due to the two layers of horizontal supporting plates. 50 punched fixing holes are formed in each layer of horizontal supporting plate; hole grooves corresponding to the fixing holes of the horizontal supporting plate are formed in the base, and the depth of the hole grooves is half of the thickness of the base. The fixing holes in the top-layer horizontal supporting plate are numbered from 1 to 50, a gradienter is arranged in the middle of the top-layer horizontal supporting plate, and the blood sedimentation frame is made of an acrylic material, so that the blood sedimentation frame is conveniently soaked and cleaned by a disinfectant; the double-layer horizontal supporting plate is arranged to ensure that the erythrocyte sedimentation tube can be perpendicular to the erythrocyte sedimentation frame and the result is accurate and reliable.

A specimen information detection device and a specimen information detection method are provided, which can detect the state of a specimen with high accuracy and efficiency. The specimen information detection device according to the embodiment comprises: a photographing device that photographs a specimen container containing a specimen; a lighting device that irradiates the specimen container with light from a direction intersecting with the photographing direction during the photographing; and an information processing unit that detects the state inside the specimen container through image processing based on image information of the specimen container acquired by photographing the specimen container.

The present invention relates to a method for acquiring an image of a biological sample in a cuvette.

A device for performing a full blood count and for determining a sedimentation rate comprises a first group (4) arranged to collect a blood sample from a tube and to carry out a full blood count on this sample, characterized in that it comprises a second group (6) arranged to take a blood sample from a tube and to carry out a sedimentation rate determination. This device comprises at least one sampling member (8) controllable for a measurement by the first group (4) and a measurement by the second group (6) for taking a blood sample so that a sample taken for the first group (4) is not used by the second group (6), and that a sample taken for the second group (6) is not used by the first group (4), the second group (6) being provided with a sensor (20) comprising an infrared light source (12) and an optical sensor (14) which are arranged substantially opposite each other around a tube (16) connected to an outlet end of the at least one sampling member (8) so that the light emitted by the infrared light source (12) reaches the optical sensor (14) after passing through said tube (16). The device further comprises a converter (10) arranged to receive one or more light-transmission measurements from the optical sensor (14) and to determine a sedimentation rate.

A container (30) is provided with an isolation chamber (33), a collection chamber (34), a waste liquid chamber (35), a siphon flow path (33a), and a siphon flow path (34a). The isolation chamber (33) holds a specific gravity adjusting agent (L2) and blood (L1), which have been layered. The collection chamber (34) holds a centrifuged mononuclear cell layer (L4), some of the specific gravity adjusting agent (L2), and plasma (L5), and allows the mononuclear cell layer (L4) to settle in a liquid after being suspended. The waste liquid chamber (35) holds the supernatant liquid of the suspension as waste liquid. The siphon flow path (33a) connects the isolation chamber (33) and the collection chamber (34), and uses siphoning to send a liquid containing the mononuclear cell layer (L4). The siphon flow path (34a) connects the collection chamber (34) and the waste liquid chamber (35), and uses siphoning to send the waste liquid.

An apparatus for performing a complete blood count and determining a sedimentation rate, comprising a first group (4) arranged to sample a blood sample from a tube and perform a complete blood count on said sample, and a second group (6) arranged to sample a blood sample from the tube and perform a sedimentation rate determination, the apparatus comprising at least one sampling member (8) which can be controlled for measurements by the first group (4) and by the second group (6) to sample a blood sample such that a sample sampled for the first group (4) is not used by the second group (6) and a sample sampled for the second group (6) is not used by the first group (4), the second group (6) being provided with a sensor (20) having an infrared light source (12) and an optical sensor (14) arranged substantially opposite each other around a tube (16) connected to an output end of the at least one sampling member (8), such that light emitted by the infrared light source (12) reaches the optical sensor (14) after traversing the tube (16). The apparatus further comprises a converter (10) arranged to receive one or more light transmission measurements from the optical sensor (14) and determine a sedimentation velocity.

A device for determining a sedimentation rate comprises at least one member (8) for sampling a blood sample, and a sensor (20) comprising an infrared light source (12) and an optical sensor (14) arranged substantially opposite each other around a substantially transparent portion (16) of the sampling member (8) so that the light emitted by the infrared light source (12) reaches the optical sensor (14) after having passed through said substantially transparent portion (16). The optical sensor (14) is arranged so as to carry out a blank measurement, the device further comprising a converter (10) arranged so as to receive one or more light transmission measurement(s) from the optical sensor (14), to calculate the ratio between the blank measurement and the one or more light transmission measurement(s) and to return a sedimentation rate.

An apparatus for analysing a sample, the apparatus comprising: a centrifuge rotor having an analysis site suitable for receiving a sample holder having an elongate sample chamber, the analysis site extending between an inner end, which is at a first distance from a centre of rotation of the rotor, and an outer end, which is at a second distance from the centre of rotation of the rotor, the inner end being closer to a centre of rotation of the rotor than the outer end; a carriage having an illumination arrangement and an image sensor; and a drive arrangement operable to drive the carriage along a trajectory with respect to the rotor, the trajectory extending between a first location which is relatively close to the centre of rotation of the rotor, and a second location which is relatively far from the centre of rotation of the rotor, the trajectory extending over at least part of the radial distance between the inner and outer ends of the analysis site; wherein the carriage is operable, at a plurality of locations along the trajectory, to illuminate a part of the analysis site with the illumination arrangement, and to capture an image of at least a portion of the illuminated part of the analysis site with the image sensor.

This invention belongs to the field of DNA detection technology, specifically a holographic dynamic analysis system for blood sedimentation assays. Addressing the limitation of existing systems that cannot simultaneously acquire high-dimensional dynamic phenotypic information (such as three-dimensional cell movement trajectories and instantaneous morphology) and corresponding molecular information (such as pathogen DNA and gene characteristics obtained through DNA detection) of the blood sedimentation process, and thus achieve automated correlation and intelligent interpretation between the two, thereby restricting the system's ability to directly infer microscopic etiologies from macroscopic sedimentation phenomena, this invention proposes the following solution. It includes a sample loading module connected to a sedimentation sample pool module. Through holographic dynamic three-dimensional analysis, simultaneous nucleic acid extraction and DNA detection, and multimodal AI fusion, this invention achieves correlation analysis and intelligent diagnosis of the blood sedimentation process from macroscopic dynamics to microscopic molecular mechanisms, significantly improving the system's ability to infer etiologies and support clinical decision-making.

The invention relates to the technical field of biomedical treatment, and discloses an erythrocyte sedimentation rate detection device and method and a storage medium, the erythrocyte sedimentation rate detection device comprises a controller, a sample introduction container, an optical detection instrument and a sample container provided with a sample pool communicated with the sample introduction container, the sample container is installed on the optical detection instrument, and the optical detection instrument is connected with the controller. The optical detection instrument comprises an optical measurement assembly and a movable light source assembly, the light source assembly and the optical measurement assembly are arranged on the two opposite sides of the sample cell respectively, the controller is connected with the optical measurement assembly and the light source assembly, and first light source information of light at the first height position is obtained through the optical detection instrument; and moving the optical detection instrument to obtain second light source information of the light at the second height position, and determining a sedimentation rate detection result of the to-be-detected blood according to the first light source information and the second light source information. The blood sedimentation rate detection efficiency is improved, and the accuracy of collected data is improved.