122results about "Sedimentation analysis" patented technology

The invention relates to the technical field of biochemical detection, and discloses a blood analysis system and method and a controller. In the blood analysis system, a sample introduction module comprises a sample storage container and a sample introduction driving device mounted on a sample introduction pipeline; a detection space is arranged on the sample cell assembly; the sample discharging module comprises a recovery container and a sample discharging driving device mounted on a sample discharging pipeline; the recovery container is communicated with the sample storage container through the detection space; the blood analysis module is mounted on the sample pool assembly; after the to-be-analyzed blood sample is driven by the sample injection driving device to enter the detection space from the sample storage container and the detection space is filled with the to-be-analyzed blood sample, the blood analysis module is controlled to perform blood analysis on the blood sample in the detection space according to preset analysis setting parameters, and a blood analysis result is obtained; and the blood sample in the detection space is driven to be output into the recovery container through the sample output driving device. According to the invention, batch continuous detection of blood samples can be realized, and blood analysis stability and blood analysis efficiency are improved.

To provide a technique which enables accurate identification of a target portion of a biological sample to be measured regardless of a label orientation without using a large image capturing mechanism when measuring the biological sample that is stored in a labeled container and separated into multiple component regions.SOLUTION: A biological sample measurement device disclosed herein is configured to identify a midpoint of luminance values of a captured image to identify an upper surface boundary and lower surface boundary of a measurement target portion, and applies a correction amounting to a meniscus width to a position of the identified upper surface boundary.SELECTED DRAWING: Figure 1

Reading device (10) for measuring the erythrocyte sedimentation rate starting from a blood sample consisting of a drop of a few microliters, which exploits capillarity to move the sample.

A system for measuring erythrocyte sedimentation rates in blood samples is described having a support for a tube containing a blood sample, an agitating element to agitate the tube, a detection unit to perform an optical measurement on the blood sample, moving means to cause movement between the detection unit and the tube during the optical measurement, and a processing unit to process signals from the detection unit. The processing unit creates a reading curve corresponding to the absorption of radiation emitted by the detection unit as a function of the relative movement between the detection unit and the tube and defines an ideal trapezoidal curve to approximate the reading curve to generate an optimized ideal curve, and generate a value indicative of the erythrocyte sedimentation rate of the blood sample in the tube. The system also includes output means to output measurement results based on the generated values.

Device and method for determining sedimentation rate A device for determining sedimentation rate comprises at least one member (8) for collecting a blood sample, and a sensor (20) comprising an infrared light source (12) and an optical sensor (14) arranged substantially opposite each other around a substantially transparent portion (16) of the sampling member (8) so that the light emitted by the infrared light source (12) reaches the optical sensor (14) after passing through said substantially transparent portion (16). The optical sensor (14) is arranged to carry out a blank measurement, the device further comprising a converter (10) arranged to receive one or more light transmission measurements from the optical sensor (14), to calculate the ratio between the blank measurement and the one or more light transmission measurements and to return a sedimentation rate. Fig.1

The visible component detection accommodating device and the detection device comprise a detection part A and a detection part E; the detection part A comprises a cavity A, the cavity A is used for accommodating a sample A, the cavity A is used for shooting a microscopic magnification image of the microscopic examination sample, and the microscopic magnification image is used for visible component analysis; the detection part E comprises a cavity E; the cavity E is used for accommodating a sample E for static layering; the hierarchical information of the sample E is used to calculate the volume of the component in the visible component. The detecting device is matched with the visible component detecting and accommodating device; comprising a microscopic amplification digital imaging assembly and a layered detection assembly, the microscopic magnification digital imaging assembly is used for shooting a microscopic magnification image of the microscopic examination sample; obtaining an image of the sample in the cavity A for visible component analysis; the layering detection assembly is used for obtaining layering information of the sample E.

The present invention relates to reduction of erythrocyte sedimentation rate in a blood sample. In particular, formulations, compositions, articles of manufacture, kits and methods for reduced erythrocyte sedimentation rate in a blood sample are provided.

The invention discloses a POCT (Point of Care Testing) hematology analyzer. In the application, the first bearing position is arranged on the sample injection module to bear the detection card for receiving the first to-be-detected sample, and the second bearing position is arranged on the first detection module to bear the detection card after receiving the first to-be-detected sample, so that the receiving and detection of the first to-be-detected sample are separately carried out at different bearing positions of different modules; the transfer module is arranged at the output end of the driving module of the preprocessing module, so that the driving module can drive the transfer module to transfer the detection card from the first bearing position to the second bearing position after driving the pipetting consumable through the loading module to transfer the first to-be-detected sample into the detection card at the first bearing position; therefore, the driving module is ingeniously used for driving the transfer module, and a driving device special for driving the transfer module is avoided, so that the overall structure of the analyzer is simpler, the production cost is reduced, and the analyzer is more compact and miniaturized in structure.

A method of analyzing a blood sample from a subject includes loading the blood sample into a single chamber; acquiring, via an imaging system, a stack of serial focal plane images of the blood sample from a plurality of fields of view of the chamber; creating a virtual three dimensional image of the blood sample from selected ones of the stacks of serial focal plane images; and analyzing the virtual three dimensional image to identify blood formed elements within the blood sample. Identifying blood formed elements within the blood sample may include identifying a type and amount of white blood cells, and / or identifying an amount of red blood cells and / or hematocrit, and / or identifying an amount of platelets. Identifying blood formed elements within the blood sample may include determining numbers and percentage by volume in the blood sample of one or more types of white blood cells.

An apparatus for diffusion or staining and determination of sedimentation rate, comprising a first group (4) arranged to sample and perform a smear test on a blood sample in a test tube, and a second group (6) arranged to sample and perform a sedimentation rate determination on a blood sample in a test tube. The apparatus comprises at least one sampling member (8) which is controllable by said first group (4) and by said second group (6) to sample a blood sample, such that the sample taken for said first group (4) is not used by said second group (6) and the sample taken for said second group (6) is not used by said first group (4), said second group (6) being equipped with a sensor (20) comprising an infrared light source (12) and an optical sensor (14), said infrared light source (12) and said optical sensor (14) being arranged substantially opposite each other around a test tube (16) connected to an output of said at least one sampling member (8), such that light emitted by said infrared light source (12) reaches said optical sensor (14) after passing through said test tube (16). The apparatus further comprises a converter (10) arranged to receive one or more light transmission measurements from the optical sensor (14) and determine a sedimentation rate.

An object of the disclosure is to provide a technique in which when measuring a biological sample stored in a container, to which a label is attached, and separated into a plurality of component regions, a target portion that is a measurement target can be accurately specified regardless of an orientation of the label without using a large-sized imaging mechanism. A biological sample measuring device according to the disclosure specifies an upper surface boundary and a lower surface boundary of a measurement target portion by specifying an intermediate point of luminance values of a captured image, and applies a correction amount of a meniscus width to a position of the specified upper surface boundary (see FIG. 1).

The utility model provides a novel Westernstatten method erythrocyte sedimentation stand which is a cube. The novel Westernstatten method erythrocyte sedimentation stand comprises a base, wherein four adjusting screws are arranged below the base; the two sides and the back face of the upper portion of the base are each provided with a vertical supporting plate, and the whole blood sedimentation frame is firm and not prone to shaking due to the two layers of horizontal supporting plates. 50 punched fixing holes are formed in each layer of horizontal supporting plate; hole grooves corresponding to the fixing holes of the horizontal supporting plate are formed in the base, and the depth of the hole grooves is half of the thickness of the base. The fixing holes in the top-layer horizontal supporting plate are numbered from 1 to 50, a gradienter is arranged in the middle of the top-layer horizontal supporting plate, and the blood sedimentation frame is made of an acrylic material, so that the blood sedimentation frame is conveniently soaked and cleaned by a disinfectant; the double-layer horizontal supporting plate is arranged to ensure that the erythrocyte sedimentation tube can be perpendicular to the erythrocyte sedimentation frame and the result is accurate and reliable.

The present invention relates to a method for acquiring an image of a biological sample in a cuvette.

A container (30) is provided with an isolation chamber (33), a collection chamber (34), a waste liquid chamber (35), a siphon flow path (33a), and a siphon flow path (34a). The isolation chamber (33) holds a specific gravity adjusting agent (L2) and blood (L1), which have been layered. The collection chamber (34) holds a centrifuged mononuclear cell layer (L4), some of the specific gravity adjusting agent (L2), and plasma (L5), and allows the mononuclear cell layer (L4) to settle in a liquid after being suspended. The waste liquid chamber (35) holds the supernatant liquid of the suspension as waste liquid. The siphon flow path (33a) connects the isolation chamber (33) and the collection chamber (34), and uses siphoning to send a liquid containing the mononuclear cell layer (L4). The siphon flow path (34a) connects the collection chamber (34) and the waste liquid chamber (35), and uses siphoning to send the waste liquid.

An apparatus for performing a complete blood count and determining a sedimentation rate, comprising a first group (4) arranged to sample a blood sample from a tube and perform a complete blood count on said sample, and a second group (6) arranged to sample a blood sample from the tube and perform a sedimentation rate determination, the apparatus comprising at least one sampling member (8) which can be controlled for measurements by the first group (4) and by the second group (6) to sample a blood sample such that a sample sampled for the first group (4) is not used by the second group (6) and a sample sampled for the second group (6) is not used by the first group (4), the second group (6) being provided with a sensor (20) having an infrared light source (12) and an optical sensor (14) arranged substantially opposite each other around a tube (16) connected to an output end of the at least one sampling member (8), such that light emitted by the infrared light source (12) reaches the optical sensor (14) after traversing the tube (16). The apparatus further comprises a converter (10) arranged to receive one or more light transmission measurements from the optical sensor (14) and determine a sedimentation velocity.

An apparatus for analysing a sample, the apparatus comprising: a centrifuge rotor having an analysis site suitable for receiving a sample holder having an elongate sample chamber, the analysis site extending between an inner end, which is at a first distance from a centre of rotation of the rotor, and an outer end, which is at a second distance from the centre of rotation of the rotor, the inner end being closer to a centre of rotation of the rotor than the outer end; a carriage having an illumination arrangement and an image sensor; and a drive arrangement operable to drive the carriage along a trajectory with respect to the rotor, the trajectory extending between a first location which is relatively close to the centre of rotation of the rotor, and a second location which is relatively far from the centre of rotation of the rotor, the trajectory extending over at least part of the radial distance between the inner and outer ends of the analysis site; wherein the carriage is operable, at a plurality of locations along the trajectory, to illuminate a part of the analysis site with the illumination arrangement, and to capture an image of at least a portion of the illuminated part of the analysis site with the image sensor.

This invention belongs to the field of DNA detection technology, specifically a holographic dynamic analysis system for blood sedimentation assays. Addressing the limitation of existing systems that cannot simultaneously acquire high-dimensional dynamic phenotypic information (such as three-dimensional cell movement trajectories and instantaneous morphology) and corresponding molecular information (such as pathogen DNA and gene characteristics obtained through DNA detection) of the blood sedimentation process, and thus achieve automated correlation and intelligent interpretation between the two, thereby restricting the system's ability to directly infer microscopic etiologies from macroscopic sedimentation phenomena, this invention proposes the following solution. It includes a sample loading module connected to a sedimentation sample pool module. Through holographic dynamic three-dimensional analysis, simultaneous nucleic acid extraction and DNA detection, and multimodal AI fusion, this invention achieves correlation analysis and intelligent diagnosis of the blood sedimentation process from macroscopic dynamics to microscopic molecular mechanisms, significantly improving the system's ability to infer etiologies and support clinical decision-making.

The invention relates to the technical field of biomedical treatment, and discloses an erythrocyte sedimentation rate detection device and method and a storage medium, the erythrocyte sedimentation rate detection device comprises a controller, a sample introduction container, an optical detection instrument and a sample container provided with a sample pool communicated with the sample introduction container, the sample container is installed on the optical detection instrument, and the optical detection instrument is connected with the controller. The optical detection instrument comprises an optical measurement assembly and a movable light source assembly, the light source assembly and the optical measurement assembly are arranged on the two opposite sides of the sample cell respectively, the controller is connected with the optical measurement assembly and the light source assembly, and first light source information of light at the first height position is obtained through the optical detection instrument; and moving the optical detection instrument to obtain second light source information of the light at the second height position, and determining a sedimentation rate detection result of the to-be-detected blood according to the first light source information and the second light source information. The blood sedimentation rate detection efficiency is improved, and the accuracy of collected data is improved.

Apparatus and method for determining information associated with particles, such as cells, in a fluid, in which images are generated at various focal lengths / depths and various times, from which particle motion over time, and therefrom density and / or type, is determined for a plurality of individual cells, bacteria, platelets, etc.

This invention provides a means to obtain more clinically useful information when analyzing particles contained in blood samples using metachromatic positive dyes. In a particle analysis method for analyzing particles contained in blood samples, particles are stained with a metachromatic positive dye; the stained particles are irradiated with light; the intensity of a first fluorescence from the stacking component of the metachromatic positive dye and the intensity of a second fluorescence from the embedded component of the metachromatic positive dye are measured, the first and second fluorescence being emitted by each particle contained in the blood sample; the intensities of the first and second fluorescence emitted by each particle are normalized according to the size of each particle to obtain the fluorescence concentration of each of the first and second fluorescence in each particle; in a two-dimensional plot of the normalized fluorescence concentrations, each particle is clustered into multiple particle clusters, including at least two of erythrocyte clusters, platelet clusters, and nucleated cell clusters; and a histogram is created where the intensity of the first fluorescence is a histogram of the RNA amount of the class and the intensity of the second fluorescence is a histogram of the DNA amount of the class included in at least one of the multiple particle clusters.

Disclosed is a blood contamination detection apparatus. The blood contamination detection apparatus comprises a computer-based contamination determining module configured to receive: one or more baseline quantified test results on an uncontaminated blood sample obtained from a patient; one or more quantified test results for one or more analytes of a blood sample or a blood component; and data input on a type of IV fluid infusion that the patient has received that is able to affect the one or more quantified test results. The computer-based contamination determining module comprises a contamination determining routine executable on a computer and configured to compare differences between the one or more baseline quantified test results and the one or more quantified test results against preset threshold difference values and / or directions and provide a contamination output. Sample contamination detection method are provided, as are other aspects.

Embodiments of the present application disclose a sample analyzer, a signal acquisition method and a computer storage medium, so that the collected light signal does not cause adverse effects on the results of blood sedimentation analysis. Embodiments of the present application comprise: a control module controls the opening or closing of a light signal generation module, a light signal acquisition module and a heating module connected in communication therewith; the control module controls the light signal acquisition module to collect light signals outside the time period when the heating module brings interference signals; the collection of light signals can not be disturbed; the control module controls the light signal acquisition module to suspend the collection of light signals within the time period when the heating module brings interference signals, thereby avoiding the collection of disturbed light signals. Through the linkage control of the light signal acquisition module and other modules, pure and undisturbed light signals can be collected in the whole signal acquisition process, which is beneficial to the subsequent signal processing and analysis process.

The present disclosure provides impedance-based detection of nucleic acids for screening of cancer. The present disclosure is based on the use of impedance spectroscopy to detect nucleic acids in solution in the clinical concentration range, without using any labels, amplification steps, bioreceptors, surface modification or complex electrode geometries. More particularly, the present disclosure leverages the structural variations in nucleic acids of healthy and cancer patients, to classify samples as cancer-positive or cancer-negative purely based on their electrophysiochemical properties. The present disclosure also provides a simple rapid, label-free miniaturized biosensor for detection and screening of cancer.

Devices and methods of the disclosure use an intravascular catheter with deployable sealing elements to create a fluid trap around an outlet of a lymphatic duct and drain lymph passively to a collection vessel that may be pressurized to a predetermined pressure or a partial vacuum. Due to the fixed pressure, the device creates a low-pressure area at the lymphatic duct, which drains lymph passively without any mechanical pump or impeller. In certain aspects, a device includes a catheter for insertion into a vein of the venous angle of a patient, with proximal and distal sealing elements deployable to seal the vein to thereby define a fluid trap around the lymphatic outlet. A port within the fluid trap opens to a drainage lumen extending along the catheter to a collection vessel. The device may be configured such that the drainage lumen passively drains the fluid trap into the collection vessel.

A method for collecting plasma includes determining the weight and hematocrit of a donor, and inserting a venous-access device into the donor. The method then withdraws blood from the donor through a draw line connected to a blood component separation device, and introduces anticoagulant into the withdrawn blood. The blood component separation device separates the blood into a plasma component and a second blood component, and the plasma component is collected from the blood component separation device and into a plasma collection container. The method may then calculate (1) a percentage of anticoagulant in the collected plasma component, and (2) a volume of pure plasma collected within the plasma collection container. The volume of pure plasma may be based, at least in part, on the calculated percentage of anticoagulant. The method may continue until a target volume of pure plasma is collected within the plasma collection container.