Microchip and blood monitoring device

A micro-chip technology, applied in measuring devices, biological testing, transportation and packaging, etc., can solve the problems of blood coagulation, large micro-chips, difficult to observe, etc., to achieve longer residence time, prevent blood coagulation, and inhibit blood coagulation The effect of activation

Active Publication Date: 2010-10-27
FUJIMORI KOGYO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if these stirring members proposed above are used to stir liquids such as whole blood, platelet-rich plasma, and their drug treatment liquids in microchips, activation is sometimes caused to cause blood coagulation, etc., for example, in When observing blood coagulation or platelet function, etc., it is difficult to accurately observe
In addition, although it is conceivable to make the liquid in the microchips mix naturally by making the flow path longer, this will cause the microchips to become larger
In addition, in order to prevent the microchip from becoming larger, if the flow path is bent many times into a zigzag shape, the area where the liquid stays is activated, and blood coagulation and other phenomena occur, making accurate observation impossible.

Method used

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  • Microchip and blood monitoring device
  • Microchip and blood monitoring device
  • Microchip and blood monitoring device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0225] Fabrication of microflakes and blood observation devices

[0226] prepare as figure 1 The first substrate 100 shown in (A) and the figure 1 The second substrate 110 shown in (B) is two transparent substrates (injection molded products manufactured by Richell Corporation). The flow path opening side of the first substrate 100 is opposed to the opening side of the second substrate 110 which is the hole of the stirring part 113, and they are laminated using an adhesive, as figure 1 (C), figure 1 (D) Microflake 1 shown. Furthermore, the depth of each flow path was 0.12 mm, the width of the first flow path 101 was 1.2 mm, and the width of the constricted part of the joining flow path 103 was 0.3 mm. The stirrer 117 is a cylindrical shape with a diameter of 1 mm and a length of 2 mm formed by covering an iron cylinder with PVLA, and the stirrer 117 is accommodated in the stirring unit 113 . The hole serving as the stirring portion 113 is a through hole having a circula...

Embodiment 2

[0233] microflakes

[0234] prepare as figure 2 The first substrate 200 shown in (A) and the figure 2 The second substrate 210 shown in (B) is two transparent substrates (injection molded products manufactured by Fluidware Technologies Inc.) and a transparent acrylic plate such as figure 2 (C) shows the third substrate 220 . The opening surface of the flow path of the first substrate 200 is opposed to the opening surface of the second substrate 210 which is the hole of the stirring part 213, and they are laminated with an adhesive. The opening of the hole of the stirring part 213 of the second substrate 200 is closed by the third substrate 220 using an adhesive, as figure 2 (D) and figure 2 (E) Microflake 2 shown. Furthermore, the thickness of the second substrate 210 is 1.2 mm, which matches the depth of the hole serving as the stirring part 213 . The hole as the stirring part 213 of the second substrate 210 is as follows figure 2 (B) and figure 2 The shape s...

Embodiment 3

[0239] Except that the stirring part 213 of the second substrate 210 in Example 2 is a single circular through hole with an inner diameter of 3 mm, the microchip 2 and the blood observation device were produced in the same manner as in Example 2, and were confirmed in the same manner as in Example 2. Mixed State Experiments. As a result, although the two liquids are uniformly mixed, air remains in the stirring part.

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Abstract

A microchip which comprises therein a first channel for the inflow of a first liquid selected from among whole blood, platelet-rich plasma or a liquid prepared by treating the same with a chemical, a second channel connected to the first channel for the inflow of a second liquid containing a chemical capable of reacting with the first liquid as described above, and a confluence channel extended from the connection section of the first channel with the second channel, characterized in that a stirring section provided with a stirrer for mixing the above-described first liquid with the above-described second liquid is provided in the confluence channel as described above, and a blood monitoring device using the microchip.

Description

technical field [0001] The present invention relates to a sheet for effectively mixing a small amount of blood and a drug to examine the reactivity or properties of blood, and more specifically, to a microchip for observing blood such as blood coagulation ability or platelet function , and a blood observation device using the microchip. Background technique [0002] Myocardial infarction and other atherosclerotic (atheroma) thrombosis is the rupture of atherosclerotic plaque on the site of arteriosclerosis, platelets adhere to the collagen containing tissue factor exposed to the blood stream, platelets re-aggregate, complex Causes the activation of the blood coagulation system, resulting in the generation of occlusive severe thrombus. In Japan, death due to heart disease such as myocardial infarction is the second most common cause of death, making it a serious disease. [0003] However, in myocardial infarction and the like, thrombus is continuously formed only in the art...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/86G01N33/48G01N35/02G01N35/08G01N37/00
CPCA61B5/14546B01L3/5027G01N1/38B01F5/0646B01F5/0654G01N33/4905B01F13/0059B01F25/4337B01F25/433B01F33/30
Inventor 细川和也和田朋子
Owner FUJIMORI KOGYO CO LTD
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