17 results about "Dengue fever" patented technology

The invention relates to the technical field of computers, and discloses a multi-mode risk layering system and method and terminal equipment. The system comprises a feature module used for carrying out feature extraction on a target part image to obtain an image feature vector; the vector module is used for determining a sign feature vector based on the static sign data and the dynamic sign data of the target object; the conversion module is used for converting the acquired inquiry information into text feature vectors according to reference semantics in an infectious disease semantic library; the fusion module is used for fusing the text feature vector, the image feature vector and the sign feature vector to obtain a fused feature vector; and the evaluation module is used for processing the fusion feature vector through a danger calculation model to obtain a danger evaluation result. By adopting the system, intelligent, multi-mode, interpretable and low-delay continuous evaluation of risk levels of patients with infectious diseases such as dengue fever and the like can be realized.

The invention relates to an immunoassay reagent for dengue fever NS1 antigen detection and a preparation method thereof. According to the self-driven micro-fluidic chip, an up-conversion luminescent nano material (UCP) is adopted to mark a dengue fever NS1 antigen specific antibody. The invention further relates to a testing and using method of the up-conversion luminescence method self-driven micro-fluidic chip, the method is used for quantitatively determining the content of the dengue NS1 antigen, the method has the advantages of being short in detection period, high in sensitivity and low in background interference, and support is provided for prevention, diagnosis and treatment of dengue.

The application discloses a dengue fever prediction and early warning system based on heterogeneous data fusion and a graph neural network, and relates to the technical field of infectious disease prediction and early warning. The data acquisition module is used for acquiring case data, meteorological data, remote sensing vegetation index data, population flow data and social media sentiment data. The dengue fever prediction and early warning system based on heterogeneous data fusion and the graph neural network effectively improves the accuracy and precision of dengue fever epidemic prediction by integrating multi-source heterogeneous data and constructing a dynamic multi-dimensional graph structure for spatio-temporal coupling prediction. The use of a graph attention network and a time convolution network captures complex spatial dependence and temporal dynamics, and the use of a parallel model cross-verification and arbitration mechanism enhances the reliability of the prediction results, improves the sensitivity and stability of risk identification, and reduces false positives.

The invention relates to a mosquito and egg trapping solution, and solves the problems of high monitoring cost and low monitoring efficiency of aedes albopictus in the prior art. The mosquito and egg trapping solution is prepared by fermenting 3%-10% by mass of bamboo leaf powder and 90%-97% by mass of water in a natural environment at the temperature of 20-24 DEG C for 24-96 hours. The preparation method comprises the following steps: step A, collecting bamboo leaves and drying; step B, grinding the dried bamboo leaves into powder; and step C, uniformly mixing 3%-10% by mass of bamboo leaf powder and 90%-97% by mass of water, and fermenting in a natural environment at the temperature of 20-24 DEG C for 24-96 hours. The Aedes albopictus monitoring device is simple in structure, easy in material taking and simple to manufacture, especially the Aedes albopictus can achieve the spawning effect of dozens of times of clear water within one day, the Aedes albopictus monitoring efficiency is greatly improved, meanwhile, dengue fever can be timely and accurately pre-warned and forecasted, the cost is low, and monitoring is convenient and efficient. In addition, the mosquito killer can be daily used for luring and killing mosquitoes.

The application relates to a dengue fever risk prediction method and device based on multi-dimensional index fusion. The application comprises the following steps: in response to a risk prediction instruction, a plurality of characteristic indexes uploaded by a client are acquired, and the missing proportion of the characteristic indexes is determined; different characteristic processing is performed according to different missing proportions of the characteristic indexes; pathological correlation characteristics are determined according to a pathological mechanism related to dengue fever; the characteristic indexes and the pathological correlation characteristics are input into a preset risk prediction model to obtain a dengue fever risk prediction result output by the risk prediction model. Through the fusion of multi-dimensional indexes, fine missing data processing and feature engineering driven by a pathological mechanism, a robust and accurate dengue fever risk prediction system is constructed, the system can solve the problems of incomplete indexes, improper data processing and insufficient model performance in the prior art, and provides auxiliary information with guiding significance for doctors.

The rapid dengue fever detection kit comprises a kit body, the upper end face of the kit body is provided with a window and a sample adding hole, a rotating rod is arranged in a sliding groove in a sliding and rotating mode, a limiting rod is installed above the end face of the kit body, the outer wall of the limiting rod is in a U shape, the limiting rod is arranged in an inclined mode, and the outer wall of the limiting rod is in a U shape. One end of the limiting rod vertically extends to the end face of the kit body, and limiting mechanisms for limiting the guide ring and the dustproof cover are mounted on the outer walls of the guide ring and the dustproof cover. By arranging the guide ring, the limiting rod, the dustproof cover and other components, it is ensured that the dropper is always accurately aligned with the sample adding hole in the sample adding process, reagents are prevented from being scattered or polluting the peripheral area, meanwhile, the dustproof cover is tightly attached to the sample adding hole through the elastic reset force of the spring in the non-sample adding stage, a dynamic sealing barrier is formed, and the sample adding effect is improved. External environmental pollution is effectively isolated, and the reliability of a detection result and the reagent utilization rate are remarkably improved.

The present invention refers to a process for preparing an attenuated tetravalent dengue vaccine and its product. The present invention also refers to a process for preparing a tetravalent dengue vaccine for administration to a subject, to a method for inducing an immune response to virus dengue serotype 1, 2, 3 and 4 in a patient and to a tetravalent dengue vaccine kit.

The present application provides nucleoside analog compounds of Formula I-V for use in the treatment of dengue (DF). The present application further provides compositions and combinations thereof and methods of treating dengue fever using the nucleoside compounds of Formula I-V and compositions and combinations thereof.

This invention provides a method for prioritizing dengue fever prevention and control at the individual building scale. Using grid cells as the basic spatial unit, this invention calculates urban morphology type, meteorological factors, and socioeconomic factors, and constructs classification target variables by combining local dengue fever case data. Based on the influencing factor data and classification target variables, an interpretable machine learning model is constructed to predict the risk of dengue fever occurrence, draw a risk map, and identify potential high-risk areas. Furthermore, individual building attribute data within potential high-risk areas are obtained, and building weights are constructed by comprehensively considering building volume, social function attributes, and building aging effects. Risk is then allocated to the grid risk using a risk conservation principle to obtain the relative dengue fever risk of individual buildings and to classify building prevention and control priority levels. This invention can reveal the correlation between urban morphology type and dengue fever occurrence risk, improving the precision of risk identification and prevention and control positioning.

The invention relates to the field of traditional Chinese medicines, in particular to a pharmaceutical composition for treating fever symptoms of dengue fever. The composition is prepared by compatibility of cyperus rotundus, pseudo-ginseng, sargentgloryvine stem, sargentgloryvine stem, dutchmanspipe root, costus root, Zhenmei borneol and fresh pteris multifida according to a specific proportion, and quick fever abatement and symptom relief are realized by accurately controlling a medicinal material processing technology, a grinding mode and a mixing taking condition. Rapid control of dengue fever is achieved through multi-target intervention (clearing away heat and toxic materials, promoting blood circulation to remove blood stasis and regulating qi and blood), the problems of liver and kidney toxicity and drug resistance of chemical drugs are avoided, and the traditional Chinese medicine composition is particularly suitable for emergency treatment in areas lack of medical resources and has the advantages of being high in safety, easy and convenient to prepare and high in adaptability.

The invention discloses a dengue virus NS1 antibody and application thereof. The antibody provided by the invention has good binding activity and high specificity to the dengue virus NS1 protein, provides an efficient and accurate detection tool for primary medical institutions and epidemic situation field screening, provides a new powerful means for prevention and control work of dengue fever, and has a wide application prospect.

A method of treating a viral disease associated with targeting of PDZ domain proteins by a viral disease-inducing virus, in a subject in need of such therapy, comprising administering to the subject an inhibitor of at least one of 20s proteasome subunit β6 (Prosβ6), 20s proteasome subunit β2 (Prosβ2), and β-Transducin repeat-containing protein (βTrCP), thereby causing the death of cells that have been infected by the viral disease-inducing virus. The viral disease-inducing virus may be, for example, HPV, Adenovirus, Influenza A, HTLV-1, HIV, West Nile, Dengue, or SARS-CoV. Hie HPV may be a high-risk HPV strain such as HPV strain 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, or 68. The viral disease may be an HPV-induced cancer.

The present invention provides advantageous high-dose therapeutic compositions and combinations to treat or prevent Dengue virus infections that may be serotype 1, 2, 3 or 4 as well as a process of manufacture.

The portable dengue fever antibody rapid detection pen comprises a fixed shell, a movable shell, a plurality of pieces of detection test paper and a display assembly, openings are formed in the fixed shell and the movable shell, the display assembly and glass are arranged in one of the openings, a contact groove corresponding to the detection test paper is formed in the display assembly, and the glass is arranged in the contact groove. A portable frame is installed on the fixed shell, a connecting ring is arranged on the movable shell, a connecting groove is formed in the fixed shell, and an upper top groove is formed in the connecting ring. The detection pen is provided with six pieces of detection test paper, six times of detection can be carried out, the whole detection pen does not need to be frequently replaced, the cost is reduced, and meanwhile the detection requirement for a plurality of samples in the same detection scene can be met.

A dengue vaccine for use in a method of protecting against dengue disease in a pregnant and / or breastfeeding human subject.

A combination of sodium thiosulfate, zinc and magnesium and, optionally, Vitamin C is used to treat dengue fever. The components may be used or ingested or administered either simultaneously or sequentially in about 30 minutes separate administration. These Supplements are used to replace the zinc and magnesium which may be depleted from the body during treatment. Also, Vitamin C is used as an anti-viral composition. In cases where the patient is critically ill, a quantity of acetylsalicylic acid is administered.