37 results about "Dengue fever" patented technology

The invention relates to the technical field of disease prevention and control, in particular to a dengue epidemic situation intelligent prediction and early warning system based on multi-source monitoring data, comprising a prediction and early warning system for monitoring, predicting and early warning the dengue epidemic situation, the prediction and early warning system comprising: a data acquisition module for collecting multi-source monitoring data related to the dengue epidemic situation; the data processing module is used for cleaning, integrating and standardizing the collected original data to form a data set which can be used for analysis and prediction; the information early warning module is used for carrying out deep analysis on the processed data by utilizing a big data analysis technology and an intelligent algorithm, establishing a prediction model and predicting the epidemic trend and risk of the dengue epidemic situation; according to the system, through multi-region mosquito-borne monitoring points and integration of data in multiple fields of hospitals, disease control centers, meteorology, telecom operators, social media platforms and the like, a big data analysis technology and an intelligent algorithm are applied, and the dengue epidemic situation prediction accuracy is greatly improved.

This invention relates to herbal medicine compositions for the treatment of dengue and their production. The herbal medicine compositions consist of dried and finely powdered leaves of Lagerstroemia speciosa; dried and finely powdered aerial parts of Euphorbia hirta; dried and finely powdered rhizome of Zingiber officinale; and a fixed-dose combination of all three. In another version of the formulation, the spray-dried aqueous, ethanolic, methanolic or hydroalcoholic extract of the mentioned plants were used instead.

The invention relates to the technical field of computers, and discloses a multi-mode risk layering system and method and terminal equipment. The system comprises a feature module used for carrying out feature extraction on a target part image to obtain an image feature vector; the vector module is used for determining a sign feature vector based on the static sign data and the dynamic sign data of the target object; the conversion module is used for converting the acquired inquiry information into text feature vectors according to reference semantics in an infectious disease semantic library; the fusion module is used for fusing the text feature vector, the image feature vector and the sign feature vector to obtain a fused feature vector; and the evaluation module is used for processing the fusion feature vector through a danger calculation model to obtain a danger evaluation result. By adopting the system, intelligent, multi-mode, interpretable and low-delay continuous evaluation of risk levels of patients with infectious diseases such as dengue fever and the like can be realized.

A production device, method and application of nano-sized zinc molybdate. The device includes a double-cone mixer; an elevator is obliquely provided at a bottom of a discharge port of the double-cone mixer; a rear end of the elevator is located above a feeder; the feeder is connected to one end of an electric heating converter, an other end of the electric heating converter is connected to a finished product bin; a top of the finished product bin is provided with an atomizing nozzle for adding nanomaterial dispersant; the atomizing nozzle is connected to a syringe pump by pipeline. High-purity nano-sized molybdenum trioxide and nano-sized zinc oxide are adopted to synthesize nano-sized zinc molybdate in an electric heating converter. The nano-sized zinc molybdate prepared by the device and method can be used for treatment of African swine fever virus, coronavirus, and AIDS phase I, Ebola, dengue fever, polio viruses.

The invention relates to an immunoassay reagent for dengue fever NS1 antigen detection and a preparation method thereof. According to the self-driven micro-fluidic chip, an up-conversion luminescent nano material (UCP) is adopted to mark a dengue fever NS1 antigen specific antibody. The invention further relates to a testing and using method of the up-conversion luminescence method self-driven micro-fluidic chip, the method is used for quantitatively determining the content of the dengue NS1 antigen, the method has the advantages of being short in detection period, high in sensitivity and low in background interference, and support is provided for prevention, diagnosis and treatment of dengue.

The application discloses a dengue fever prediction and early warning system based on heterogeneous data fusion and a graph neural network, and relates to the technical field of infectious disease prediction and early warning. The data acquisition module is used for acquiring case data, meteorological data, remote sensing vegetation index data, population flow data and social media sentiment data. The dengue fever prediction and early warning system based on heterogeneous data fusion and the graph neural network effectively improves the accuracy and precision of dengue fever epidemic prediction by integrating multi-source heterogeneous data and constructing a dynamic multi-dimensional graph structure for spatio-temporal coupling prediction. The use of a graph attention network and a time convolution network captures complex spatial dependence and temporal dynamics, and the use of a parallel model cross-verification and arbitration mechanism enhances the reliability of the prediction results, improves the sensitivity and stability of risk identification, and reduces false positives.

The invention relates to a mosquito and egg trapping solution, and solves the problems of high monitoring cost and low monitoring efficiency of aedes albopictus in the prior art. The mosquito and egg trapping solution is prepared by fermenting 3%-10% by mass of bamboo leaf powder and 90%-97% by mass of water in a natural environment at the temperature of 20-24 DEG C for 24-96 hours. The preparation method comprises the following steps: step A, collecting bamboo leaves and drying; step B, grinding the dried bamboo leaves into powder; and step C, uniformly mixing 3%-10% by mass of bamboo leaf powder and 90%-97% by mass of water, and fermenting in a natural environment at the temperature of 20-24 DEG C for 24-96 hours. The Aedes albopictus monitoring device is simple in structure, easy in material taking and simple to manufacture, especially the Aedes albopictus can achieve the spawning effect of dozens of times of clear water within one day, the Aedes albopictus monitoring efficiency is greatly improved, meanwhile, dengue fever can be timely and accurately pre-warned and forecasted, the cost is low, and monitoring is convenient and efficient. In addition, the mosquito killer can be daily used for luring and killing mosquitoes.

The invention relates to a method for preventing dengue disease and hepatitis A in a subject or subject population by simultaneously administering a unit dose of a dengue vaccine composition and a hepatitis A vaccine on the same day. The unit dose of a dengue vaccine composition includes constructs of each dengue serotype, such as TDV-1, TDV-2, TDV-3 and TDV-4, at various concentrations in order to improve protection from dengue infection.

The application discloses a dengue fever prediction method and device considering extreme weather driving and a medium. The method comprises the following steps: acquiring case data and multi-source data of a target area, wherein the multi-source data comprises meteorological data, environmental data and socio-economic data; constructing extreme weather characteristics according to the meteorological data and a preset extreme weather threshold; obtaining epidemic spatiotemporal lag data according to the spatial autocorrelation relationship and the temporal autocorrelation relationship of the case data; adding the epidemic spatiotemporal lag term in a zero-inflated negative binomial regression model to obtain an initial epidemic prediction model; the epidemic prediction model comprises a quadratic term of the extreme weather characteristics; and performing parameter fitting on the initial epidemic prediction model based on the case data, the extreme weather characteristics, the epidemic spatiotemporal lag data and the multi-source data to obtain a fitted epidemic prediction model, so as to predict future epidemics. The application can effectively improve the credibility of regional dengue fever epidemic prediction under the background of climate change.

The invention discloses a dengue fashion trend prediction method and device, electronic equipment and a computer storage medium. The dengue epidemic trend prediction method comprises the following steps: S1, collecting dengue historical case data, meteorological data, mosquito-borne monitoring data and social attention data; preprocessing the dengue history case data, the meteorological data, the mosquito-borne monitoring data and the social attention data; s2, inputting the meteorological data into an SARIMA model for prediction to obtain a predicted meteorological variable result; s3, combining the meteorological variable prediction result with mosquito-borne monitoring data and social attention data to construct a multiple regression model, training by using a least square method, estimating regression coefficients of respective variables, and minimizing prediction errors of the model; and S4, applying the trained multiple regression model to regional dengue prediction, and predicting the number of future dengue cases. The method can accurately predict the trend of the dengue fever.

The application relates to a dengue fever risk prediction method and device based on multi-dimensional index fusion. The application comprises the following steps: in response to a risk prediction instruction, a plurality of characteristic indexes uploaded by a client are acquired, and the missing proportion of the characteristic indexes is determined; different characteristic processing is performed according to different missing proportions of the characteristic indexes; pathological correlation characteristics are determined according to a pathological mechanism related to dengue fever; the characteristic indexes and the pathological correlation characteristics are input into a preset risk prediction model to obtain a dengue fever risk prediction result output by the risk prediction model. Through the fusion of multi-dimensional indexes, fine missing data processing and feature engineering driven by a pathological mechanism, a robust and accurate dengue fever risk prediction system is constructed, the system can solve the problems of incomplete indexes, improper data processing and insufficient model performance in the prior art, and provides auxiliary information with guiding significance for doctors.

The invention relates to compounds that are inhibitors of Flavivirus NS2B-NS3 proteases and inhibit replication of flavivirus in cells. Compounds of this invention are useful alone or in combination with other agents for use in the treatment of infections caused by Flaviviruses, in particular by Dengue, West Nile, Zika, Japan Encephalitis viruses.

The invention relates to an insecticidal varnish composed of a colourless, water-based acrylic copolymer with a satin finish and very low odour, the aqueous formulation of which contains microcapsules of lambda-cyhalothrin (C23H19ClF3NO3 - alpha-cyano-3-phenoxybenzyl-3-(2-chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarboxylate) in concentrations ranging from 0.001% w / w to a permitted maximum of 10% w / w, which, when broken by mechanical contact, release the insecticide slowly, gradually and safely, making the surface lethal to insects, with mortality efficacy levels of 100% in 24 hours for the dengue mosquito (Aedes aegypt) and 82.5% in 72 hours for cockroaches (Periplaneta americana).

The rapid dengue fever detection kit comprises a kit body, the upper end face of the kit body is provided with a window and a sample adding hole, a rotating rod is arranged in a sliding groove in a sliding and rotating mode, a limiting rod is installed above the end face of the kit body, the outer wall of the limiting rod is in a U shape, the limiting rod is arranged in an inclined mode, and the outer wall of the limiting rod is in a U shape. One end of the limiting rod vertically extends to the end face of the kit body, and limiting mechanisms for limiting the guide ring and the dustproof cover are mounted on the outer walls of the guide ring and the dustproof cover. By arranging the guide ring, the limiting rod, the dustproof cover and other components, it is ensured that the dropper is always accurately aligned with the sample adding hole in the sample adding process, reagents are prevented from being scattered or polluting the peripheral area, meanwhile, the dustproof cover is tightly attached to the sample adding hole through the elastic reset force of the spring in the non-sample adding stage, a dynamic sealing barrier is formed, and the sample adding effect is improved. External environmental pollution is effectively isolated, and the reliability of a detection result and the reagent utilization rate are remarkably improved.

The present invention relates to the use of a combination comprising Compound A selected from a compound of formula (I) or (I'): (I) (I') wherein R1, R2, R3, R1', R2', R3',and R4' have the same meaning as that defined in the claims and the description, or a stereo-isomeric form, a pharmaceutically acceptable salt, solvate or polymorph thereof and Compound B or a stereo- isomeric form, a pharmaceutically acceptable salt, solvate or polymorph thereof. The present invention also relates to compositions, in particular pharmaceuticals, comprising such combination, and to uses and methods of treatment of such combinations and compositions in the prevention and / or treatment of dengue viral infections.

The present disclosure provides compounds for the treatment of a variety of diseases such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola virus, Zika virus, West Nile virus, Dengue fever, and HCV.

The utility model discloses a dengue fever NS1 antigen detection kit, which comprises a kit main body and test paper, the inner side of the kit main body is fixedly connected with the test paper, the inner side of a sample adding hole of the kit main body is provided with a diversion column, and the bottom end of the diversion column penetrates through the test paper and is fixedly connected with the inner side of the bottom end of the kit main body. A through hole is formed in the inner side of the flow guide column, the flow guide column is slidably connected with a pricking needle through the through hole, blood flowing out of fingers can quickly flow to the inner side of the sample adding hole along the flow guide column and the flow guide ribs, blood vessels do not need to be transferred through a suction pipe, primary use of non-professional personnel is facilitated, the fingers face downwards when blood is added, and the blood sampling efficiency is improved. The blood can be blocked by fingers, so that the time for seeing the blood by a user is shortened, the device is also convenient for the user who sees the blood and feels uncomfortable to use, the pricking needle and the kit main body are combined into a whole, a suction tube is not used, and the device is also convenient for the user to carry and store.

The invention relates to compounds that are inhibitors of Flavivirus NS2B-NS3 proteases and inhibit replication of flavivirus in cells. Compounds of this invention are useful alone or in combination with other agents for use in the treatment of infections caused by Flaviviruses, in particular by Dengue, West Nile, Zika, Japan Encephalitis viruses.

The present invention refers to a process for preparing an attenuated tetravalent dengue vaccine and its product. The present invention also refers to a process for preparing a tetravalent dengue vaccine for administration to a subject, to a method for inducing an immune response to virus dengue serotype 1, 2, 3 and 4 in a patient and to a tetravalent dengue vaccine kit.

The present application provides nucleoside analog compounds of Formula I-V for use in the treatment of dengue (DF). The present application further provides compositions and combinations thereof and methods of treating dengue fever using the nucleoside compounds of Formula I-V and compositions and combinations thereof.

This invention provides a method for prioritizing dengue fever prevention and control at the individual building scale. Using grid cells as the basic spatial unit, this invention calculates urban morphology type, meteorological factors, and socioeconomic factors, and constructs classification target variables by combining local dengue fever case data. Based on the influencing factor data and classification target variables, an interpretable machine learning model is constructed to predict the risk of dengue fever occurrence, draw a risk map, and identify potential high-risk areas. Furthermore, individual building attribute data within potential high-risk areas are obtained, and building weights are constructed by comprehensively considering building volume, social function attributes, and building aging effects. Risk is then allocated to the grid risk using a risk conservation principle to obtain the relative dengue fever risk of individual buildings and to classify building prevention and control priority levels. This invention can reveal the correlation between urban morphology type and dengue fever occurrence risk, improving the precision of risk identification and prevention and control positioning.

The invention relates to the field of traditional Chinese medicines, in particular to a pharmaceutical composition for treating fever symptoms of dengue fever. The composition is prepared by compatibility of cyperus rotundus, pseudo-ginseng, sargentgloryvine stem, sargentgloryvine stem, dutchmanspipe root, costus root, Zhenmei borneol and fresh pteris multifida according to a specific proportion, and quick fever abatement and symptom relief are realized by accurately controlling a medicinal material processing technology, a grinding mode and a mixing taking condition. Rapid control of dengue fever is achieved through multi-target intervention (clearing away heat and toxic materials, promoting blood circulation to remove blood stasis and regulating qi and blood), the problems of liver and kidney toxicity and drug resistance of chemical drugs are avoided, and the traditional Chinese medicine composition is particularly suitable for emergency treatment in areas lack of medical resources and has the advantages of being high in safety, easy and convenient to prepare and high in adaptability.

The invention discloses a dengue prediction method and device considering extreme weather driving and a medium, and the method comprises the steps: obtaining case data and multi-source data of a target region, the multi-source data comprising meteorological data, environmental data and social economic data; according to the meteorological data and a preset extreme weather threshold value, constructing extreme weather characteristics; obtaining epidemic situation time-space lag data according to the spatial autocorrelation and the time autocorrelation of the case data; adding an epidemic situation time-space lag item into the zero-expansion negative binomial regression model to obtain an initial epidemic situation prediction model; the epidemic situation prediction model comprises quadratic terms of extreme weather characteristics; and performing parameter fitting on the initial epidemic situation prediction model based on case data, extreme weather characteristics, epidemic situation time-space lag data and multi-source data to obtain a fitted epidemic situation prediction model so as to predict future epidemic situations. According to the method, the credibility of regional dengue epidemic situation prediction under the climate change background can be effectively improved.

The invention discloses a dengue virus NS1 antibody and application thereof. The antibody provided by the invention has good binding activity and high specificity to the dengue virus NS1 protein, provides an efficient and accurate detection tool for primary medical institutions and epidemic situation field screening, provides a new powerful means for prevention and control work of dengue fever, and has a wide application prospect.

A method of treating a viral disease associated with targeting of PDZ domain proteins by a viral disease-inducing virus, in a subject in need of such therapy, comprising administering to the subject an inhibitor of at least one of 20s proteasome subunit β6 (Prosβ6), 20s proteasome subunit β2 (Prosβ2), and β-Transducin repeat-containing protein (βTrCP), thereby causing the death of cells that have been infected by the viral disease-inducing virus. The viral disease-inducing virus may be, for example, HPV, Adenovirus, Influenza A, HTLV-1, HIV, West Nile, Dengue, or SARS-CoV. Hie HPV may be a high-risk HPV strain such as HPV strain 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, or 68. The viral disease may be an HPV-induced cancer.

Methods for treating hyperinflammatory conditions such as hemophagocytic lymphohistiocytosis (HLH), dengue hemorrhagic fever, and dengue shock syndrome using lipid binding protein-based complexes.

To provide a novel marker having a diagnostic and prognostic added value compared to a commonly used NS1 marker, in particular, enable better medical care for patients at risk of developing severe dengue, and reduce mortality.SOLUTION: The present invention relates to a method for early detection, monitoring and prognosis of flavivirus-induced infection, comprising detecting a complex formed in a biological sample by flavivirus nonstructural glycoprotein NS1 and plasma lipoprotein particles during the clinical phase of infection.SELECTED DRAWING: Figure 5-1

The present invention provides advantageous high-dose therapeutic compositions and combinations to treat or prevent Dengue virus infections that may be serotype 1, 2, 3 or 4 as well as a process of manufacture.

Provided is an isolated binding protein including an antigen binding domain binding to an NS1 protein, and including specific heavy chain CDR and light chain CDR. The binding protein can specifically identify and bind to NS1, and has relatively high sensitivity and specificity, so as to detect dengue vims. Moreover, the binding protein does not need to be produced by injecting hybridoma cells into mouse peritoneal cavity, while simplifying production, thus stabilizing antibody functionality.