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Patient sample classification based upon low angle light scattering

Inactive Publication Date: 2007-03-08
ORTHO-CLINICAL DIAGNOSTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0028] Yet another advantage of the present invention is that the herein described system and method can be added to already existing equipment without significant modification thereto.
[0029] Yet another advantage of the present invention is that the above described method provides an effective qualitative determination of agglutination strength.

Problems solved by technology

As a consequence, a number of characteristics of the systems, while supporting the manual determination of a positive reaction, do not support facile automation.
Automated reading of the distribution of red color is complex and requires a vision system that is coupled with relatively sophisticated software algorithms in order to appropriately classify the wide range of color distribution patterns that can be encountered.

Method used

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  • Patient sample classification based upon low angle light scattering
  • Patient sample classification based upon low angle light scattering
  • Patient sample classification based upon low angle light scattering

Examples

Experimental program
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Embodiment Construction

[0042] The following description relates to certain preferred embodiments of the present invention, and to a particular methodology for blood typing by detection of agglutination strength by means of a low angle light scattering / detection system. As will be readily apparent from the discussion, the inventive concepts described herein can also be suitably applied to other reaction processes in addition to blood typing to detect antigens, antibodies, proteins, viruses, and the like wherein a reaction can create a moving flow field. In addition, such terms as “top”, “bottom”, “lateral”, “above”, “below” and the like are also used in order to provide a convenient frame of reference for use with the accompanying drawings. These terms, unless stated specifically otherwise, however, are not intended to be limiting of the present invention.

[0043] Referring to FIG. 1, the results of a prior art blood typing system are herein described briefly for purposes of background. In this system, as m...

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Abstract

An apparatus for classifying a liquid patient sample includes at least one sample container having a quantity of a sample that is aggressively acted upon so as to create a flow field. A measurement mechanism includes at least one low angle light emitter aligned with a measurement window of the at least one sample container and a detector oppositely disposed relative to the measurement window. Measurement of the scattered light detects particle characteristics of a moving flow field from the sample to determine, for example, the amount of agglutination of the sample so as to perform blood typing or other classifications without spatial separation.

Description

CROSS REFERENCE TO RELATED APPLICATION [0001] This application is based upon a provisional application, U.S. Ser. No. 60 / 513,753 filed Oct. 23, 2003, the entire contents of which are incorporated herein by reference.FIELD OF THE INVENTION [0002] The invention is directed to the field of clinical chemistry and more particularly to apparatus and a related method for blood typing patient samples. BACKGROUND OF THE INVENTION [0003] Currently known column blood-typing systems, including, for example, the AutoVue systems manufactured by Ortho Clinical Diagnostics Inc., of Raritan, N.J., among others, were originally optimized for manual testing. As a consequence, a number of characteristics of the systems, while supporting the manual determination of a positive reaction, do not support facile automation. [0004] First, agglutination strength is determined in a manner that is optimized for a subjective visual read. This determination is based upon a perceived distribution of red color from ...

Claims

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Application Information

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IPC IPC(8): G01N33/86G01N15/00G01N15/02G01N15/04G01N33/49G01N33/80
CPCG01N15/0211G01N33/80G01N33/4905G01N15/042G01N15/05
Inventor JACOBS, MERRIT N.SUNDBERG, MICHAEL W.DING, ZHONG
Owner ORTHO-CLINICAL DIAGNOSTICS
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