The invention relates to a kind of flour, in particular to a coarse grain mixed bean flour, wherein, the mixed bean flour comprises brown rice flour, corn flour, black rice flour, black sesame powder, soybean powder, peanut powder, millet flour, sorghum flour, potato powder, sunflower seed powder, walnut powder, pine nut powder, lotus seed powder, and Gordon euryale seed powder; or the mixed bean flour comprises wheat kernel powder, black sesame powder, soybean flour, peanut flour, sunflower seed powder, walnut powder and pine nut powder; or the mixed bean flour comprises brown rice flour, pearl barley powder, lotus seed powder and Gordon euryale seed powder. The preparation method of the coarse grain mixed bean flour adds three processing procedures on the processing method of ordinary flour production, namely, stir-frying, weighing and mixing. The coarse grain mixed bean flour has good therapeutic effects on abnormal blood glucose, whole-blood viscosity, ESR erythrocyte sedimentation rate, erythrocyte sedimentation rate equation K and other indexes; besides, the raw materials of the mixed bean flour are reasonably matched and low in price as well as rich in taste; the coarse grain mixed bean flour can be consumed by people of various ages and is an ideal product to replace the existing flour made of single material.